{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:04:33Z","timestamp":1777590273114,"version":"3.51.4"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1038\/s41390-020-01124-8","type":"journal-article","created":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T17:03:27Z","timestamp":1599930207000},"page":"1742-1750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of high maternal blood alpha-fetoprotein level with risk of delivering small for gestational age: a meta-analysis"],"prefix":"10.1038","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5870-8122","authenticated-orcid":false,"given":"Eita","family":"Goto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"key":"1124_CR1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.pedneo.2014.07.007","volume":"56","author":"LY Tsai","year":"2015","unstructured":"Tsai, L. Y., Chen, Y. L., Tsou, K. I. & Mu, S. C. Taiwan Premature Infant Developmental Collaborative Study Group. The impact of small-for-gestational-age on neonatal outcome among very-low-birth-weight infants. Pediatr. Neonatol. 56, 101\u2013107 (2015).","journal-title":"Pediatr. Neonatol."},{"key":"1124_CR2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2431-4-9","volume":"4","author":"P Sharma","year":"2004","unstructured":"Sharma, P., McKay, K., Rosenkrantz, T. S. & Hussain, N. Comparisons of mortality and pre-discharge respiratory outcomes in small-for-gestational-age and appropriate-for-gestational-age premature infants. BMC Pediatr. 4, 9 (2004).","journal-title":"BMC Pediatr."},{"key":"1124_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3109\/14767058.2011.565837","volume":"25","author":"V Giapros","year":"2012","unstructured":"Giapros, V., Drougia, A., Krallis, N., Theocharis, P. & Andronikou, S. Morbidity and mortality patterns in small-for-gestational age infants born preterm. J. Matern. Fetal Neonatal Med. 25, 153\u2013157 (2012).","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"1124_CR4","first-page":"8","volume":"1","author":"R Romero","year":"1996","unstructured":"Romero, R. The child is the father of the man. Prenat. Neonatal Med. 1, 8\u201311 (1996).","journal-title":"Prenat. Neonatal Med."},{"key":"1124_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ejogrb.2016.05.042","volume":"203","author":"E Goto","year":"2016","unstructured":"Goto, E. Maternal anthropometry to predict small for gestational age: a meta-analysis. Eur. J. Obstet. Gynecol. Reprod. Biol. 203, 193\u2013198 (2016).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"1124_CR6","first-page":"260","volume":"24","author":"E Goto","year":"2015","unstructured":"Goto, E. Diagnostic value of maternal anthropometric measurements for predicting low birth weight in developing countries: a meta-analysis. Asia. Pac. J. Clin. Nutr. 24, 260\u2013272 (2015).","journal-title":"Asia. Pac. J. Clin. Nutr."},{"key":"1124_CR7","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00404-015-3721-2","volume":"292","author":"E Goto","year":"2015","unstructured":"Goto, E. Maternal anthropometric measurements as predictors of low birth weight in developing and developed countries. Arch. Gynecol. Obstet. 292, 829\u2013842 (2015).","journal-title":"Arch. Gynecol. Obstet."},{"key":"1124_CR8","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41430-019-0432-y","volume":"74","author":"E Goto","year":"2020","unstructured":"Goto, E. Dose-response associations of maternal height and weight with small for gestational age: a meta-analysis. Eur. J. Clin. Nutr. 74, 106\u2013111 (2020).","journal-title":"Eur. J. Clin. Nutr."},{"key":"1124_CR9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3109\/14767058.2016.1169519","volume":"30","author":"E Goto","year":"2017","unstructured":"Goto, E. Dose-response association between maternal body mass index and small for gestational age: a meta-analysis. J. Matern. Fetal Neonatal Med. 30, 213\u2013218 (2017).","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"1124_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000485748","volume":"72","author":"E Goto","year":"2018","unstructured":"Goto, E. Maternal and cord blood adiponectin concentrations in small for gestational age: a meta-analysis. Ann. Nutr. Metab. 72, 57\u201364 (2018).","journal-title":"Ann. Nutr. Metab."},{"key":"1124_CR11","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s00431-019-03351-6","volume":"178","author":"E Goto","year":"2019","unstructured":"Goto, E. Maternal blood leptin concentration in small for gestational age: a meta-analysis. Eur. J. Pediatr. 178, 763\u2013770 (2019).","journal-title":"Eur. J. Pediatr."},{"key":"1124_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/sj.ijo.0803106","volume":"30","author":"D Jaquet","year":"2006","unstructured":"Jaquet, D., Deghmoun, S., Chevenne, D., Czernichow, P. & L\u00e9vy-Marchal, C. Low serum adiponectin levels in subjects born small for gestational age: impact on insulin sensitivity. Int. J. Obes. 30, 83\u201387 (2006).","journal-title":"Int. J. Obes."},{"key":"1124_CR13","doi-asserted-by":"publisher","first-page":"E335","DOI":"10.1152\/ajpendo.00312.2014","volume":"308","author":"JF Briffa","year":"2015","unstructured":"Briffa, J. F., McAinch, A. J., Romano, T., Wlodek, M. E. & Hryciw, D. H. Leptin in pregnancy and development: a contributor to adulthood disease? Am. J. Physiol. Endocrinol. Metab. 308, E335\u2013E350 (2015).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"1124_CR14","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1253\/circj.CJ-16-0861","volume":"80","author":"TA Fick","year":"2016","unstructured":"Fick, T. A. & Backes, C. H. Cardiovascular remodeling in the small for gestational age infant - implications and future directions. Circ. J. 80, 2096\u20132097 (2016).","journal-title":"Circ. J."},{"key":"1124_CR15","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/pr.2016.24","volume":"79","author":"E Cohen","year":"2016","unstructured":"Cohen, E., Wong, F. Y., Horne, R. S. & Yiallourou, S. R. Intrauterine growth restriction: impact on cardiovascular development and function throughout infancy. Pediatr. Res. 79, 821\u2013830 (2016).","journal-title":"Pediatr. Res."},{"key":"1124_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16346-x","volume":"11","author":"TJ Kaitu\u2019u-Lino","year":"2020","unstructured":"Kaitu\u2019u-Lino, T. J. et al. Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction. Nat. Commun. 11, 2411 (2020).","journal-title":"Nat. Commun."},{"key":"1124_CR17","doi-asserted-by":"publisher","first-page":"e39748","DOI":"10.1371\/journal.pone.0039784","volume":"7","author":"PJ Dutton","year":"2012","unstructured":"Dutton, P. J. et al. Predictors of poor perinatal outcome following maternal perception of reduced fetal movements\u2013a prospective cohort study. PLoS ONE 7, e39748 (2012).","journal-title":"PLoS ONE"},{"key":"1124_CR18","first-page":"CD011202","volume":"11","author":"AE Heazell","year":"2015","unstructured":"Heazell, A. E., Whitworth, M., Duley, L. & Thornton, J. G. Use of biochemical tests of placental function for improving pregnancy outcome. Cochrane Database Syst. Rev. 11, CD011202 (2015).","journal-title":"Cochrane Database Syst. Rev."},{"key":"1124_CR19","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/ijgo.12517","volume":"142","author":"E Goto","year":"2018","unstructured":"Goto, E. Meta-regression analysis to evaluate relationships between maternal blood levels of placentation biomarkers and low delivery weight. Int. J. Gynaecol. Obstet. 142, 148\u2013155 (2018).","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"1124_CR20","unstructured":"Wells, G. A. et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp (2014). Accessed 11 May 2020."},{"key":"1124_CR21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger, M., Davey Smith, G., Schneider, M. & Minder, C. Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629\u2013634 (1997).","journal-title":"BMJ"},{"key":"1124_CR22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0020-7292(96)80004-X","volume":"53","author":"AA Akinbiyi","year":"1996","unstructured":"Akinbiyi, A. A. Unexplained elevated maternal serum alpha-fetoprotein in singleton pregnancies as a predictor of fetal risk. Int. J. Gynaecol. Obstet. 53, 17\u201321 (1996).","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"1124_CR23","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1159\/000081369","volume":"20","author":"F Audibert","year":"2005","unstructured":"Audibert, F., Benchimol, Y., Benattar, C., Champagne, C. & Frydman, R. Prediction of preeclampsia or intrauterine growth restriction by second trimester serum screening and uterine Doppler velocimetry. Fetal Diagn. Ther. 20, 48\u201353 (2005).","journal-title":"Fetal Diagn. Ther."},{"key":"1124_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5603\/GP.a2017.0061","volume":"88","author":"D Ba\u015fbu\u011f","year":"2017","unstructured":"Ba\u015fbu\u011f, D., Ba\u015fbu\u011f, A. & G\u00fclerman, C. Is unexplained elevated maternal serum alpha-fetoprotein still important predictor for adverse pregnancy outcome? Ginekol. Pol. 88, 325\u2013330 (2017).","journal-title":"Ginekol. Pol."},{"key":"1124_CR25","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/0002-9378(94)90028-0","volume":"171","author":"WF Brazerol","year":"1994","unstructured":"Brazerol, W. F., Grover, S. & Donnenfeld, A. E. Unexplained elevated maternal serum alpha-fetoprotein levels and perinatal outcome in an urban clinic population. Am. J. Obstet. Gynecol. 171, 1030\u20131035 (1994).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"1124_CR26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1515\/jpme.1984.12.3.127","volume":"12","author":"CM Buckland","year":"1984","unstructured":"Buckland, C. M., Thom, H. & Campbell, A. G. Maternal serum alpha-fetoprotein levels in low birth weight singleton pregnancies. J. Perinat. Med. 12, 127\u2013132 (1984).","journal-title":"J. Perinat. Med."},{"key":"1124_CR27","first-page":"257","volume":"37","author":"EL Capeless","year":"1992","unstructured":"Capeless, E. L., Kelleher, P. C. & Walters, C. P. Elevated maternal serum alpha-fetoprotein levels and maternal risk factors. Their association with pregnancy complications. J. Reprod. Med. 37, 257\u2013260 (1992).","journal-title":"J. Reprod. Med."},{"key":"1124_CR28","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1515\/jpme.1997.25.6.476","volume":"25","author":"S Cho","year":"1997","unstructured":"Cho, S., Durfee, K. K., Keel, B. A. & Parks, L. H. Perinatal outcomes in a prospective matched pair study of pregnancy and unexplained elevated or low AFP screening. J. Perinat. Med. 25, 476\u2013483 (1997).","journal-title":"J. Perinat. Med."},{"key":"1124_CR29","first-page":"155","volume":"10","author":"MM Di","year":"1998","unstructured":"Di, M. M. et al. A simultaneous evaluation of second trimester serum AFP, hCG and unconjugated oestriol as predictors of small for gestational age births. Ital. J. Gynaecol. Obstet. 10, 155\u2013159 (1998).","journal-title":"Ital. J. Gynaecol. Obstet."},{"key":"1124_CR30","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/01.AOG.0000172419.37410.eb","volume":"106","author":"L Dugoff","year":"2005","unstructured":"Dugoff, L. et al. Quad screen as a predictor of adverse pregnancy outcome. Obstet. Gynecol. 106, 260\u2013267 (2005).","journal-title":"Obstet. Gynecol."},{"key":"1124_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/S0301-2115(03)00081-2","volume":"110","author":"K Duric","year":"2003","unstructured":"Duric, K. et al. Second trimester total human chorionic gonadotropin, alpha-fetoprotein and unconjugated estriol in predicting pregnancy complications other than fetal aneuploidy. Eur. J. Obstet. Gynecol. Reprod. Biol. 110, 12\u201315 (2003).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"1124_CR32","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/0002-9378(79)90064-4","volume":"133","author":"YB Gordon","year":"1979","unstructured":"Gordon, Y. B. et al. Maternal serum alpha-fetoprotein levels as an index of fetal risk. Am. J. Obstet. Gynecol. 133, 422\u2013424 (1979).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"1124_CR33","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3109\/01443615.2012.759915","volume":"33","author":"N G\u00fcd\u00fcc\u00fc","year":"2013","unstructured":"G\u00fcd\u00fcc\u00fc, N., G\u00f6nen\u00e7, G., I\u015f\u00e7i, H., Yi\u011fiter, A. B. & D\u00fcnder, I. Can quadruple test parameters predict SGA infants? J. Obstet. Gynaecol. 33, 269\u2013271 (2013).","journal-title":"J. Obstet. Gynaecol."},{"key":"1124_CR34","first-page":"465","volume":"65","author":"MP Hamilton","year":"1985","unstructured":"Hamilton, M. P., Abdalla, H. I. & Whitfield, C. R. Significance of raised maternal serum alpha-fetoprotein in singleton pregnancies with normally formed fetuses. Obstet. Gynecol. 65, 465\u2013470 (1985).","journal-title":"Obstet. Gynecol."},{"key":"1124_CR35","first-page":"319","volume":"102","author":"PL Kuo","year":"2003","unstructured":"Kuo, P. L., Lin, C. C., Lin, Y. H. & Guo, H. R. Placental sonolucency and pregnancy outcome in women with elevated second trimester serum alpha-fetoprotein levels. J. Formos. Med. Assoc. 102, 319\u2013325 (2003).","journal-title":"J. Formos. Med. Assoc."},{"key":"1124_CR36","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.1479-828X.1985.tb00741.x","volume":"25","author":"M Legge","year":"1985","unstructured":"Legge, M., Duff, G. B., Pike, L. & Aickin, D. R. Second trimester maternal serum alpha-fetoprotein as an indicator of fetal risk. Aust. NZ J. Obstet. Gynaecol. 25, 266\u2013268 (1985).","journal-title":"Aust. NZ J. Obstet. Gynaecol."},{"key":"1124_CR37","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1002\/pd.1970151109","volume":"15","author":"LP Morssink","year":"1995","unstructured":"Morssink, L. P., Kornman, L. H., Beekhuis, J. R., De Wolf, B. T. & Mantingh, A. Abnormal levels of maternal serum human chorionic gonadotropin and alpha-fetoprotein in the second trimester: relation to fetal weight and preterm delivery. Prenat. Diagn. 15, 1041\u20131046 (1995).","journal-title":"Prenat. Diagn."},{"key":"1124_CR38","first-page":"104","volume":"36","author":"J Pandey","year":"1993","unstructured":"Pandey, J., Talib, V. H., Loganey, D. & Yadav, S. Diagnostic value of maternal serum alpha fetoprotein for predicting pregnancy outcome in high risk pregnancies: an epidemiological perspective. Indian J. Pathol. Microbiol. 36, 104\u2013109 (1993).","journal-title":"Indian J. Pathol. Microbiol."},{"key":"1124_CR39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00404-014-3606-9","volume":"292","author":"P Puntachai","year":"2015","unstructured":"Puntachai, P. et al. Associations between pregnancy outcomes and unexplained high and low maternal serum alpha-fetoprotein levels. Arch. Gynecol. Obstet. 292, 81\u201385 (2015).","journal-title":"Arch. Gynecol. Obstet."},{"key":"1124_CR40","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1471-0528.1976.tb00725.x","volume":"83","author":"CH Rodeck","year":"1976","unstructured":"Rodeck, C. H., Campbell, S. & Biswas, S. Maternal plasma alpha-fetoprotein in normal and complicated pregnancies. Br. J. Obstet. Gynaecol. 83, 24\u201332 (1976).","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"1124_CR41","first-page":"779","volume":"40","author":"AP Roop","year":"1991","unstructured":"Roop, A. P., Boughman, J. A. & Blitzer, M. G. Study of the relationship between elevated maternal serum alpha-fetoprotein and adverse pregnancy outcome. MD Med. J. 40, 779\u2013784 (1991).","journal-title":"MD Med. J."},{"key":"1124_CR42","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1055\/s-2007-999919","volume":"2","author":"NJ Secher","year":"1985","unstructured":"Secher, N. J., Eriksen, P. S., Hansen, P. K., Lenstrup, C. & Thisted, J. High maternal serum alpha-fetoprotein and low birthweight. A study concerning possible correlation between maternal weight, smoking, and serum alpha-fetoprotein and subsequent birthweight and gestational age. Am. J. Perinatol. 2, 78\u201381 (1985).","journal-title":"Am. J. Perinatol."},{"key":"1124_CR43","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1111\/j.1471-0528.1980.tb04480.x","volume":"87","author":"ML Smith","year":"1980","unstructured":"Smith, M. L. Raised maternal serum alpha-fetoprotein levels and low birth weight babies. Br. J. Obstet. Gynaecol. 87, 1099\u20131102 (1980).","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"1124_CR44","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1055\/s-2007-999393","volume":"8","author":"CP Weiner","year":"1991","unstructured":"Weiner, C. P., Grant, S. S. & Williamson, R. A. Relationship between second trimester maternal serum alpha-fetoprotein and umbilical artery Doppler velocimetry and their association with preterm delivery. Am. J. Perinatol. 8, 263\u2013268 (1991).","journal-title":"Am. J. Perinatol."},{"key":"1124_CR45","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/0002-9378(92)91733-Q","volume":"167","author":"KD Wenstrom","year":"1992","unstructured":"Wenstrom, K. D. et al. Prediction of pregnancy outcome with single versus serial maternal serum alpha-fetoprotein tests. Am. J. Obstet. Gynecol. 167, 1529\u20131533 (1992).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"1124_CR46","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0029-7844(95)00377-0","volume":"87","author":"KD Wenstrom","year":"1996","unstructured":"Wenstrom, K. D., Owen, J., Davis, R. O. & Brumfield, C. G. Prognostic significance of unexplained elevated amniotic fluid alpha-fetoprotein. Obstet. Gynecol. 87, 213\u2013216 (1996).","journal-title":"Obstet. Gynecol."},{"key":"1124_CR47","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/S0002-9378(12)80033-0","volume":"167","author":"MA Williams","year":"1992","unstructured":"Williams, M. A. et al. Elevated maternal serum alpha-fetoprotein levels and midtrimester placental abnormalities in relation to subsequent adverse pregnancy outcomes. Am. J. Obstet. Gynecol. 167, 1032\u20131037 (1992).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"1124_CR48","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1159\/000458409","volume":"42","author":"E Yefet","year":"2017","unstructured":"Yefet, E., Kuzmin, O., Schwartz, N., Basson, F. & Nachum, Z. Predictive Value of Second-trimester biomarkers and maternal features for adverse pregnancy outcomes. Fetal Diagn. Ther. 42, 285\u2013293 (2017).","journal-title":"Fetal Diagn. Ther."},{"key":"1124_CR49","unstructured":"Sch\u00fcnemann, H., Bro\u017cek, J., Guyatt, G. & Oxman, A. GRADE handbook. https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html#h.trgki08omk7z (2013). Accessed 11 May 2020."},{"key":"1124_CR50","unstructured":"Egger, M., Smith, G. D. & Altman, D. G. Systematic Reviews in Healthcare: Meta-analysis in Context 2nd edn (BMJ, London, 2007)."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01124-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01124-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01124-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T01:14:13Z","timestamp":1650244453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01124-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,12]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["1124"],"URL":"https:\/\/doi.org\/10.1038\/s41390-020-01124-8","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,12]]},"assertion":[{"value":"13 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declares no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Patient consent was not required, because this study did not use the primary data of human subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent"}}]}}