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All mouse experiments were performed according to the European Community Council Directive 2010\/63\/EU and carried out under the approval of the Institutional Animal Care Committee and Ministry of Health (protocol n. C1368.26). Patient-derived colorectal cancer stem cells were obtained in accordance with the ethical standards regarding Human Experimentation and informed consent was obtained from each patient in this study under Institutional Review Board protocols (authorization CE9\/2015, Policlinico Paolo Giaccone, Palermo, Italy).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}