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We declare that the content of this manuscript is original and has not been published or accepted for publication, in whole or in part, in any form (other than as an abstract or other preliminary publication). We also confirm that no part of this manuscript is currently under consideration for publication elsewhere.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The research protocol was approved by an Institutional Review Board. All human participants provided signed informed consent, and the study was conducted in accordance with the ethical standards of the institutional research committee and with the Helsinki Declaration. Formal approval was granted by the Ethics Committee of the First Affiliated Hospital of Nanchang University (Registration No: IIT2024489). All animal studies were conducted in compliance with institutional guidelines and were approved by the Animal Care and Use Committee of the First Affiliated Hospital of Nanchang University (ethics approval no. CDYFY - IACUC-202404QR031).","order":2,"name":"Ethics","label":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}