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A copy of the written consent is available for review by the Editor-in-Chief of this journal on request. And ethical approval was granted by the Ethics Committee of Changhai Hospital (No. CHEC2023-306), and Shanghai General Hospital (No. 2025SQ347). All experiments were conducted in accordance with the International Ethical Guidelines for Biomedical Research Involving Human Subjects (CIOMS). All animal experiments were reviewed and approved by the Laboratory Animal Welfare & Ethics Committee of Shanghai General Hospital (IACUC No. 2025AWS509). The protocol was evaluated through an expedited review process and received approval on February 26, 2025. According to the committee\u2019s regulations, the approval is valid for 10 months, and the study will undergo ongoing ethical oversight. 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