{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:14:27Z","timestamp":1793621667795,"version":"4.5.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"34","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2025,9,8]]},"DOI":"10.1038\/s41388-025-03474-1","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:36:17Z","timestamp":1751376977000},"page":"3096-3112","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation"],"prefix":"10.1038","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5627-9650","authenticated-orcid":false,"given":"Yongbo","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2902-6533","authenticated-orcid":false,"given":"Youmiao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9689-8622","authenticated-orcid":false,"given":"Yuanhao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiheng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4413-776X","authenticated-orcid":false,"given":"Wenbang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lailai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2541-2683","authenticated-orcid":false,"given":"Kaixuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuepei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5855-956X","authenticated-orcid":false,"given":"Bin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7360-1582","authenticated-orcid":false,"given":"Fengyan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-6946","authenticated-orcid":false,"given":"Lijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1552-948X","authenticated-orcid":false,"given":"Chaohui","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"3474_CR1","doi-asserted-by":"publisher","first-page":"e076743","DOI":"10.1136\/bmj-2023-076743","volume":"384","author":"A Lopez-Beltran","year":"2024","unstructured":"Lopez-Beltran A, Cookson MS, Guercio BJ, Cheng L. Advances in diagnosis and treatment of bladder cancer. BMJ. 2024;384:e076743.","journal-title":"BMJ"},{"key":"3474_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41572-023-00468-9","volume":"9","author":"L Dyrskj\u00f8t","year":"2023","unstructured":"Dyrskj\u00f8t L, Hansel DE, Efstathiou JA, Knowles MA, Galsky MD, Teoh J, et al. Bladder cancer. Nat Rev Dis Prim. 2023;9:58.","journal-title":"Nat Rev Dis Prim"},{"key":"3474_CR3","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/S1470-2045(21)00094-2","volume":"22","author":"EY Yu","year":"2021","unstructured":"Yu EY, Petrylak DP, O\u2019Donnell PH, Lee JL, van der Heijden MS, Loriot Y, et al. Enfortumab vedotin after PD-1 or PD-L1 inhibitors in cisplatin-ineligible patients with advanced urothelial carcinoma (EV\u2011201): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2021;22:872\u201382.","journal-title":"Lancet Oncol"},{"key":"3474_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.hoc.2021.02.011","volume":"35","author":"C Thibault","year":"2021","unstructured":"Thibault C, Loriot Y. Emerging targeted therapy for bladder cancer. Hematol Oncol Clin North Am. 2021;35:585\u201396.","journal-title":"Hematol Oncol Clin North Am"},{"key":"3474_CR5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.eururo.2022.05.002","volume":"82","author":"AO Siefker-Radtke","year":"2022","unstructured":"Siefker-Radtke AO, Cho DC, Diab A, Sznol M, Bilen MA, Balar AV, et al. Bempegaldesleukin plus nivolumab in first-line metastatic urothelial carcinoma: results from PIVOT-02. Eur Urol. 2022;82:365\u201373.","journal-title":"Eur Urol"},{"key":"3474_CR6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/S1470-2045(21)00660-4","volume":"23","author":"AO Siefker-Radtke","year":"2022","unstructured":"Siefker-Radtke AO, Necchi A, Park SH, Garc\u00eda-Donas J, Huddart RA, Burgess EF, et al. Efficacy and safety of erdafitinib in patients with locally advanced or metastatic urothelial carcinoma: long-term follow-up of a phase 2 study. Lancet Oncol. 2022;23:248\u201358.","journal-title":"Lancet Oncol"},{"key":"3474_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12:31\u201346.","journal-title":"Cancer Discov"},{"key":"3474_CR8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrc3483","volume":"13","author":"A Carracedo","year":"2013","unstructured":"Carracedo A, Cantley LC, Pandolfi PP. Cancer metabolism: fatty acid oxidation in the limelight. Nat Rev Cancer. 2013;13:227\u201332.","journal-title":"Nat Rev Cancer"},{"key":"3474_CR9","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1021\/acs.chemrev.7b00510","volume":"118","author":"CT Walsh","year":"2018","unstructured":"Walsh CT, Tu BP, Tang Y. Eight kinetically stable but thermodynamically activated molecules that power cell metabolism. Chem Rev. 2018;118:1460\u201394.","journal-title":"Chem Rev"},{"key":"3474_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202310146","volume":"11","author":"M Xie","year":"2024","unstructured":"Xie M, Zhou L, Li T, Lin Y, Zhang R, Zheng X, et al. Targeting the KAT8\/YEATS4 axis represses tumor growth and increases cisplatin sensitivity in bladder cancer. Adv Sci. 2024;11:e2310146.","journal-title":"Adv Sci"},{"key":"3474_CR11","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1158\/0008-5472.CAN-21-4349","volume":"82","author":"M An","year":"2022","unstructured":"An M, Zheng H, Huang J, Lin Y, Luo Y, Kong Y, et al. Aberrant nuclear export of circNCOR1 underlies SMAD7-mediated lymph node metastasis of bladder cancer. Cancer Res. 2022;82:2239\u201353.","journal-title":"Cancer Res"},{"key":"3474_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.738","volume":"12","author":"G Wang","year":"2022","unstructured":"Wang G, Zhang M, Zhang Y, Xie Y, Zou J, Zhong J, et al. NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression. Clin Transl Med. 2022;12:e738.","journal-title":"Clin Transl Med"},{"key":"3474_CR13","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1042\/BST20120041","volume":"40","author":"A Adina-Zada","year":"2012","unstructured":"Adina-Zada A, Zeczycki TN, St Maurice M, Jitrapakdee S, Cleland WW, Attwood PV. Allosteric regulation of the biotin-dependent enzyme pyruvate carboxylase by acetyl-CoA. Biochem Soc Trans. 2012;40:567\u201372.","journal-title":"Biochem Soc Trans"},{"key":"3474_CR14","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41568-022-00543-5","volume":"23","author":"DA Guertin","year":"2023","unstructured":"Guertin DA, Wellen KE. Acetyl-CoA metabolism in cancer. Nat Rev Cancer. 2023;23:156\u201372.","journal-title":"Nat Rev Cancer"},{"key":"3474_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102294","volume":"97","author":"Q Zeng","year":"2024","unstructured":"Zeng Q, Gong Y, Zhu N, Shi Y, Zhang C, Qin L. Lipids and lipid metabolism in cellular senescence: emerging targets for age-related diseases. Ageing Res Rev. 2024;97:102294.","journal-title":"Ageing Res Rev"},{"key":"3474_CR16","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186:243\u201378.","journal-title":"Cell"},{"key":"3474_CR17","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nrd.2017.116","volume":"16","author":"BG Childs","year":"2017","unstructured":"Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, et al. Senescent cells: an emerging target for diseases of ageing. Nat Rev Drug Discov. 2017;16:718\u201335.","journal-title":"Nat Rev Drug Discov"},{"key":"3474_CR18","doi-asserted-by":"publisher","first-page":"841","DOI":"10.7150\/thno.49384","volume":"11","author":"L Zhou","year":"2021","unstructured":"Zhou L, Song Z, Hu J, Liu L, Hou Y, Zhang X, et al. ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3. Theranostics. 2021;11:841\u201360.","journal-title":"Theranostics"},{"key":"3474_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12234-5","volume":"24","author":"L Zhou","year":"2024","unstructured":"Zhou L, Zeng Y, Liu Y, Du K, Luo Y, Dai Y, et al. Cellular senescence and metabolic reprogramming model based on bulk\/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC. BMC Cancer. 2024;24:451.","journal-title":"BMC Cancer"},{"key":"3474_CR20","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.21873\/invivo.13301","volume":"37","author":"JI Noh","year":"2023","unstructured":"Noh JI, Ahn EJ, Noh MG, Moon KS, Chung E, Choi C, et al. Orthotopic mouse models of urinary bladder cancer. In Vivo. 2023;37:2039\u201343.","journal-title":"In Vivo"},{"key":"3474_CR21","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","volume":"18","author":"LC Li","year":"2002","unstructured":"Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics. 2002;18:1427\u201331.","journal-title":"Bioinformatics"},{"key":"3474_CR22","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.cmet.2024.01.012","volume":"36","author":"Y Lai","year":"2024","unstructured":"Lai Y, Gao Y, Lin J, Liu F, Yang L, Zhou J, et al. Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5. Cell Metab. 2024;36:822\u201338.e8.","journal-title":"Cell Metab"},{"key":"3474_CR23","first-page":"353","volume":"28","author":"NT Gaisa","year":"2013","unstructured":"Gaisa NT, Reinartz A, Schneider U, Klaus C, Heidenreich A, Jakse G, et al. Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation. Histol Histopathol. 2013;28:353\u201364.","journal-title":"Histol Histopathol"},{"key":"3474_CR24","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.it.2020.06.002","volume":"41","author":"L Villanueva","year":"2020","unstructured":"Villanueva L, \u00c1lvarez-Errico D, Esteller M. The contribution of epigenetics to cancer immunotherapy. Trends Immunol. 2020;41:676\u201391.","journal-title":"Trends Immunol"},{"key":"3474_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.449","volume":"11","author":"L Zhou","year":"2021","unstructured":"Zhou L, Zhang C, Yang X, Liu L, Hu J, Hou Y, et al. Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1. Clin Transl Med. 2021;11:e449.","journal-title":"Clin Transl Med"},{"key":"3474_CR26","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","volume":"150","author":"MA Dawson","year":"2012","unstructured":"Dawson MA, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150:12\u201327.","journal-title":"Cell"},{"key":"3474_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36847-9","volume":"14","author":"OJ Mainwaring","year":"2023","unstructured":"Mainwaring OJ, Weishaupt H, Zhao M, Ros\u00e9n G, Borgenvik A, Breinschmid L, et al. ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors. Nat Commun. 2023;14:1221.","journal-title":"Nat Commun"},{"key":"3474_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","volume":"78","author":"SM Houten","year":"2016","unstructured":"Houten SM, Violante S, Ventura FV, Wanders RJ. The biochemistry and physiology of mitochondrial fatty acid \u03b2-oxidation and its genetic disorders. Annu Rev Physiol. 2016;78:23\u201344.","journal-title":"Annu Rev Physiol"},{"key":"3474_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.canlet.2017.05.002","volume":"401","author":"Q Liu","year":"2017","unstructured":"Liu Q, Luo Q, Halim A, Song G. Targeting lipid metabolism of cancer cells: a promising therapeutic strategy for cancer. Cancer Lett. 2017;401:39\u201345.","journal-title":"Cancer Lett"},{"key":"3474_CR30","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","volume":"5","author":"BY Lee","year":"2006","unstructured":"Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, et al. Senescence-associated beta-galactosidase is lysosomal beta-galactosidase. Aging Cell. 2006;5:187\u201395.","journal-title":"Aging Cell"},{"key":"3474_CR31","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41556-018-0249-2","volume":"21","author":"S Lee","year":"2019","unstructured":"Lee S, Schmitt CA. The dynamic nature of senescence in cancer. Nat Cell Biol. 2019;21:94\u2013101.","journal-title":"Nat Cell Biol"},{"key":"3474_CR32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cell.2017.06.009","volume":"170","author":"DK Simanshu","year":"2017","unstructured":"Simanshu DK, Nissley DV, McCormick F. RAS proteins and their regulators in human disease. Cell. 2017;170:17\u201333.","journal-title":"Cell"},{"key":"3474_CR33","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.ccr.2012.04.027","volume":"21","author":"JG Jackson","year":"2012","unstructured":"Jackson JG, Pant V, Li Q, Chang LL, Quint\u00e1s-Cardama A, Garza D, et al. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell. 2012;21:793\u2013806.","journal-title":"Cancer Cell"},{"key":"3474_CR34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41580-018-0081-3","volume":"20","author":"T Narita","year":"2019","unstructured":"Narita T, Weinert BT, Choudhary C. Functions and mechanisms of non-histone protein acetylation. Nat Rev Mol Cell Biol. 2019;20:156\u201374.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3474_CR35","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.trecan.2020.02.003","volume":"6","author":"J Cao","year":"2020","unstructured":"Cao J, Yan Q. Cancer epigenetics, tumor immunity, and immunotherapy. Trends Cancer. 2020;6:580\u201392.","journal-title":"Trends Cancer"},{"key":"3474_CR36","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","volume":"33","author":"L Shi","year":"2015","unstructured":"Shi L, Tu BP. Acetyl-CoA and the regulation of metabolism: mechanisms and consequences. Curr Opin Cell Biol. 2015;33:125\u201331.","journal-title":"Curr Opin Cell Biol"},{"key":"3474_CR37","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/nrm3841","volume":"15","author":"C Choudhary","year":"2014","unstructured":"Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014;15:536\u201350.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3474_CR38","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ccell.2019.12.011","volume":"37","author":"S Sivanand","year":"2020","unstructured":"Sivanand S, Vander Heiden MG. Emerging roles for branched-chain amino acid metabolism in cancer. Cancer Cell. 2020;37:147\u201356.","journal-title":"Cancer Cell"},{"key":"3474_CR39","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1016\/j.molcel.2022.10.027","volume":"82","author":"S Park","year":"2022","unstructured":"Park S, Mossmann D, Chen Q, Wang X, Dazert E, Colombi M, et al. Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Mol Cell. 2022;82:4246\u201361.e11.","journal-title":"Mol Cell"},{"key":"3474_CR40","doi-asserted-by":"crossref","unstructured":"Fong CS, Mazo G, Das T, Goodman J, Kim M, O\u2019Rourke BP, et al. 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis. Elife. 2016;5:e16270.","DOI":"10.7554\/eLife.16270"},{"key":"3474_CR41","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.celrep.2017.04.055","volume":"19","author":"M Arora","year":"2017","unstructured":"Arora M, Moser J, Phadke H, Basha AA, Spencer SL. Endogenous replication stress in mother cells leads to quiescence of daughter cells. Cell Rep. 2017;19:1351\u201364.","journal-title":"Cell Rep"},{"key":"3474_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14728","volume":"8","author":"AR Barr","year":"2017","unstructured":"Barr AR, Cooper S, Heldt FS, Butera F, Stoy H, Mansfeld J, et al. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun. 2017;8:14728.","journal-title":"Nat Commun"},{"key":"3474_CR43","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1080\/15384101.2017.1383578","volume":"17","author":"A Lezaja","year":"2018","unstructured":"Lezaja A, Altmeyer M. Inherited DNA lesions determine G1 duration in the next cell cycle. Cell Cycle. 2018;17:24\u201332.","journal-title":"Cell Cycle"},{"key":"3474_CR44","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1126\/science.aax3769","volume":"366","author":"C Pohl","year":"2019","unstructured":"Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 2019;366:818\u201322.","journal-title":"Science"},{"key":"3474_CR45","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1093\/nar\/gkx1208","volume":"46","author":"X Guo","year":"2018","unstructured":"Guo X, Bai Y, Zhao M, Zhou M, Shen Q, Yun CH, et al. Acetylation of 53BP1 dictates the DNA double strand break repair pathway. Nucleic Acids Res. 2018;46:689\u2013703.","journal-title":"Nucleic Acids Res"},{"key":"3474_CR46","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3181\/0710-MR-287","volume":"233","author":"E Soupene","year":"2008","unstructured":"Soupene E, Kuypers FA. Mammalian long-chain acyl-CoA synthetases. Exp Biol Med. 2008;233:507\u201321.","journal-title":"Exp Biol Med"},{"key":"3474_CR47","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1194\/jlr.M072512","volume":"58","author":"EL Klett","year":"2017","unstructured":"Klett EL, Chen S, Yechoor A, Lih FB, Coleman RA. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. J Lipid Res. 2017;58:884\u201394.","journal-title":"J Lipid Res"},{"key":"3474_CR48","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1159\/000449205","volume":"84","author":"H Ohmori","year":"2017","unstructured":"Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, et al. Elaidic acid, a trans-fatty acid, enhances the metastasis of colorectal cancer cells. Pathobiology J Immunopathol Mol Cell Biol. 2017;84:144\u201351.","journal-title":"Pathobiology J Immunopathol Mol Cell Biol"},{"key":"3474_CR49","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/nrneph.2017.59","volume":"13","author":"HI Wettersten","year":"2017","unstructured":"Wettersten HI, Aboud OA, Lara PN Jr, Weiss RH. Metabolic reprogramming in clear cell renal cell carcinoma. Nat Rev Nephrol. 2017;13:410\u20139.","journal-title":"Nat Rev Nephrol"},{"key":"3474_CR50","first-page":"254","volume":"20","author":"C Corbet","year":"2017","unstructured":"Corbet C, Feron O. Emerging roles of lipid metabolism in cancer progression. Curr Opin Clin Nutr Metab Care. 2017;20:254\u201360.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"3474_CR51","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s11684-022-0942-1","volume":"17","author":"W Ye","year":"2023","unstructured":"Ye W, Wang J, Huang J, He X, Ma Z, Li X, et al. ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt\/\u03b2-catenin signaling by palmitoylation modification. Front Med. 2023;17:685\u201398.","journal-title":"Front Med"},{"key":"3474_CR52","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/onc.2008.355","volume":"28","author":"T Mashima","year":"2009","unstructured":"Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H. Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions. Oncogene. 2009;28:9\u201319.","journal-title":"Oncogene"},{"key":"3474_CR53","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1111\/j.1349-7006.2009.01203.x","volume":"100","author":"T Mashima","year":"2009","unstructured":"Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, et al. Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide. Cancer Sci. 2009;100:1556\u201362.","journal-title":"Cancer Sci"},{"key":"3474_CR54","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.prp.2016.09.002","volume":"213","author":"F Hartmann","year":"2017","unstructured":"Hartmann F, Sparla D, Tute E, Tamm M, Schneider U, Jeon MK, et al. Low acyl-CoA synthetase 5 expression in colorectal carcinomas is prognostic for early tumour recurrence. Pathol Res Pract. 2017;213:261\u20136.","journal-title":"Pathol Res Pract"},{"key":"3474_CR55","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1161\/ATVBAHA.107.148429","volume":"27","author":"Y Zhou","year":"2007","unstructured":"Zhou Y, Abidi P, Kim A, Chen W, Huang TT, Kraemer FB, et al. Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation. Arterioscler Thromb Vasc Biol. 2007;27:2198\u2013205.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3474_CR56","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1080\/15384047.2018.1564565","volume":"20","author":"W Ma","year":"2019","unstructured":"Ma W, Li T, Wu S, Li J, Wang X, Li H. LOX and ACSL5 as potential relapse markers for pancreatic cancer patients. Cancer Biol Ther. 2019;20:787\u201398.","journal-title":"Cancer Biol Ther"},{"key":"3474_CR57","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1056\/NEJMra023075","volume":"349","author":"JG Herman","year":"2003","unstructured":"Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349:2042\u201354.","journal-title":"N Engl J Med"},{"key":"3474_CR58","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/sj.onc.1204104","volume":"20","author":"AS Fleisher","year":"2001","unstructured":"Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, et al. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. Oncogene. 2001;20:329\u201335.","journal-title":"Oncogene"},{"key":"3474_CR59","first-page":"3455","volume":"58","author":"JM Cunningham","year":"1998","unstructured":"Cunningham JM, Christensen ER, Tester DJ, Kim CY, Roche PC, Burgart LJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res. 1998;58:3455\u201360.","journal-title":"Cancer Res"},{"key":"3474_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.310","volume":"11","author":"L Tao","year":"2021","unstructured":"Tao L, Mu X, Chen H, Jin D, Zhang R, Zhao Y, et al. FTO modifies the m6A level of MALAT and promotes bladder cancer progression. Clin Transl Med. 2021;11:e310.","journal-title":"Clin Transl Med"},{"key":"3474_CR61","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/s41586-021-03392-8","volume":"592","author":"P Libby","year":"2021","unstructured":"Libby P. The changing landscape of atherosclerosis. Nature. 2021;592:524\u201333.","journal-title":"Nature"},{"key":"3474_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40975-7","volume":"14","author":"Z Gong","year":"2023","unstructured":"Gong Z, Zhu J, Chen J, Feng F, Zhang H, Zhang Z, et al. CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications. Nat Commun. 2023;14:5242.","journal-title":"Nat Commun"},{"key":"3474_CR63","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1378\/chest.11-2091","volume":"142","author":"T Kikuchi","year":"2012","unstructured":"Kikuchi T, Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, et al. Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. Chest. 2012;142:329\u201337.","journal-title":"Chest"},{"key":"3474_CR64","doi-asserted-by":"publisher","first-page":"L1028","DOI":"10.1152\/ajplung.00351.2015","volume":"310","author":"Y Hashimoto","year":"2016","unstructured":"Hashimoto Y, Sugiura H, Togo S, Koarai A, Abe K, Yamada M, et al. 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. Am J Physiol Lung Cell Mol Physiol. 2016;310:L1028\u201341.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3474_CR65","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","volume":"18","author":"E Currie","year":"2013","unstructured":"Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr. Cellular fatty acid metabolism and cancer. Cell Metab. 2013;18:153\u201361.","journal-title":"Cell Metab"},{"key":"3474_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15208","volume":"8","author":"YH Kim","year":"2017","unstructured":"Kim YH, Choi YW, Lee J, Soh EY, Kim JH, Park TJ. Senescent tumor cells lead the collective invasion in thyroid cancer. Nat Commun. 2017;8:15208.","journal-title":"Nat Commun"},{"key":"3474_CR67","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.arr.2018.02.001","volume":"43","author":"DGA Burton","year":"2018","unstructured":"Burton DGA, Stolzing A. Cellular senescence: immunosurveillance and future immunotherapy. Ageing Res Rev. 2018;43:17\u201325.","journal-title":"Ageing Res Rev"},{"key":"3474_CR68","doi-asserted-by":"crossref","unstructured":"Paramos-de-Carvalho D, Jacinto A, Sa\u00fade L. The right time for senescence. eLife. 2021;10:e72449.","DOI":"10.7554\/eLife.72449"},{"key":"3474_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101458","volume":"71","author":"E Sikora","year":"2021","unstructured":"Sikora E, Bielak-Zmijewska A, Mosieniak G. A common signature of cellular senescence; does it exist?. Ageing Res Rev. 2021;71:101458.","journal-title":"Ageing Res Rev"},{"key":"3474_CR70","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.cell.2009.04.050","volume":"137","author":"JP Kruse","year":"2009","unstructured":"Kruse JP, Gu W. Modes of p53 regulation. Cell. 2009;137:609\u201322.","journal-title":"Cell"},{"key":"3474_CR71","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13398","volume":"56","author":"T Oda","year":"2023","unstructured":"Oda T, Gotoh N, Kasamatsu T, Handa H, Saitoh T, Sasaki N. DNA damage-induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation. Cell Prolif. 2023;56:e13398.","journal-title":"Cell Prolif"},{"key":"3474_CR72","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35795-8","volume":"14","author":"JM Lee","year":"2023","unstructured":"Lee JM, Hammar\u00e9n HM, Savitski MM, Baek SH. Control of protein stability by post-translational modifications. Nat Commun. 2023;14:201.","journal-title":"Nat Commun"},{"key":"3474_CR73","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41588-017-0026-3","volume":"50","author":"J Chen","year":"2018","unstructured":"Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, et al. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018;50:219\u201328.","journal-title":"Nat Genet"},{"key":"3474_CR74","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.cmet.2017.09.018","volume":"26","author":"M Rios Garcia","year":"2017","unstructured":"Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, et al. Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence. Cell Metab. 2017;26:842\u201355.e5.","journal-title":"Cell Metab"},{"key":"3474_CR75","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.molcel.2011.03.019","volume":"42","author":"A Bothmer","year":"2011","unstructured":"Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, et al. Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell. 2011;42:319\u201329.","journal-title":"Mol Cell"},{"key":"3474_CR76","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/sj.emboj.7600109","volume":"23","author":"A Insinga","year":"2004","unstructured":"Insinga A, Monestiroli S, Ronzoni S, Carbone R, Pearson M, Pruneri G, et al. Impairment of p53 acetylation, stability and function by an oncogenic transcription factor. EMBO J. 2004;23:1144\u201354.","journal-title":"EMBO J"},{"key":"3474_CR77","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1093\/advances\/nmz125","volume":"11","author":"AB Oteng","year":"2020","unstructured":"Oteng AB, Kersten S. Mechanisms of action of trans fatty acids. Adv Nutr. 2020;11:697\u2013708.","journal-title":"Adv Nutr"},{"key":"3474_CR78","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3892\/ijo.2016.3797","volume":"50","author":"K Fujii","year":"2017","unstructured":"Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, et al. Pro-metastatic intracellular signaling of the elaidic trans fatty acid. Int J Oncol. 2017;50:85\u201392.","journal-title":"Int J Oncol"},{"key":"3474_CR79","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/s41577-022-00707-2","volume":"22","author":"N Pishesha","year":"2022","unstructured":"Pishesha N, Harmand TJ, Ploegh HL. A guide to antigen processing and presentation. Nat Rev Immunol. 2022;22:751\u201364.","journal-title":"Nat Rev Immunol"},{"key":"3474_CR80","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/137579","volume":"2013","author":"D Estadella","year":"2013","unstructured":"Estadella D, da Penha Oller do Nascimento CM, Oyama LM, Ribeiro EB, D\u00e2maso AR, de Piano A. Lipotoxicity: effects of dietary saturated and transfatty acids. Mediators Inflamm. 2013;2013:137579.","journal-title":"Mediators Inflamm"},{"key":"3474_CR81","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jjcc.2016.12.012","volume":"70","author":"T Monguchi","year":"2017","unstructured":"Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, et al. Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia. J Cardiol. 2017;70:121\u20137.","journal-title":"J Cardiol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03474-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03474-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03474-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T01:03:44Z","timestamp":1757207024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03474-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":81,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2025,9,8]]}},"alternative-id":["3474"],"URL":"https:\/\/doi.org\/10.1038\/s41388-025-03474-1","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"assertion":[{"value":"10 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All patients who provided tissue samples before enrollment also provided written informed consent. Human studies and animal experiments were approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University (Zhengzhou, China) and Welfare Ethics Committee of the Experimental Animal Platform of the Academy of Medical Sciences at Zhengzhou University (Zhengzhou, China).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}