{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T23:01:25Z","timestamp":1780009285413,"version":"3.53.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"22","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2026,6,19]]},"DOI":"10.1038\/s41388-026-03801-0","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:24:12Z","timestamp":1776745452000},"page":"2155-2170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting YRDC blocks codon-biased FABP7 translation and lipid droplet formation to overcome chemoresistance in glioblastoma"],"prefix":"10.1038","volume":"45","author":[{"given":"Yuchao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingpu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2993-3763","authenticated-orcid":false,"given":"Kejun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-7065","authenticated-orcid":false,"given":"Nu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-0778","authenticated-orcid":false,"given":"Xujia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"3801_CR1","first-page":"299","volume":"70","author":"AC Tan","year":"2020","unstructured":"Tan AC, Ashley DM, L\u00f3pez GY, Malinzak M, Friedman HS, Khasraw M. Management of glioblastoma: state of the art and future directions. CA Cancer J Clin. 2020;70:299\u2013312.","journal-title":"CA Cancer J Clin"},{"key":"3801_CR2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987\u201396.","journal-title":"N Engl J Med"},{"key":"3801_CR3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41580-021-00342-0","volume":"22","author":"T Suzuki","year":"2021","unstructured":"Suzuki T. The expanding world of tRNA modifications and their disease relevance. Nat Rev Mol Cell Biol. 2021;22:375\u201392.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3801_CR4","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41576-022-00501-9","volume":"23","author":"EA Orellana","year":"2022","unstructured":"Orellana EA, Siegal E, Gregory RI. tRNA dysregulation and disease. Nat Rev Genet. 2022;23:651\u201364.","journal-title":"Nat Rev Genet"},{"key":"3801_CR5","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1038\/s43018-025-00977-4","volume":"6","author":"EW Tao","year":"2025","unstructured":"Tao EW, Wang Y, Tan J, Chen Y, Sun TY, Hao Y, et al. TRMT6-mediated tRNA m1A modification acts as a translational checkpoint of histone synthesis and facilitates colorectal cancer progression. Nat Cancer. 2025;6:1458\u201376.","journal-title":"Nat Cancer"},{"key":"3801_CR6","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/s41586-022-04898-5","volume":"607","author":"S Delaunay","year":"2022","unstructured":"Delaunay S, Pascual G, Feng B, Klann K, Behm M, Hotz-Wagenblatt A, et al. Mitochondrial RNA modifications shape metabolic plasticity in metastasis. Nature. 2022;607:593\u2013603.","journal-title":"Nature"},{"key":"3801_CR7","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.4161\/15476286.2014.992277","volume":"11","author":"PC Thiaville","year":"2015","unstructured":"Thiaville PC, Iwata-Reuyl D, de Cr\u00e9cy-Lagard V. Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t6A), a universal modification of tRNA. RNA Biol. 2015;11:1529\u201339.","journal-title":"RNA Biol"},{"key":"3801_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11951-x","volume":"10","author":"C Arrondel","year":"2019","unstructured":"Arrondel C, Missoury S, Snoek R, Patat J, Menara G, Collinet B, et al. Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. Nat Commun. 2019;10:3967.","journal-title":"Nat Commun"},{"key":"3801_CR9","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/s43018-024-00748-7","volume":"5","author":"X Wu","year":"2024","unstructured":"Wu X, Yuan H, Wu Q, Gao Y, Duan T, Yang K, et al. Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming. Nat Cancer. 2024;5:1024\u201344.","journal-title":"Nat Cancer"},{"key":"3801_CR10","doi-asserted-by":"publisher","first-page":"445","DOI":"10.3892\/ijo.2017.4033","volume":"51","author":"H Zeng","year":"2017","unstructured":"Zeng H, Xu N, Liu Y, Liu B, Yang Z, Fu Z, et al. Genomic profiling of long non-coding RNA and mRNA expression associated with acquired temozolomide resistance in glioblastoma cells. Int J Oncol. 2017;51:445\u201355.","journal-title":"Int J Oncol"},{"key":"3801_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.111","volume":"5","author":"JL Munoz","year":"2014","unstructured":"Munoz JL, Rodriguez-Cruz V, Greco SJ, Ramkissoon SH, Ligon KL, Rameshwar P. Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43. Cell Death Dis. 2014;5:e1145.","journal-title":"Cell Death Dis"},{"key":"3801_CR12","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ccell.2024.05.001","volume":"42","author":"J Zhong","year":"2024","unstructured":"Zhong J, Xing X, Gao Y, Pei L, Lu C, Sun H, et al. Distinct roles of TREM2 in central nervous system cancers and peripheral cancers. Cancer Cell. 2024;42:968\u201384.e9.","journal-title":"Cancer Cell"},{"key":"3801_CR13","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","volume":"596","author":"J Jumper","year":"2021","unstructured":"Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, et al. Highly accurate protein structure prediction with AlphaFold. Nature. 2021;596:583\u20139.","journal-title":"Nature"},{"key":"3801_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"CA Lipinski","year":"2001","unstructured":"Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 2001;46:3\u201326.","journal-title":"Adv Drug Deliv Rev"},{"key":"3801_CR15","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1602\/neurorx.2.4.541","volume":"2","author":"H Pajouhesh","year":"2005","unstructured":"Pajouhesh H, Lenz GR. Medicinal chemical properties of successful central nervous system drugs. NeuroRx. 2005;2:541\u201353.","journal-title":"NeuroRx"},{"key":"3801_CR16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"CA Lipinski","year":"2004","unstructured":"Lipinski CA. Lead- and drug-like compounds: the rule-of-five revolution. Drug Discov Today: Technol. 2004;1:337\u201341.","journal-title":"Drug Discov Today: Technol"},{"key":"3801_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. 2017;7:42717.","journal-title":"Sci Rep"},{"key":"3801_CR18","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/cmdc.201600182","volume":"11","author":"A Daina","year":"2016","unstructured":"Daina A, Zoete V. A BOILED-egg to predict gastrointestinal absorption and brain penetration of small molecules. ChemMedChem. 2016;11:1117\u201321.","journal-title":"ChemMedChem"},{"key":"3801_CR19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1126\/science.1233606","volume":"341","author":"D Martinez Molina","year":"2013","unstructured":"Martinez Molina D, Jafari R, Ignatushchenko M, Seki T, Larsson EA, Dan C, et al. Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science. 2013;341:84\u20137.","journal-title":"Science"},{"key":"3801_CR20","doi-asserted-by":"publisher","first-page":"D213","DOI":"10.1093\/nar\/gkx997","volume":"46","author":"JM Rodriguez","year":"2018","unstructured":"Rodriguez JM, Rodriguez-Rivas J, Di Domenico T, V\u00e1zquez J, Valencia A, Tress ML. APPRIS 2017: principal isoforms for multiple gene sets. Nucleic Acids Res. 2018;46:D213\u20137.","journal-title":"Nucleic Acids Res"},{"key":"3801_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28372-y","volume":"13","author":"N Abdelfattah","year":"2022","unstructured":"Abdelfattah N, Kumar P, Wang C, Leu JS, Flynn WF, Gao R, et al. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nat Commun. 2022;13:767.","journal-title":"Nat Commun"},{"key":"3801_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/neuonc\/now247","volume":"19","author":"RL Bowman","year":"2017","unstructured":"Bowman RL, Wang Q, Carro A, Verhaak RGW, Squatrito M. GlioVis data portal for visualization and analysis of brain tumor expression datasets. Neuro Oncol. 2017;19:139\u201341.","journal-title":"Neuro Oncol"},{"key":"3801_CR23","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47:W556\u201360.","journal-title":"Nucleic Acids Res"},{"key":"3801_CR24","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.gendis.2016.04.007","volume":"3","author":"SY Lee","year":"2016","unstructured":"Lee SY. Temozolomide resistance in glioblastoma multiforme. Genes Dis. 2016;3:198\u2013210.","journal-title":"Genes Dis"},{"key":"3801_CR25","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al. Identification of human brain tumour initiating cells. Nature. 2004;432:396\u2013401.","journal-title":"Nature"},{"key":"3801_CR26","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/neuonc\/nox142","volume":"20","author":"D Garnier","year":"2018","unstructured":"Garnier D, Meehan B, Kislinger T, Daniel P, Sinha A, Abdulkarim B, et al. Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization. Neuro Oncol. 2018;20:236\u201348.","journal-title":"Neuro Oncol"},{"key":"3801_CR27","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cell.2014.02.030","volume":"157","author":"ML Suv\u00e0","year":"2014","unstructured":"Suv\u00e0 ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, et al. Reconstructing and reprogramming the tumor propagating potential of glioblastoma stem-like cells. Cell. 2014;157:580\u201394.","journal-title":"Cell"},{"key":"3801_CR28","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ajhg.2009.08.004","volume":"85","author":"A Zeharia","year":"2009","unstructured":"Zeharia A, Shaag A, Pappo O, Mager-Heckel AM, Saada A, Beinat M, et al. Acute infantile liver failure due to mutations in the TRMU gene. Am J Hum Genet. 2009;85:401\u20137.","journal-title":"Am J Hum Genet"},{"key":"3801_CR29","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1016\/j.molcel.2024.06.013","volume":"84","author":"TY Lin","year":"2024","unstructured":"Lin TY, Kleemann L, Je\u017cowski J, Dobosz D, Rawski M, Indyka P, et al. The molecular basis of tRNA selectivity by human pseudouridine synthase 3. Mol Cell. 2024;84:2472\u201389.","journal-title":"Mol Cell"},{"key":"3801_CR30","doi-asserted-by":"crossref","unstructured":"Zhang D, Li B, Xu H, Li J, Ma C, Ge W, et al. Identification of FBLL1 as a neuron-specific RNA 2\u2032-O-methyltransferase mediating neuronal differentiation. Proc Natl Acad Sci USA. 121:e2406961121.","DOI":"10.1073\/pnas.2406961121"},{"key":"3801_CR31","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1093\/nar\/gkae013","volume":"52","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Zhou JB, Yin Y, Wang ED, Zhou XL. Multifaceted roles of t6A biogenesis in efficiency and fidelity of mitochondrial gene expression. Nucleic Acids Res. 2024;52:3213.","journal-title":"Nucleic Acids Res"},{"key":"3801_CR32","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.1007\/s12035-019-1489-2","volume":"56","author":"A Islam","year":"2019","unstructured":"Islam A, Kagawa Y, Miyazaki H, Shil SK, Umaru BA, Yasumoto Y, et al. FABP7 protects astrocytes against ROS toxicity via lipid droplet formation. Mol Neurobiol. 2019;56:5763\u201379.","journal-title":"Mol Neurobiol"},{"key":"3801_CR33","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1002\/glia.23879","volume":"68","author":"KM Killoy","year":"2020","unstructured":"Killoy KM, Harlan BA, Pehar M, Vargas MR. FABP7 up-regulation induces a neurotoxic phenotype in astrocytes. Glia. 2020;68:2693\u2013704.","journal-title":"Glia"},{"key":"3801_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-08044-7","volume":"16","author":"Y Wu","year":"2025","unstructured":"Wu Y, Shen J, Gao S, Li M, Weng Q, Zheng K, et al. Fatty acid synthase-mediated lipid droplet formation enhances macrophage killing of Staphylococcus aureus. Cell Death Dis. 2025;16:715.","journal-title":"Cell Death Dis"},{"key":"3801_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02198-2","volume":"24","author":"MA Freitas-Cortez","year":"2025","unstructured":"Freitas-Cortez MA, Masrorpour F, Jiang H, Mahmud I, Lu Y, Huang A, et al. Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins. Mol Cancer. 2025;24:40.","journal-title":"Mol Cancer"},{"key":"3801_CR36","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.gendis.2019.09.010","volume":"7","author":"L Tirinato","year":"2019","unstructured":"Tirinato L, Pagliari F, Di Franco S, Sogne E, Marafioti MG, Jansen J, et al. ROS and lipid droplet accumulation induced by high glucose exposure in healthy colon and colorectal cancer stem cells. Genes Dis. 2019;7:620\u201335.","journal-title":"Genes Dis"},{"key":"3801_CR37","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s41420-023-01493-z","volume":"9","author":"Y Jin","year":"2023","unstructured":"Jin Y, Tan Y, Wu J, Ren Z. Lipid droplets: a cellular organelle vital in cancer cells. Cell Death Discov. 2023;9:254.","journal-title":"Cell Death Discov"},{"key":"3801_CR38","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1038\/nprot.2014.138","volume":"9","author":"R Jafari","year":"2014","unstructured":"Jafari R, Almqvist H, Axelsson H, Ignatushchenko M, Lundb\u00e4ck T, Nordlund P, et al. The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc. 2014;9:2100\u201322.","journal-title":"Nat Protoc"},{"key":"3801_CR39","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/s43018-021-00238-0","volume":"2","author":"Q Cui","year":"2021","unstructured":"Cui Q, Yin K, Zhang X, Ye P, Chen X, Chao J, et al. Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis. Nat Cancer. 2021;2:932\u201349.","journal-title":"Nat Cancer"},{"key":"3801_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29125-7","volume":"13","author":"H Han","year":"2022","unstructured":"Han H, Yang C, Ma J, Zhang S, Zheng S, Ling R, et al. N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR\/ULK1\/autophagy axis. Nat Commun. 2022;13:1478.","journal-title":"Nat Commun"},{"key":"3801_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17186-5","volume":"11","author":"CP Couturier","year":"2020","unstructured":"Couturier CP, Ayyadhury S, Le PU, Nadaf J, Monlong J, Riva G, et al. Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy. Nat Commun. 2020;11:3406.","journal-title":"Nat Commun"},{"key":"3801_CR42","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nrclinonc.2017.166","volume":"15","author":"I Dagogo-Jack","year":"2018","unstructured":"Dagogo-Jack I, Shaw AT. Tumour heterogeneity and resistance to cancer therapies. Nat Rev Clin Oncol. 2018;15:81\u201394.","journal-title":"Nat Rev Clin Oncol"},{"key":"3801_CR43","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.7150\/ijbs.80233","volume":"19","author":"W Cui","year":"2023","unstructured":"Cui W, Zhao D, Jiang J, Tang F, Zhang C, Duan C. tRNA modifications and modifying enzymes in disease, the potential therapeutic targets. Int J Biol Sci. 2023;19:1146\u201362.","journal-title":"Int J Biol Sci"},{"key":"3801_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-128","volume":"10","author":"D Beier","year":"2011","unstructured":"Beier D, Schulz JB, Beier CP. Chemoresistance of glioblastoma cancer stem cells - much more complex than expected. Mol Cancer. 2011;10:128.","journal-title":"Mol Cancer"},{"key":"3801_CR45","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1093\/nar\/gks1287","volume":"41","author":"L Perrochia","year":"2013","unstructured":"Perrochia L, Crozat E, Hecker A, Zhang W, Bareille J, Collinet B, et al. In vitro biosynthesis of a universal t6A tRNA modification in archaea and eukarya. Nucleic Acids Res. 2013;41:1953\u201364.","journal-title":"Nucleic Acids Res"},{"key":"3801_CR46","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1261\/rna.077537.120","volume":"26","author":"P Wolff","year":"2020","unstructured":"Wolff P, Villette C, Zumsteg J, Heintz D, Antoine L, Chane-Woon-Ming B, et al. Comparative patterns of modified nucleotides in individual tRNA species from a mesophilic and two thermophilic archaea. RNA. 2020;26:1957\u201375.","journal-title":"RNA"},{"key":"3801_CR47","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1002\/hep.32585","volume":"77","author":"X Zeng","year":"2023","unstructured":"Zeng X, Liao G, Li S, Liu H, Zhao X, Li S, et al. Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation. Hepatology. 2023;77:1122.","journal-title":"Hepatology"},{"key":"3801_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105780","volume":"171","author":"W Wu","year":"2021","unstructured":"Wu W, Klockow JL, Zhang M, Lafortune F, Chang E, Jin L, et al. Glioblastoma multiforme (GBM): an overview of current therapies and mechanisms of resistance. Pharm Res. 2021;171:105780.","journal-title":"Pharm Res"},{"key":"3801_CR49","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S1470-2045(02)00786-6","volume":"3","author":"M Bredel","year":"2002","unstructured":"Bredel M, Zentner J. Brain-tumour drug resistance: the bare essentials. Lancet Oncol. 2002;3:397\u2013406.","journal-title":"Lancet Oncol"},{"key":"3801_CR50","doi-asserted-by":"publisher","first-page":"3994","DOI":"10.3390\/curroncol31070296","volume":"31","author":"M Jezierza\u0144ski","year":"2024","unstructured":"Jezierza\u0144ski M, Nafalska N, Stopyra M, Furgo\u0142 T, Miciak M, Kabut J, et al. Temozolomide (TMZ) in the treatment of glioblastoma multiforme\u2014a literature review and clinical outcomes. Curr Oncol. 2024;31:3994\u20134002.","journal-title":"Curr Oncol"},{"key":"3801_CR51","unstructured":"Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025. Nucleic Acids Res. 2024;53:D30\u201344."},{"key":"3801_CR52","doi-asserted-by":"publisher","DOI":"10.1093\/gpbjnl\/qzaf072","volume":"23","author":"S Zhang","year":"2025","unstructured":"Zhang S, Chen X, Jin E, Wang A, Chen T, Zhang X, et al. The GSA Family in 2025: a broadened sharing platform for multi-omics and multimodal data. Genomics Proteom Bioinforma. 2025;23:qzaf072.","journal-title":"Genomics Proteom Bioinforma"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03801-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03801-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03801-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T22:01:43Z","timestamp":1780005703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41388-026-03801-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":52,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,19]]}},"alternative-id":["3801"],"URL":"https:\/\/doi.org\/10.1038\/s41388-026-03801-0","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"3 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}