{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:02:11Z","timestamp":1792612931638,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"32","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2025,8,25]]},"DOI":"10.1038\/s41388-025-03460-7","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T10:16:08Z","timestamp":1749032168000},"page":"2893-2906","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["SFXN1 promotes bladder cancer metastasis by restraining PINK1-dependent mitophagy"],"prefix":"10.1038","volume":"44","author":[{"given":"Baochao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-3111","authenticated-orcid":false,"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4042-2526","authenticated-orcid":false,"given":"Meng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"3460_CR1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.eururo.2016.06.010","volume":"71","author":"S Antoni","year":"2017","unstructured":"Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A, Bray F. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017;71:96\u2013108.","journal-title":"Eur Urol"},{"key":"3460_CR2","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.eururo.2023.03.029","volume":"84","author":"I Jubber","year":"2023","unstructured":"Jubber I, Ong S, Bukavina L, Black PC, Comp\u00e9rat E, Kamat AM, et al. Epidemiology of bladder cancer in 2023: a systematic review of risk factors. Eur Urol. 2023;84:176\u201390.","journal-title":"Eur Urol"},{"key":"3460_CR3","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1200\/JCO.20.01665","volume":"39","author":"JWF Catto","year":"2021","unstructured":"Catto JWF, Gordon K, Collinson M, Poad H, Twiddy M, Johnson M, et al. Radical cystectomy against intravesical BCG for high-risk high-grade nonmuscle invasive bladder cancer: results from the randomized controlled BRAVO-feasibility study. J Clin Oncol. 2021;39:202\u201314.","journal-title":"J Clin Oncol"},{"key":"3460_CR4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37696-2","volume":"14","author":"M Minoli","year":"2023","unstructured":"Minoli M, Cantore T, Hanhart D, Kiener M, Fedrizzi T, La Manna F, et al. Bladder cancer organoids as a functional system to model different disease stages and therapy response. Nat Commun. 2023;14:2214.","journal-title":"Nat Commun"},{"key":"3460_CR5","first-page":"271","volume":"66","author":"KD Miller","year":"2016","unstructured":"Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66:271\u201389.","journal-title":"CA Cancer J Clin"},{"key":"3460_CR6","first-page":"11536","volume":"24","author":"G Facchini","year":"2020","unstructured":"Facchini G, Cavaliere C, Romis L, Mordente S, Facchini S, Iovane G, et al. Advanced\/metastatic bladder cancer: current status and future directions. Eur Rev Med Pharm Sci. 2020;24:11536\u201352.","journal-title":"Eur Rev Med Pharm Sci"},{"key":"3460_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.eururo.2020.03.055","volume":"79","author":"JA Witjes","year":"2021","unstructured":"Witjes JA, Bruins HM, Cathomas R, Comp\u00e9rat EM, Cowan NC, Gakis G, et al. European association of urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines. Eur Urol. 2021;79:82\u2013104.","journal-title":"Eur Urol"},{"key":"3460_CR8","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/s41586-022-04898-5","volume":"607","author":"S Delaunay","year":"2022","unstructured":"Delaunay S, Pascual G, Feng B, Klann K, Behm M, Hotz-Wagenblatt A, et al. Mitochondrial RNA modifications shape metabolic plasticity in metastasis. Nature. 2022;607:593\u2013603.","journal-title":"Nature"},{"key":"3460_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13045-022-01313-4","volume":"15","author":"P Jin","year":"2022","unstructured":"Jin P, Jiang J, Zhou L, Huang Z, Nice EC, Huang C, et al. Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management. J Hematol Oncol. 2022;15:97.","journal-title":"J Hematol Oncol"},{"key":"3460_CR10","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41556-018-0133-0","volume":"20","author":"V Eisner","year":"2018","unstructured":"Eisner V, Picard M, Hajnoczky G. Mitochondrial dynamics in adaptive and maladaptive cellular stress responses. Nat Cell Biol. 2018;20:755\u201365.","journal-title":"Nat Cell Biol"},{"key":"3460_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.semcancer.2019.07.015","volume":"66","author":"DP Panigrahi","year":"2020","unstructured":"Panigrahi DP, Praharaj PP, Bhol CS, Mahapatra KK, Patra S, Behera BP, et al. The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics. Semin Cancer Biol. 2020;66:45\u201358.","journal-title":"Semin Cancer Biol"},{"key":"3460_CR12","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1080\/15548627.2020.1850609","volume":"17","author":"R Deng","year":"2021","unstructured":"Deng R, Zhang HL, Huang JH, Cai RZ, Wang Y, Chen YH, et al. MAPK1\/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy. 2021;17:3011\u201329.","journal-title":"Autophagy"},{"key":"3460_CR13","doi-asserted-by":"crossref","unstructured":"Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, et al. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science. 2018;362:eaat9528.","DOI":"10.1126\/science.aat9528"},{"key":"3460_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108869","volume":"34","author":"MG Acoba","year":"2021","unstructured":"Acoba MG, Alpergin ESS, Renuse S, Fern\u00e1ndez-Del-R\u00edo L, Lu YW, Khalimonchuk O, et al. The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep. 2021;34:108869.","journal-title":"Cell Rep"},{"key":"3460_CR15","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2023.2279800","volume":"12","author":"B Wang","year":"2023","unstructured":"Wang B, Jiang B, Du L, Chen W, Zhang Q, Chen W, et al. Tumor-intrinsic RGS1 potentiates checkpoint blockade response via ATF3-IFNGR1 axis. Oncoimmunology. 2023;12:2279800.","journal-title":"Oncoimmunology"},{"key":"3460_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102956","volume":"68","author":"L Meng","year":"2023","unstructured":"Meng L, Gao J, Mo W, Wang B, Shen H, Cao W, et al. MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3\/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. Redox Biol. 2023;68:102956.","journal-title":"Redox Biol"},{"key":"3460_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111918","volume":"132","author":"Y Li","year":"2024","unstructured":"Li Y, Yang W, Liu C, Zhou S, Liu X, Zhang T, et al. SFXN1-mediated immune cell infiltration and tumorigenesis in lung adenocarcinoma: a potential therapeutic target. Int Immunopharmacol. 2024;132:111918.","journal-title":"Int Immunopharmacol"},{"key":"3460_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217008","volume":"597","author":"L Andriani","year":"2024","unstructured":"Andriani L, Ling YX, Yang SY, Zhao Q, Ma XY, Huang MY, et al. Sideroflexin-1 promotes progression and sensitivity to lapatinib in triple-negative breast cancer by inhibiting TOLLIP-mediated autophagic degradation of CIP2A. Cancer Lett. 2024;597:217008.","journal-title":"Cancer Lett"},{"key":"3460_CR19","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1007\/s00018-021-03774-1","volume":"78","author":"LP Poole","year":"2021","unstructured":"Poole LP, Macleod KF. Mitophagy in tumorigenesis and metastasis. Cell Mol Life Sci. 2021;78:3817\u201351.","journal-title":"Cell Mol Life Sci"},{"key":"3460_CR20","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3389\/fcell.2020.00413","volume":"8","author":"Y Wang","year":"2020","unstructured":"Wang Y, Liu HH, Cao YT, Zhang LL, Huang F, Yi C. The role of mitochondrial dynamics and mitophagy in carcinogenesis, metastasis and therapy. Front Cell Dev Biol. 2020;8:413.","journal-title":"Front Cell Dev Biol"},{"key":"3460_CR21","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1080\/15548627.2021.2007027","volume":"18","author":"J Yao","year":"2022","unstructured":"Yao J, Wang J, Xu Y, Guo Q, Sun Y, Liu J, et al. CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma. Autophagy. 2022;18:1879\u201397.","journal-title":"Autophagy"},{"key":"3460_CR22","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.devcel.2007.11.019","volume":"14","author":"A Cassidy-Stone","year":"2008","unstructured":"Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax\/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008;14:193\u2013204.","journal-title":"Dev Cell"},{"key":"3460_CR23","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.molmed.2022.06.007","volume":"28","author":"A Ajoolabady","year":"2022","unstructured":"Ajoolabady A, Chiong M, Lavandero S, Klionsky DJ, Ren J. Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment. Trends Mol Med. 2022;28:836\u201349.","journal-title":"Trends Mol Med"},{"key":"3460_CR24","doi-asserted-by":"publisher","first-page":"736","DOI":"10.7150\/thno.79876","volume":"13","author":"Y Lu","year":"2023","unstructured":"Lu Y, Li Z, Zhang S, Zhang T, Liu Y, Zhang L. Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation. Theranostics. 2023;13:736\u201366.","journal-title":"Theranostics"},{"key":"3460_CR25","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1038\/s42255-023-00930-8","volume":"5","author":"A Picca","year":"2023","unstructured":"Picca A, Faitg J, Auwerx J, Ferrucci L, D\u2019Amico D. Mitophagy in human health, ageing and disease. Nat Metab. 2023;5:2047\u201361.","journal-title":"Nat Metab"},{"key":"3460_CR26","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1080\/15548627.2019.1656957","volume":"16","author":"K Niu","year":"2020","unstructured":"Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, et al. USP33 deubiquitinates PRKN\/parkin and antagonizes its role in mitophagy. Autophagy. 2020;16:724\u201334.","journal-title":"Autophagy"},{"key":"3460_CR27","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1080\/15548627.2022.2139080","volume":"19","author":"R Han","year":"2023","unstructured":"Han R, Liu Y, Li S, Li XJ, Yang W. PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models. Autophagy. 2023;19:1396\u2013405.","journal-title":"Autophagy"},{"key":"3460_CR28","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/nchembio.2287","volume":"13","author":"ND Georgakopoulos","year":"2017","unstructured":"Georgakopoulos ND, Wells G, Campanella M. The pharmacological regulation of cellular mitophagy. Nat Chem Biol. 2017;13:136\u201346.","journal-title":"Nat Chem Biol"},{"key":"3460_CR29","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.tcb.2020.07.003","volume":"30","author":"B Bakir","year":"2020","unstructured":"Bakir B, Chiarella AM, Pitarresi JR, Rustgi AK. EMT, MET, plasticity, and tumor metastasis. Trends Cell Biol. 2020;30:764\u201376.","journal-title":"Trends Cell Biol"},{"key":"3460_CR30","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.devcel.2019.04.010","volume":"49","author":"W Lu","year":"2019","unstructured":"Lu W, Kang Y. Epithelial-mesenchymal plasticity in cancer progression and metastasis. Dev Cell. 2019;49:361\u201374.","journal-title":"Dev Cell"},{"key":"3460_CR31","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13045-022-01347-8","volume":"15","author":"Y Huang","year":"2022","unstructured":"Huang Y, Hong W, Wei X. The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol. 2022;15:129.","journal-title":"J Hematol Oncol"},{"key":"3460_CR32","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108647","volume":"40","author":"S Brabletz","year":"2021","unstructured":"Brabletz S, Schuhwerk H, Brabletz T, Stemmler MP. Dynamic EMT: a multi-tool for tumor progression. EMBO J. 2021;40:e108647.","journal-title":"EMBO J"},{"key":"3460_CR33","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/cac2.12138","volume":"41","author":"G Pan","year":"2021","unstructured":"Pan G, Liu Y, Shang L, Zhou F, Yang S. EMT-associated microRNAs and their roles in cancer stemness and drug resistance. Cancer Commun. 2021;41:199\u2013217.","journal-title":"Cancer Commun"},{"key":"3460_CR34","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.trecan.2020.06.005","volume":"6","author":"V Ramesh","year":"2020","unstructured":"Ramesh V, Brabletz T, Ceppi P. Targeting EMT in cancer with repurposed metabolic inhibitors. Trends Cancer. 2020;6:942\u201350.","journal-title":"Trends Cancer"},{"key":"3460_CR35","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.semcancer.2022.09.004","volume":"86","author":"JH Lee","year":"2022","unstructured":"Lee JH, Massague J. TGF-beta in developmental and fibrogenic EMTs. Semin Cancer Biol. 2022;86:136\u201345.","journal-title":"Semin Cancer Biol"},{"key":"3460_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcancer.2023.10.004","volume":"97","author":"X Wang","year":"2023","unstructured":"Wang X, Eichhorn PJA, Thiery JP. TGF-beta, EMT, and resistance to anti-cancer treatment. Semin Cancer Biol. 2023;97:1\u201311.","journal-title":"Semin Cancer Biol"},{"key":"3460_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcancer.2024.04.001","volume":"101","author":"YE Zhang","year":"2024","unstructured":"Zhang YE, Stuelten CH. Alternative splicing in EMT and TGF-beta signaling during cancer progression. Semin Cancer Biol. 2024;101:1\u201311.","journal-title":"Semin Cancer Biol"},{"key":"3460_CR38","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s13046-021-01960-4","volume":"40","author":"CH Chang","year":"2021","unstructured":"Chang CH, Pauklin S. ROS and TGFbeta: from pancreatic tumour growth to metastasis. J Exp Clin Cancer Res. 2021;40:152.","journal-title":"J Exp Clin Cancer Res"},{"key":"3460_CR39","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33862-0","volume":"13","author":"Z Li","year":"2022","unstructured":"Li Z, Low V, Luga V, Sun J, Earlie E, Parang B, et al. Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nat Commun. 2022;13:6239.","journal-title":"Nat Commun"},{"key":"3460_CR40","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1158\/2159-8290.CD-19-0292","volume":"9","author":"RK Amaravadi","year":"2019","unstructured":"Amaravadi RK, Kimmelman AC, Debnath J. Targeting autophagy in cancer: recent advances and future directions. Cancer Discov. 2019;9:1167\u201381.","journal-title":"Cancer Discov"},{"key":"3460_CR41","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1093\/hmg\/ddr048","volume":"20","author":"NC Chan","year":"2011","unstructured":"Chan NC, Salazar AM, Pham AH, Sweredoski MJ, Kolawa NJ, Graham RL, et al. Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet. 2011;20:1726\u201337.","journal-title":"Hum Mol Genet"},{"key":"3460_CR42","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/embor.2013.168","volume":"14","author":"GF Allen","year":"2013","unstructured":"Allen GF, Toth R, James J, Ganley IG. Loss of iron triggers PINK1\/Parkin-independent mitophagy. EMBO Rep. 2013;14:1127\u201335.","journal-title":"EMBO Rep"},{"key":"3460_CR43","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1158\/0008-5472.CAN-22-2370","volume":"83","author":"Y Li","year":"2023","unstructured":"Li Y, Chen H, Xie X, Yang B, Wang X, Zhang J, et al. PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells. Cancer Res. 2023;83:398\u2013413.","journal-title":"Cancer Res"},{"key":"3460_CR44","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1080\/15548627.2021.1997052","volume":"18","author":"M Di Rienzo","year":"2022","unstructured":"Di Rienzo M, Romagnoli A, Ciccosanti F, Refolo G, Consalvi V, Arena G, et al. AMBRA1 regulates mitophagy by interacting with ATAD3A and promoting PINK1 stability. Autophagy. 2022;18:1752\u201362.","journal-title":"Autophagy"},{"key":"3460_CR45","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41590-017-0002-1","volume":"19","author":"G Jin","year":"2018","unstructured":"Jin G, Xu C, Zhang X, Long J, Rezaeian AH, Liu C, et al. Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. Nat Immunol. 2018;19:29\u201340.","journal-title":"Nat Immunol"},{"key":"3460_CR46","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.biopha.2018.06.128","volume":"106","author":"L Liu","year":"2018","unstructured":"Liu L, Zuo Z, Lu S, Wang L, Liu A, Liu X. Silencing of PINK1 represses cell growth, migration and induces apoptosis of lung cancer cells. Biomed Pharmacother. 2018;106:333\u201341.","journal-title":"Biomed Pharmacother"},{"key":"3460_CR47","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1245\/s10434-017-6096-8","volume":"24","author":"K Yamashita","year":"2017","unstructured":"Yamashita K, Miyata H, Makino T, Masuike Y, Furukawa H, Tanaka K, et al. High expression of the mitophagy-related protein Pink1 is associated with a poor response to chemotherapy and a poor prognosis for patients treated with neoadjuvant chemotherapy for esophageal squamous cell carcinoma. Ann Surg Oncol. 2017;24:4025\u201332.","journal-title":"Ann Surg Oncol"},{"key":"3460_CR48","doi-asserted-by":"publisher","first-page":"1903616","DOI":"10.1002\/advs.201903616","volume":"7","author":"Q Chen","year":"2020","unstructured":"Chen Q, Lei JH, Bao J, Wang H, Hao W, Li L, et al. BRCA1 deficiency impairs mitophagy and promotes inflammasome activation and mammary tumor metastasis. Adv Sci. 2020;7:1903616.","journal-title":"Adv Sci"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03460-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03460-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03460-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T18:55:49Z","timestamp":1757184949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03460-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":48,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,8,25]]}},"alternative-id":["3460"],"URL":"https:\/\/doi.org\/10.1038\/s41388-025-03460-7","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All study participants provided informed consent, and the study design was approved by Institutional Ethics Committee of the Nanjing Drum Tower Hospital approved this study (2022-493-01). All authors consent to the publication of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}