{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:57:21Z","timestamp":1781045841174,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"24","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2026,7,1]]},"DOI":"10.1038\/s41388-026-03741-9","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T22:12:22Z","timestamp":1778019142000},"page":"2385-2404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PinX1 inhibits migrasomes-mediated mitochondrial transfer to confer cisplatin sensitivity in nasopharyngeal carcinoma"],"prefix":"10.1038","volume":"45","author":[{"given":"Juan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingfeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenchao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6142-3328","authenticated-orcid":false,"given":"Chaosheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"3741_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","volume":"394","author":"YP Chen","year":"2019","unstructured":"Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019;394:64\u201380.","journal-title":"Lancet"},{"key":"3741_CR2","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.2147\/CMAR.S341472","volume":"14","author":"R Jiromaru","year":"2022","unstructured":"Jiromaru R, Nakagawa T, Yasumatsu R. Advanced nasopharyngeal carcinoma: current and emerging treatment options. Cancer Manag Res. 2022;14:2681\u20139.","journal-title":"Cancer Manag Res"},{"key":"3741_CR3","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/jjco\/hyu212","volume":"45","author":"T Yoshizaki","year":"2015","unstructured":"Yoshizaki T, Kondo S, Murono S, Endo K, Tsuji A, Nakanishi Y, et al. Progress and controversy for the role of chemotherapy in nasopharyngeal carcinoma. Jpn J Clin Oncol. 2015;45:244\u20137.","journal-title":"Jpn J Clin Oncol"},{"key":"3741_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112758","volume":"207","author":"S Guan","year":"2020","unstructured":"Guan S, Wei J, Huang L, Wu L. Chemotherapy and chemo-resistance in nasopharyngeal carcinoma. Eur J Med Chem. 2020;207:112758.","journal-title":"Eur J Med Chem"},{"key":"3741_CR5","doi-asserted-by":"publisher","first-page":"7246","DOI":"10.1111\/febs.16183","volume":"289","author":"S Yu","year":"2022","unstructured":"Yu S, Yu L. Migrasome biogenesis and functions. FEBS J. 2022;289:7246\u201354.","journal-title":"FEBS J"},{"key":"3741_CR6","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/s41422-023-00811-5","volume":"33","author":"T Ding","year":"2023","unstructured":"Ding T, Ji J, Zhang W, Liu Y, Liu B, Han Y, et al. The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation. Cell Res. 2023;33:617\u201327.","journal-title":"Cell Res"},{"key":"3741_CR7","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/s41556-023-01188-8","volume":"25","author":"H Liang","year":"2023","unstructured":"Liang H, Ma X, Zhang Y, Liu Y, Liu N, Zhang W, et al. The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells. Nat Cell Biol. 2023;25:1173\u201384.","journal-title":"Nat Cell Biol"},{"key":"3741_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36596-9","volume":"14","author":"R Dharan","year":"2023","unstructured":"Dharan R, Huang Y, Cheppali SK, Goren S, Shendrik P, Wang W, et al. Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes. Nat Commun. 2023;14:1037.","journal-title":"Nat Commun"},{"key":"3741_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01673-x","volume":"9","author":"X Zhang","year":"2023","unstructured":"Zhang X, Yao L, Meng Y, Li B, Yang Y, Gao F. Migrasome: a new functional extracellular vesicle. Cell Death Discov. 2023;9:381.","journal-title":"Cell Death Discov"},{"key":"3741_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39693-x","volume":"14","author":"M Hu","year":"2023","unstructured":"Hu M, Li T, Ma X, Liu S, Li C, Huang Z, et al. Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model. Nat Commun. 2023;14:3945.","journal-title":"Nat Commun"},{"key":"3741_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206432","volume":"10","author":"T Li","year":"2023","unstructured":"Li T, Su X, Lu P, Kang X, Hu M, Li C, et al. Bone marrow mesenchymal stem cell-derived dermcidin-containing migrasomes enhance LC3-associated phagocytosis of pulmonary macrophages and protect against post-stroke pneumonia. Adv Sci. 2023;10:e2206432.","journal-title":"Adv Sci"},{"key":"3741_CR12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13045-022-01313-4","volume":"15","author":"P Jin","year":"2022","unstructured":"Jin P, Jiang J, Zhou L, Huang Z, Nice EC, Huang C, et al. Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management. J Hematol Oncol. 2022;15:97.","journal-title":"J Hematol Oncol"},{"key":"3741_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112033","volume":"42","author":"Y He","year":"2023","unstructured":"He Y, Ji Z, Gong Y, Fan L, Xu P, Chen X, et al. Numb\/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation. Cell Rep. 2023;42:112033.","journal-title":"Cell Rep"},{"key":"3741_CR14","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1182\/bloodadvances.2020003661","volume":"5","author":"K Saito","year":"2021","unstructured":"Saito K, Zhang Q, Yang H, Yamatani K, Ai T, Ruvolo V, et al. Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition. Blood Adv. 2021;5:4233\u201355.","journal-title":"Blood Adv"},{"key":"3741_CR15","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.1016\/j.cell.2021.04.027","volume":"184","author":"H Jiao","year":"2021","unstructured":"Jiao H, Jiang D, Hu X, Du W, Ji L, Yang Y, et al. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell. 2021;184:2896\u20132910 e2813.","journal-title":"Cell"},{"key":"3741_CR16","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add0960","volume":"9","author":"YQ Wang","year":"2023","unstructured":"Wang YQ, Wu DH, Wei D, Shen JY, Huang ZW, Liang XY, et al. TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma. Sci Adv. 2023;9:eadd0960.","journal-title":"Sci Adv"},{"key":"3741_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34993-0","volume":"13","author":"L Yan","year":"2022","unstructured":"Yan L, Zhang T, Wang K, Chen Z, Yang Y, Shan B, et al. SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation. Nat Commun. 2022;13:7153.","journal-title":"Nat Commun"},{"key":"3741_CR18","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1756-9966-31-12","volume":"31","author":"XF Lai","year":"2012","unstructured":"Lai XF, Shen CX, Wen Z, Qian YH, Yu CS, Wang JQ, et al. PinX1 regulation of telomerase activity and apoptosis in nasopharyngeal carcinoma cells. J Exp Clin Cancer Res. 2012;31:12.","journal-title":"J Exp Clin Cancer Res"},{"key":"3741_CR19","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41419-022-04510-8","volume":"13","author":"W Tian","year":"2022","unstructured":"Tian W, Lei N, Zhou J, Chen M, Guo R, Qin B, et al. Extracellular vesicles in ovarian cancer chemoresistance, metastasis, and immune evasion. Cell Death Dis. 2022;13:64.","journal-title":"Cell Death Dis"},{"key":"3741_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12311","volume":"12","author":"PP Marie","year":"2023","unstructured":"Marie PP, Fan SJ, Mason J, Wells A, Mendes CC, Wainwright SM, et al. Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. J Extracell Vesicles. 2023;12:e12311.","journal-title":"J Extracell Vesicles"},{"key":"3741_CR21","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s12964-024-01795-4","volume":"22","author":"LR Jansen","year":"2024","unstructured":"Jansen LR, Welch MA, Plant LD, Baro DJ. Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation. Cell Commun Signal. 2024;22:422.","journal-title":"Cell Commun Signal"},{"key":"3741_CR22","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.molmed.2023.05.006","volume":"29","author":"D Han","year":"2023","unstructured":"Han D, Wang L, Jiang S, Yang Q. The ubiquitin-proteasome system in breast cancer. Trends Mol Med. 2023;29:599\u2013621.","journal-title":"Trends Mol Med"},{"key":"3741_CR23","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1002\/hep.31222","volume":"72","author":"X Liu","year":"2020","unstructured":"Liu X, Liu J, Xiao W, Zeng Q, Bo H, Zhu Y, et al. SIRT1 regulates N(6) -methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2-dependent FTO SUMOylation. Hepatology. 2020;72:2029\u201350.","journal-title":"Hepatology"},{"key":"3741_CR24","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41418-024-01257-x","volume":"31","author":"B Zhang","year":"2024","unstructured":"Zhang B, Li J, Wang Y, Liu X, Yang X, Liao Z, et al. Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16\/TOP2A axis. Cell Death Differ. 2024;31:309\u201321.","journal-title":"Cell Death Differ"},{"key":"3741_CR25","doi-asserted-by":"crossref","unstructured":"Zampieri LX, Silva-Almeida C, Rondeau JD, Sonveaux P. Mitochondrial transfer in cancer: a comprehensive review. International J Mol Sci. 2021;22:3245.","DOI":"10.3390\/ijms22063245"},{"key":"3741_CR26","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s12672-024-00942-0","volume":"15","author":"S Deng","year":"2024","unstructured":"Deng S, Wu Y, Huang S, Yang X. Novel insights into the roles of migrasome in cancer. Discov Oncol. 2024;15:166.","journal-title":"Discov Oncol"},{"key":"3741_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217289","volume":"605","author":"R Zhang","year":"2024","unstructured":"Zhang R, Peng J, Zhang Y, Zheng K, Chen Y, Liu L, et al. Pancreatic cancer cell-derived migrasomes promote cancer progression by fostering an immunosuppressive tumor microenvironment. Cancer Lett. 2024;605:217289.","journal-title":"Cancer Lett"},{"key":"3741_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.994828","volume":"13","author":"Y Qin","year":"2022","unstructured":"Qin Y, Yang J, Liang C, Liu J, Deng Z, Yan B, et al. Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: a bulk omics research and single cell sequencing validation. Front Immunol. 2022;13:994828.","journal-title":"Front Immunol"},{"key":"3741_CR29","first-page":"5485","volume":"11","author":"J Kang","year":"2021","unstructured":"Kang J, Park JH, Kong JS, Kim MJ, Lee SS, Park S, et al. PINX1 promotes malignant transformation of thyroid cancer through the activation of the AKT\/MAPK\/beta-catenin signaling pathway. Am J Cancer Res. 2021;11:5485\u201395.","journal-title":"Am J Cancer Res"},{"key":"3741_CR30","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s10456-019-09675-z","volume":"22","author":"P Hou","year":"2019","unstructured":"Hou P, Li H, Yong H, Chen F, Chu S, Zheng J, et al. PinX1 represses renal cancer angiogenesis via the mir-125a-3p\/VEGF signaling pathway. Angiogenesis. 2019;22:507\u201319.","journal-title":"Angiogenesis"},{"key":"3741_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0332-2","volume":"14","author":"M Shi","year":"2015","unstructured":"Shi M, Cao M, Song J, Liu Q, Li H, Meng F, et al. PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-kappaB\/MMP-9 signaling pathway. Mol Cancer. 2015;14:66.","journal-title":"Mol Cancer"},{"key":"3741_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13046-020-1530-3","volume":"39","author":"C Yu","year":"2020","unstructured":"Yu C, Chen F, Wang X, Cai Z, Yang M, Zhong Q, et al. Pin2 telomeric repeat factor 1-interacting telomerase inhibitor 1 (PinX1) inhibits nasopharyngeal cancer cell stemness: implication for cancer progression and therapeutic targeting. J Exp Clin cancer Res: Cr. 2020;39:31.","journal-title":"J Exp Clin cancer Res: Cr"},{"key":"3741_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188966","volume":"1878","author":"RJ Guo","year":"2023","unstructured":"Guo RJ, Cao YF, Li EM, Xu LY. Multiple functions and dual characteristics of RAB11A in cancers. Biochim Biophys Acta Rev Cancer. 2023;1878:188966.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"3741_CR34","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.job.2023.11.007","volume":"66","author":"K Yoshida","year":"2024","unstructured":"Yoshida K, Htike K, Eguchi T, Kawai H, Eain HS, Tran MT, et al. Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion. J Oral Biosci. 2024;66:205\u201316.","journal-title":"J Oral Biosci"},{"key":"3741_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12465","volume":"13","author":"JD Mason","year":"2024","unstructured":"Mason JD, Marks E, Fan SJ, McCormick K, Wilson C, Harris AL, et al. Stress-induced Rab11a-exosomes induce amphiregulin-mediated cetuximab resistance in colorectal cancer. J Extracell Vesicles. 2024;13:e12465.","journal-title":"J Extracell Vesicles"},{"key":"3741_CR36","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.omtn.2021.12.023","volume":"27","author":"S Bai","year":"2022","unstructured":"Bai S, Hou W, Yao Y, Meng J, Wei Y, Hu F, et al. Exocyst controls exosome biogenesis via Rab11a. Mol Ther Nucleic acids. 2022;27:535\u201346.","journal-title":"Mol Ther Nucleic acids"},{"key":"3741_CR37","first-page":"1081","volume":"52","author":"ZJ Han","year":"2018","unstructured":"Han ZJ, Feng YH, Gu BH, Li YM, Chen H. The post-translational modification, SUMOylation, and cancer (Review). Int J Oncol. 2018;52:1081\u201394.","journal-title":"Int J Oncol"},{"key":"3741_CR38","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1002\/1873-3468.14749","volume":"597","author":"S Desgraupes","year":"2023","unstructured":"Desgraupes S, Etienne L, Arhel NJ. RANBP2 evolution and human disease. FEBS Lett. 2023;597:2519\u201333.","journal-title":"FEBS Lett"},{"key":"3741_CR39","doi-asserted-by":"crossref","unstructured":"Li J, Su L, Jiang J, Wang YE, Ling Y, Qiu Y, et al. RanBP2\/Nup358 mediates sumoylation of STAT1 and antagonizes interferon-alpha-mediated antiviral innate immunity. Int J Mol Sci. 2023;25:299.","DOI":"10.3390\/ijms25010299"},{"key":"3741_CR40","doi-asserted-by":"crossref","unstructured":"Qian L, Liang Z, Wang Z, Wang J, Li X, Zhao J, et al. Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma. J Mol Cell Biol. 2023;15:mjad027.","DOI":"10.1093\/jmcb\/mjad027"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03741-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03741-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03741-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:02:44Z","timestamp":1781042564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03741-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":40,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["3741"],"URL":"https:\/\/doi.org\/10.1038\/s41388-026-03741-9","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"20 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}