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The study was approved by the Shanghai Ruijin Hospital Review Board (Approval number: 2022-317), and written informed consent was obtained from all patients in accordance with the Declaration of Helsinki. All animal experiments were conducted in strict accordance with protocols approved by the Animal Ethics Committee of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (Approval number: RJ2025036). This manuscript does not contain any identifiable images of human participants.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Ethics"}}]}}