{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T20:56:58Z","timestamp":1763499418436},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1038\/s41390-018-0093-x","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T11:46:12Z","timestamp":1530791172000},"page":"552-557","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical utility of endomyocardial biopsies in the diagnosis of arrhythmogenic right ventricular cardiomyopathy in children"],"prefix":"10.1038","volume":"84","author":[{"given":"Shayenthiran","family":"Sreetharan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciorsti J.","family":"MacIntyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena","family":"Fatah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew E.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"93_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1161\/01.CIR.68.2.251","volume":"68","author":"DE Manyari","year":"1983","unstructured":"Manyari, D. E. et al. Arrhythmogenic right ventricular dysplasia: a generalized cardiomyopathy? Circulation 68, 251\u2013257 (1983).","journal-title":"Circulation"},{"key":"93_CR2","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/0002-9149(86)90043-3","volume":"58","author":"JG Webb","year":"1986","unstructured":"Webb, J. G., Kerr, C. R., Huckell, V. F., Mizgala, H. F. & Ricci, D. R. Left ventricular abnormalities in arrhythmogenic right ventricular dysplasia. Am. J. Cardiol. 58, 568\u2013570 (1986).","journal-title":"Am. J. Cardiol."},{"key":"93_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1136\/hrt.58.5.477","volume":"58","author":"C Blomstrom-Lundqvist","year":"1987","unstructured":"Blomstrom-Lundqvist, C., Sabel, K. G. & Olsson, S. B. A long term follow up of 15 patients with arrhythmogenic right ventricular dysplasia. Heart 58, 477\u2013488 (1987).","journal-title":"Heart"},{"key":"93_CR4","doi-asserted-by":"crossref","unstructured":"Romero J., Mejia-Lopez E., Manrique C., & Lucariello R. Arrhythmogenic right ventricular cardiomyopathy (ARVC\/D): a systematic literature review. Clin. Med. Insights Cardiol. 97, 97\u2013114 (2013).","DOI":"10.4137\/CMC.S10940"},{"key":"93_CR5","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1161\/CIRCULATIONAHA.105.616490","volume":"113","author":"D Corrado","year":"2006","unstructured":"Corrado, D. & Thiene, G. Arrhythmogenic right ventricular cardiomyopathy\/dysplasia: clinical impact of molecular genetic studies. Circulation 113, 1634\u20131637 (2006).","journal-title":"Circulation"},{"key":"93_CR6","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1093\/europace\/euq104","volume":"12","author":"V Fressart","year":"2010","unstructured":"Fressart, V. et al. Desmosomal gene analysis in arrhythmogenic right ventricular dysplasia\/cardiomyopathy: spectrum of mutations and clinical impact in practice. EP Eur. 12, 861\u2013868 (2010).","journal-title":"EP Eur."},{"key":"93_CR7","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/j.jacc.2013.01.073","volume":"61","author":"FI Marcus","year":"2013","unstructured":"Marcus, F. I., Edson, S. & Towbin, J. A. Genetics of arrhythmogenic right ventricular cardiomyopathy. J. Am. Coll. Cardiol. 61, 1945\u20131948 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"key":"93_CR8","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/ng1461","volume":"36","author":"B Gerull","year":"2004","unstructured":"Gerull, B. et al. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat. Genet. 36, 1162\u20131164 (2004).","journal-title":"Nat. Genet."},{"key":"93_CR9","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1086\/509122","volume":"79","author":"P Syrris","year":"2006","unstructured":"Syrris, P. et al. Arrhythmogenic right ventricular dysplasia\/cardiomyopathy associated with mutations in the desmosomal gene desmocollin-2. Am. J. Hum. Genet. 79, 978\u2013984 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"93_CR10","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1161\/CIRCULATIONAHA.105.583674","volume":"113","author":"K Pilichou","year":"2006","unstructured":"Pilichou, K. et al. Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy. Circulation 113, 1171\u20131179 (2006).","journal-title":"Circulation"},{"key":"93_CR11","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1161\/01.RES.0000241482.19382.c6","volume":"99","author":"Z Yang","year":"2006","unstructured":"Yang, Z. et al. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Circ. Res. 99, 646\u2013655 (2006).","journal-title":"Circ. Res."},{"key":"93_CR12","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1161\/01.CIR.0000108396.65446.21","volume":"108","author":"A Tabib","year":"2003","unstructured":"Tabib, A. et al. Circumstances of death and gross and microscopic observations in a series of 200 cases of sudden death associated with arrhythmogenic right ventricular cardiomyopathy and\/or dysplasia. Circulation 108, 3000\u20133005 (2003).","journal-title":"Circulation"},{"key":"93_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1136\/hrt.71.3.215","volume":"71","author":"WJ McKenna","year":"1994","unstructured":"McKenna, W. J. et al. Diagnosis of arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society and Federation of Cardiology. Br. Heart J. 71, 215\u2013218 (1994).","journal-title":"Br. Heart J."},{"key":"93_CR14","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","volume":"31","author":"FI Marcus","year":"2010","unstructured":"Marcus, F. I. et al. Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the Task Force Criteria. Eur. Heart J. 31, 806\u2013814 (2010).","journal-title":"Eur. Heart J."},{"key":"93_CR15","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.jacc.2014.12.041","volume":"65","author":"Y Etoom","year":"2015","unstructured":"Etoom, Y. et al. Importance of CMR within the task force criteria for the diagnosis of ARVC in children and adolescents. J. Am. Coll. Cardiol. 65, 987\u2013995 (2015).","journal-title":"J. Am. Coll. Cardiol."},{"key":"93_CR16","doi-asserted-by":"crossref","unstructured":"Osler W. The Principles and Practice of Medicine (Appleton, New York, 1905).","DOI":"10.2307\/3403146"},{"key":"93_CR17","first-page":"197","volume":"91","author":"HSM Uhl","year":"1952","unstructured":"Uhl, H. S. M. A previously undescribed congenital malformation of the heart: almost total absence of the myocardium of the right ventricle. Bull. Johns Hopkins Hosp. 91, 197\u2013209 (1952).","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"93_CR18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0002-8703(61)90513-0","volume":"61","author":"S Dalla-Volta","year":"1961","unstructured":"Dalla-Volta, S., Battaglia, G. & Zerbini, E. \u201cAuricularization\u201d of right ventricular pressure curve. Am. Heart J. 61, 25\u201333 (1961).","journal-title":"Am. Heart J."},{"key":"93_CR19","first-page":"361","volume":"75","author":"G Fontaine","year":"1982","unstructured":"Fontaine, G. et al. Arrhythmogenic right ventricular dysplasia and Uhl\u2019s disease. Arch. Mal. Coeur. Vaiss. 75, 361\u2013371 (1982).","journal-title":"Arch. Mal. Coeur. Vaiss."},{"key":"93_CR20","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1161\/01.CIR.65.2.384","volume":"65","author":"FI Marcus","year":"1982","unstructured":"Marcus, F. I. et al. Right ventricular dysplasia: a report of 24 adult cases. Circulation 65, 384\u2013398 (1982).","journal-title":"Circulation"},{"key":"93_CR21","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1536\/ihj.37.195","volume":"37","author":"S Peters","year":"1996","unstructured":"Peters, S., Davies, M. J. & Mckenna, W. J. Diagnostic value of endomyocardial biopsies of the right ventricular septum in arrhythmias originating from the right ventricle. Jpn Heart J. 37, 195\u2013202 (1996).","journal-title":"Jpn Heart J."},{"key":"93_CR22","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/S0002-9149(97)01012-6","volume":"81","author":"L Vecchia La","year":"1998","unstructured":"La Vecchia, L. et al. Ventricular late potentials, interstitial fibrosis, and right ventricular function in patients with ventricular tachycardia and normal left ventricular function. Am. J. Cardiol. 81, 790\u2013792 (1998).","journal-title":"Am. J. Cardiol."},{"key":"93_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0167-5273(93)90011-5","volume":"40","author":"A Angelini","year":"1993","unstructured":"Angelini, A. et al. Endomyocardial biopsy in right ventricular cardiomyopathy. Int. J. Cardiol. 40, 273\u2013282 (1993).","journal-title":"Int. J. Cardiol."},{"key":"93_CR24","doi-asserted-by":"publisher","first-page":"2305","DOI":"10.1016\/j.jacc.2003.12.056","volume":"43","author":"C Chimenti","year":"2004","unstructured":"Chimenti, C., Pieroni, M., Maseri, A. & Frustaci, A. Histologic findings in patients with clinical and instrumental diagnosis of sporadic arrhythmogenic right ventricular dysplasia. J. Am. Coll. Cardiol. 43, 2305\u20132313 (2004).","journal-title":"J. Am. Coll. Cardiol."},{"key":"93_CR25","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.jacc.2012.11.087","volume":"62","author":"ASJM Riele te","year":"2013","unstructured":"te Riele, A. S. J. M. et al. Incremental value of cardiac magnetic resonance imaging in arrhythmic risk stratification of arrhythmogenic right ventricular dysplasia\/cardiomyopathy\u2013associated desmosomal mutation carriers. J. Am. Coll. Cardiol. 62, 1761\u20131769 (2013).","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41390-018-0093-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-018-0093-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-018-0093-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:23:31Z","timestamp":1684617811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-018-0093-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["93"],"URL":"https:\/\/doi.org\/10.1038\/s41390-018-0093-x","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]},"assertion":[{"value":"22 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}