{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:04:15Z","timestamp":1792631055493,"version":"4.5.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"29","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2025,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Wnt\/\u03b2-catenin signalling is important for normal hematopoietic stem\/progenitor cell (HSPC) biology and heavily implicated in acute and chronic myeloid leukaemia (AML and CML). The central mediator \u03b2-catenin is an attractive therapeutic target in myeloid neoplasms however its targeting has been hampered by a poor characterisation of its molecular interactions in haematopoietic cells, which will differ from its network in solid tissues. Our previous \u03b2-catenin interactome study identified the significant enrichment of RNA-binding proteins (RBP) implying post-transcriptional roles for \u03b2-catenin in myeloid cells. To identify \u03b2-catenin interacting mRNAs we performed \u03b2-catenin RNA-immunoprecipitation coupled to RNA-sequencing (RIP-seq) and identified significantly enriched Wnt signalling pathway transcripts. Using \u03b2-catenin cross-linking immunoprecipitation (CLIP) we demonstrated a limited capacity for \u03b2-catenin to bind RNA directly, implying dependence on other RBPs. \u03b2-Catenin was found to interact with Musashi-2 (MSI2) in both myeloid cell lines and primary AML patient samples, where expression was significantly correlated. MSI2 knockdown reduced Wnt signalling output (TCF\/LEF activity), through suppression of LEF-1 expression and nuclear localisation. Through both RIP and CLIP we demonstrate MSI2 binds\n                    <jats:italic>LEF1<\/jats:italic>\n                    mRNA in a partly \u03b2-catenin dependent fashion, and may impact the post-transcriptional control of LEF-1 expression. Finally, we show that MSI2-mediated expansion of human HSPCs could be partly driven through\n                    <jats:italic>LEF1<\/jats:italic>\n                    regulation. This is the first study to experimentally demonstrate functional crosstalk between MSI2 and Wnt signalling in human cells, and indicates potential novel post-transcriptional roles for \u03b2-catenin in a haematological context.\n                  <\/jats:p>","DOI":"10.1038\/s41388-025-03415-y","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T20:29:37Z","timestamp":1745958577000},"page":"2490-2503","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["\u03b2-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells"],"prefix":"10.1038","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-8676","authenticated-orcid":false,"given":"M.","family":"Wagstaff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-3913","authenticated-orcid":false,"given":"O.","family":"Sevim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-9298","authenticated-orcid":false,"given":"A.","family":"Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Raynor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1895-2504","authenticated-orcid":false,"given":"H.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-7898","authenticated-orcid":false,"given":"E. J.","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-0009","authenticated-orcid":false,"given":"D. T. T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-1906","authenticated-orcid":false,"given":"T.","family":"Chevassut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9759-5156","authenticated-orcid":false,"given":"A.","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-4829","authenticated-orcid":false,"given":"L.","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-3258","authenticated-orcid":false,"given":"S.","family":"Newbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7884-1131","authenticated-orcid":false,"given":"B.","family":"Towler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-6294","authenticated-orcid":false,"given":"R. G.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"3415_CR1","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","volume":"169","author":"R Nusse","year":"2017","unstructured":"Nusse R, Clevers H. Wnt\/beta-catenin signaling, disease, and emerging therapeutic modalities. Cell. 2017;169:985\u201399. https:\/\/doi.org\/10.1016\/j.cell.2017.05.016.","journal-title":"Cell"},{"key":"3415_CR2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nature01593","volume":"423","author":"T Reya","year":"2003","unstructured":"Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423:409\u201314.","journal-title":"Nature"},{"key":"3415_CR3","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1182\/blood.2019004664","volume":"136","author":"P Danek","year":"2020","unstructured":"Danek P, Kardosova M, Janeckova L, Karkoulia E, Vanickova K, Fabisik M, et al. beta-Catenin-TCF\/LEF signaling promotes steady-state and emergency granulopoiesis via G-CSF receptor upregulation. Blood. 2020;136:2574\u201387. https:\/\/doi.org\/10.1182\/blood.2019004664.","journal-title":"Blood"},{"key":"3415_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.diff.2011.08.003","volume":"83","author":"AL Brown","year":"2012","unstructured":"Brown AL, Salerno DG, Sadras T, Engler GA, Kok CH, Wilkinson CR, et al. The GM-CSF receptor utilizes beta-catenin and Tcf4 to specify macrophage lineage differentiation. Differentiation. 2012;83:47\u201359. https:\/\/doi.org\/10.1016\/j.diff.2011.08.003.","journal-title":"Differentiation"},{"key":"3415_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09273-z","volume":"10","author":"P Shooshtarizadeh","year":"2019","unstructured":"Shooshtarizadeh P, Helness A, Vadnais C, Brouwer N, Beauchemin H, Chen R, et al. Gfi1b regulates the level of Wnt\/beta-catenin signaling in hematopoietic stem cells and megakaryocytes. Nat Commun. 2019;10:1270. https:\/\/doi.org\/10.1038\/s41467-019-09273-z.","journal-title":"Nat Commun"},{"key":"3415_CR6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/leu.2011.387","volume":"26","author":"TC Luis","year":"2012","unstructured":"Luis TC, Ichii M, Brugman MH, Kincade P, Staal FJ. Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia. 2012;26:414\u201321. https:\/\/doi.org\/10.1038\/leu.2011.387.","journal-title":"Leukemia"},{"key":"3415_CR7","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.stem.2011.07.017","volume":"9","author":"Luis","year":"2011","unstructured":"Luis, Naber TC, Roozen BA, Brugman PP, de Haas MH, Ghazvini EF, et al. Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell. 2011;9:345\u201356.","journal-title":"Cell Stem Cell"},{"key":"3415_CR8","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3324\/haematol.2018.202846","volume":"104","author":"RG Morgan","year":"2019","unstructured":"Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, et al. LEF-1 drives aberrant beta-catenin nuclear localization in myeloid leukemia cells. Haematologica. 2019;104:1365\u201377. https:\/\/doi.org\/10.3324\/haematol.2018.202846.","journal-title":"Haematologica"},{"key":"3415_CR9","doi-asserted-by":"publisher","unstructured":"Wagstaff M, Coke B, Hodgkiss GR, and Morgan RG Targeting beta-catenin in acute myeloid leukaemia: past, present, and future perspectives. Biosci Rep. 2022; https:\/\/doi.org\/10.1042\/BSR20211841.","DOI":"10.1042\/BSR20211841"},{"key":"3415_CR10","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1038\/sj.onc.1208431","volume":"24","author":"M Simon","year":"2005","unstructured":"Simon M, Grandage VL, Linch DC, Khwaja A. Constitutive activation of the Wnt\/beta-catenin signalling pathway in acute myeloid leukaemia. Oncogene. 2005;24:2410\u201320.","journal-title":"Oncogene"},{"key":"3415_CR11","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/sj.leu.2404239","volume":"20","author":"L Ysebaert","year":"2006","unstructured":"Ysebaert L, Chicanne G, Demur C, De TF, Prade-Houdellier N, Ruidavets JB, et al. Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia. 2006;20:1211\u20136.","journal-title":"Leukemia"},{"key":"3415_CR12","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.3324\/haematol.2014.113118","volume":"100","author":"EA Griffiths","year":"2015","unstructured":"Griffiths EA, Golding MC, Srivastava P, Povinelli BJ, James SR, Ford LA, et al. Pharmacological targeting of beta-catenin in normal karyotype acute myeloid leukemia blasts. Haematologica. 2015;100:e49\u201352. https:\/\/doi.org\/10.3324\/haematol.2014.113118.","journal-title":"Haematologica"},{"key":"3415_CR13","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1158\/1078-0432.CCR-17-1556","volume":"24","author":"X Jiang","year":"2018","unstructured":"Jiang X, Mak PY, Mu H, Tao W, Mak DH, Kornblau S, et al. Disruption of Wnt\/beta-catenin exerts antileukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia. Clin Cancer Res. 2018;24:2417\u201329. https:\/\/doi.org\/10.1158\/1078-0432.CCR-17-1556.","journal-title":"Clin Cancer Res"},{"key":"3415_CR14","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1158\/0008-5472.CAN-17-0202","volume":"77","author":"L Li","year":"2017","unstructured":"Li L, Sheng Y, Li W, Hu C, Mittal N, Tohyama K, et al. beta-Catenin is a candidate therapeutic target for myeloid neoplasms with del(5q). Cancer Res. 2017;77:4116\u201326. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-0202.","journal-title":"Cancer Res"},{"key":"3415_CR15","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1182\/blood-2016-08-736454","volume":"129","author":"A Stoddart","year":"2017","unstructured":"Stoddart A, Wang J, Hu C, Fernald AA, Davis EM, Cheng JX, et al. Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apc(del\/+) MDS mouse model. Blood. 2017;129:2959\u201370. https:\/\/doi.org\/10.1182\/blood-2016-08-736454.","journal-title":"Blood"},{"key":"3415_CR16","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1038\/sj.leu.2404961","volume":"21","author":"A Tonks","year":"2007","unstructured":"Tonks A, Pearn L, Musson M, Gilkes A, Mills KI, Burnett AK, et al. Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia. Leukemia. 2007;21:2495\u2013505.","journal-title":"Leukemia"},{"key":"3415_CR17","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1128\/MCB.24.7.2890-2904.2004","volume":"24","author":"C Muller-Tidow","year":"2004","unstructured":"Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol. 2004;24:2890\u2013904.","journal-title":"Mol Cell Biol"},{"key":"3415_CR18","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1126\/science.1186624","volume":"327","author":"Y Wang","year":"2010","unstructured":"Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, et al. The Wnt\/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010;327:1650\u20133.","journal-title":"Science"},{"key":"3415_CR19","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.ccr.2010.10.032","volume":"18","author":"J Yeung","year":"2010","unstructured":"Yeung J, Esposito MT, Gandillet A, Zeisig BB, Griessinger E, Bonnet D, et al. beta-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell. 2010;18:606\u201318.","journal-title":"Cancer Cell"},{"key":"3415_CR20","doi-asserted-by":"publisher","first-page":"3284","DOI":"10.1182\/blood-2013-10-532523","volume":"124","author":"PA Dietrich","year":"2014","unstructured":"Dietrich PA, Yang C, Leung HH, Lynch JR, Gonzales E, Liu B, et al. GPR84 sustains aberrant beta-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis. Blood. 2014;124:3284\u201394. https:\/\/doi.org\/10.1182\/blood-2013-10-532523.","journal-title":"Blood"},{"key":"3415_CR21","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/nature14888","volume":"525","author":"CY Fong","year":"2015","unstructured":"Fong CY, Gilan O, Lam EY, Rubin AF, Ftouni S, Tyler D, et al. BET inhibitor resistance emerges from leukaemia stem cells. Nature. 2015;525:538\u201342. https:\/\/doi.org\/10.1038\/nature14888.","journal-title":"Nature"},{"key":"3415_CR22","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41556-020-0507-y","volume":"22","author":"JM Perry","year":"2020","unstructured":"Perry JM, Tao F, Roy A, Lin T, He XC, Chen S, et al. Overcoming Wnt-beta-catenin dependent anticancer therapy resistance in leukaemia stem cells. Nat Cell Biol. 2020;22:689\u2013700. https:\/\/doi.org\/10.1038\/s41556-020-0507-y.","journal-title":"Nat Cell Biol"},{"key":"3415_CR23","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1182\/bloodadvances.2022008405","volume":"7","author":"T Sakoda","year":"2023","unstructured":"Sakoda T, Kikushige Y, Miyamoto T, Irifune H, Harada T, Hatakeyama K, et al. TIM-3 signaling hijacks the canonical Wnt\/beta-catenin pathway to maintain cancer stemness in acute myeloid leukemia. Blood Adv. 2023;7:2053\u201365. https:\/\/doi.org\/10.1182\/bloodadvances.2022008405.","journal-title":"Blood Adv"},{"key":"3415_CR24","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.ccr.2007.11.003","volume":"12","author":"C Zhao","year":"2007","unstructured":"Zhao C, Blum J, Chen A, Kwon HY, Jung SH, Cook JM, et al. Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell. 2007;12:528\u201341.","journal-title":"Cancer Cell"},{"key":"3415_CR25","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1056\/NEJMoa040258","volume":"351","author":"CH Jamieson","year":"2004","unstructured":"Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004;351:657\u201367.","journal-title":"N Engl J Med"},{"key":"3415_CR26","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.cell.2005.09.020","volume":"123","author":"S Yamada","year":"2005","unstructured":"Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ. Deconstructing the cadherin-catenin-actin complex. Cell. 2005;123:889\u2013901. https:\/\/doi.org\/10.1016\/j.cell.2005.09.020.","journal-title":"Cell"},{"key":"3415_CR27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3324\/haematol.2021.280294","volume":"108","author":"M Wagstaff","year":"2023","unstructured":"Wagstaff M, Tsaponina O, Caalim G, Greenfield H, Milton-Harris L, Mancini EJ, et al. Crosstalk between beta-catenin and WT1 signaling activity in acute myeloid leukemia. Haematologica. 2023;108:283\u20139. https:\/\/doi.org\/10.3324\/haematol.2021.280294.","journal-title":"Haematologica"},{"key":"3415_CR28","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1182\/blood-2018-10-839985","volume":"133","author":"DJ Hodson","year":"2019","unstructured":"Hodson DJ, Screen M, Turner M. RNA-binding proteins in hematopoiesis and hematological malignancy. Blood. 2019;133:2365\u201373. https:\/\/doi.org\/10.1182\/blood-2018-10-839985.","journal-title":"Blood"},{"key":"3415_CR29","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/ejh.13846","volume":"109","author":"S Olaitan","year":"2022","unstructured":"Olaitan S, Wagstaff M, Sevim O, Akieme R, Toska V, Humphreys C, et al. Assessment of mononuclear cell populations derived from human umbilical cord blood. Eur J Haematol. 2022;109:787\u20138. https:\/\/doi.org\/10.1111\/ejh.13846.","journal-title":"Eur J Haematol"},{"key":"3415_CR30","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/leu.2012.221","volume":"27","author":"RG Morgan","year":"2013","unstructured":"Morgan RG, Pearn L, Liddiard K, Pumford SL, Burnett AK, Tonks A, et al. gamma-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of beta-catenin. Leukemia. 2013;27:336\u201343. https:\/\/doi.org\/10.1038\/leu.2012.221.","journal-title":"Leukemia"},{"key":"3415_CR31","doi-asserted-by":"publisher","unstructured":"Martin M Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. 2011;17:3. https:\/\/doi.org\/10.14806\/ej.17.1.200.","DOI":"10.14806\/ej.17.1.200"},{"key":"3415_CR32","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim D, Paggi JM, Park C, Bennett C, Salzberg SL. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol. 2019;37:907\u201315. https:\/\/doi.org\/10.1038\/s41587-019-0201-4.","journal-title":"Nat Biotechnol"},{"key":"3415_CR33","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","volume":"25","author":"H Li","year":"2009","unstructured":"Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The Sequence Alignment\/Map format and SAMtools. Bioinformatics. 2009;25:2078\u20139. https:\/\/doi.org\/10.1093\/bioinformatics\/btp352.","journal-title":"Bioinformatics"},{"key":"3415_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8.","journal-title":"Genome Biol"},{"key":"3415_CR35","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.21105\/joss.01686","volume":"4","author":"H Wickham","year":"2019","unstructured":"Wickham H, Averick M, Bryan J, Chang W, McGowan L, Fran\u00e7ois R, et al. Welcome to the tidyverse. J Open Source Softw. 2019;4:1686. https:\/\/doi.org\/10.21105\/joss.01686.","journal-title":"J Open Source Softw"},{"key":"3415_CR36","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","volume":"32","author":"ZG Gu","year":"2016","unstructured":"Gu ZG, Eils R, Schlesner M. Complex heatmaps reveal patterns and correlations in multidimensional genomic data. Bioinformatics. 2016;32:2847\u20139. https:\/\/doi.org\/10.1093\/bioinformatics\/btw313.","journal-title":"Bioinformatics"},{"key":"3415_CR37","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1128\/MCB.16.3.745","volume":"16","author":"M Van de Wetering","year":"1996","unstructured":"Van de Wetering M, Castrop J, Korinek V, Clevers H. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol Cell Biol. 1996;16:745\u201352.","journal-title":"Mol Cell Biol"},{"key":"3415_CR38","doi-asserted-by":"publisher","first-page":"6863","DOI":"10.1093\/nar\/gks331","volume":"40","author":"I Kim","year":"2012","unstructured":"Kim I, Kwak H, Lee HK, Hyun S, Jeong S. beta-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3\u2019-UTR and interacts with HuR in colon cancer cells. Nucleic Acids Res. 2012;40:6863\u201372. https:\/\/doi.org\/10.1093\/nar\/gks331.","journal-title":"Nucleic Acids Res"},{"key":"3415_CR39","doi-asserted-by":"publisher","first-page":"5705","DOI":"10.1093\/nar\/gkl698","volume":"34","author":"HK Lee","year":"2006","unstructured":"Lee HK, Jeong S. Beta-catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3\u2019-UTR. Nucleic Acids Res. 2006;34:5705\u201314. https:\/\/doi.org\/10.1093\/nar\/gkl698.","journal-title":"Nucleic Acids Res"},{"key":"3415_CR40","doi-asserted-by":"publisher","first-page":"e80742","DOI":"10.1371\/journal.pone.0080742","volume":"8","author":"G D\u2019Uva","year":"2013","unstructured":"D\u2019Uva G, Bertoni S, Lauriola M, De Carolis S, Pacilli A, D\u2019Anello L, et al. Beta-catenin\/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia. PloS One. 2013;8:e80742. https:\/\/doi.org\/10.1371\/journal.pone.0080742.","journal-title":"PloS One"},{"key":"3415_CR41","doi-asserted-by":"publisher","first-page":"e4797","DOI":"10.1371\/journal.pone.0004797","volume":"4","author":"AK Farina","year":"2009","unstructured":"Farina AK, Bong YS, Feltes CM, Byers SW. Post-transcriptional regulation of cadherin-11 expression by GSK-3 and beta-catenin in prostate and breast cancer cells. PloS One. 2009;4:e4797. https:\/\/doi.org\/10.1371\/journal.pone.0004797.","journal-title":"PloS One"},{"key":"3415_CR42","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.semcancer.2022.01.010","volume":"86","author":"Y Zhao","year":"2022","unstructured":"Zhao Y, Mir C, Garcia-Mayea Y, Paciucci R, Kondoh H, LLeonart ME. RNA-binding proteins: underestimated contributors in tumorigenesis. Semin Cancer Biol. 2022;86:431\u201344. https:\/\/doi.org\/10.1016\/j.semcancer.2022.01.010.","journal-title":"Semin Cancer Biol"},{"key":"3415_CR43","doi-asserted-by":"publisher","first-page":"4141","DOI":"10.1016\/j.molcel.2023.10.023","volume":"83","author":"T Gui","year":"2023","unstructured":"Gui T, Fleming C, Manzato C, Bourgeois B, Sirati N, Heuer J, et al. Targeted perturbation of signaling-driven condensates. Mol Cell. 2023;83:4141\u20134157 e4111. https:\/\/doi.org\/10.1016\/j.molcel.2023.10.023.","journal-title":"Mol Cell"},{"key":"3415_CR44","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.tibs.2015.08.012","volume":"40","author":"S Calabretta","year":"2015","unstructured":"Calabretta S, Richard S. Emerging roles of disordered sequences in RNA-binding proteins. Trends Biochem Sci. 2015;40:662\u201372. https:\/\/doi.org\/10.1016\/j.tibs.2015.08.012.","journal-title":"Trends Biochem Sci"},{"key":"3415_CR45","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.gde.2017.11.006","volume":"48","author":"S Moore","year":"2018","unstructured":"Moore S, Jarvelin AI, Davis I, Bond GL, Castello A. Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer. Curr Opin Genet Dev. 2018;48:112\u201320. https:\/\/doi.org\/10.1016\/j.gde.2017.11.006.","journal-title":"Curr Opin Genet Dev"},{"key":"3415_CR46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1080\/15476286.2024.2386498","volume":"21","author":"Z Yang","year":"2024","unstructured":"Yang Z, Zhou J, Li Z, Guo J, Fang L, Xiao X, et al. Identification of whole-cell dsRNA-binding proteins by phase separation. RNA Biol. 2024;21:32\u201345. https:\/\/doi.org\/10.1080\/15476286.2024.2386498.","journal-title":"RNA Biol"},{"key":"3415_CR47","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/nmeth.2557","volume":"10","author":"D Mellacheruvu","year":"2013","unstructured":"Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, et al. The CRAPome: a contaminant repository for affinity purification-mass spectrometry data. Nat Methods. 2013;10:730\u20136. https:\/\/doi.org\/10.1038\/nmeth.2557.","journal-title":"Nat Methods"},{"key":"3415_CR48","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.trecan.2017.03.007","volume":"3","author":"MG Kharas","year":"2017","unstructured":"Kharas MG, Lengner CJ. Stem cells, cancer, and MUSASHI in blood and guts. Trends Cancer. 2017;3:347\u201356. https:\/\/doi.org\/10.1016\/j.trecan.2017.03.007.","journal-title":"Trends Cancer"},{"key":"3415_CR49","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.stem.2010.06.007","volume":"7","author":"KJ Hope","year":"2010","unstructured":"Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, et al. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity. Cell Stem Cell. 2010;7:101\u201313. https:\/\/doi.org\/10.1016\/j.stem.2010.06.007.","journal-title":"Cell Stem Cell"},{"key":"3415_CR50","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","volume":"630","author":"J Abramson","year":"2024","unstructured":"Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature. 2024;630:493\u2013500. https:\/\/doi.org\/10.1038\/s41586-024-07487-w.","journal-title":"Nature"},{"key":"3415_CR51","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","volume":"372","author":"E Krissinel","year":"2007","unstructured":"Krissinel E, Henrick K. Inference of macromolecular assemblies from crystalline state. J Mol Biol. 2007;372:774\u201397. https:\/\/doi.org\/10.1016\/j.jmb.2007.05.022.","journal-title":"J Mol Biol"},{"key":"3415_CR52","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1182\/blood-2011-04-346767","volume":"118","author":"RJ Byers","year":"2011","unstructured":"Byers RJ, Currie T, Tholouli E, Rodig SJ, Kutok JL. MSI2 protein expression predicts unfavorable outcomes in acute myeloid leukemia. Blood. 2011;118:2857\u201367. https:\/\/doi.org\/10.1182\/blood-2011-04-346767.","journal-title":"Blood"},{"key":"3415_CR53","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00277-012-1637-5","volume":"92","author":"F Thol","year":"2013","unstructured":"Thol F, Winschel C, Sonntag AK, Damm F, Wagner K, Chaturvedi A, et al. Prognostic significance of expression levels of stem cell regulators MSI2 and NUMB in acute myeloid leukemia. Ann Hematol. 2013;92:315\u201323. https:\/\/doi.org\/10.1007\/s00277-012-1637-5.","journal-title":"Ann Hematol"},{"key":"3415_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15814-8","volume":"11","author":"DTT Nguyen","year":"2020","unstructured":"Nguyen DTT, Lu Y, Chu KL, Yang X, Park SM, Choo ZN, et al. HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells. Nat Commun. 2020;11:2026. https:\/\/doi.org\/10.1038\/s41467-020-15814-8.","journal-title":"Nat Commun"},{"key":"3415_CR55","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/nm.2187","volume":"16","author":"MG Kharas","year":"2010","unstructured":"Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med. 2010;16:903\u20138. https:\/\/doi.org\/10.1038\/nm.2187.","journal-title":"Nat Med"},{"key":"3415_CR56","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/leu.2013.238","volume":"28","author":"KE Edmaier","year":"2014","unstructured":"Edmaier KE, Stahnke K, Vegi N, Mulaw M, Ihme S, Scheffold A, et al. Expression of the lymphoid enhancer factor 1 is required for normal hematopoietic stem and progenitor cell function. Leukemia. 2014;28:227\u201330. https:\/\/doi.org\/10.1038\/leu.2013.238.","journal-title":"Leukemia"},{"key":"3415_CR57","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/s41375-019-0635-1","volume":"34","author":"K Feder","year":"2020","unstructured":"Feder K, Edmaier-Schroger K, Rawat VPS, Kirsten N, Metzeler K, Kraus JM, et al. Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis. Leukemia. 2020;34:1027\u201337. https:\/\/doi.org\/10.1038\/s41375-019-0635-1.","journal-title":"Leukemia"},{"key":"3415_CR58","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nature17665","volume":"532","author":"S Rentas","year":"2016","unstructured":"Rentas S, Holzapfel N, Belew MS, Pratt G, Voisin V, Wilhelm BT, et al. Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells. Nature. 2016;532:508\u201311. https:\/\/doi.org\/10.1038\/nature17665.","journal-title":"Nature"},{"key":"3415_CR59","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/88264","volume":"28","author":"K Hovanes","year":"2001","unstructured":"Hovanes K, Li TW, Munguia JE, Truong T, Milovanovic T, Lawrence Marsh J, et al. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat Genet. 2001;28:53\u201357. https:\/\/doi.org\/10.1038\/88264.","journal-title":"Nat Genet"},{"key":"3415_CR60","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","volume":"449","author":"N Barker","year":"2007","unstructured":"Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449:1003\u20137. https:\/\/doi.org\/10.1038\/nature06196.","journal-title":"Nature"},{"key":"3415_CR61","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-213x-2-8","volume":"2","author":"J Willert","year":"2002","unstructured":"Willert J, Epping M, Pollack JR, Brown PO, Nusse R. A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol. 2002;2:8. https:\/\/doi.org\/10.1186\/1471-213x-2-8.","journal-title":"BMC Dev Biol"},{"key":"3415_CR62","doi-asserted-by":"publisher","first-page":"14973","DOI":"10.1073\/pnas.261574498","volume":"98","author":"D Yan","year":"2001","unstructured":"Yan D, Wiesmann M, Rohan M, Chan V, Jefferson AB, Guo L, et al. Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt\/beta-catenin signaling is activated in human colon tumors. Proc Natl Acad Sci USA. 2001;98:14973\u20138. https:\/\/doi.org\/10.1073\/pnas.261574498.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3415_CR63","doi-asserted-by":"publisher","first-page":"e86582","DOI":"10.1371\/journal.pone.0086582","volume":"9","author":"N Takahashi","year":"2014","unstructured":"Takahashi N, Yamaguchi K, Ikenoue T, Fujii T, Furukawa Y. Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene. PloS One. 2014;9:e86582. https:\/\/doi.org\/10.1371\/journal.pone.0086582.","journal-title":"PloS One"},{"key":"3415_CR64","doi-asserted-by":"publisher","first-page":"8520","DOI":"10.1038\/sj.onc.1207892","volume":"23","author":"A Niida","year":"2004","unstructured":"Niida A, Hiroko T, Kasai M, Furukawa Y, Nakamura Y, Suzuki Y, et al. DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin\/TCF pathway. Oncogene. 2004;23:8520\u20136. https:\/\/doi.org\/10.1038\/sj.onc.1207892.","journal-title":"Oncogene"},{"key":"3415_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106649","volume":"26","author":"S Patil","year":"2023","unstructured":"Patil S, Chalkiadaki K, Mergiya TF, Krimbacher K, Amorim IS, Akerkar S, et al. eIF4E phosphorylation recruits beta-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. iScience. 2023;26:106649. https:\/\/doi.org\/10.1016\/j.isci.2023.106649.","journal-title":"iScience"},{"key":"3415_CR66","doi-asserted-by":"publisher","unstructured":"Ehyai S, Miyake T, Williams D, Vinayak J, Bayfield MA, McDermott, JC FMRP recruitment of beta-catenin to the translation pre-initiation complex represses translation. EMBO Rep. 2018;19. https:\/\/doi.org\/10.15252\/embr.201745536.","DOI":"10.15252\/embr.201745536"},{"key":"3415_CR67","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202216554","volume":"15","author":"V Garcia-Hernandez","year":"2023","unstructured":"Garcia-Hernandez V, Arambilet D, Guillen Y, Lobo-Jarne T, Maqueda M, Gekas C, et al. beta-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia. EMBO Mol Med. 2023;15:e16554. https:\/\/doi.org\/10.15252\/emmm.202216554.","journal-title":"EMBO Mol Med"},{"key":"3415_CR68","doi-asserted-by":"publisher","first-page":"10560","DOI":"10.1158\/0008-5472.CAN-06-2526","volume":"66","author":"HK Lee","year":"2006","unstructured":"Lee HK, Choi YS, Park YA, Jeong S. Modulation of oncogenic transcription and alternative splicing by beta-catenin and an RNA aptamer in colon cancer cells. Cancer Res. 2006;66:10560\u20136. https:\/\/doi.org\/10.1158\/0008-5472.CAN-06-2526.","journal-title":"Cancer Res"},{"key":"3415_CR69","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1053\/j.gastro.2005.07.025","volume":"129","author":"S Sato","year":"2005","unstructured":"Sato S, Idogawa M, Honda K, Fujii G, Kawashima H, Takekuma K, et al. beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Gastroenterology. 2005;129:1225\u201336. https:\/\/doi.org\/10.1053\/j.gastro.2005.07.025.","journal-title":"Gastroenterology"},{"key":"3415_CR70","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1038\/ng.3854","volume":"49","author":"LP Vu","year":"2017","unstructured":"Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, et al. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nat Genet. 2017;49:866\u201375. https:\/\/doi.org\/10.1038\/ng.3854.","journal-title":"Nat Genet"},{"key":"3415_CR71","doi-asserted-by":"publisher","unstructured":"Wagstaff M, Nguyen D, Blair A, Towler B, Newbury S, and Morgan, R A \u03b2-catenin:MSI2 axis regulates the expression of LEF1 and subsequent human haematopoietic stem\/progenitor cell proliferation. bioRxiv, 2024;2024.2001.2028.577638. https:\/\/doi.org\/10.1101\/2024.01.28.577638.","DOI":"10.1101\/2024.01.28.577638"},{"key":"3415_CR72","doi-asserted-by":"publisher","unstructured":"Zhang H, Guo R, Li Z, Ma R, Xu S, Yin L, et al. MSI2 mediates WNT\/beta-Catenin pathway function in hematopoietic stem cells. Leukemia. 2024; https:\/\/doi.org\/10.1038\/s41375-024-02447-9.","DOI":"10.1038\/s41375-024-02447-9"},{"key":"3415_CR73","first-page":"1089","volume":"5","author":"MH Wang","year":"2015","unstructured":"Wang MH, Qin SY, Zhang SG, Li GX, Yu ZH, Wang K, et al. Musashi-2 promotes hepatitis B-virus related hepatocellular carcinoma progression via the Wnt\/beta-catenin pathway. Am J Cancer Res. 2015;5:1089\u20131100.","journal-title":"Am J Cancer Res"},{"key":"3415_CR74","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1182\/blood-2010-12-322081","volume":"118","author":"L de Andres-Aguayo","year":"2011","unstructured":"de Andres-Aguayo L, Varas F, Kallin EM, Infante JF, Wurst W, Floss T, et al. Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice. Blood. 2011;118:554\u201364. https:\/\/doi.org\/10.1182\/blood-2010-12-322081.","journal-title":"Blood"},{"key":"3415_CR75","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1084\/jem.20130736","volume":"211","author":"SM Park","year":"2014","unstructured":"Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, et al. Musashi-2 controls cell fate, lineage bias, and TGF-beta signaling in HSCs. J Exp Med. 2014;211:71\u201387. https:\/\/doi.org\/10.1084\/jem.20130736.","journal-title":"J Exp Med"},{"key":"3415_CR76","doi-asserted-by":"publisher","first-page":"11148","DOI":"10.1074\/jbc.M116.717801","volume":"291","author":"S Yu","year":"2016","unstructured":"Yu S, Li F, Xing S, Zhao T, Peng W, Xue HH. Hematopoietic and leukemic stem cells have distinct dependence on Tcf1 and Lef1 transcription factors. J Biol Chem. 2016;291:11148\u201360. https:\/\/doi.org\/10.1074\/jbc.M116.717801.","journal-title":"J Biol Chem"},{"key":"3415_CR77","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcac015","volume":"4","author":"S Karmakar","year":"2022","unstructured":"Karmakar S, Ramirez O, Paul KV, Gupta AK, Kumari V, Botti V, et al. Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2). NAR Cancer. 2022;4:zcac015. https:\/\/doi.org\/10.1093\/narcan\/zcac015.","journal-title":"NAR Cancer"},{"key":"3415_CR78","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/cas.14280","volume":"111","author":"J Zhao","year":"2020","unstructured":"Zhao J, Zhang Y, Liu XS, Zhu FM, Xie F, Jiang CY, et al. RNA-binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression. Cancer Sci. 2020;111:369\u201382. https:\/\/doi.org\/10.1111\/cas.14280.","journal-title":"Cancer Sci"},{"key":"3415_CR79","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s13046-020-01587-x","volume":"39","author":"M Li","year":"2020","unstructured":"Li M, Li AQ, Zhou SL, Lv H, Wei P, Yang WT. RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer. J Exp Clin Cancer Res. 2020;39:92. https:\/\/doi.org\/10.1186\/s13046-020-01587-x.","journal-title":"J Exp Clin Cancer Res"},{"key":"3415_CR80","doi-asserted-by":"publisher","first-page":"3788","DOI":"10.1093\/nar\/gkw207","volume":"44","author":"CG Bennett","year":"2016","unstructured":"Bennett CG, Riemondy K, Chapnick DA, Bunker E, Liu X, Kuersten S, et al. Genome-wide analysis of Musashi-2 targets reveals novel functions in governing epithelial cell migration. Nucleic Acids Res. 2016;44:3788\u20133800. https:\/\/doi.org\/10.1093\/nar\/gkw207.","journal-title":"Nucleic Acids Res"},{"key":"3415_CR81","doi-asserted-by":"publisher","first-page":"15359","DOI":"10.1074\/jbc.RA118.002243","volume":"293","author":"S Duggimpudi","year":"2018","unstructured":"Duggimpudi S, Kloetgen A, Maney SK, Munch PC, Hezaveh K, Shaykhalishahi H, et al. Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2\u2019s RNA-binding activity on IL-6 signaling. J Biol Chem. 2018;293:15359\u201369. https:\/\/doi.org\/10.1074\/jbc.RA118.002243.","journal-title":"J Biol Chem"},{"key":"3415_CR82","doi-asserted-by":"publisher","first-page":"5365","DOI":"10.1128\/MCB.00113-07","volume":"27","author":"V Dormoy-Raclet","year":"2007","unstructured":"Dormoy-Raclet V, Menard I, Clair E, Kurban G, Mazroui R, Di Marco S, et al. The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Mol Cell Biol. 2007;27:5365\u201380. https:\/\/doi.org\/10.1128\/MCB.00113-07.","journal-title":"Mol Cell Biol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03415-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03415-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03415-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T13:02:29Z","timestamp":1757163749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03415-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":82,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2025,8,4]]}},"alternative-id":["3415"],"URL":"https:\/\/doi.org\/10.1038\/s41388-025-03415-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5921123\/v1","asserted-by":"object"}]},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]},"assertion":[{"value":"28 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}