{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:08:49Z","timestamp":1793239729725,"version":"4.5.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T00:00:00Z","timestamp":1624665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1038\/s41390-021-01623-2","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T07:02:41Z","timestamp":1624690961000},"page":"1012-1014","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Presence of \u201cACKR1\/DARC null\u201d polymorphism in Arabs from Jisr az-Zarqa with benign ethnic neutropenia"],"prefix":"10.1038","volume":"91","author":[{"given":"Dana","family":"Elhadad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos J.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yotam","family":"Bronstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Yana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nechama","family":"Sharon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,26]]},"reference":[{"key":"1623_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1053\/lc.1999.v133.a94931","volume":"133","author":"TB Haddy","year":"1999","unstructured":"Haddy, T. B., Rana, S. R. & Castro, O. Benign ethnic neutropenia: what is a normal absolute neutrophil count? J. Lab. Clin. Med. 133, 15\u201322 (1999).","journal-title":"J. Lab. Clin. Med."},{"key":"1623_CR2","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/bjh.15730","volume":"184","author":"N Rappoport","year":"2019","unstructured":"Rappoport, N., Simon, A. J., Amariglio, N. & Rechavi, G. The Duffy antigen receptor for chemokines, ACKR 1,\u2013 \u2018Jeanne DARC\u2019 of benign neutropenia. Br. J. Haematol. 184, 497\u2013507 (2019).","journal-title":"Br. J. Haematol."},{"key":"1623_CR3","doi-asserted-by":"publisher","first-page":"100586","DOI":"10.1016\/j.blre.2019.06.003","volume":"37","author":"SA Atallah-Yunes","year":"2019","unstructured":"Atallah-Yunes, S. A., Ready, A. & Newburger, P. E. Benign ethnic neutropenia. Blood Rev. 37, 100586 (2019).","journal-title":"Blood Rev."},{"key":"1623_CR4","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/bjh.13345","volume":"170","author":"N Rappoport","year":"2015","unstructured":"Rappoport, N. et al. Correlation between \u2018 ACKR1\/DARC null\u2019 polymorphism and benign neutropenia in Yemenite Jews. Br. J. Haematol. 170, 892\u2013895 (2015).","journal-title":"Br. J. Haematol."},{"key":"1623_CR5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000206841","volume":"69","author":"HG Jumean","year":"1983","unstructured":"Jumean, H. G. & Sudah, F. I. Chronic benign idiopathic neutropenia in Jordanians. Acta Haematol. 69, 59\u201360 (1983).","journal-title":"Acta Haematol."},{"key":"1623_CR6","first-page":"3","volume":"9","author":"S Denic","year":"2009","unstructured":"Denic, S. et al. Prevalence, phenotype and inheritance of benign neutropenia in Arabs. BMC Blood Disord. 9, 3 (2009).","journal-title":"BMC Blood Disord."},{"key":"1623_CR7","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1600-0609.1988.tb01192.x","volume":"41","author":"Y Shoenfeld","year":"1988","unstructured":"Shoenfeld, Y., Alkan, M. L., Asaly, A., Carmeli, Y. & Katz, M. Benign familial leukopenia and neutropenia in different ethnic groups. Eur. J. Haematol. 41, 273\u2013277 (1988).","journal-title":"Eur. J. Haematol."},{"key":"1623_CR8","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1365-2141.2008.07335.x","volume":"143","author":"VR Grann","year":"2008","unstructured":"Grann, V. R. et al. Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean. Br. J. Haematol. 143, 288\u2013293 (2008).","journal-title":"Br. J. Haematol."},{"key":"1623_CR9","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1073\/pnas.61.3.949","volume":"61","author":"RP Donahue","year":"1968","unstructured":"Donahue, R. P., Bias, W. B., Renwick, J. H. & McKusick, V. A. Probable assignment of the Duffy blood group locus to chromosome 1 in man. Proc. Natl Acad. Sci. USA 61, 949\u2013955 (1968).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1623_CR10","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/ng0695-224","volume":"10","author":"C Tournamille","year":"1995","unstructured":"Tournamille, C., Colin, Y., Cartron, J. P. & Van Kim, C. L. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy\u2013negative individuals. Nat. Genet. 10, 224\u2013228 (1995).","journal-title":"Nat. Genet."},{"key":"1623_CR11","doi-asserted-by":"publisher","first-page":"e1000360","DOI":"10.1371\/journal.pgen.1000360","volume":"5","author":"D Reich","year":"2009","unstructured":"Reich, D. et al. Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet. 5, e1000360 (2009).","journal-title":"PLoS Genet."},{"key":"1623_CR12","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1086\/302879","volume":"66","author":"MT Hamblin","year":"2000","unstructured":"Hamblin, M. T. & Di Rienzo, A. Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus. Am. J. Hum. Genet. 66, 1669\u20131679 (2000).","journal-title":"Am. J. Hum. Genet."},{"key":"1623_CR13","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1158\/0008-5472.CAN-06-3801","volume":"67","author":"M Iiizumi","year":"2007","unstructured":"Iiizumi, M., Bandyopadhyay, S. & Watabe, K. Interaction of duffy antigen receptor for chemokines and KAI1: A critical step in metastasis suppression. Cancer Res. 67, 1411\u20131414 (2007).","journal-title":"Cancer Res."},{"key":"1623_CR14","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/tpj.2017.16","volume":"18","author":"SJ Glisovic","year":"2018","unstructured":"Glisovic, S. J. et al. Impact of genetic polymorphisms determining leukocyte\/neutrophil count on chemotherapy toxicity. Pharmacogenomics J. 18, 270\u2013274 (2018).","journal-title":"Pharmacogenomics J."},{"key":"1623_CR15","unstructured":"Stenvall, A. Tourism and the social business concept: exploratory studies of tourism development in the old city of Nazareth and Jisr az-Zarqa in Israel http:\/\/www.diva-portal.org\/smash\/record.jsf?pid=diva2%3A727891&dswid=-195 (2014)."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01623-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01623-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01623-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T04:11:05Z","timestamp":1653019865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01623-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,26]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1623"],"URL":"https:\/\/doi.org\/10.1038\/s41390-021-01623-2","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,26]]},"assertion":[{"value":"2 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Patient consent was obtained as required by our hospital\u2019s Helsinki committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}}]}}