{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:23:43Z","timestamp":1789579423711,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1038\/s41390-020-01230-7","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T15:02:47Z","timestamp":1605625367000},"page":"419-426","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia"],"prefix":"10.1038","volume":"90","author":[{"given":"Ellen","family":"van der Plas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Leigh","family":"Spencer Noakes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darci T.","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Weksberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Galin-Corini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Wanstall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Te","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Guger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Hitzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell J.","family":"Schachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Nieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"1230_CR1","unstructured":"Howlader, N. et al. National Cancer Institute SEER Cancer Statistics Review 1975\u22122014 (National Cancer Institute, Bethesda, MD, 2017)."},{"key":"1230_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.neubiorev.2015.03.016","volume":"53","author":"YT Cheung","year":"2015","unstructured":"Cheung, Y. T. & Krull, K. R. Neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia treated on contemporary treatment protocols: a systematic review. Neurosci. Biobehav. Rev. 53, 108\u2013120 (2015).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"1230_CR3","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1080\/09297049.2017.1386170","volume":"24","author":"E van der Plas","year":"2018","unstructured":"van der Plas, E. et al. Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures. Child Neuropsychol. 24, 999\u20131014 (2018).","journal-title":"Child Neuropsychol."},{"key":"1230_CR4","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1182\/blood-2015-02-627414","volume":"126","author":"NS Iyer","year":"2015","unstructured":"Iyer, N. S., Balsamo, L. M., Bracken, M. B. & Kadan-Lottick, N. S. Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis. Blood 126, 346\u2013353 (2015).","journal-title":"Blood"},{"key":"1230_CR5","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S2215-0366(16)30283-8","volume":"3","author":"LM Jacola","year":"2016","unstructured":"Jacola, L. M. et al. Cognitive, behavior and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Lancet Psychiatry 3, 965\u2013972 (2016).","journal-title":"Lancet Psychiatry"},{"key":"1230_CR6","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1200\/JCO.2015.64.3205","volume":"34","author":"LM Jacola","year":"2016","unstructured":"Jacola, L. M. et al. Longitudinal assessment of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy protocol. J. Clin. Oncol. 34, 1239\u20131247 (2016).","journal-title":"J. Clin. Oncol."},{"key":"1230_CR7","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s11764-018-0679-7","volume":"12","author":"W Liu","year":"2018","unstructured":"Liu, W. et al. Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only. J. Cancer Surviv. 12, 398\u2013406 (2018).","journal-title":"J. Cancer Surviv."},{"key":"1230_CR8","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s11065-020-09446-4","volume":"30","author":"PBG Godoy","year":"2020","unstructured":"Godoy, P. B. G., Simionato, N. M., de Mello, C. B. & Suchecki, D. Assessment of executive functions after treatment of childhood acute lymphoid leukemia: a systematic review. Neuropsychol. Rev. 30, 386\u2013406 (2020).","journal-title":"Neuropsychol. Rev."},{"key":"1230_CR9","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1651-2227.2008.01055.x","volume":"98","author":"GE Lofstad","year":"2009","unstructured":"Lofstad, G. E., Reinfjell, T., Hestad, K. & Diseth, T. H. Cognitive outcome in children and adolescents treated for acute lymphoblastic leukaemia with chemotherapy only. Acta Paediatr. 98, 180\u2013186 (2009).","journal-title":"Acta Paediatr."},{"key":"1230_CR10","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1093\/jpepsy\/jsr119","volume":"37","author":"LA Harshman","year":"2012","unstructured":"Harshman, L. A. et al. Population-based exploration of academic achievement outcomes in pediatric acute lymphoblastic leukemia survivors. J. Pediatr. Psychol. 37, 458\u2013466 (2012).","journal-title":"J. Pediatr. Psychol."},{"key":"1230_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/cdep.12059","volume":"8","author":"R Bull","year":"2014","unstructured":"Bull, R. & Lee, K. Executive functioning and mathematics achievement. Child Dev. Perspect. 8, 36\u201341 (2014).","journal-title":"Child Dev. Perspect."},{"key":"1230_CR12","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1158\/1055-9965.EPI-11-0239","volume":"20","author":"AC Kirchhoff","year":"2011","unstructured":"Kirchhoff, A. C. et al. Physical, mental and neurocognitive status and employment outcomes in the Childhood Cancer Survivor Study Cohort. Cancer Epidemiol. Biomark. Prev. 20, 1838\u20131849 (2011).","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"1230_CR13","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/pon.3470","volume":"23","author":"A Kunin-Batson","year":"2014","unstructured":"Kunin-Batson, A., Kadan-Lottick, N. & Neglia, J. P. The contribution of neurocognitive functioning to quality of life after childhood acute lymphoblastic leukemia. Psychooncology 23, 692\u2013699 (2014).","journal-title":"Psychooncology"},{"key":"1230_CR14","doi-asserted-by":"crossref","unstructured":"Fardell, J. E. et al. Health-related quality of life of children on treatment for acute lymphoblastic leukemia: a systematic review. Pediatr. Blood Cancer 64, e26489 (2017).","DOI":"10.1002\/pbc.26489"},{"key":"1230_CR15","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/cncr.31085","volume":"124","author":"DJ Zheng","year":"2018","unstructured":"Zheng, D. J. et al. Longitudinal analysis of quality-of-life outcomes in children during treatment for acute lymphoblastic leukemia: a report from the Children\u2019s Oncology Group AALL0932 trial. Cancer 124, 571\u2013579 (2018).","journal-title":"Cancer"},{"key":"1230_CR16","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/leu.2009.262","volume":"24","author":"PS Gaynon","year":"2010","unstructured":"Gaynon, P. S. et al. Long-term results of the children\u2019s cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children\u2019s Oncology Group Report. Leukemia 24, 285\u2013297 (2010).","journal-title":"Leukemia"},{"key":"1230_CR17","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1182\/blood-2005-12-011809","volume":"108","author":"Y Matloub","year":"2006","unstructured":"Matloub, Y. et al. Intrathecal triple therapy decreases central nervous system relapse but fails to improve event-free survival when compared with intrathecal methotrexate: results of the Children\u2019s Cancer Group (CCG) 1952 study for standard-risk acute lymphoblastic leukemia, reported by the Children\u2019s Oncology Group. Blood 108, 1165\u20131173 (2006).","journal-title":"Blood"},{"key":"1230_CR18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2","volume":"3","author":"JW Varni","year":"2003","unstructured":"Varni, J. W., Burwinkle, T. M., Seid, M. & Skarr, D. The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity. Ambul. Pediatr. 3, 329\u2013341 (2003).","journal-title":"Ambul. Pediatr."},{"key":"1230_CR19","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.1200\/JCO.2015.61.6672","volume":"33","author":"HM Conklin","year":"2015","unstructured":"Conklin, H. M. et al. Computerized cognitive training for amelioration of cognitive late effects among childhood cancer survivors: a randomized controlled trial. J. Clin. Oncol. 33, 3894\u20133902 (2015).","journal-title":"J. Clin. Oncol."},{"key":"1230_CR20","doi-asserted-by":"publisher","first-page":"102428","DOI":"10.1016\/j.nicl.2020.102428","volume":"28","author":"E van der Plas","year":"2020","unstructured":"van der Plas, E. et al. Quantitative MRI outcomes in child and adolescent leukemia survivors: evidence for global alterations in gray and white matter. NeuroImage: Clin. 28, 102428 (2020).","journal-title":"NeuroImage: Clin."},{"key":"1230_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1755-618X.2008.00003.x","volume":"45","author":"M Boyd","year":"2008","unstructured":"Boyd, M. A socioeconomic scale for Canada: measuring occupational status from the census. Can. Rev. Sociol.\/Rev. canadienne de. sociologie 45, 51\u201391 (2008).","journal-title":"Can. Rev. Sociol.\/Rev. canadienne de. sociologie"},{"key":"1230_CR22","doi-asserted-by":"crossref","unstructured":"Wechsler, D. The Wechsler Intelligence Scale for Children 4th edn (Pearson Assessment, London, 2004).","DOI":"10.1037\/t15174-000"},{"key":"1230_CR23","doi-asserted-by":"crossref","unstructured":"Wechsler, D. Wechsler Adult Intelligence Scale 4th edn (Pearson Assessment, San Antonio, TX, 2008).","DOI":"10.1037\/t15169-000"},{"key":"1230_CR24","unstructured":"Wechsler, D. Wechsler Individual Achievement Test\u2014Third Edition (NCS Pearson, San Antonio, TX, 2009)."},{"key":"1230_CR25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/15374417909532912","volume":"8","author":"RA Gardner","year":"1979","unstructured":"Gardner, R. A. & Broman, M. The Purdue pegboard: normative data on 1334 school children. J. Clin. Child Psychol. 8, 156\u2013162 (1979).","journal-title":"J. Clin. Child Psychol."},{"key":"1230_CR26","unstructured":"Conners, C. Conners 3 Manual 3rd edn (Multi-Health Systems Inc., Toronto, ON, 2008)."},{"key":"1230_CR27","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1097\/00005650-200108000-00006","volume":"39","author":"JW Varni","year":"2001","unstructured":"Varni, J. W., Seid, M. & Kurtin, P. S. PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med. Care 39, 800\u2013812 (2001).","journal-title":"Med. Care"},{"key":"1230_CR28","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing [Internet] (R Foundation for Statistical Computing, Vienna, Austria) https:\/\/www.R-project.org\/ (2020)."},{"key":"1230_CR29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11136-008-9412-8","volume":"18","author":"JA Panepinto","year":"2009","unstructured":"Panepinto, J. A. et al. Impact of family income and sickle cell disease on the health-related quality of life of children. Qual. Life Res. 18, 5\u201313 (2009).","journal-title":"Qual. Life Res."},{"key":"1230_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1037\/a0037864","volume":"27","author":"ME Narad","year":"2015","unstructured":"Narad, M. E. et al. Parent-teacher agreement on ADHD symptoms across development. Psychol. Assess. 27, 239\u2013248 (2015).","journal-title":"Psychol. Assess."},{"key":"1230_CR31","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1037\/pas0000265","volume":"28","author":"VW Willard","year":"2016","unstructured":"Willard, V. W. et al. Concordance of parent-, teacher- and self-report ratings on the Conners 3 in adolescent survivors of cancer. Psychol. Assess. 28, 1110\u20131118 (2016).","journal-title":"Psychol. Assess."},{"key":"1230_CR32","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1477-7525-5-2","volume":"5","author":"JW Varni","year":"2007","unstructured":"Varni, J. W., Limbers, C. A. & Burwinkle, T. M. Parent proxy-report of their children\u2019s health-related quality of life: an analysis of 13,878 parents\u2019 reliability and validity across age subgroups using the PedsQL 4.0 Generic Core Scales. Health Qual. Life Outcomes 5, 2 (2007).","journal-title":"Health Qual. Life Outcomes"},{"key":"1230_CR33","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1002\/pbc.22982","volume":"57","author":"A Kunin-Batson","year":"2011","unstructured":"Kunin-Batson, A. et al. Predictors of independent living status in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Pediatr. Blood Cancer 57, 1197\u20131203 (2011).","journal-title":"Pediatr. Blood Cancer"},{"key":"1230_CR34","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/cncr.31019","volume":"124","author":"MJ Ehrhardt","year":"2018","unstructured":"Ehrhardt, M. J. et al. Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma. Cancer 124, 417\u2013425 (2018).","journal-title":"Cancer"},{"key":"1230_CR35","first-page":"78","volume":"2","author":"LE Cox","year":"2015","unstructured":"Cox, L. E. et al. Feasibility and acceptability of a remotely administered computerized intervention to address cognitive late effects among childhood cancer survivors. Neurooncol Pr. 2, 78\u201387 (2015).","journal-title":"Neurooncol Pr."},{"key":"1230_CR36","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1200\/JCO.2010.28.4026","volume":"28","author":"HM Conklin","year":"2010","unstructured":"Conklin, H. M. et al. Long-term efficacy of methylphenidate in enhancing attention regulation, social skills, and academic abilities of childhood cancer survivors. J. Clin. Oncol. 28, 4465\u20134472 (2010).","journal-title":"J. Clin. Oncol."},{"key":"1230_CR37","first-page":"220","volume":"42","author":"HM Conklin","year":"2017","unstructured":"Conklin, H. M. et al. Long-term efficacy of computerized cognitive training among survivors of childhood cancer: a single-blind randomized controlled trial. J. Pediatr. Psychol. 42, 220\u2013231 (2017).","journal-title":"J. Pediatr. Psychol."},{"key":"1230_CR38","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1016\/j.ejca.2013.05.023","volume":"49","author":"EF Smithson","year":"2013","unstructured":"Smithson, E. F., Phillips, R., Harvey, D. W. & Morrall, M. C. H. J. The use of stimulant medication to improve neurocognitive and learning outcomes in children diagnosed with brain tumours: a systematic review. Eur. J. Cancer 49, 3029\u20133040 (2013).","journal-title":"Eur. J. Cancer"},{"key":"1230_CR39","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1093\/jpepsy\/jsq102","volume":"36","author":"KL Netson","year":"2011","unstructured":"Netson, K. L. et al. Parent and teacher ratings of attention during a year-long methylphenidate trial in children treated for cancer. J. Pediatr. Psychol. 36, 438\u2013450 (2011).","journal-title":"J. Pediatr. Psychol."},{"key":"1230_CR40","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1111\/jpc.13407","volume":"52","author":"MS Didsbury","year":"2016","unstructured":"Didsbury, M. S. et al. Socio-economic status and quality of life in children with chronic disease: a systematic review. J. Paediatr. Child Health 52, 1062\u20131069 (2016).","journal-title":"J. Paediatr. Child Health"},{"key":"1230_CR41","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1002\/cncr.31123","volume":"124","author":"A Hiyoshi","year":"2018","unstructured":"Hiyoshi, A., Montgomery, S., Bottai, M. & Hov\u00e9n, E. I. Trajectories of income and social benefits for mothers and fathers of children with cancer: a national cohort study in Sweden. Cancer 124, 1492\u20131500 (2018).","journal-title":"Cancer"},{"key":"1230_CR42","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1007\/s11136-018-1788-5","volume":"27","author":"J Vetsch","year":"2018","unstructured":"Vetsch, J. et al. Health-related quality of life of survivors of childhood acute lymphoblastic leukemia: a systematic review. Qual. Life Res. 27, 1431\u20131443 (2018).","journal-title":"Qual. Life Res."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01230-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01230-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01230-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T07:08:27Z","timestamp":1632380907000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-020-01230-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,17]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1230"],"URL":"https:\/\/doi.org\/10.1038\/s41390-020-01230-7","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,17]]},"assertion":[{"value":"12 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"R.J.S. has performed consulting work with Ironshore Pharmaceutic and Development, Inc., Purdue Pharma and Lilly Corp. He is the Toronto Dominion Bank Chair in Child and Adolescent Psychiatry. The other authors have no conflicts of interest to disclose.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All participants and\/or their parents\/guardians provided written, informed consent prior to participation in the study. Assent was obtained from participants too young or otherwise unable to provide informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}}]}}