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Dosing recommendations of various therapeutic agents including antimicrobials were not specifically available for the neonates undergoing TH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search methodology was used to identify pharmacokinetic (PK) studies of antimicrobials during TH. Antimicrobials with multiple PK studies were identified to create a generalizable PK model. Pharmacometric simulations were performed using the PUMAS software platform to reproduce the results of published studies. A suitable model that could reproduce the results of all other published studies was identified. With the help of a generalizable model, an optimal dosage regimen was designed considering the important covariates of the identified model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With the systematic search, only gentamicin had multiple PK reports during TH. A generalizable model was identified and the model predictions could match the reported\/observed concentrations of publications. Birth weight and serum creatinine were the significant covariates influencing the PK of gentamicin in neonates. A dosage nomogram was designed using pharmacometric simulations to maintain gentamicin concentrations below 10\u2009\u03bcg\/mL at peak and below 2\u2009\u03bcg\/mL at trough.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A generalizable PK model for gentamicin during TH in neonates was identified. Using the model, a dosing nomogram for gentamicin was designed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Impact<\/jats:title><jats:p><jats:list list-type=\"bullet\"><jats:list-item><jats:p>Dosing guidelines for antimicrobials during TH in neonates is lacking.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>This is the first study to identify the generalizable model for gentamicin during TH in neonates.<\/jats:p><\/jats:list-item><jats:list-item><jats:p>Nomogram, proposed in the study, will aid the clinicians to individualize gentamicin dosing regimen for neonates considering the birth weight and serum creatinine.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1038\/s41390-021-01714-0","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T18:02:44Z","timestamp":1631037764000},"page":"249-254","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia"],"prefix":"10.1038","volume":"92","author":[{"given":"Saikumar","family":"Matcha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elstin Anbu","family":"Raj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramya","family":"Mahadevan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun Prasath","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Rajesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie Edward","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surulivelrajan","family":"Mallayasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"1714_CR1","doi-asserted-by":"publisher","first-page":"7000","DOI":"10.3390\/molecules20047000","volume":"20","author":"C Fattuoni","year":"2015","unstructured":"Fattuoni, C., Palmas, F., Noto, A., Fanos, V. & Barberini, L. 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