{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:46:37Z","timestamp":1791809197849,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1038\/s41390-021-01705-1","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T13:02:52Z","timestamp":1629982972000},"page":"233-241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Distinct cord blood C-peptide, adipokine, and lipidomic signatures by in utero HIV exposure"],"prefix":"10.1038","volume":"92","author":[{"given":"Jennifer","family":"Jao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Balmert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kirmse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhoda S.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine J.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon","family":"Myer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Arpadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell E.","family":"Geffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"LeRoith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin J.","family":"Kurland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"1705_CR1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/338371a0","volume":"338","author":"DJ Barker","year":"1989","unstructured":"Barker, D. J. Rise and fall of Western diseases. Nature 338, 371\u2013372 (1989).","journal-title":"Nature"},{"key":"1705_CR2","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1016\/S2214-109X(19)30448-6","volume":"8","author":"AL Slogrove","year":"2020","unstructured":"Slogrove, A. L., Powis, K. M., Johnson, L. F., Stover, J. & Mahy, M. Estimates of the global population of children who are HIV-exposed and uninfected, 2000-18: a modelling study. Lancet Glob. Health 8, e67\u2013e75 (2020).","journal-title":"Lancet Glob. Health"},{"key":"1705_CR3","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1001\/archinte.165.10.1179","volume":"165","author":"TT Brown","year":"2005","unstructured":"Brown, T. T. et al. Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch. Intern. Med. 165, 1179\u20131184 (2005).","journal-title":"Arch. Intern. Med."},{"key":"1705_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11904-014-0219-7","volume":"11","author":"LM Nix","year":"2014","unstructured":"Nix, L. M. & Tien, P. C. Metabolic syndrome, diabetes, and cardiovascular risk in HIV. Curr. HIV\/AIDS Rep. 11, 271\u2013278 (2014).","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"1705_CR5","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1097\/QAD.0000000000001248","volume":"30","author":"PM Grant","year":"2016","unstructured":"Grant, P. M. et al. Long-term body composition changes in antiretroviral-treated Hiv-infected individuals. AIDS 30, 2805\u20132813 (2016).","journal-title":"AIDS"},{"key":"1705_CR6","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1097\/INF.0000000000000224","volume":"33","author":"J Jao","year":"2014","unstructured":"Jao, J. & Abrams, E. J. Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infants. Pediatr. Infect. Dis. J. 33, 734\u2013740 (2014).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"1705_CR7","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1210\/JC.2015-2198","volume":"100","author":"J Jao","year":"2015","unstructured":"Jao, J. et al. Lower preprandial insulin and altered fuel use in HIV\/antiretroviral-exposed infants in Cameroon. J. Clin. Endocrinol. Metab. 100, 3260\u20133269 (2015).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1705_CR8","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1097\/QAD.0000000000001647","volume":"31","author":"J Jao","year":"2017","unstructured":"Jao, J. et al. Lower mitochondrial DNA and altered mitochondrial fuel metabolism in HIV-exposed uninfected infants in Cameroon. AIDS 31, 2475\u20132481 (2017).","journal-title":"AIDS"},{"key":"1705_CR9","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1093\/infdis\/jis553","volume":"206","author":"JY Chen","year":"2012","unstructured":"Chen, J. Y. et al. Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana. J. Infect. Dis. 206, 1695\u20131705 (2012).","journal-title":"J. Infect. Dis."},{"key":"1705_CR10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1086\/591253","volume":"198","author":"HC Cote","year":"2008","unstructured":"Cote, H. C. et al. Perinatal exposure to antiretroviral therapy is associated with increased blood mitochondrial DNA levels and decreased mitochondrial gene expression in infants. J. Infect. Dis. 198, 851\u2013859 (2008).","journal-title":"J. Infect. Dis."},{"key":"1705_CR11","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/infdis\/jix291","volume":"216","author":"JC Schoeman","year":"2017","unstructured":"Schoeman, J. C. et al. Fetal metabolic stress disrupts immune homeostasis and induces proinflammatory responses in human immunodeficiency virus type 1- and combination antiretroviral therapy-exposed infants. J. Infect. Dis. 216, 436\u2013446 (2017).","journal-title":"J. Infect. Dis."},{"key":"1705_CR12","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.2337\/db10-1189","volume":"60","author":"N Regnault","year":"2011","unstructured":"Regnault, N. et al. Higher cord C-peptide concentrations are associated with slower growth rate in the 1st year of life in girls but not in boys. Diabetes 60, 2152\u20132159 (2011).","journal-title":"Diabetes"},{"key":"1705_CR13","doi-asserted-by":"publisher","first-page":"e0121350","DOI":"10.1371\/journal.pone.0121350","volume":"10","author":"EM Carlsen","year":"2015","unstructured":"Carlsen, E. M. et al. The association between newborn regional body composition and cord blood concentrations of C-peptide and insulin-like growth factor I. PLoS ONE 10, e0121350 (2015).","journal-title":"PLoS ONE"},{"key":"1705_CR14","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1111\/dme.13671","volume":"35","author":"DL Zhang","year":"2018","unstructured":"Zhang, D. L. et al. Cord blood insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin, and their associations with insulin sensitivity, beta-cell function and adiposity in infancy. Diabet. Med. 35, 1412\u20131419 (2018).","journal-title":"Diabet. Med."},{"key":"1705_CR15","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/0002-9378(82)90349-0","volume":"144","author":"MW Carpenter","year":"1982","unstructured":"Carpenter, M. W. & Coustan, D. R. Criteria for screening tests for gestational diabetes. Am. J. Obstet. Gynecol. 144, 768\u2013773 (1982).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"1705_CR16","doi-asserted-by":"publisher","first-page":"e214","DOI":"10.1542\/peds.2009-0913","volume":"125","author":"IE Olsen","year":"2010","unstructured":"Olsen, I. E., Groveman, S. A., Lawson, M. L., Clark, R. H. & Zemel, B. S. New intrauterine growth curves based on United States data. Pediatrics 125, e214\u2013e224 (2010).","journal-title":"Pediatrics"},{"key":"1705_CR17","doi-asserted-by":"publisher","first-page":"372","DOI":"10.2337\/dc18-1646","volume":"42","author":"WL Lowe Jr.","year":"2019","unstructured":"Lowe, W. L. Jr. et al. Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (Hapo Fus): Maternal Gestational Diabetes Mellitus and Childhood Glucose Metabolism. Diabetes Care 42, 372\u2013380 (2019).","journal-title":"Diabetes Care"},{"key":"1705_CR18","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/cem.1006","volume":"20","author":"M Bylesj\u00f6","year":"2006","unstructured":"Bylesj\u00f6, M. et al. Opls discriminant analysis: combining the strengths of PLS-DA and Simca classification. J. Chemometrics 20, 341\u2013351 (2006).","journal-title":"J. Chemometrics"},{"key":"1705_CR19","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1093\/biostatistics\/kxm045","volume":"9","author":"J Friedman","year":"2008","unstructured":"Friedman, J., Hastie, T. & Tibshirani, R. Sparse inverse covariance estimation with the Graphical Lasso. Biostatistics 9, 432\u2013441 (2008).","journal-title":"Biostatistics"},{"key":"1705_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","volume":"112","author":"J Cohen","year":"1992","unstructured":"Cohen, J. A power primer. Psychol. Bull. 112, 155\u2013159 (1992).","journal-title":"Psychol. Bull."},{"key":"1705_CR21","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1111\/dme.12159","volume":"30","author":"AG Jones","year":"2013","unstructured":"Jones, A. G. & Hattersley, A. T. The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabet. Med. 30, 803\u2013817 (2013).","journal-title":"Diabet. Med."},{"key":"1705_CR22","doi-asserted-by":"publisher","first-page":"856","DOI":"10.2337\/diacare.28.4.856","volume":"28","author":"P El Beitune","year":"2005","unstructured":"El Beitune, P. et al. Effect of maternal use of antiretroviral agents on serum insulin levels of the newborn infant. Diabetes Care 28, 856\u2013859 (2005).","journal-title":"Diabetes Care"},{"key":"1705_CR23","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1097\/AOG.0b013e318291b15c","volume":"121","author":"SB Sridhar","year":"2013","unstructured":"Sridhar, S. B., Ferrara, A., Ehrlich, S. F., Brown, S. D. & Hedderson, M. M. Risk of large-for-gestational-age newborns in women with gestational diabetes by race and ethnicity and body mass index categories. Obstet. Gynecol. 121, 1255\u20131262 (2013).","journal-title":"Obstet. Gynecol."},{"key":"1705_CR24","doi-asserted-by":"publisher","first-page":"812","DOI":"10.2337\/diabetes.52.3.812","volume":"52","author":"J Spranger","year":"2003","unstructured":"Spranger, J. et al. Inflammatory cytokines and the risk to develop Type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52, 812\u2013817 (2003).","journal-title":"Diabetes"},{"key":"1705_CR25","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1001\/archinte.167.15.1676","volume":"167","author":"S Liu","year":"2007","unstructured":"Liu, S. et al. A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Arch. Intern. Med. 167, 1676\u20131685 (2007).","journal-title":"Arch. Intern. Med."},{"key":"1705_CR26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1001\/jama.286.3.327","volume":"286","author":"AD Pradhan","year":"2001","unstructured":"Pradhan, A. D., Manson, J. E., Rifai, N., Buring, J. E. & Ridker, P. M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286, 327\u2013334 (2001).","journal-title":"JAMA"},{"key":"1705_CR27","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.diabres.2015.05.035","volume":"109","author":"R Vinitha","year":"2015","unstructured":"Vinitha, R. et al. Adiponectin, leptin, interleukin\u22126 and Hba1c in the prediction of incident type 2 diabetes: a nested case-control study in Asian Indian men with impaired glucose tolerance. Diabetes Res. Clin. Pract. 109, 340\u2013346 (2015).","journal-title":"Diabetes Res. Clin. Pract."},{"key":"1705_CR28","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1097\/QAI.0000000000000354","volume":"67","author":"ADC Betene","year":"2014","unstructured":"Betene, A. D. C. et al. Interleukin\u22126, high sensitivity C-reactive protein, and the development of Type 2 diabetes among HIV-positive patients taking antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 67, 538\u2013546 (2014).","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"1705_CR29","first-page":"1","volume":"149","author":"D Kamimura","year":"2003","unstructured":"Kamimura, D., Ishihara, K. & Hirano, T. Il-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol. Biochem. Pharmacol. 149, 1\u201338 (2003).","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"1705_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1096\/fj.99-1003rev","volume":"15","author":"SA Jones","year":"2001","unstructured":"Jones, S. A., Horiuchi, S., Topley, N., Yamamoto, N. & Fuller, G. M. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 15, 43\u201358 (2001).","journal-title":"FASEB J."},{"key":"1705_CR31","doi-asserted-by":"publisher","first-page":"S114","DOI":"10.2337\/diabetes.54.suppl_2.S114","volume":"54","author":"OP Kristiansen","year":"2005","unstructured":"Kristiansen, O. P. & Mandrup-Poulsen, T. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes 54, S114\u2013S124 (2005).","journal-title":"Diabetes"},{"key":"1705_CR32","doi-asserted-by":"publisher","first-page":"5563","DOI":"10.1210\/jc.2004-0736","volume":"89","author":"PC Ng","year":"2004","unstructured":"Ng, P. C. et al. Plasma Ghrelin and Resistin concentrations are suppressed in infants of insulin-dependent diabetic mothers. J. Clin. Endocrinol. Metab. 89, 5563\u20135568 (2004).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1705_CR33","doi-asserted-by":"publisher","first-page":"558","DOI":"10.5114\/aoms.2010.14468","volume":"6","author":"MH Mohamed","year":"2010","unstructured":"Mohamed, M. H. et al. Cord blood Resistin and Adiponectin in term newborns of diabetic mothers. Arch. Med. Sci. 6, 558\u2013566 (2010).","journal-title":"Arch. Med. Sci."},{"key":"1705_CR34","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.bbrc.2005.06.202","volume":"334","author":"N Silswal","year":"2005","unstructured":"Silswal, N. et al. Human Resistin stimulates the pro-inflammatory cytokines Tnf-Alpha and Il-12 in macrophages by Nf-Kappab-dependent pathway. Biochem. Biophys. Res. Commun. 334, 1092\u20131101 (2005).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"1705_CR35","doi-asserted-by":"publisher","first-page":"11252","DOI":"10.1074\/jbc.C100028200","volume":"276","author":"KH Kim","year":"2001","unstructured":"Kim, K. H., Lee, K., Moon, Y. S. & Sul, H. S. A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J. Biol. Chem. 276, 11252\u201311256 (2001).","journal-title":"J. Biol. Chem."},{"key":"1705_CR36","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.2337\/dc08-2077","volume":"32","author":"PM Catalano","year":"2009","unstructured":"Catalano, P. M., Presley, L., Minium, J. & Hauguel-de Mouzon, S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care 32, 1076\u20131080 (2009).","journal-title":"Diabetes Care"},{"key":"1705_CR37","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1210\/jc.2002-020795","volume":"88","author":"CL Addy","year":"2003","unstructured":"Addy, C. L. et al. Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J. Clin. Endocrinol. Metab. 88, 627\u2013636 (2003).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1705_CR38","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.2337\/diabetes.53.9.2473","volume":"53","author":"BB Duncan","year":"2004","unstructured":"Duncan, B. B. et al. Adiponectin and the development of Type 2 diabetes: The Atherosclerosis Risk in Communities Study. Diabetes. 53, 2473\u20132478 (2004).","journal-title":"Diabetes."},{"key":"1705_CR39","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/oby.20250","volume":"21","author":"ZC Luo","year":"2013","unstructured":"Luo, Z. C. et al. Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity. Obesity 21, 210\u2013216 (2013).","journal-title":"Obesity"},{"key":"1705_CR40","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/oby.2008.667","volume":"17","author":"S Basu","year":"2009","unstructured":"Basu, S. et al. In utero gender dimorphism of adiponectin reflects insulin sensitivity and adiposity of the fetus. Obesity 17, 1144\u20131149 (2009).","journal-title":"Obesity"},{"key":"1705_CR41","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1210\/jc.2008-0009","volume":"93","author":"H Pinar","year":"2008","unstructured":"Pinar, H. et al. High molecular mass multimer complexes and vascular expression contribute to high adiponectin in the fetus. J. Clin. Endocrinol. Metab. 93, 2885\u20132890 (2008).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"1705_CR42","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1373\/clinchem.2006.071019","volume":"52","author":"M Weyermann","year":"2006","unstructured":"Weyermann, M., Beermann, C., Brenner, H. & Rothenbacher, D. Adiponectin and leptin in maternal serum, cord blood, and breast milk. Clin. Chem. 52, 2095\u20132102 (2006).","journal-title":"Clin. Chem."},{"key":"1705_CR43","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.2047-6310.2012.00087.x","volume":"8","author":"SE McCormack","year":"2013","unstructured":"McCormack, S. E. et al. Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatr. Obes. 8, 52\u201361 (2013).","journal-title":"Pediatr. Obes."},{"key":"1705_CR44","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","volume":"9","author":"CB Newgard","year":"2009","unstructured":"Newgard, C. B. et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 9, 311\u2013326 (2009).","journal-title":"Cell Metab."},{"key":"1705_CR45","doi-asserted-by":"publisher","first-page":"347S","DOI":"10.1093\/jn\/128.2.347S","volume":"128","author":"TA Davis","year":"1998","unstructured":"Davis, T. A., Burrin, D. G., Fiorotto, M. L., Reeds, P. J. & Jahoor, F. Roles of insulin and amino acids in the regulation of protein synthesis in the neonate. J. Nutr. 128, 347S\u2013350S (1998).","journal-title":"J. Nutr."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01705-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01705-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01705-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T16:04:54Z","timestamp":1661443494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01705-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1705"],"URL":"https:\/\/doi.org\/10.1038\/s41390-021-01705-1","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,26]]},"assertion":[{"value":"25 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants provided written informed consent. This study was approved by the Institutional Review Board of the Icahn School of Medicine at Mount Sinai.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}