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Written informed consent was obtained from all the participants prior to participation in the study. All animal experiments were performed following the protocol approved by the Animal Ethical and Welfare Committee (AEWC) of Tianjin Medical University (Protocol number SYXK 2019-0004).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"9"}}