{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:00:29Z","timestamp":1792670429221,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1038\/s41390-019-0346-3","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T06:03:15Z","timestamp":1550815395000},"page":"777-785","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multisite measurement of regional oxygen saturation in Fontan patients with and\u00a0without protein-losing enteropathy at rest and during exercise"],"prefix":"10.1038","volume":"85","author":[{"given":"Simon","family":"Schr\u00f6er","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian B.","family":"Fahlbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"M\u00fcnch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhannad","family":"Alkassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan R.","family":"Toka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Rauh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"R\u00fcffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cesnjevar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Dittrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Toka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Moosmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"key":"346_CR1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1136\/thx.26.3.240","volume":"26","author":"F Fontan","year":"1971","unstructured":"Fontan, F. & Baudet, E. Surgical repair of tricuspid atresia. Thorax 26, 240\u2013248 (1971).","journal-title":"Thorax"},{"key":"346_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.107.738559","volume":"117","author":"P Khairy","year":"2008","unstructured":"Khairy, P. et al. Long-term survival, modes of death, and predictors of mortality in patients with Fontan surgery. Circulation 117, 85\u201392 (2008).","journal-title":"Circulation"},{"key":"346_CR3","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1053\/j.semtcvs.2017.06.002","volume":"29","author":"TG Wilson","year":"2017","unstructured":"Wilson, T. G. et al. Twenty-five year outcomes of the lateral tunnel Fontan procedure. Semin. Thorac. Cardiovasc. Surg. 29, 347\u2013353 (2017).","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"346_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jtcvs.2017.01.056","volume":"154","author":"TE Downing","year":"2017","unstructured":"Downing, T. E. et al. Long-term survival after the Fontan operation: twenty years of experience at a single center. J. Thorac. Cardiovasc. Surg. 154, 243\u2013253.e2 (2017).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"346_CR5","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/j.jacc.2015.07.065","volume":"66","author":"KN Pundi","year":"2015","unstructured":"Pundi, K. N. et al. 40-Year follow-up after the fontan operation: long-term outcomes of 1,052 patients. J. Am. Coll. Cardiol. 66, 1700\u20131710 (2015).","journal-title":"J. Am. Coll. Cardiol."},{"key":"346_CR6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1136\/heartjnl-2015-307467","volume":"102","author":"M Gewillig","year":"2016","unstructured":"Gewillig, M. & Brown, S. C. The Fontan circulation after 45 years: update in physiology. Heart 102, 1081\u20131086 (2016).","journal-title":"Heart"},{"key":"346_CR7","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1510\/icvts.2009.218594","volume":"10","author":"M Gewillig","year":"2010","unstructured":"Gewillig, M. et al. The Fontan circulation: who controls cardiac output? Interact. Cardiovasc. Thorac. Surg. 10, 428\u2013433 (2010).","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"346_CR8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1053\/j.pcsu.2015.11.006","volume":"19","author":"J Rychik","year":"2016","unstructured":"Rychik, J. The relentless effects of the Fontan paradox. Semin. Thorac. Cardiovasc. Surg. Pediatr. Card. Surg. Annu. 19, 37\u201343 (2016).","journal-title":"Semin. Thorac. Cardiovasc. Surg. Pediatr. Card. Surg. Annu."},{"key":"346_CR9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1136\/heartjnl-2016-310108","volume":"103","author":"T Alsaied","year":"2017","unstructured":"Alsaied, T. et al. Factors associated with long-term mortality after Fontan procedures: a systematic review. Heart 103, 104\u2013110 (2017).","journal-title":"Heart"},{"key":"346_CR10","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00246-014-0881-y","volume":"35","author":"M Mori","year":"2014","unstructured":"Mori, M. et al. Beyond a broken heart: circulatory dysfunction in the failing Fontan. Pediatr. Cardiol. 35, 569\u2013579 (2014).","journal-title":"Pediatr. Cardiol."},{"key":"346_CR11","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1111\/ped.13054","volume":"58","author":"M Mizuno","year":"2016","unstructured":"Mizuno, M. et al. Diverse multi-organ histopathologic changes in a failed Fontan patient. Pediatr. Int. 58, 1061\u20131065 (2016).","journal-title":"Pediatr. Int."},{"key":"346_CR12","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s00246-014-1047-7","volume":"36","author":"T Fleck","year":"2015","unstructured":"Fleck, T. et al. Propofol effect on cerebral oxygenation in children with congenital heart disease. Pediatr. Cardiol. 36, 543\u2013549 (2015).","journal-title":"Pediatr. Cardiol."},{"key":"346_CR13","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s00246-013-0817-y","volume":"35","author":"RS Loomba","year":"2014","unstructured":"Loomba, R. S. et al. Effect of Fontan fenestration on regional venous oxygen saturation during exercise: further insights into Fontan fenestration closure. Pediatr. Cardiol. 35, 514\u2013520 (2014).","journal-title":"Pediatr. Cardiol."},{"key":"346_CR14","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.jtcvs.2012.12.060","volume":"146","author":"GM Hoffman","year":"2013","unstructured":"Hoffman, G. M. et al. Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome. J. Thorac. Cardiovasc. Surg. 146, 1153\u20131164 (2013).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"346_CR15","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00246-009-9393-6","volume":"30","author":"RP Rao","year":"2009","unstructured":"Rao, R. P. et al. Measurement of regional tissue bed venous weighted oximetric trends during exercise by near infrared spectroscopy. Pediatr. Cardiol. 30, 465\u2013471 (2009).","journal-title":"Pediatr. Cardiol."},{"key":"346_CR16","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s00246-009-9585-0","volume":"31","author":"RP Rao","year":"2010","unstructured":"Rao, R. P. et al. Cerebral hemodynamics in the presence of decreased systemic venous compliance in patients with Fontan physiology may limit anaerobic exercise capacity. Pediatr. Cardiol. 31, 208\u2013214 (2010).","journal-title":"Pediatr. Cardiol."},{"key":"346_CR17","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/pr.2017.154","volume":"82","author":"E Forman","year":"2017","unstructured":"Forman, E. et al. Noninvasive continuous cardiac output and cerebral perfusion monitoring in term infants with neonatal encephalopathy: assessment of feasibility and reliability. Pediatr. Res. 82, 789\u2013795 (2017).","journal-title":"Pediatr. Res."},{"key":"346_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0760-9","volume":"19","author":"B Ruf","year":"2015","unstructured":"Ruf, B. et al. Intraoperative renal near-infrared spectroscopy indicates developing acute kidney injury in infants undergoing cardiac surgery with cardiopulmonary bypass: a case-control study. Crit. Care 19, 27 (2015).","journal-title":"Crit. Care"},{"key":"346_CR19","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1203\/PDR.0b013e3182226b75","volume":"70","author":"XW Su","year":"2011","unstructured":"Su, X. W. et al. Improved cerebral oxygen saturation and blood flow pulsatility with pulsatile perfusion during pediatric cardiopulmonary bypass. Pediatr. Res. 70, 181\u2013185 (2011).","journal-title":"Pediatr. Res."},{"key":"346_CR20","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.amjcard.2016.02.042","volume":"117","author":"D Navaratnam","year":"2016","unstructured":"Navaratnam, D. et al. Exercise-induced systemic venous hypertension in the Fontan circulation. Am. J. Cardiol. 117, 1667\u20131671 (2016).","journal-title":"Am. J. Cardiol."},{"key":"346_CR21","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s001120170107","volume":"149","author":"K Kromeyer-Hauschild","year":"2001","unstructured":"Kromeyer-Hauschild, K. et al. Perzentile f\u00fcr den body-mass-Index f\u00fcr das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Mon. Kinderheilkd. 149, 807\u2013818 (2001).","journal-title":"Mon. Kinderheilkd."},{"key":"346_CR22","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1017\/S1047951112002272","volume":"24","author":"Y Horibata","year":"2014","unstructured":"Horibata, Y., Murakami, T. & Niwa, K. Effect of the oral vasopressin receptor antagonist tolvaptan on congestive cardiac failure in a child with restrictive cardiomyopathy. Cardiol. Young-. 24, 155\u2013157 (2014).","journal-title":"Cardiol. Young-."},{"key":"346_CR23","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.jpedsurg.2010.02.110","volume":"45","author":"NP Bernal","year":"2010","unstructured":"Bernal, N. P. et al. Cerebral and somatic near-infrared spectroscopy in normal newborns. J. Pediatr. Surg. 45, 1306\u20131310 (2010).","journal-title":"J. Pediatr. Surg."},{"key":"346_CR24","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1177\/2150135111411932","volume":"2","author":"C Colasacco","year":"2011","unstructured":"Colasacco, C. et al. Near-infrared spectroscopy monitoring to predict postoperative renal insufficiency following repair of congenital heart disease. World J. Pediatr. Congenit. Heart Surg. 2, 536\u2013540 (2011).","journal-title":"World J. Pediatr. Congenit. Heart Surg."},{"key":"346_CR25","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1053\/j.jvca.2013.12.005","volume":"28","author":"DK Choi","year":"2014","unstructured":"Choi, D. K. et al. Intraoperative renal regional oxygen desaturation can be a predictor for acute kidney injury after cardiac surgery. J. Cardiothorac. Vasc. Anesth. 28, 564\u2013571 (2014).","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"346_CR26","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/j.jtcvs.2005.07.051","volume":"130","author":"CL Dent","year":"2005","unstructured":"Dent, C. L. et al. Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. J. Thorac. Cardiovasc. Surg. 130, 1523\u20131530 (2005).","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"346_CR27","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","volume":"41","author":"F Faul","year":"2009","unstructured":"Faul, F. et al. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav. Res. Methods 41, 1149\u20131160 (2009).","journal-title":"Behav. Res. Methods"},{"key":"346_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul, F. et al. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39, 175\u2013191 (2007).","journal-title":"Behav. Res. Methods"},{"key":"346_CR29","first-page":"14","volume":"34","author":"M Callewaert","year":"2013","unstructured":"Callewaert, M. et al. Quadriceps muscle fatigue in trained and untrained boys. Int. J. Sports Med. 34, 14\u201320 (2013).","journal-title":"Int. J. Sports Med."},{"key":"346_CR30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-1-4939-3023-4_2","volume":"876","author":"TS Bowen","year":"2016","unstructured":"Bowen, T. S. et al. The spatial distribution of absolute skeletal muscle deoxygenation during ramp-incremental exercise is not influenced by hypoxia. Adv. Exp. Med. Biol. 876, 19\u201326 (2016).","journal-title":"Adv. Exp. Med. Biol."},{"key":"346_CR31","first-page":"1313","volume":"2015","author":"D Okushima","year":"1985","unstructured":"Okushima, D. et al. Muscle deoxygenation in the quadriceps during ramp incremental cycling: deep vs. superficial heterogeneity. J. Appl. Physiol. 2015, 1313\u20131319 (1985).","journal-title":"J. Appl. Physiol."},{"key":"346_CR32","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s00392-014-0694-2","volume":"103","author":"A Hager","year":"2014","unstructured":"Hager, A. et al. Predictors of sildenafil effects on exercise capacity in adolescents and adults with Fontan circulation. Clin. Res. Cardiol. 103, 641\u2013646 (2014).","journal-title":"Clin. Res. Cardiol."},{"key":"346_CR33","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S0002-9149(00)01364-3","volume":"87","author":"PM Fredriksen","year":"2001","unstructured":"Fredriksen, P. M. et al. Aerobic capacity in adults with various congenital heart diseases. Am. J. Cardiol. 87, 310\u2013314 (2001).","journal-title":"Am. J. Cardiol."},{"key":"346_CR34","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/ccd.26498","volume":"88","author":"EA Bradley","year":"2016","unstructured":"Bradley, E. A., Berman, D. & Daniels, C. J. First implantable hemodynamic monitoring device placement in single ventricle fontan anatomy. Catheter. Cardiovasc. Interv. 88, 248\u2013252 (2016).","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"346_CR35","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1177\/2150135117713696","volume":"8","author":"S Talwar","year":"2017","unstructured":"Talwar, S. et al. Outcomes of patients undergoing primary fontan operation beyond first decade of life. World J. Pediatr. Congenit. Heart Surg. 8, 487\u2013494 (2017).","journal-title":"World J. Pediatr. Congenit. Heart Surg."},{"issue":"Suppl 3","key":"346_CR36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1017\/S1047951105001629","volume":"15","author":"H Ohuchi","year":"2005","unstructured":"Ohuchi, H. Cardiopulmonary response to exercise in patients with the Fontan circulation. Cardiol. Young-. 15(Suppl 3), 39\u201344 (2005).","journal-title":"Cardiol. Young-."},{"key":"346_CR37","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1136\/heartjnl-2014-306337","volume":"101","author":"RH Khiabani","year":"2015","unstructured":"Khiabani, R. H. et al. Exercise capacity in single-ventricle patients after Fontan correlates with haemodynamic energy loss in TCPC. Heart 101, 139\u2013143 (2015).","journal-title":"Heart"},{"key":"346_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3121\/cmr.2015.1282","volume":"14","author":"Q Fu","year":"2016","unstructured":"Fu, Q., Colgan, S. P. & Shelley, C. S. Hypoxia: the force that drives chronic kidney disease. Clin. Med. Res. 14, 15\u201339 (2016).","journal-title":"Clin. Med. Res."},{"key":"346_CR39","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1136\/heartjnl-2016-309729","volume":"103","author":"AR Opotowsky","year":"2016","unstructured":"Opotowsky, A. R. et al. Estimated glomerular filtration rate and urine biomarkers in patients with single-ventricle Fontan circulation. Heart 103, 434\u2013442 (2016).","journal-title":"Heart"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0346-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0346-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0346-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:25:50Z","timestamp":1684617950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-019-0346-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,22]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["346"],"URL":"https:\/\/doi.org\/10.1038\/s41390-019-0346-3","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,22]]},"assertion":[{"value":"16 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}