{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:29:54Z","timestamp":1778632194434,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1038\/s41390-019-0281-3","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T17:03:12Z","timestamp":1547658192000},"page":"533-538","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of endogenous hydrogen sulfide production improves viral elimination in CVB3-infected myocardium in mice"],"prefix":"10.1038","volume":"85","author":[{"given":"Wang","family":"Hua","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangqi","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"key":"281_CR1","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.bbrc.2009.08.064","volume":"388","author":"W Hua","year":"2009","unstructured":"Hua, W. et al. The dual role of the cystathionine gamma-lyase\/hydrogen sulfide pathway in CVB3-induced myocarditis in mice. Biochem. Biophys. Res. Commun. 388, 595\u2013600 (2009).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"281_CR2","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/j.lfs.2013.10.007","volume":"93","author":"W Hua","year":"2013","unstructured":"Hua, W. et al. Cardioprotection of H2S by downregulating iNOS and upregulating HO-1 expression in mice with CVB3-induced myocarditis. Life Sci. 93, 949\u2013954 (2013).","journal-title":"Life Sci."},{"key":"281_CR3","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1165\/rcmb.2015-0385OC","volume":"55","author":"T Ivanciuc","year":"2016","unstructured":"Ivanciuc, T. et al. Hydrogen sulfide is an antiviral and antiinflammatory endogenous gasotransmitter in the airways. Role in respiratory syncytial virus infection. Am. J. Respir. Cell. Mol. Biol. 55, 684\u2013696 (2016).","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"281_CR4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1053\/j.gastro.2009.04.012","volume":"137","author":"JL Wallace","year":"2009","unstructured":"Wallace, J. L., Vong, L., McKnight, W., Dicay, M. & Martin, G. R. Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. Gastroenterology 137, 569\u201378, 578.e1 (2009).","journal-title":"Gastroenterology"},{"key":"281_CR5","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.jtcvs.2008.08.074","volume":"138","author":"NR Sodha","year":"2009","unstructured":"Sodha, N. R. et al. Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia\/reperfusion injury. J. Thorac. Cardiovasc. Surg. 138, 977\u2013984 (2009).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"281_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0488-8","volume":"13","author":"M Lee","year":"2016","unstructured":"Lee, M., McGeer, E. G. & McGeer, P. L. Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. J. Neuroinflamm. 13, 32 (2016).","journal-title":"J. Neuroinflamm."},{"key":"281_CR7","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.3892\/mmr.2016.5407","volume":"14","author":"NR Kim","year":"2016","unstructured":"Kim, N. R., Nam, S. Y., Ryu, K. J., Kim, H. M. & Jeong, H. J. Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity. Mol. Med. Rep. 14, 1673\u20131680 (2016).","journal-title":"Mol. Med. Rep."},{"key":"281_CR8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.brainresbull.2015.12.007","volume":"121","author":"K Ji","year":"2016","unstructured":"Ji, K., Xue, L., Cheng, J. & Bai, Y. Preconditioning of H2S inhalation protects against cerebral ischemia\/reperfusion injury by induction of HSP70 through PI3K\/Akt\/Nrf2 pathway. Brain Res. Bull. 121, 68\u201374 (2016).","journal-title":"Brain Res. Bull."},{"key":"281_CR9","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.bbrc.2006.03.170","volume":"344","author":"JM Kim","year":"2006","unstructured":"Kim, J. M. et al. TNFR-Fc fusion protein expressed by in vivo electroporation improves survival rates and myocardial injury in coxsackievirus induced murine myocarditis. Biochem. Biophys. Res. Commun. 344, 765\u2013771 (2006).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"281_CR10","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1161\/01.CIR.103.5.743","volume":"103","author":"H Wada","year":"2001","unstructured":"Wada, H. et al. Tumor necrosis factor-alpha (TNF-alpha) plays a protective role in acute viralmyocarditis in mice: a study using mice lacking TNF-alpha. Circulation 103, 743\u2013749 (2001).","journal-title":"Circulation"},{"key":"281_CR11","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1006\/jmcc.2001.1428","volume":"33","author":"T Tanaka","year":"2001","unstructured":"Tanaka, T. et al. Overexpression of interleukin-6 aggravates viral myocarditis: impaired increase in tumor necrosis factor-alpha. J. Mol. Cell. Cardiol. 33, 1627\u20131635 (2001).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"281_CR12","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2006.03.021","volume":"41","author":"GS Oh","year":"2006","unstructured":"Oh, G. S. et al. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic. Biol. Med. 41, 106\u2013119 (2006).","journal-title":"Free Radic. Biol. Med."},{"key":"281_CR13","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.joca.2014.04.031","volume":"22","author":"EF Burguera","year":"2014","unstructured":"Burguera, E. F., Vela-Anero, A., Magalh\u00e3es, J., Meijide-Fa\u00edlde, R. & Blanco, F. J. Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1\u03b2-stimulated human articular chondrocytes. Osteoarthr. Cartil. 22, 1026\u20131035 (2014).","journal-title":"Osteoarthr. Cartil."},{"key":"281_CR14","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.intimp.2016.07.009","volume":"39","author":"D Campos","year":"2016","unstructured":"Campos, D. et al. Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation. Int. Immunopharmacol. 39, 57\u201362 (2016).","journal-title":"Int. Immunopharmacol."},{"key":"281_CR15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1089\/vim.2005.18.355","volume":"18","author":"N Jarasch","year":"2005","unstructured":"Jarasch, N. et al. Interferon-gamma-induced activation of nitric oxide-mediated antiviral activity of macrophages caused by a recombinant coxsackievirus B3. Viral Immunol. 18, 355\u2013364 (2005).","journal-title":"Viral Immunol."},{"key":"281_CR16","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1073\/pnas.95.5.2469","volume":"95","author":"C Zaragoza","year":"1998","unstructured":"Zaragoza, C. et al. The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis. Proc. Natl Acad. Sci. USA 95, 2469\u20132474 (1998).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"281_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00430-003-0198-6","volume":"193","author":"R Zell","year":"2004","unstructured":"Zell, R. et al. Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice. Med. Microbiol. Immunol. 193, 91\u2013100 (2004).","journal-title":"Med. Microbiol. Immunol."},{"key":"281_CR18","doi-asserted-by":"publisher","first-page":"11731","DOI":"10.1073\/pnas.0400518101","volume":"101","author":"E Padalko","year":"2004","unstructured":"Padalko, E. et al. Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry. Proc. Natl Acad. Sci. USA 101, 11731\u201311736 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"281_CR19","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/jcp.21151","volume":"213","author":"P Mirandola","year":"2007","unstructured":"Mirandola, P. et al. Exogenous hydrogen sulfide induces functional inhibition and cell death of cytotoxic lymphocytes subsets. J. Cell. Physiol. 213, 826\u2013833 (2007).","journal-title":"J. Cell. Physiol."},{"key":"281_CR20","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bbrc.2006.02.154","volume":"343","author":"M Whiteman","year":"2006","unstructured":"Whiteman, M. et al. Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide. Biochem. Biophys. Res. Commun. 343, 303\u2013310 (2006).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"281_CR21","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.bbrc.2009.10.128","volume":"390","author":"Z Tomaskova","year":"2009","unstructured":"Tomaskova, Z. et al. Lipids modulate H(2)S\/HS(\u2212) induced NO release from S-nitrosoglutathione. Biochem. Biophys. Res. Commun. 390, 1241\u20131244 (2009).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"281_CR22","doi-asserted-by":"publisher","first-page":"H2159","DOI":"10.1152\/ajpheart.00872.2001","volume":"282","author":"H Funakoshi","year":"2002","unstructured":"Funakoshi, H. et al. Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha. Am. J. Physiol. Heart Circ. Physiol. 282, H2159\u2013H2166 (2002).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0281-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0281-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0281-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:25:15Z","timestamp":1684617915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-019-0281-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["281"],"URL":"https:\/\/doi.org\/10.1038\/s41390-019-0281-3","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,16]]},"assertion":[{"value":"31 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}