{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:00:30Z","timestamp":1793354430379,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"41","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272697"],"award-info":[{"award-number":["81272697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA190429"],"award-info":[{"award-number":["R01CA190429"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA236890"],"award-info":[{"award-number":["R01CA236890"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA264983"],"award-info":[{"award-number":["R01CA264983"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA278852"],"award-info":[{"award-number":["R01CA278852"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2025,10,28]]},"DOI":"10.1038\/s41388-025-03543-5","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T16:14:24Z","timestamp":1756224864000},"page":"3939-3954","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Slc7a5 promotes T cell anti-tumor immunity through sustaining cytotoxic T lymphocyte effector function"],"prefix":"10.1038","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-9434","authenticated-orcid":false,"given":"Chunwan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingcui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakota","family":"Poschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Zoccheddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei","family":"Bombin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-3439","authenticated-orcid":false,"given":"Han-Fei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-3390","authenticated-orcid":false,"given":"Huidong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-7240","authenticated-orcid":false,"given":"Kebin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"3543_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.it.2015.02.007","volume":"36","author":"PJ Siska","year":"2015","unstructured":"Siska PJ, Rathmell JC. T cell metabolic fitness in antitumor immunity. Trends Immunol. 2015;36:257\u201364.","journal-title":"Trends Immunol"},{"key":"3543_CR2","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.ccell.2023.05.015","volume":"41","author":"Y Qian","year":"2023","unstructured":"Qian Y, Galan-Cobo A, Guijarro I, Dang M, Molkentine D, Poteete A, et al. MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma. Cancer Cell. 2023;41:1363\u201380.e1367.","journal-title":"Cancer Cell"},{"key":"3543_CR3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2221352120","volume":"120","author":"W Zhang","year":"2023","unstructured":"Zhang W, Cao X, Zhong X, Wu H, Shi Y, Feng M, et al. SRC2 controls CD4(+) T cell activation via stimulating c-Myc-mediated upregulation of amino acid transporter Slc7a5. Proc Natl Acad Sci USA. 2023;120:e2221352120.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3543_CR4","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abo2709","volume":"16","author":"N Kedia-Mehta","year":"2023","unstructured":"Kedia-Mehta N, Pisarska MM, Rollings C, O\u2019Neill C, De Barra C, Foley C, et al. The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis. Sci Signal. 2023;16:eabo2709.","journal-title":"Sci Signal"},{"key":"3543_CR5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.molcel.2020.09.006","volume":"80","author":"W Wang","year":"2020","unstructured":"Wang W, Zou W. Amino acids and their transporters in T cell immunity and cancer therapy. Mol Cell. 2020;80:384\u201395.","journal-title":"Mol Cell"},{"key":"3543_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111963","volume":"42","author":"JW Dean","year":"2023","unstructured":"Dean JW, Helm EY, Fu Z, Xiong L, Sun N, Oliff KN, et al. The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8(+) T cell differentiation and function. Cell Rep. 2023;42:111963.","journal-title":"Cell Rep."},{"key":"3543_CR7","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/ni.1915","volume":"11","author":"R Gandhi","year":"2010","unstructured":"Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010;11:846\u201353.","journal-title":"Nat Immunol"},{"key":"3543_CR8","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.cmet.2023.06.004","volume":"35","author":"C Xue","year":"2023","unstructured":"Xue C, Li G, Zheng Q, Gu X, Shi Q, Su Y, et al. Tryptophan metabolism in health and disease. Cell Metab. 2023;35:1304\u201326.","journal-title":"Cell Metab"},{"key":"3543_CR9","doi-asserted-by":"crossref","unstructured":"Cervenka I, Agudelo LZ, Ruas JL. Kynurenines: Tryptophan\u2019s metabolites in exercise, inflammation, and mental health. Science 2017;357:eaaf9794.","DOI":"10.1126\/science.aaf9794"},{"key":"3543_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature10491","volume":"478","author":"CA Opitz","year":"2011","unstructured":"Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011;478:197\u2013203.","journal-title":"Nature"},{"key":"3543_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2017.12.012","volume":"48","author":"C Gutierrez-Vazquez","year":"2018","unstructured":"Gutierrez-Vazquez C, Quintana FJ. Regulation of the immune response by the aryl hydrocarbon receptor. Immunity. 2018;48:19\u201333.","journal-title":"Immunity"},{"key":"3543_CR12","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1074\/jbc.273.5.2895","volume":"273","author":"T Ikuta","year":"1998","unstructured":"Ikuta T, Eguchi H, Tachibana T, Yoneda Y, Kawajiri K. Nuclear localization and export signals of the human aryl hydrocarbon receptor. J Biol Chem. 1998;273:2895\u2013904.","journal-title":"J Biol Chem"},{"key":"3543_CR13","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.ccell.2018.02.005","volume":"33","author":"Y Liu","year":"2018","unstructured":"Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, et al. Tumor-repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480\u201394.e487.","journal-title":"Cancer Cell"},{"key":"3543_CR14","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.cell.2023.03.011","volume":"186","author":"MJ Bender","year":"2023","unstructured":"Bender MJ, McPherson AC, Phelps CM, Pandey SP, Laughlin CR, Shapira JH, et al. Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment. Cell. 2023;186:1846\u201362.e1826.","journal-title":"Cell"},{"key":"3543_CR15","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.cell.2020.07.038","volume":"182","author":"A Sadik","year":"2020","unstructured":"Sadik A, Somarribas Patterson LF, Ozturk S, Mohapatra SR, Panitz V, Secker PF, et al. IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell. 2020;182:1252\u201370.e1234.","journal-title":"Cell"},{"key":"3543_CR16","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.immuni.2022.01.006","volume":"55","author":"K Hezaveh","year":"2022","unstructured":"Hezaveh K, Shinde RS, Klotgen A, Halaby MJ, Lamorte S, Ciudad MT, et al. Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity. Immunity. 2022;55:324\u201340.e328.","journal-title":"Immunity"},{"key":"3543_CR17","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.tibs.2018.05.003","volume":"43","author":"P Kandasamy","year":"2018","unstructured":"Kandasamy P, Gyimesi G, Kanai Y, Hediger MA. Amino acid transporters revisited: New views in health and disease. Trends Biochem Sci. 2018;43:752\u201389.","journal-title":"Trends Biochem Sci"},{"key":"3543_CR18","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1016\/j.immuni.2021.10.009","volume":"54","author":"KM Grzes","year":"2021","unstructured":"Grzes KM, Sanin DE, Kabat AM, Stanczak MA, Edwards-Hicks J, Matsushita M, et al. Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters. Immunity. 2021;54:2514\u2013530.e2517.","journal-title":"Immunity"},{"key":"3543_CR19","doi-asserted-by":"publisher","first-page":"4080","DOI":"10.4049\/jimmunol.1300923","volume":"191","author":"K Hayashi","year":"2013","unstructured":"Hayashi K, Jutabha P, Endou H, Sagara H, Anzai N. LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells. J Immunol. 2013;191:4080\u20135.","journal-title":"J Immunol"},{"key":"3543_CR20","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ni.2556","volume":"14","author":"LV Sinclair","year":"2013","unstructured":"Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM, Cantrell DA. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol. 2013;14:500\u20138.","journal-title":"Nat Immunol"},{"key":"3543_CR21","doi-asserted-by":"publisher","first-page":"117","DOI":"10.4049\/jimmunol.0804132","volume":"183","author":"TJ Stewart","year":"2009","unstructured":"Stewart TJ, Liewehr DJ, Steinberg SM, Greeneltch KM, Abrams SI. Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells. J Immunol. 2009;183:117\u201328.","journal-title":"J Immunol"},{"key":"3543_CR22","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.4049\/jimmunol.167.8.4286","volume":"167","author":"MH Ryan","year":"2001","unstructured":"Ryan MH, Bristol JA, McDuffie E, Abrams SI. Regression of extensive pulmonary metastases in mice by adoptive transfer of antigen-specific CD8(+) CTL reactive against tumor cells expressing a naturally occurring rejection epitope. J Immunol. 2001;167:4286\u201392.","journal-title":"J Immunol"},{"key":"3543_CR23","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.4049\/jimmunol.171.5.2402","volume":"171","author":"SA Caldwell","year":"2003","unstructured":"Caldwell SA, Ryan MH, McDuffie E, Abrams SI. The Fas\/Fas ligand pathway is important for optimal tumor regression in a mouse model of CTL adoptive immunotherapy of experimental CMS4 lung metastases. J Immunol. 2003;171:2402\u201312.","journal-title":"J Immunol"},{"key":"3543_CR24","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.ccell.2023.02.005","volume":"41","author":"JD Klement","year":"2023","unstructured":"Klement JD, Redd PS, Lu C, Merting AD, Poschel DB, Yang D, et al. Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment. Cancer Cell. 2023;41:620\u201336.e629.","journal-title":"Cancer Cell"},{"key":"3543_CR25","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.cmet.2013.11.004","volume":"18","author":"J Ding","year":"2013","unstructured":"Ding J, Li T, Wang X, Zhao E, Choi JH, Yang L, et al. The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab. 2013;18:896\u2013907.","journal-title":"Cell Metab"},{"key":"3543_CR26","doi-asserted-by":"crossref","unstructured":"Pang Z, Lu Y, Zhou G, Hui F, Xu L, Viau C, et al. MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation. Nucleic Acids Res 2024;52:W398\u2013W406.","DOI":"10.1093\/nar\/gkae253"},{"key":"3543_CR27","doi-asserted-by":"crossref","unstructured":"Lu C, Paschall AV, Shi H, Savage N, Waller JL, Sabbatini ME, et al. The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion. J Natl Cancer Inst 2017;109:djw283.","DOI":"10.1093\/jnci\/djw283"},{"key":"3543_CR28","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/s41591-021-01323-8","volume":"27","author":"A Bassez","year":"2021","unstructured":"Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, et al. A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer. Nat Med. 2021;27:820\u201332.","journal-title":"Nat Med"},{"key":"3543_CR29","doi-asserted-by":"publisher","first-page":"9730","DOI":"10.1073\/pnas.93.18.9730","volume":"93","author":"AY Huang","year":"1996","unstructured":"Huang AY, Gulden PH, Woods AS, Thomas MC, Tong CD, Wang W, et al. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proc Natl Acad Sci USA. 1996;93:9730\u20135.","journal-title":"Proc Natl Acad Sci USA"},{"key":"3543_CR30","doi-asserted-by":"crossref","unstructured":"Golstein P, Griffiths GM An early history of T cell-mediated cytotoxicity. Nat Rev Immunol 2018;18:527\u201335.","DOI":"10.1038\/s41577-018-0009-3"},{"key":"3543_CR31","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1126\/science.7518614","volume":"265","author":"D Kagi","year":"1994","unstructured":"Kagi D, Vignaux F, Ledermann B, Burki K, Depraetere V, Nagata S, et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science. 1994;265:528\u201330.","journal-title":"Science"},{"key":"3543_CR32","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1084\/jem.188.9.1717","volume":"188","author":"LB Owen-Schaub","year":"1998","unstructured":"Owen-Schaub LB, van Golen KL, Hill LL, Price JE. Fas and Fas ligand interactions suppress melanoma lung metastasis. J Exp Med. 1998;188:1717\u201323.","journal-title":"J Exp Med"},{"key":"3543_CR33","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.4049\/jimmunol.168.7.3484","volume":"168","author":"N Seki","year":"2002","unstructured":"Seki N, Brooks AD, Carter CR, Back TC, Parsoneault EM, Smyth MJ, et al. Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin. J Immunol. 2002;168:3484\u201392.","journal-title":"J Immunol"},{"key":"3543_CR34","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nm.3442","volume":"20","author":"S Afshar-Sterle","year":"2014","unstructured":"Afshar-Sterle S, Zotos D, Bernard NJ, Scherger AK, Rodling L, Alsop AE, et al. Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nat Med. 2014;20:283\u201390.","journal-title":"Nat Med"},{"key":"3543_CR35","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nature08402","volume":"461","author":"O La","year":"2009","unstructured":"La O, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, et al. Membrane-bound Fas ligand only is essential for Fas-induced apoptosis. Nature. 2009;461:659\u201363.","journal-title":"Nature"},{"key":"3543_CR36","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209610","volume":"16","author":"F Hikmet","year":"2020","unstructured":"Hikmet F, Mear L, Edvinsson A, Micke P, Uhlen M, Lindskog C. The protein expression profile of ACE2 in human tissues. Mol Syst Biol. 2020;16:e9610.","journal-title":"Mol Syst Biol"},{"key":"3543_CR37","doi-asserted-by":"crossref","unstructured":"Jin J, Kim C, Xia Q, Gould TM, Cao W, Zhang H, et al. Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals. Sci Immunol 2021;6:eabg0791.","DOI":"10.1126\/sciimmunol.abg0791"},{"key":"3543_CR38","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1016\/j.celrep.2019.04.037","volume":"27","author":"DR Myers","year":"2019","unstructured":"Myers DR, Norlin E, Vercoulen Y, Roose JP. Active tonic mTORC1 signals shape baseline translation in naive T cells. Cell Rep. 2019;27:1858\u201374.e1856.","journal-title":"Cell Rep"},{"key":"3543_CR39","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/s42255-022-00730-6","volume":"5","author":"H Cheng","year":"2023","unstructured":"Cheng H, Qiu Y, Xu Y, Chen L, Ma K, Tao M, et al. Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness. Nat Metab. 2023;5:314\u201330.","journal-title":"Nat Metab"},{"key":"3543_CR40","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/ni.1912","volume":"11","author":"L Apetoh","year":"2010","unstructured":"Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010;11:854\u201361.","journal-title":"Nat Immunol"},{"key":"3543_CR41","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1002\/eji.201747121","volume":"47","author":"AK Ehrlich","year":"2017","unstructured":"Ehrlich AK, Pennington JM, Tilton S, Wang X, Marshall NB, Rohlman D, et al. AhR activation increases IL-2 production by alloreactive CD4(+) T cells initiating the differentiation of mucosal-homing Tim3(+) Lag3(+) Tr1 cells. Eur J Immunol. 2017;47:1989\u20132001.","journal-title":"Eur J Immunol"},{"key":"3543_CR42","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nm.3868","volume":"21","author":"ID Mascanfroni","year":"2015","unstructured":"Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, et al. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-alpha. Nat Med. 2015;21:638\u201346.","journal-title":"Nat Med"},{"key":"3543_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17750-z","volume":"11","author":"LF Campesato","year":"2020","unstructured":"Campesato LF, Budhu S, Tchaicha J, Weng CH, Gigoux M, Cohen IJ, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020;11:4011.","journal-title":"Nat Commun"},{"key":"3543_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.100942","volume":"78","author":"S Lamorte","year":"2021","unstructured":"Lamorte S, Shinde R, McGaha TL. Nuclear receptors, the aryl hydrocarbon receptor, and macrophage function. Mol Asp Med. 2021;78:100942.","journal-title":"Mol Asp Med"},{"key":"3543_CR45","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1016\/j.immuni.2021.09.005","volume":"54","author":"MD Sharma","year":"2021","unstructured":"Sharma MD, Pacholczyk R, Shi H, Berrong ZJ, Zakharia Y, Greco A, et al. Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity. Immunity. 2021;54:2354\u201371.e2358.","journal-title":"Immunity"},{"key":"3543_CR46","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.it.2018.10.010","volume":"39","author":"R Shinde","year":"2018","unstructured":"Shinde R, McGaha TL. The Aryl hydrocarbon receptor: connecting immunity to the microenvironment. Trends Immunol. 2018;39:1005\u201320.","journal-title":"Trends Immunol"},{"key":"3543_CR47","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1158\/0008-5472.CAN-22-3042","volume":"83","author":"X Huang","year":"2023","unstructured":"Huang X, Sun T, Wang J, Hong X, Chen H, Yan T, et al. Metformin Reprograms Tryptophan Metabolism to Stimulate CD8+ T-cell Function in Colorectal Cancer. Cancer Res. 2023;83:2358\u201371.","journal-title":"Cancer Res"},{"key":"3543_CR48","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41586-023-05728-y","volume":"615","author":"J Tintelnot","year":"2023","unstructured":"Tintelnot J, Xu Y, Lesker TR, Schonlein M, Konczalla L, Giannou AD, et al. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature. 2023;615:168\u201374.","journal-title":"Nature"},{"key":"3543_CR49","doi-asserted-by":"crossref","unstructured":"Walcheck MT, Schwartz PB, Carrillo ND, Matkowsky KA, Nukaya M, Bradfield CA et al. Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model. Pancreas 2024;53:e670\u2013e680.","DOI":"10.1097\/MPA.0000000000002357"},{"key":"3543_CR50","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1182\/blood-2004-08-3036","volume":"105","author":"Y Maeda","year":"2005","unstructured":"Maeda Y, Levy RB, Reddy P, Liu C, Clouthier SG, Teshima T, et al. Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Blood. 2005;105:2023\u20137.","journal-title":"Blood"},{"key":"3543_CR51","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.molcel.2016.01.009","volume":"61","author":"Q Fu","year":"2016","unstructured":"Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, et al. Structural Basis and Functional Role of Intramembrane Trimerization of the Fas\/CD95 Death Receptor. Mol Cell. 2016;61:602\u201313.","journal-title":"Mol Cell"},{"key":"3543_CR52","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2051-1426-1-3","volume":"1","author":"A Morales-Kastresana","year":"2013","unstructured":"Morales-Kastresana A, Catalan E, Hervas-Stubbs S, Palazon A, Azpilikueta A, Bolanos E, et al. Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb. J Immunother Cancer. 2013;1:3.","journal-title":"J Immunother Cancer"},{"key":"3543_CR53","doi-asserted-by":"crossref","unstructured":"Paschall AV, Yang D, Lu C, Choi JH, Li X, Liu F, et al. H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance. J Immunol 2015;195:1868\u201382.","DOI":"10.4049\/jimmunol.1402243"},{"key":"3543_CR54","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1158\/2326-6066.CIR-18-0065","volume":"6","author":"LK Hong","year":"2018","unstructured":"Hong LK, Chen Y, Smith CC, Montgomery SA, Vincent BG, Dotti G, et al. CD30-Redirected Chimeric Antigen Receptor T Cells Target CD30(+) and CD30(-) Embryonal Carcinoma via Antigen-Dependent and Fas\/FasL Interactions. Cancer Immunol Res. 2018;6:1274\u201387.","journal-title":"Cancer Immunol Res"},{"key":"3543_CR55","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1158\/2159-8290.CD-20-0756","volume":"11","author":"R Upadhyay","year":"2021","unstructured":"Upadhyay R, Boiarsky JA, Pantsulaia G, Svensson-Arvelund J, Lin MJ, Wroblewska A, et al. A critical role for fas-mediated off-target tumor killing in T cell immunotherapy. Cancer Discov. 2021;11:599\u2013613.","journal-title":"Cancer Discov"},{"key":"3543_CR56","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1158\/2159-8290.CD-19-0813","volume":"10","author":"N Singh","year":"2020","unstructured":"Singh N, Lee YG, Shestova O, Ravikumar P, Hayer KE, Hong SJ, et al. Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction. Cancer Discov. 2020;10:552\u201367.","journal-title":"Cancer Discov"},{"key":"3543_CR57","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1182\/blood.2019002121","volume":"135","author":"O Dufva","year":"2020","unstructured":"Dufva O, Koski J, Maliniemi P, Ianevski A, Klievink J, Leitner J, et al. Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity. Blood. 2020;135:597\u2013609.","journal-title":"Blood"},{"key":"3543_CR58","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41588-020-00753-3","volume":"53","author":"AK Najumudeen","year":"2021","unstructured":"Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, et al. The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nat Genet. 2021;53:16\u201326.","journal-title":"Nat Genet"},{"key":"3543_CR59","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s10637-020-00924-3","volume":"38","author":"N Okano","year":"2020","unstructured":"Okano N, Naruge D, Kawai K, Kobayashi T, Nagashima F, Endou H, et al. First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors. Invest N. Drugs. 2020;38:1495\u2013506.","journal-title":"Invest N. Drugs"},{"key":"3543_CR60","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1182\/blood.2019004500","volume":"136","author":"L Fultang","year":"2020","unstructured":"Fultang L, Booth S, Yogev O, Martins da Costa B, Tubb V, Panetti S, et al. Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity. Blood. 2020;136:1155\u201360.","journal-title":"Blood"},{"key":"3543_CR61","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1182\/bloodadvances.2022008272","volume":"7","author":"S Panetti","year":"2023","unstructured":"Panetti S, McJannett N, Fultang L, Booth S, Gneo L, Scarpa U, et al. Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment. Blood Adv. 2023;7:1754\u201361.","journal-title":"Blood Adv"},{"key":"3543_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.624324","volume":"12","author":"M Nachef","year":"2021","unstructured":"Nachef M, Ali AK, Almutairi SM, Lee SH. Targeting SLC1A5 and SLC3A2\/SLC7A5 as a potential strategy to strengthen anti-tumor immunity in the tumor microenvironment. Front Immunol. 2021;12:624324.","journal-title":"Front Immunol"},{"key":"3543_CR63","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1158\/2326-6066.CIR-21-0459","volume":"9","author":"C Han","year":"2021","unstructured":"Han C, Ge M, Ho PC, Zhang L. Fueling T-cell antitumor immunity: amino acid metabolism revisited. Cancer Immunol Res. 2021;9:1373\u201382.","journal-title":"Cancer Immunol Res"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03543-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03543-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03543-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T22:03:30Z","timestamp":1759788210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-025-03543-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":63,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2025,10,28]]}},"alternative-id":["3543"],"URL":"https:\/\/doi.org\/10.1038\/s41388-025-03543-5","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"18 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors decalre no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All methods were performed in accordance with the relevant guidelines and regulations. Approval has been obtained from the Institutional Animal Care and Use Committee of Tianjin University (Approval #TJUE-2021-016. Approval date: 1 March 2021). Informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}