{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T10:09:54Z","timestamp":1776247794648,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1038\/s41390-019-0396-6","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T08:03:39Z","timestamp":1555315419000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cystathionine \u03b3-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke"],"prefix":"10.1038","volume":"86","author":[{"given":"Teodora","family":"Ivanciuc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sbrana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Casola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto P.","family":"Garofalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"396_CR1","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1164\/rccm.200510-1552OC","volume":"173","author":"H Moshammer","year":"2006","unstructured":"Moshammer, H. et al. Parental smoking and lung function in children: an international study. Am. J. Respir. Crit. Care Med 173, 1255\u20131263 (2006).","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"396_CR2","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/S0140-6736(04)16855-4","volume":"364","author":"RA Pauwels","year":"2004","unstructured":"Pauwels, R. A. & Rabe, K. F. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364, 613\u2013620 (2004).","journal-title":"Lancet"},{"key":"396_CR3","doi-asserted-by":"publisher","first-page":"L222","DOI":"10.1152\/ajplung.00148.2005","volume":"290","author":"V Phaybouth","year":"2006","unstructured":"Phaybouth, V. et al. Cigarette smoke suppresses Th1 cytokine production and increases RSV expression in a neonatal model. Am. J. Physiol. Lung Cell. Mol. Physiol. 290, L222\u2013L231 (2006).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"396_CR4","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1056\/NEJMoa0804877","volume":"360","author":"CB Hall","year":"2009","unstructured":"Hall, C. B. et al. The burden of respiratory syncytial virus infection in young children. N. Engl. J. Med. 360, 588\u2013598 (2009).","journal-title":"N. Engl. J. Med."},{"key":"396_CR5","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/S0022-3476(95)70547-3","volume":"126","author":"EE Wang","year":"1995","unstructured":"Wang, E. E., Law, B. J. & Stephens, D. Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J. Pediatr. 126, 212\u2013219 (1995).","journal-title":"J. Pediatr."},{"key":"396_CR6","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1086\/430008","volume":"191","author":"JP Devincenzo","year":"2005","unstructured":"Devincenzo, J. P., El Saleeby, C. M. & Bush, A. J. Respiratory syncytial virus load predicts disease severity in previously healthy infants. J. Infect. Dis. 191, 1861\u20131868 (2005).","journal-title":"J. Infect. Dis."},{"key":"396_CR7","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1093\/infdis\/jir494","volume":"204","author":"CM El Saleeby","year":"2011","unstructured":"El Saleeby, C. M., Bush, A. J., Harrison, L. M., Aitken, J. A. & Devincenzo, J. P. Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J. Infect. Dis. 204, 996\u20131002 (2011).","journal-title":"J. Infect. Dis."},{"key":"396_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/1471-2431-12-81","volume":"12","author":"JR Difranza","year":"2012","unstructured":"Difranza, J. R., Masaquel, A., Barrett, A. M., Colosia, A. D. & Mahadevia, P. J. Systematic literature review assessing tobacco smoke exposure as a risk factor for serious respiratory syncytial virus disease among infants and young children. BMC Pediatr. 12, 81 (2012).","journal-title":"BMC Pediatr."},{"key":"396_CR9","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1542\/peds.2004-0059","volume":"115","author":"JP Bradley","year":"2005","unstructured":"Bradley, J. P. et al. Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy. Pediatrics 115, e7\u2013e14 (2005).","journal-title":"Pediatrics"},{"key":"396_CR10","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/ppul.10047","volume":"33","author":"M Lanari","year":"2002","unstructured":"Lanari, M. et al. Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association between respiratory syncytial virus infection risk factors and disease severity. Pediatr. Pulmonol. 33, 458\u2013465 (2002).","journal-title":"Pediatr. Pulmonol."},{"key":"396_CR11","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1023\/A:1007658411953","volume":"16","author":"F Gurkan","year":"2000","unstructured":"Gurkan, F., Kiral, A., Dagli, E. & Karakoc, F. The effect of passive smoking on the development of respiratory syncytial virus bronchiolitis. Eur. J. Epidemiol. 16, 465\u2013468 (2000).","journal-title":"Eur. J. Epidemiol."},{"key":"396_CR12","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nrd2425","volume":"6","author":"C Szabo","year":"2007","unstructured":"Szabo, C. Hydrogen sulphide and its therapeutic potential. Nat. Rev. Drug Discov. 6, 917\u2013935 (2007).","journal-title":"Nat. Rev. Drug Discov."},{"key":"396_CR13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.tibs.2015.08.007","volume":"40","author":"BD Paul","year":"2015","unstructured":"Paul, B. D. & Snyder, S. H. H2S: a novel gasotransmitter that signals by sulfhydration. Trends Biochem. Sci. 40, 687\u2013700 (2015).","journal-title":"Trends Biochem. Sci."},{"key":"396_CR14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/978-3-319-18144-8_3","volume":"230","author":"H Kimura","year":"2015","unstructured":"Kimura, H. Physiological roles of hydrogen sulfide and polysulfides. Handb. Exp. Pharmacol. 230, 61\u201381 (2015).","journal-title":"Handb. Exp. Pharmacol."},{"key":"396_CR15","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrd4433","volume":"14","author":"JL Wallace","year":"2015","unstructured":"Wallace, J. L. & Wang, R. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat. Rev. Drug Discov. 14, 329\u2013345 (2015).","journal-title":"Nat. Rev. Drug Discov."},{"key":"396_CR16","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1165\/rcmb.2017-0114TR","volume":"57","author":"N Bazhanov","year":"2017","unstructured":"Bazhanov, N., Ansar, M., Ivanciuc, T., Garofal, R. P. & Casola, A. Hydrogen sulfide: a novel player in airway development, pathophysiology of respiratory diseases, and antiviral defenses. Am. J. Respir. Cell. Mol. Biol. 57, 403\u2013410 (2017).","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"396_CR17","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1128\/JVI.72.6.4756-4764.1998","volume":"72","author":"B Olszewska-Pazdrak","year":"1998","unstructured":"Olszewska-Pazdrak, B. et al. Cell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus. J. Virol. 72, 4756\u20134764 (1998).","journal-title":"J. Virol."},{"key":"396_CR18","doi-asserted-by":"publisher","first-page":"854","DOI":"10.3389\/fimmu.2018.00854","volume":"9","author":"T Ivanciuc","year":"2018","unstructured":"Ivanciuc, T., Sbrana, E., Casola, A. & Garofalo, R. P. Protective role of nuclear factor erythroid 2-related factor 2 against respiratory syncytial virus and human metapneumovirus infections. Front. Immunol. 9, 854 (2018).","journal-title":"Front. Immunol."},{"key":"396_CR19","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1126\/science.1162667","volume":"322","author":"G Yang","year":"2008","unstructured":"Yang, G. et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322, 587\u2013590 (2008).","journal-title":"Science"},{"key":"396_CR20","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1165\/rcmb.2015-0385OC","volume":"55","author":"T Ivanciuc","year":"2016","unstructured":"Ivanciuc, T. et al. Hydrogen sulfide is an antiviral and antiinflammatory endogenous gasotransmitter in the airways. role in respiratory syncytial virus infection. Am. J. Respir. Cell. Mol. Biol. 55, 684\u2013696 (2016).","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"396_CR21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.resp.2012.03.009","volume":"184","author":"Y Chen","year":"2012","unstructured":"Chen, Y. & Wang, R. The message in the air: hydrogen sulfide metabolism in chronic respiratory diseases. Respir. Physiol. Neurobiol. 184, 130\u2013138 (2012).","journal-title":"Respir. Physiol. Neurobiol."},{"key":"396_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cyto.2008.11.009","volume":"45","author":"YH Chen","year":"2009","unstructured":"Chen, Y. H. et al. Endogenous hydrogen sulfide reduces airway inflammation and remodeling in a rat model of asthma. Cytokine 45, 117\u2013123 (2009).","journal-title":"Cytokine"},{"key":"396_CR23","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.ajpath.2012.12.008","volume":"182","author":"G Zhang","year":"2013","unstructured":"Zhang, G., Wang, P., Yang, G., Cao, Q. & Wang, R. The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma. Am. J. Pathol. 182, 1188\u20131195 (2013).","journal-title":"Am. J. Pathol."},{"key":"396_CR24","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1152\/ajplung.00389.2017","volume":"315","author":"C Glynos","year":"2018","unstructured":"Glynos, C. et al. Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 315, 662\u2013672 (2018).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"396_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12931-016-0392-x","volume":"17","author":"YA Mebratu","year":"2016","unstructured":"Mebratu, Y. A., Smith, K. R., Agga, G. E. & Tesfaigzi, Y. Inflammation and emphysema in cigarette smoke-exposed mice when instilled with poly (I:C) or infected with influenza A or respiratory syncytial viruses. Respir. Res. 17, 75 (2016).","journal-title":"Respir. Res."},{"key":"396_CR26","doi-asserted-by":"publisher","first-page":"e90567","DOI":"10.1371\/journal.pone.0090567","volume":"9","author":"RF Foronjy","year":"2014","unstructured":"Foronjy, R. F., Dabo, A. J., Taggart, C. C., Weldon, S. & Geraghty, P. Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice. PLoS ONE 9, e90567 (2014).","journal-title":"PLoS ONE"},{"key":"396_CR27","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1378\/chest.128.5.3205","volume":"128","author":"YH Chen","year":"2005","unstructured":"Chen, Y. H. et al. Endogenous hydrogen sulfide in patients with COPD. Chest 128, 3205\u20133211 (2005).","journal-title":"Chest"},{"key":"396_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/srep14971","volume":"5","author":"Y Sun","year":"2015","unstructured":"Sun, Y. et al. Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity. Sci. Rep. 5, 14971 (2015).","journal-title":"Sci. Rep."},{"key":"396_CR29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.4187\/respcare.03519","volume":"60","author":"J Zhang","year":"2015","unstructured":"Zhang, J., Wang, X., Chen, Y. & Yao, W. Exhaled hydrogen sulfide predicts airway inflammation phenotype in COPD. Respir. Care 60, 251\u2013258 (2015).","journal-title":"Respir. Care"},{"key":"396_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3892\/mmr.2012.904","volume":"6","author":"M Tian","year":"2012","unstructured":"Tian, M. et al. Correlation between serum H2S and pulmonary function in children with bronchial asthma. Mol. Med. Rep. 6, 335\u2013338 (2012).","journal-title":"Mol. Med. Rep."},{"key":"396_CR31","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/resp.12372","volume":"19","author":"J Zhang","year":"2014","unstructured":"Zhang, J., Wang, X., Chen, Y. & Yao, W. Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma. Respirology 19, 1165\u20131169 (2014).","journal-title":"Respirology"},{"key":"396_CR32","doi-asserted-by":"publisher","first-page":"L710","DOI":"10.1152\/ajplung.00134.2015","volume":"309","author":"A Madurga","year":"2015","unstructured":"Madurga, A. et al. The H2S-generating enzymes cystathionine beta-synthase and cystathionine gamma-lyase play a role in vascular development during normal lung alveolarization. Am. J. Physiol. Lung Cell. Mol. Physiol. 309, L710\u2013L724 (2015).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"396_CR33","doi-asserted-by":"publisher","first-page":"L684","DOI":"10.1152\/ajplung.00361.2013","volume":"306","author":"A Madurga","year":"2014","unstructured":"Madurga, A. et al. Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasia. Am. J. Physiol. Lung Cell. Mol. Physiol. 306, L684\u2013L697 (2014).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"396_CR34","doi-asserted-by":"publisher","first-page":"5557","DOI":"10.1128\/JVI.00264-15","volume":"89","author":"H Li","year":"2015","unstructured":"Li, H. et al. Role of hydrogen sulfide in paramyxovirus infections. J. Virol. 89, 5557\u20135568 (2015).","journal-title":"J. Virol."},{"key":"396_CR35","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.bbrc.2014.02.129","volume":"446","author":"R Fitzgerald","year":"2014","unstructured":"Fitzgerald, R. et al. H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel. Biochem. Biophys. Res. Commun. 446, 393\u2013398 (2014).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"396_CR36","doi-asserted-by":"publisher","first-page":"5999","DOI":"10.1113\/jphysiol.2013.257790","volume":"591","author":"I Castro-Piedras","year":"2013","unstructured":"Castro-Piedras, I. & Perez-Zoghbi, J. F. Hydrogen sulphide inhibits Ca2+ release through InsP3 receptors and relaxes airway smooth muscle. J. Physiol. 591, 5999\u20136015 (2013).","journal-title":"J. Physiol."},{"key":"396_CR37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1465-9921-12-5","volume":"12","author":"LL Jones","year":"2011","unstructured":"Jones, L. L. et al. Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis. Respir. Res. 12, 5 (2011).","journal-title":"Respir. Res."},{"key":"396_CR38","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1067\/S0022-3476(03)00511-0","volume":"143","author":"EAF Simoes","year":"2003","unstructured":"Simoes, E. A. F. Environmental and demographic risk factors for respiratory syncytial virus lower respiratory tract disease. J. Pediatr. 143, 118\u2013126 (2003).","journal-title":"J. Pediatr."},{"key":"396_CR39","doi-asserted-by":"publisher","first-page":"e22425","DOI":"10.1371\/journal.pone.0022425","volume":"6","author":"MG Semple","year":"2011","unstructured":"Semple, M. G., Taylor-Robinson, D. C., Lane, S. & Smyth, R. L. Household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation: prospective cohort study. PLoS ONE 6, e22425 (2011).","journal-title":"PLoS ONE"},{"key":"396_CR40","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/ajcn\/61.5.1067","volume":"61","author":"J Vina","year":"1995","unstructured":"Vina, J. et al. l-Cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency. Am. J. Clin. Nutr. 61, 1067\u20131069 (1995).","journal-title":"Am. J. Clin. Nutr."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-019-0396-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-019-0396-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-019-0396-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T05:13:15Z","timestamp":1744175595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-019-0396-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["396"],"URL":"https:\/\/doi.org\/10.1038\/s41390-019-0396-6","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,15]]},"assertion":[{"value":"27 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}