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All animal procedures were approved by the Sun Yat-sen University Institutional Animal Care and Use Committee (Approval No. SYSU-IACUC-2022-001151). And the research involving human tissues was approved by the Clinical Research of the First Affiliated Hospital of Sun Yat-sen University Ethical Committee. All patient samples were collected in accordance with the Declaration of Helsinki, with written informed consent obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}