{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:14:22Z","timestamp":1793740462738,"version":"4.6.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974451"],"award-info":[{"award-number":["81974451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902888"],"award-info":[{"award-number":["81902888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702956"],"award-info":[{"award-number":["81702956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030087"],"award-info":[{"award-number":["82030087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2025,2,10]]},"DOI":"10.1038\/s41388-024-03207-w","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T23:45:50Z","timestamp":1731023150000},"page":"228-240","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer"],"prefix":"10.1038","volume":"44","author":[{"given":"Ming","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuohang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengbo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-1918","authenticated-orcid":false,"given":"Zhiyong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningbo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0558-5250","authenticated-orcid":false,"given":"Lunquan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-8668","authenticated-orcid":false,"given":"Rong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"3207_CR1","doi-asserted-by":"publisher","first-page":"4620","DOI":"10.1200\/JCO.2006.06.7629","volume":"24","author":"JP G\u00e9rard","year":"2006","unstructured":"G\u00e9rard JP, Conroy T, Bonnetain F, Bouche O, Chapet O, Closon-Dejardin MT, et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers:: Results of FFCD 9203. J Clin Oncol. 2006;24:4620\u20135.","journal-title":"J Clin Oncol"},{"key":"3207_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1200\/JCO.18.00032","volume":"37","author":"A Ogura","year":"2019","unstructured":"Ogura A, Konishi T, Cunningham C, Garcia-Aguilar J, Iversen H, Toda S, et al. Neoadjuvant (Chemo)radiotherapy with total mesorectal excision only is not sufficient to prevent lateral local recurrence in enlarged nodes: results of the multicenter lateral node study of patients with low cT3\/4 rectal cancer. J Clin Oncol. 2019;37:33\u201343.","journal-title":"J Clin Oncol"},{"key":"3207_CR3","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","volume":"20","author":"HJ Forman","year":"2021","unstructured":"Forman HJ, Zhang HQ. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 2021;20:689\u2013709.","journal-title":"Nat Rev Drug Discov"},{"key":"3207_CR4","doi-asserted-by":"crossref","unstructured":"Sharma V, Mehdi MM. Oxidative stress, inflammation and hormesis: the role of dietary and lifestyle modifications on aging. Neurochem Int. 2023;164:105490.","DOI":"10.1016\/j.neuint.2023.105490"},{"key":"3207_CR5","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1126\/science.aam7344","volume":"355","author":"CJ Lord","year":"2017","unstructured":"Lord CJ, Ashworth A. PARP inhibitors: Synthetic lethality in the clinic. Science. 2017;355:1152\u20138.","journal-title":"Science"},{"key":"3207_CR6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.molcel.2013.08.026","volume":"52","author":"S Jungmichel","year":"2013","unstructured":"Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML. Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. Mol Cell. 2013;52:272\u201385.","journal-title":"Mol Cell"},{"key":"3207_CR7","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/nmeth.2603","volume":"10","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Wang J, Ding M, Yu Y. Site-specific characterization of the Asp- and Glu-ADP-ribosylated proteome. Nat Methods. 2013;10:981\u20134.","journal-title":"Nat Methods"},{"key":"3207_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4419-9967-2_1","volume":"754","author":"BL Jin","year":"2013","unstructured":"Jin BL, Robertson KD. DNA methyltransferases, DNA damage repair, and cancer. Adv Exp Med Biol. 2013;754:3\u201329.","journal-title":"Adv Exp Med Biol"},{"key":"3207_CR9","doi-asserted-by":"crossref","unstructured":"Wang XS, Huang ZY, Li L, Yang YT, Zhang JY, Wang L, et al. The role of alternative splicing factors, DDB2-related ageing and DNA damage repair in the progression and prognosis of stomach adenocarcinoma patients. Genes 2023;14:39.","DOI":"10.3390\/genes14010039"},{"key":"3207_CR10","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/s41586-018-0670-5","volume":"563","author":"YJ He","year":"2018","unstructured":"He YJ, Meghani K, Caron MC, Yang C, Ronato DA, Bian J, et al. DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells. Nature. 2018;563:522\u20136.","journal-title":"Nature"},{"key":"3207_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41586-018-0629-6","volume":"563","author":"H Liu","year":"2018","unstructured":"Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, et al. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature. 2018;563:131\u20136.","journal-title":"Nature"},{"key":"3207_CR12","doi-asserted-by":"crossref","unstructured":"Xie J, Wen M, Zhang J, Wang Z, Wang M, Qiu Y, et al. The roles of RNA helicases in DNA damage repair and tumorigenesis reveal precision therapeutic strategies. Cancer Res. 2022;82:872\u201384.","DOI":"10.1158\/0008-5472.CAN-21-2187"},{"key":"3207_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1134\/S0006297916090030","volume":"81","author":"MY Shubina","year":"2016","unstructured":"Shubina MY, Musinova YR, Sheval EV. Nucleolar methyltransferase fibrillarin: evolution of structure and functions. Biochem-Mosc\u2009+\u2009. 2016;81:941\u201350.","journal-title":"Biochem-Mosc\u2009+"},{"key":"3207_CR14","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1016\/j.ajpath.2010.12.040","volume":"178","author":"CM Koh","year":"2011","unstructured":"Koh CM, Gurel B, Sutcliffe S, Aryee MJ, Schultz D, Iwata T, et al. Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the oncogene. Am J Pathol. 2011;178:1824\u201334.","journal-title":"Am J Pathol"},{"key":"3207_CR15","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1038\/onc.2013.89","volume":"33","author":"H Su","year":"2014","unstructured":"Su H, Xu T, Ganapathy S, Shadfan M, Long M, Huang THM, et al. Elevated snoRNA biogenesis is essential in breast cancer. Oncogene. 2014;33:1348\u201358.","journal-title":"Oncogene"},{"key":"3207_CR16","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.cell.2019.03.030","volume":"177","author":"S Vasaikar","year":"2019","unstructured":"Vasaikar S, Huang C, Wang X, Petyuk VA, Savage SR, Wen B, et al. Proteogenomic analysis of human colon cancer reveals new therapeutic opportunities. Cell. 2019;177:1035\u201349 e1019.","journal-title":"Cell"},{"key":"3207_CR17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nature13438","volume":"513","author":"B Zhang","year":"2014","unstructured":"Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, et al. Proteogenomic characterization of human colon and rectal cancer. Nature. 2014;513:382\u20137.","journal-title":"Nature"},{"key":"3207_CR18","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2020.03.048","volume":"181","author":"L Zhang","year":"2020","unstructured":"Zhang L, Li Z, Skrzypczynska KM, Fang Q, Zhang W, O\u2019Brien SA, et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell. 2020;181:442\u201359 e429.","journal-title":"Cell"},{"key":"3207_CR19","first-page":"387","volume":"180","author":"DP Nusinow","year":"2020","unstructured":"Nusinow DP, Szpyt J, Ghandi M, Rose CM, McDonald ER 3rd, Kalocsay M, et al. Quantitative proteomics of the cancer. Cell Line Encycl Cell. 2020;180:387\u2013402 e316.","journal-title":"Cell Line Encycl Cell"},{"key":"3207_CR20","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1038\/nprot.2006.201","volume":"1","author":"TK Kerppola","year":"2006","unstructured":"Kerppola TK. Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells. Nat Protoc. 2006;1:1278\u201386.","journal-title":"Nat Protoc"},{"key":"3207_CR21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0076-6879(05)09029-4","volume":"409","author":"F Dantzer","year":"2006","unstructured":"Dantzer F, Ame JC, Schreiber V, Nakamura J, Menissier-de Murcia J, de Murcia G. Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair. Methods Enzymol. 2006;409:493\u2013510.","journal-title":"Methods Enzymol"},{"key":"3207_CR22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nrm3376","volume":"13","author":"BA Gibson","year":"2012","unstructured":"Gibson BA, Kraus WL. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nat Rev Mol Cell Biol. 2012;13:411\u201324.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3207_CR23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.tibs.2012.06.001","volume":"37","author":"T Kalisch","year":"2012","unstructured":"Kalisch T, Am\u00e9 JC, Dantzer F, Schreiber V. New readers and interpretations of poly(ADP-ribosyl)ation. Trends Biochemical Sci. 2012;37:381\u201390.","journal-title":"Trends Biochemical Sci"},{"key":"3207_CR24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nature06420","volume":"451","author":"I Ahel","year":"2008","unstructured":"Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, et al. Poly(ADP-ribose)-binding zinc finger motifs in DNA repair\/checkpoint proteins. Nature. 2008;451:81\u2013U12.","journal-title":"Nature"},{"key":"3207_CR25","doi-asserted-by":"publisher","first-page":"4243","DOI":"10.1073\/pnas.0900066106","volume":"106","author":"N Dani","year":"2009","unstructured":"Dani N, Stilla A, Marchegiani A, Tamburro A, Till S, Ladurner AG, et al. Combining affinity purification by ADP-ribose-binding macro domains with mass spectrometry to define the mammalian ADP-ribosyl proteome. Proc Natl Acad Sci USA. 2009;106:4243\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3207_CR26","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1038\/sj.emboj.7600664","volume":"24","author":"GI Karras","year":"2005","unstructured":"Karras GI, Kustatscher G, Buhecha HR, Allen MD, Pugieux C, Sait F, et al. The macro domain is an ADP-ribose binding module. EMBO J. 2005;24:1911\u201320.","journal-title":"EMBO J"},{"key":"3207_CR27","doi-asserted-by":"crossref","unstructured":"Zhang H, Cai B, Geng A, Tang H, Zhang W, Li S, et al. Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells. Aging Cell. 2019;19:e13062.","DOI":"10.1111\/acel.13062"},{"key":"3207_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nprot.2006.5","volume":"1","author":"PL Olive","year":"2006","unstructured":"Olive PL, Banath JP. The comet assay: a method to measure DNA damage in individual cells. Nat Protoc. 2006;1:23\u20139.","journal-title":"Nat Protoc"},{"key":"3207_CR29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrm1963","volume":"7","author":"V Schreiber","year":"2006","unstructured":"Schreiber V, Dantzer F, Am\u00e9 JC, de Murcia G. Poly(ADP-ribose):: novel functions for an old molecule. Nat Rev Mol Cell Bio. 2006;7:517\u201328.","journal-title":"Nat Rev Mol Cell Bio"},{"key":"3207_CR30","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/s41422-019-0141-z","volume":"29","author":"YJ Duan","year":"2019","unstructured":"Duan YJ, Du AY, Gu JG, Duan G, Wang C, Gui XR, et al. PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins. Cell Res. 2019;29:233\u201347.","journal-title":"Cell Res"},{"key":"3207_CR31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10549-023-06940-0","volume":"200","author":"K Pandya","year":"2023","unstructured":"Pandya K, Scher A, Omene C, Ganesan S, Kumar S, Ohri N, et al. Clinical efficacy of PARP inhibitors in breast cancer. Breast Cancer Res Treat. 2023;200:15\u201322.","journal-title":"Breast Cancer Res Treat"},{"key":"3207_CR32","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1093\/nar\/gku601","volume":"42","author":"S Britton","year":"2014","unstructured":"Britton S, Dernoncourt E, Delteil C, Froment C, Schiltz O, Salles B, et al. DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal. Nucleic acids Res. 2014;42:9047\u201362.","journal-title":"Nucleic acids Res"},{"key":"3207_CR33","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ccr.2013.08.013","volume":"24","author":"V Marcel","year":"2013","unstructured":"Marcel V, Ghayad SE, Belin S, Therizols G, Morel AP, Solano-Gonzalez E, et al. p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer. Cancer cell. 2013;24:318\u201330.","journal-title":"Cancer cell"},{"key":"3207_CR34","doi-asserted-by":"crossref","unstructured":"Sun XR, Gao CW, Xu X, Li MY, Zhao XH, Wang YA, et al. FBL promotes cancer cell resistance to DNA damage and BRCA1 transcription via YBX1. EMBO reports. 2023;24:e56230.","DOI":"10.15252\/embr.202256230"},{"key":"3207_CR35","unstructured":"Dempste JM, Rossen J, Kazachkova M, Pan J, Kugener G, Root DE, et al. Extracting biological insights from the project achilles genome-scale CRISPR screens in cancer cell lines. BioRxiv. 2017;720243."},{"key":"3207_CR36","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1038\/ng.3984","volume":"49","author":"RM Meyers","year":"2017","unstructured":"Meyers RM, Bryan JG, McFarland JM, Weir BA, Sizemore AE, Xu H, et al. Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nat Genet. 2017;49:1779\u201384.","journal-title":"Nat Genet"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-024-03207-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-024-03207-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-024-03207-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:29:26Z","timestamp":1776936566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-024-03207-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2,10]]}},"alternative-id":["3207"],"URL":"https:\/\/doi.org\/10.1038\/s41388-024-03207-w","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"30 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. All human samples used in this study were approved by the Medical Ethics Committee of Xiangya Hospital, Central South University (ethics number: 2019030535) and informed consent was obtained from all subjects. All animal procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of Central South University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}