{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T00:56:02Z","timestamp":1794617762923,"version":"4.9.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"21","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100006755","name":"ASU | School of Life Sciences, Arizona State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006755","id-type":"DOI","asserted-by":"publisher"}]},{"name":"- School of Life Science, University of Sussex (UK) - AURCIL Association in Tours"},{"name":"Ligue Nationale Contre le Cancer \u2013 Interr\u00e9gion Grand-Ouest"},{"name":"Prix Ruban Rose Avenir 2017 from the Charity \u201cle Cancer du sein: parlons-en!"},{"name":"R\u00e9gion Centre-Val de Loire"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2022,5,20]]},"DOI":"10.1038\/s41388-022-02297-8","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T10:04:03Z","timestamp":1649671443000},"page":"2920-2931","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition"],"prefix":"10.1038","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-8232","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Chadet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Allard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-1382","authenticated-orcid":false,"given":"Lucie","family":"Brisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osbaldo","family":"Lopez-Charcas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxane","family":"Lemoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Heraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Lerondel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseline","family":"Guibon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Fromont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Le Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Angoulvant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-0411","authenticated-orcid":false,"given":"Lin-Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Murrell-Lagnado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-5248","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Roger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"2297_CR1","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/nrc2254","volume":"7","author":"R Mathew","year":"2007","unstructured":"Mathew R, Karantza-Wadsworth V, White E. Role of autophagy in cancer. Nat Rev Cancer. 2007;7:961\u20137.","journal-title":"Nat Rev Cancer"},{"key":"2297_CR2","doi-asserted-by":"crossref","unstructured":"Gouirand V, Guillaumond F, Vasseur S. Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming. Front Oncol. 2018;8. Available from: https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2018.00117\/full","DOI":"10.3389\/fonc.2018.00117"},{"key":"2297_CR3","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.cmet.2017.04.004","volume":"25","author":"AC Kimmelman","year":"2017","unstructured":"Kimmelman AC, White E. Autophagy and tumor metabolism. Cell Metab. 2017;25:1037\u201343.","journal-title":"Cell Metab"},{"key":"2297_CR4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/446745a","volume":"446","author":"B Levine","year":"2007","unstructured":"Levine B. Autophagy and cancer. Nature. 2007;446:745\u20137.","journal-title":"Nature."},{"key":"2297_CR5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10549-010-0734-1","volume":"124","author":"FT Martin","year":"2010","unstructured":"Martin FT, Dwyer RM, Kelly J, Khan S, Murphy JM, Curran C, et al. Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: Stimulation of epithelial to mesenchymal transition (EMT). Breast Cancer Res Treat. 2010;124:317\u201326.","journal-title":"Breast Cancer Res Treat"},{"key":"2297_CR6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/nrc.2017.118","volume":"18","author":"T Brabletz","year":"2018","unstructured":"Brabletz T, Kalluri R, Nieto MA, Weinberg RA. EMT in cancer. Nat Rev Cancer. 2018;18:128\u201334.","journal-title":"Nat Rev Cancer"},{"key":"2297_CR7","doi-asserted-by":"publisher","first-page":"e2520","DOI":"10.1038\/cddis.2016.415","volume":"7","author":"M Gugnoni","year":"2016","unstructured":"Gugnoni M, Sancisi V, Manzotti G, Gandolfi G, Ciarrocchi A. Autophagy and epithelial\u2013mesenchymal transition: an intricate interplay in cancer. Cell Death Dis. 2016;7:e2520\u2013e2520.","journal-title":"Cell Death Dis"},{"key":"2297_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1030-2","volume":"18","author":"H-T Chen","year":"2019","unstructured":"Chen H-T, Liu H, Mao M-J, Tan Y, Mo X-Q, Meng X-J, et al. Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy. Mol Cancer. 2019;18:101.","journal-title":"Mol Cancer"},{"key":"2297_CR9","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrm2745","volume":"10","author":"P Saftig","year":"2009","unstructured":"Saftig P, Klumperman J. Lysosome biogenesis and lysosomal membrane proteins: Trafficking meets function. Nat Rev Mol Cell Biol. 2009;10:623\u201335.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2297_CR10","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.cmet.2019.03.003","volume":"29","author":"V Lahiri","year":"2019","unstructured":"Lahiri V, Hawkins WD, Klionsky DJ. Watch what you (Self-) Eat: Autophagic mechanisms that modulate metabolism. Cell Metab. 2019;29:803\u201326.","journal-title":"Cell Metab"},{"key":"2297_CR11","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ceb.2016.02.009","volume":"39","author":"S H\u00e4m\u00e4list\u00f6","year":"2016","unstructured":"H\u00e4m\u00e4list\u00f6 S, J\u00e4\u00e4ttel\u00e4 M. Lysosomes in cancer\u2014living on the edge (of the cell). Curr Opin Cell Biol. 2016;39:69\u201376.","journal-title":"Curr Opin Cell Biol"},{"key":"2297_CR12","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1038\/onc.2012.292","volume":"32","author":"T Kallunki","year":"2013","unstructured":"Kallunki T, Olsen OD, J\u00e4\u00e4ttel\u00e4 M. Cancer-associated lysosomal changes: Friends or foes? Oncogene. 2013;32:1995\u20132004.","journal-title":"Oncogene."},{"key":"2297_CR13","doi-asserted-by":"publisher","first-page":"7117","DOI":"10.1038\/sj.onc.1209701","volume":"25","author":"E Janda","year":"2006","unstructured":"Janda E, Nevolo M, Lehmann K, Downward J, Beug H, Grieco M. Raf plus TGF \u03b2 -dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene. 2006;25:7117\u201330.","journal-title":"Oncogene."},{"key":"2297_CR14","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nrc4027","volume":"15","author":"OC Olson","year":"2015","unstructured":"Olson OC, Joyce JA. Cysteine cathepsin proteases: Regulators of cancer progression and therapeutic response. Nat Rev Cancer. 2015;15:712\u201329.","journal-title":"Nat Rev Cancer"},{"key":"2297_CR15","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1038\/s41388-018-0653-x","volume":"38","author":"DM Brix","year":"2019","unstructured":"Brix DM, Tvingsholm SA, Hansen MB, Clemmensen KB, Ohman T, Siino V, et al. Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion. Oncogene. 2019;38:3170\u201384.","journal-title":"Oncogene."},{"key":"2297_CR16","first-page":"E8479","volume":"115","author":"MJ Morgan","year":"2018","unstructured":"Morgan MJ, Fitzwalter BE, Owens CR, Powers RK, Sottnik JL, Gamez G, et al. Metastatic cells are preferentially vulnerable to lysosomal inhibition. Proc Natl Acad Sci. 2018;115:E8479\u201388.","journal-title":"Proc Natl Acad Sci"},{"key":"2297_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09634-8","volume":"10","author":"S Li","year":"2019","unstructured":"Li S, Song Y, Quach C, Guo H, Jang G-B, Maazi H, et al. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nat Commun. 2019;10:1693.","journal-title":"Nat Commun"},{"key":"2297_CR18","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.coph.2019.03.002","volume":"47","author":"RD Murrell-Lagnado","year":"2019","unstructured":"Murrell-Lagnado RD, Frick M. P2X4 and lysosome fusion. Curr Opin Pharm. 2019;47:126\u201332.","journal-title":"Curr Opin Pharm"},{"key":"2297_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s11302-013-9372-5","volume":"9","author":"G Burnstock","year":"2013","unstructured":"Burnstock G, Di Virgilio F. Purinergic signalling and cancer. Purinergic Signal. 2013;9:491\u2013540.","journal-title":"Purinergic Signal"},{"key":"2297_CR20","doi-asserted-by":"publisher","first-page":"878","DOI":"10.2174\/0929867321666141012172913","volume":"22","author":"E Adinolfi","year":"2015","unstructured":"Adinolfi E, Capece M, Amoroso F, De Marchi E, Franceschini A. Emerging Roles of P2X Receptors in Cancer. Curr Med Chem. 2015;22:878\u201390.","journal-title":"Curr Med Chem"},{"key":"2297_CR21","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11302-009-9145-3","volume":"5","author":"F Di Virgilio","year":"2009","unstructured":"Di Virgilio F, Ferrari D, Adinolfi E. P2X7: A growth-promoting receptor\u2014implications for cancer. Purinergic Signal. 2009;5:251\u20136.","journal-title":"Purinergic Signal"},{"key":"2297_CR22","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1016\/j.bbamem.2014.10.029","volume":"1848","author":"S Roger","year":"2015","unstructured":"Roger S, Jelassi B, Couillin I, Pelegrin P, Besson P, Jiang L-H. Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives. Biochim Biophys Acta. 2015;1848:2584\u2013602.","journal-title":"Biochim Biophys Acta"},{"issue":"Jun","key":"2297_CR23","doi-asserted-by":"publisher","first-page":"17658","DOI":"10.1074\/jbc.M114.552158","volume":"289","author":"P Huang","year":"2014","unstructured":"Huang P, Zou Y, Zhong XZ, Cao Q, Zhao K, Zhu MX, et al. P2X4 Forms Functional ATP-activated Cation Channels on Lysosomal Membranes Regulated by Luminal pH. J Biol Chem. 2014;289(Jun):17658\u201367.","journal-title":"J Biol Chem"},{"key":"2297_CR24","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1085\/jgp.201711963","volume":"150","author":"RD Murrell-Lagnado","year":"2018","unstructured":"Murrell-Lagnado RD. A role for P2X4 receptors in lysosome function. J Gen Physiol. 2018;150:185\u20137.","journal-title":"J Gen Physiol"},{"key":"2297_CR25","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.ccell.2016.08.005","volume":"30","author":"L Brisson","year":"2016","unstructured":"Brisson L, Ba\u0144ski P, Sboarina M, Dethier C, Danhier P, Fontenille M-J, et al. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Cancer Cell. 2016;30:418\u201331.","journal-title":"Cancer Cell"},{"key":"2297_CR26","doi-asserted-by":"crossref","unstructured":"Majora M, Sondenheimer K, Knechten M, Uthe I, Esser C, Schiavi A, et al. HDAC inhibition improves autophagic and lysosomal function to prevent loss of subcutaneous fat in a mouse model of Cockayne syndrome. Sci Transl Med. 2018;10. Available from: https:\/\/stm.sciencemag.org\/content\/10\/456\/eaam7510","DOI":"10.1126\/scitranslmed.aam7510"},{"key":"2297_CR27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0959-8049(95)00530-7","volume":"32","author":"BR Westley","year":"1996","unstructured":"Westley BR, May FEB. Cathepsin D and breast cancer. Eur J Cancer. 1996;32:15\u201324.","journal-title":"Eur J Cancer."},{"key":"2297_CR28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1085\/jgp.200910336","volume":"135","author":"E Toulme","year":"2010","unstructured":"Toulme E, Garcia A, Samways D, Egan TM, Carson MJ, Khakh BS. P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. J Gen Physiol. 2010;135:333\u201353.","journal-title":"J Gen Physiol"},{"key":"2297_CR29","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1083\/jcb.201409071","volume":"209","author":"Q Cao","year":"2015","unstructured":"Cao Q, Zhong XZ, Zou Y, Murrell-Lagnado R, Zhu MX, Dong X-P. Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. J Cell Biol. 2015;209:879\u201394.","journal-title":"J Cell Biol"},{"key":"2297_CR30","doi-asserted-by":"publisher","first-page":"10492","DOI":"10.3390\/ijms221910492","volume":"22","author":"S-L Tan","year":"2021","unstructured":"Tan S-L, Barri M, Atakpa-Adaji P, Taylor CW, St. John Smith E, Murrell-Lagnado RD. P2X4 receptors mediate Ca2+ release from lysosomes in response to stimulation of P2X7 and H1 histamine receptors. Int J Mol Sci. 2021;22:10492.","journal-title":"Int J Mol Sci"},{"key":"2297_CR31","doi-asserted-by":"crossref","unstructured":"Carnero Corrales MA, Zinken S, Konstantinidis G, Rafehi M, Abdelrahman A, Wu Y-W, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin. Cell Chem Biol. 2021; Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2451945621001021","DOI":"10.1016\/j.chembiol.2021.02.017"},{"key":"2297_CR32","first-page":"6201","volume":"60","author":"K Izuishi","year":"2000","unstructured":"Izuishi K, Kato K, Ogura T, Kinoshita T, Esumi H. Remarkable tolerance of tumor cells to nutrient deprivation: Possible new biochemical target for cancer therapy. Cancer Res. 2000;60:6201\u20137.","journal-title":"Cancer Res"},{"key":"2297_CR33","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1158\/1078-0432.CCR-13-2060","volume":"20","author":"S Chittaranjan","year":"2014","unstructured":"Chittaranjan S, Bortnik S, Dragowska WH, Xu J, Abeysundara N, Leung A, et al. Autophagy inhibition augments the anticancer effects of epirubicin treatment in anthracycline-sensitive and -resistant triple-negative breast cancer. Clin Cancer Res. 2014;20:3159\u201373.","journal-title":"Clin Cancer Res"},{"key":"2297_CR34","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.canlet.2016.04.002","volume":"376","author":"DH Liang","year":"2016","unstructured":"Liang DH, Choi DS, Ensor JE, Kaipparettu BA, Bass BL, Chang JC. The autophagy inhibitor chloroquine targets cancer stem cells in triple-negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Cancer Lett. 2016;376:249\u201358.","journal-title":"Cancer Lett"},{"key":"2297_CR35","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1158\/1078-0432.CCR-11-1282","volume":"18","author":"R Lazova","year":"2012","unstructured":"Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res. 2012;18:370\u20139.","journal-title":"Clin Cancer Res"},{"key":"2297_CR36","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1016\/j.ccr.2012.02.019","volume":"21","author":"O Mikhaylova","year":"2012","unstructured":"Mikhaylova O, Stratton Y, Hall D, Kellner E, Ehmer B, Drew AF, et al. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer Cell. 2012;21:532\u201346.","journal-title":"Cancer Cell"},{"key":"2297_CR37","doi-asserted-by":"publisher","first-page":"45117","DOI":"10.18632\/oncotarget.15155","volume":"8","author":"B Zhitomirsky","year":"2017","unstructured":"Zhitomirsky B, Assaraf YG. Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis. Oncotarget. 2017;8:45117\u201332.","journal-title":"Oncotarget."},{"key":"2297_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05013-x","volume":"9","author":"ST Kundu","year":"2018","unstructured":"Kundu ST, Grzeskowiak CL, Fradette JJ, Gibson LA, Rodriguez LB, Creighton CJ, et al. TMEM106B drives lung cancer metastasis by inducing TFEB -dependent lysosome synthesis and secretion of cathepsins. Nat Commun. 2018;9:2731.","journal-title":"Nat Commun"},{"key":"2297_CR39","doi-asserted-by":"publisher","first-page":"e45381","DOI":"10.1371\/journal.pone.0045381","volume":"7","author":"L Groth-Pedersen","year":"2012","unstructured":"Groth-Pedersen L, Aits S, Corcelle-Termeau E, Petersen NHT, Nylandsted J, J\u00e4\u00e4ttel\u00e4 M. Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells. PLOS ONE. 2012;7:e45381.","journal-title":"PLOS ONE"},{"key":"2297_CR40","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1091\/mbc.e10-03-0233","volume":"22","author":"JP Caviston","year":"2010","unstructured":"Caviston JP, Zajac AL, Tokito M, Holzbaur ELF. Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes. Mol Biol Cell. 2010;22:478\u201392.","journal-title":"Mol Biol Cell"},{"key":"2297_CR41","doi-asserted-by":"publisher","first-page":"e0209665","DOI":"10.1371\/journal.pone.0209665","volume":"14","author":"O Biskou","year":"2019","unstructured":"Biskou O, Casanova V, Hooper KM, Kemp S, Wright GP, Satsangi J, et al. The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE. 2019;14:e0209665.","journal-title":"PLOS ONE"},{"key":"2297_CR42","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.bbamcr.2013.02.024","volume":"1833","author":"L Cogli","year":"2013","unstructured":"Cogli L, Progida C, Bramato R, Bucci C. Vimentin phosphorylation and assembly are regulated by the small GTPase Rab7a. Biochim Biophys Acta BBA - Mol Cell Res. 2013;1833:1283\u201393.","journal-title":"Biochim Biophys Acta BBA - Mol Cell Res."},{"key":"2297_CR43","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4161\/sgtp.2.1.15114","volume":"2","author":"J Ivaska","year":"2011","unstructured":"Ivaska J, Vimentin. Small GTPases. 2011;2:51\u20133.","journal-title":"Small GTPases"},{"key":"2297_CR44","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/onc.2010.509","volume":"30","author":"K Vuoriluoto","year":"2011","unstructured":"Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi J-P, Nevo J, Gjerdrum C, et al. Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer. Oncogene. 2011;30:1436\u201348.","journal-title":"Oncogene."},{"key":"2297_CR45","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1096\/fj.09-151639","volume":"24","author":"MG Mendez","year":"2010","unstructured":"Mendez MG, Kojima S-I, Goldman RD. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J. 2010;24:1838\u201351.","journal-title":"FASEB J"},{"key":"2297_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18935-2","volume":"11","author":"S Ketterer","year":"2020","unstructured":"Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, et al. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. Nat Commun. 2020;11:5133.","journal-title":"Nat Commun"},{"key":"2297_CR47","doi-asserted-by":"publisher","first-page":"14503","DOI":"10.1073\/pnas.1101039108","volume":"108","author":"P Miklavc","year":"2011","unstructured":"Miklavc P, Mair N, Wittekindt OH, Haller T, Dietl P, Felder E, et al. Fusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytes. Proc Natl Acad Sci. 2011;108:14503\u20138.","journal-title":"Proc Natl Acad Sci"},{"key":"2297_CR48","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1038\/onc.2010.593","volume":"30","author":"B Jelassi","year":"2011","unstructured":"Jelassi B, Chant\u00f4me A, Alcaraz-P\u00e9rez F, Baroja-Mazo A, Cayuela ML, Pelegrin P, et al. P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness. Oncogene. 2011;30:2108\u201322.","journal-title":"Oncogene."},{"key":"2297_CR49","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1365-2818.2006.01706.x","volume":"224","author":"S Bolte","year":"2006","unstructured":"Bolte S, Cordeli\u00e8res FP. A guided tour into subcellular colocalization analysis in light microscopy. J Microsc. 2006;224:213\u201332.","journal-title":"J Microsc"},{"key":"2297_CR50","doi-asserted-by":"crossref","unstructured":"Goldman MJ, Craft B, Hastie M, Repe\u010dka K, McDade F, Kamath A, et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 2020;38:675\u20138.","DOI":"10.1038\/s41587-020-0546-8"},{"key":"2297_CR51","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.neo.2017.05.002","volume":"19","author":"DS Chandrashekar","year":"2017","unstructured":"Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK, et al. UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017;19:649\u201358.","journal-title":"Neoplasia."}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-022-02297-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-022-02297-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-022-02297-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T16:03:59Z","timestamp":1653062639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-022-02297-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":51,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2022,5,20]]}},"alternative-id":["2297"],"URL":"https:\/\/doi.org\/10.1038\/s41388-022-02297-8","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,11]]},"assertion":[{"value":"21 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}