{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:12:57Z","timestamp":1778901177916,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1038\/s41390-019-0505-6","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T11:05:38Z","timestamp":1563879938000},"page":"709-718","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tissue damage in the heart after cardiac arrest induced by asphyxia and hemorrhage in newborn pigs"],"prefix":"10.1038","volume":"86","author":[{"given":"Birte","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Robin","family":"Mendler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Pressmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Haffner-Luntzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severin","family":"H\u00f6fler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Karl","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Hummler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-0785","authenticated-orcid":false,"given":"Miriam","family":"Kalbitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"505_CR1","unstructured":"Gillam-Krakauer, M. & Gowen Jr., C. W. Birth asphyxia. Treasure Island: StatPearls; 2019. \nwww.ncbi.nlm.nih.gov\/pubmed\/28613533"},{"key":"505_CR2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.2174\/187152509789541927","volume":"7","author":"M Correale","year":"2009","unstructured":"Correale, M. et al. Troponin in newborns and pediatric patients. Cardiovasc. Hematol. Agents Med. Chem. 7, 270\u2013278 (2009).","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"issue":"Suppl. 1","key":"505_CR3","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1016\/j.jgyn.2007.11.006","volume":"37","author":"V Zupan Simunek","year":"2008","unstructured":"Zupan Simunek, V. Definition of intrapartum asphyxia and effects on outcome [Definition de l\u2019asphyxie intrapartum et consequences sur le devenir]. J. Gynecol. Obstet. Biol. Reprod. (Paris) 37(Suppl. 1), S7\u2013S15 (2008).","journal-title":"J. Gynecol. Obstet. Biol. Reprod. (Paris)"},{"key":"505_CR4","first-page":"1220","volume":"33","author":"M Shahidi","year":"2017","unstructured":"Shahidi, M., Evazi, G. & Afkhamzadeh, A. Echocardiographic evaluation of cardiovascular complications after birth asphyxia in term neonates. Pak. J. Med. Sci. 33, 1220\u20131224 (2017).","journal-title":"Pak. J. Med. Sci."},{"key":"505_CR5","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/S0022-3476(80)80833-X","volume":"96","author":"WH Donnelly","year":"1980","unstructured":"Donnelly, W. H., Bucciarelli, R. L. & Nelson, R. M. Ischemic papillary muscle necrosis in stressed newborn infants. J. Pediatr. 96, 295\u2013300 (1980).","journal-title":"J. Pediatr."},{"key":"505_CR6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2298\/VSP1402149S","volume":"71","author":"AM Simovic","year":"2014","unstructured":"Simovic, A. M. et al. The role of biochemical markers as early indicators of cardiac damage and prognostic parameters of perinatal asphyxia. Vojn. Pregl. 71, 149\u2013155 (2014).","journal-title":"Vojn. Pregl."},{"issue":"6","key":"505_CR7","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1177\/2048872617748553","volume":"7","author":"Johannes Mair","year":"2017","unstructured":"Mair, J. et al. How is cardiac troponin released from injured myocardium? Eur. Heart J. Acute Cardiovasc. Care \nhttps:\/\/doi.org\/10.1177\/2048872617748553\n\n (2017).","journal-title":"European Heart Journal: Acute Cardiovascular Care"},{"key":"505_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000112540","volume":"94","author":"AF El-Khuffash","year":"2008","unstructured":"El-Khuffash, A. F. & Molloy, E. J. Serum troponin in neonatal intensive care. Neonatology 94, 1\u20137 (2008).","journal-title":"Neonatology"},{"key":"505_CR9","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00395-009-0035-1","volume":"104","author":"A Doroszko","year":"2009","unstructured":"Doroszko, A. et al. Cardiac dysfunction in an animal model of neonatal asphyxia is associated with increased degradation of MLC1 by MMP-2. Basic Res. Cardiol. 104, 669\u2013679 (2009).","journal-title":"Basic Res. Cardiol."},{"key":"505_CR10","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1097\/SHK.0b013e3181e14f1d","volume":"34","author":"A Doroszko","year":"2010","unstructured":"Doroszko, A. et al. Neonatal asphyxia induces the nitration of cardiac myosin light chain 2 that is associated with cardiac systolic dysfunction. Shock 34, 592\u2013600 (2010).","journal-title":"Shock"},{"key":"505_CR11","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.ajem.2013.03.018","volume":"31","author":"H Yu","year":"2013","unstructured":"Yu, H., Qing, H. & Lei, Z. Cytidine diphosphate choline improves the outcome of cardiac arrest vs epinephrine in rat model. Am. J. Emerg. Med. 31, 1022\u20131028 (2013).","journal-title":"Am. J. Emerg. Med."},{"key":"505_CR12","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.febslet.2014.02.008","volume":"588","author":"E Agullo-Pascual","year":"2014","unstructured":"Agullo-Pascual, E., Cerrone, M. & Delmar, M. Arrhythmogenic cardiomyopathy and Brugada syndrome: diseases of the connexome. FEBS Lett. 588, 1322\u20131330 (2014).","journal-title":"FEBS Lett."},{"key":"505_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18088-1","volume":"7","author":"M Kalbitz","year":"2017","unstructured":"Kalbitz, M. et al. Cardiac depression in pigs after multiple trauma\u2014characterization of posttraumatic structural and functional alterations. Sci. Rep. 7, 17861 (2017).","journal-title":"Sci. Rep."},{"key":"505_CR14","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.4049\/jimmunol.1600091","volume":"197","author":"M Kalbitz","year":"2016","unstructured":"Kalbitz, M. et al. Complement destabilizes cardiomyocyte function in vivo after polymicrobial sepsis and in vitro. J. Immunol. 197, 2353\u20132361 (2016).","journal-title":"J. Immunol."},{"key":"505_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3389\/fped.2018.00192","volume":"6","author":"MR Mendler","year":"2018","unstructured":"Mendler, M. R. et al. Successful resuscitation in a model of asphyxia and hemorrhage to test different volume resuscitation strategies. a study in newborn piglets after transition. Front. Pediatr. 6, 192 (2018).","journal-title":"Front. Pediatr."},{"key":"505_CR16","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1096\/fj.14-268730","volume":"29","author":"M Kalbitz","year":"2015","unstructured":"Kalbitz, M. et al. Role of extracellular histones in the cardiomyopathy of sepsis. FASEB J. 29, 2185\u20132193 (2015).","journal-title":"FASEB J."},{"key":"505_CR17","doi-asserted-by":"publisher","first-page":"5010","DOI":"10.1096\/fj.13-236380","volume":"27","author":"M Bosmann","year":"2013","unstructured":"Bosmann, M. et al. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J. 27, 5010\u20135021 (2013).","journal-title":"FASEB J."},{"key":"505_CR18","doi-asserted-by":"publisher","first-page":"e0187327","DOI":"10.1371\/journal.pone.0187327","volume":"12","author":"CK Braun","year":"2017","unstructured":"Braun, C. K. et al. Early structural changes of the heart after experimental polytrauma and hemorrhagic shock. PLoS ONE 12, e0187327 (2017).","journal-title":"PLoS ONE"},{"key":"505_CR19","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4067\/S0370-41061991000400003","volume":"62","author":"A Bancalari","year":"1991","unstructured":"Bancalari, A. et al. Myocardial damage following neonatal severe asphyxia [Dano miocardico secundario a asfixia neonatal grave]. Rev. Chil. Pediatr. 62, 232\u2013237 (1991).","journal-title":"Rev. Chil. Pediatr."},{"key":"505_CR20","doi-asserted-by":"publisher","first-page":"e0116600","DOI":"10.1371\/journal.pone.0116600","volume":"10","author":"AN Paradis","year":"2015","unstructured":"Paradis, A. N., Gay, M. S., Wilson, C. G. & Zhang, L. Newborn hypoxia\/anoxia inhibits cardiomyocyte proliferation and decreases cardiomyocyte endowment in the developing heart. Role of endothelin-1. PLoS ONE 10, e0116600 (2015).","journal-title":"PLoS ONE"},{"key":"505_CR21","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1161\/CIRCRESAHA.115.307017","volume":"118","author":"BJ Haubner","year":"2016","unstructured":"Haubner, B. J. et al. Functional recovery of a human neonatal heart after severe myocardial infarction. Circ. Res. 118, 216\u2013221 (2016).","journal-title":"Circ. Res."},{"key":"505_CR22","volume-title":"Unique Aspects of Heart Failure in the Neonate","author":"JF Price","year":"2011","unstructured":"Price, J. F. Unique Aspects of Heart Failure in the Neonate (Springer, London, 2011)."},{"key":"505_CR23","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.2174\/138161211796197115","volume":"17","author":"T Xanthos","year":"2011","unstructured":"Xanthos, T., Vasileiou, P. V. S., Kakavas, S., Syggelou, A. & Iacovidou, N. The potential role of erythropoietin as a pleiotropic agent in post-cardiac arrest syndrome. Curr. Pharm. Des. 17, 1517\u20131529 (2011).","journal-title":"Curr. Pharm. Des."},{"key":"505_CR24","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.resuscitation.2014.01.028","volume":"85","author":"AC Miller","year":"2014","unstructured":"Miller, A. C., Rosati, S. F., Suffredini, A. F. & Schrump, D. S. A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries. Resuscitation 85, 724\u2013731 (2014).","journal-title":"Resuscitation"},{"key":"505_CR25","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.transci.2018.03.003","volume":"57","author":"L Zheng","year":"2018","unstructured":"Zheng, L., Tian, M., Zhang, Y., Dong, P. & Yang, H. Neutrophil extracellular traps were released during intraoperative blood salvage in posterior lumbar surgery. Transfus. Apher. Sci. 57, 259\u2013264 (2018).","journal-title":"Transfus. Apher. Sci."},{"key":"505_CR26","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nri2607","volume":"9","author":"V Nizet","year":"2009","unstructured":"Nizet, V. & Johnson, R. S. Interdependence of hypoxic and innate immune responses. Nat. Rev. Immunol. 9, 609\u2013617 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"505_CR27","doi-asserted-by":"publisher","first-page":"e14033","DOI":"10.14814\/phy2.14033","volume":"7","author":"M Marlinge","year":"2019","unstructured":"Marlinge, M. et al. Physiological stress markers during breath-hold diving and SCUBA diving. Physiol. Rep. 7, e14033 (2019).","journal-title":"Physiol. Rep."},{"key":"505_CR28","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.4049\/jimmunol.1301920","volume":"192","author":"CW van den Berg","year":"2014","unstructured":"van den Berg, C. W. et al. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. J. Immunol. 192, 1787\u20131795 (2014).","journal-title":"J. Immunol."},{"key":"505_CR29","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00246-009-9421-6","volume":"30","author":"Y Wei","year":"2009","unstructured":"Wei, Y., Xu, J., Xu, T., Fan, J. & Tao, S. Left ventricular systolic function of newborns with asphyxia evaluated by tissue Doppler imaging. Pediatr. Cardiol. 30, 741\u2013746 (2009).","journal-title":"Pediatr. Cardiol."},{"key":"505_CR30","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1007\/s00431-012-1764-y","volume":"171","author":"A Sehgal","year":"2012","unstructured":"Sehgal, A., Wong, F. & Mehta, S. Reduced cardiac output and its correlation with coronary blood flow and troponin in asphyxiated infants treated with therapeutic hypothermia. Eur. J. Pediatr. 171, 1511\u20131517 (2012).","journal-title":"Eur. J. Pediatr."},{"key":"505_CR31","doi-asserted-by":"publisher","first-page":"e0187270","DOI":"10.1371\/journal.pone.0187270","volume":"12","author":"M Kalbitz","year":"2017","unstructured":"Kalbitz, M. et al. Experimental blunt chest trauma-induced myocardial inflammation and alteration of gap-junction protein connexin 43. PLoS ONE 12, e0187270 (2017).","journal-title":"PLoS ONE"},{"key":"505_CR32","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1159\/000092570","volume":"42","author":"S Dhein","year":"2006","unstructured":"Dhein, S. Cardiac ischemia and uncoupling: gap junctions in ischemia and infarction. Adv. Cardiol. 42, 198\u2013212 (2006).","journal-title":"Adv. Cardiol."},{"key":"505_CR33","doi-asserted-by":"publisher","first-page":"2580","DOI":"10.1161\/CIRCULATIONAHA.107.706770","volume":"116","author":"J Wang","year":"2007","unstructured":"Wang, J., Khoury, D. S., Yue, Y., Torre-Amione, G. & Nagueh, S. F. Left ventricular untwisting rate by speckle tracking echocardiography. Circulation 116, 2580\u20132586 (2007).","journal-title":"Circulation"},{"key":"505_CR34","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1159\/000445779","volume":"110","author":"CR Breatnach","year":"2016","unstructured":"Breatnach, C. R., Levy, P. T., James, A. T., Franklin, O. & El-Khuffash, A. Novel echocardiography methods in the functional assessment of the newborn heart. Neonatology 110, 248\u2013260 (2016).","journal-title":"Neonatology"},{"key":"505_CR35","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1161\/01.RES.66.3.763","volume":"66","author":"SE Downing","year":"1990","unstructured":"Downing, S. E. & Chen, V. Myocardial hibernation in the ischemic neonatal heart. Circ. Res. 66, 763\u2013772 (1990).","journal-title":"Circ. Res."},{"key":"505_CR36","first-page":"244","volume":"24","author":"D Saha","year":"2015","unstructured":"Saha, D. et al. Association of hypoglycemia, hypocalcemia and hypomagnesemia in neonates with perinatal asphyxia. Mymensingh Med J. 24, 244\u2013250 (2015).","journal-title":"Mymensingh Med J."},{"key":"505_CR37","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cardiores.2003.10.022","volume":"61","author":"Y Nishino","year":"2004","unstructured":"Nishino, Y. et al. Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection. Cardiovasc. Res. 61, 610\u2013619 (2004).","journal-title":"Cardiovasc. Res."},{"key":"505_CR38","first-page":"7463407","volume":"2016","author":"J Kim","year":"2016","unstructured":"Kim, J. et al. The responses of tissues from the brain, heart, kidney, and liver to resuscitation following prolonged cardiac arrest by examining mitochondrial respiration in rats. Oxid. Med. Cell. Longev. 2016, 7463407 (2016).","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0505-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0505-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41390-019-0505-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:27:32Z","timestamp":1684618052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-019-0505-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["505"],"URL":"https:\/\/doi.org\/10.1038\/s41390-019-0505-6","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,23]]},"assertion":[{"value":"20 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}