{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:32:16Z","timestamp":1791923536162,"version":"4.3.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this study, the association between a novel CUS scoring system and neurodevelopmental outcome in neonates with HIE was assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>(Near-)term infants with HIE and therapeutic hypothermia, a CUS on day 1 and day 3\u20137 after birth and available outcome data were retrospectively included in cohort I. CUS findings on day 1 and day 3\u20137 were related to adverse outcome in univariate and the CUS of day 3\u20137 also in multivariable logistic regression analyses. The resistance index, the sum of deep grey matter and of white matter involvement were included in multivariable logistic regression analyses. A comparable cohort from another hospital was used for validation (cohort II).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Eighty-three infants were included in cohort I and 35 in cohort II. The final CUS scoring system contained the sum of white matter (OR\u2009=\u20092.6, 95%\u2009CI 1.5\u20134.7) and deep grey matter involvement (OR\u2009=\u20092.7, 95%\u2009CI 1.7\u20134.4). The CUS scoring system performed well in cohort I (AUC\u2009=\u20090.90) and II (AUC\u2009=\u20090.89).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This validated CUS scoring system is associated with neurodevelopmental outcome in neonates with HIE.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41390-020-0782-0","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T15:02:56Z","timestamp":1585234976000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy"],"prefix":"10.1038","volume":"87","author":[{"given":"Kim V.","family":"Annink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Vijlbrief","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Weeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Roehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Lequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Govaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon J. 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F.G. also received grant support from Neurophyxia. L.S.d.V. received lecture fees for lectures from Genesis Research Trust for the ultrasound course in Imperial College London and at the brain monitoring meeting in Cork in 2017. C.C.R. has received lecture fees from various pharmaceutical and medical devices companies on matters unrelated to the topic in this supplement, and received grant funding from Chiesi Pharamceutical Grant for investigating specific pharmacodynamics in newborn infants, also unrelated to the manuscripts in this supplement. The other authors have no conflict of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Ethical Committee of the University Medical Center Utrecht approved this retrospective study and waived the requirement to obtain written informed consent for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}