{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:33:15Z","timestamp":1793493195648,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1038\/s41390-021-01834-7","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T09:04:10Z","timestamp":1636448650000},"page":"791-798","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Differences in standardized neonatal encephalopathy exam criteria may impact therapeutic hypothermia eligibility"],"prefix":"10.1038","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4665-6884","authenticated-orcid":false,"given":"Brian H.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"El-Shibiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Munster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrie E.","family":"Inder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Dib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"1834_CR1","first-page":"CD003311","volume":"1","author":"SE Jacobs","year":"2013","unstructured":"Jacobs, S. E. et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst. Rev. 1, CD003311 (2013).","journal-title":"Cochrane Database Syst. Rev."},{"key":"1834_CR2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1469-8749.1985.tb04571.x","volume":"27","author":"C Robertson","year":"1985","unstructured":"Robertson, C. & Finer, N. Term infants with hypoxic-ischemic encephalopathy: outcome at 3.5 years. Dev. Med. Child Neurol. 27, 473\u2013484 (1985).","journal-title":"Dev. Med. Child Neurol."},{"key":"1834_CR3","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","volume":"33","author":"HB Sarnat","year":"1976","unstructured":"Sarnat, H. B. & Sarnat, M. S. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch. Neurol. 33, 696\u2013705 (1976).","journal-title":"Arch. Neurol."},{"key":"1834_CR4","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","volume":"361","author":"DV Azzopardi","year":"2009","unstructured":"Azzopardi, D. V. et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N. Engl. J. Med. 361, 1349\u20131358 (2009).","journal-title":"N. Engl. J. Med."},{"key":"1834_CR5","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran, S. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl. J. Med. 353, 1574\u20131584 (2005).","journal-title":"N. Engl. J. Med."},{"key":"1834_CR6","unstructured":"Therapeutic Hypothermia for Neonatal Encephalopathy. A BAPM framework for practice. bam.org\/resources\/237-therapeutic-hypothermia-for-neonatal-encephalopathy (2020)."},{"key":"1834_CR7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jpeds.2017.03.065","volume":"187","author":"BH Walsh","year":"2017","unstructured":"Walsh, B. H. et al. The frequency and severity of magnetic resonance imaging abnormalities in infants with mild neonatal encephalopathy. J. Pediatr. 187, 26\u201333.e1 (2017).","journal-title":"J. Pediatr."},{"key":"1834_CR8","first-page":"143","volume":"19","author":"AJ Barkovich","year":"1998","unstructured":"Barkovich, A. J. et al. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. Am. J. Neuroradiol. 19, 143\u2013149 (1998).","journal-title":"Am. J. Neuroradiol."},{"key":"1834_CR9","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1136\/archdischild-2020-320902","volume":"106","author":"L Shipley","year":"2021","unstructured":"Shipley, L., Gale, C. & Sharkey, D. Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study. Arch. Dis. Child Fetal Neonatal Ed. 106, 529\u2013534 (2021).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"1834_CR10","doi-asserted-by":"publisher","first-page":"F388","DOI":"10.1136\/archdischild-2017-313320","volume":"103","author":"V Oliveira","year":"2018","unstructured":"Oliveira, V. et al. Therapeutic hypothermia in mild neonatal encephalopathy: a national survey of practice in the UK. Arch. Dis. Child Fetal Neonatal Ed. 103, F388\u2013F390 (2018).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"1834_CR11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jpeds.2014.04.052","volume":"165","author":"B Kracer","year":"2014","unstructured":"Kracer, B., Hintz, S. R., Van Meurs, K. P. & Lee, H. C. Hypothermia therapy for neonatal hypoxic ischemic encephalopathy in the State of California. J. Pediatr. 165, 267\u2013273 (2014).","journal-title":"J. Pediatr."},{"key":"1834_CR12","doi-asserted-by":"publisher","unstructured":"Rao, R. et al. Utilization of therapeutic hypothermia and neurological injury in neonates with mild hypoxic-ischemic encephalopathy: a Report from Children\u2019s Hospital Neonatal Consortium. Am. J. Perinatol. https:\/\/doi.org\/10.1055\/s-0040-1716341 (2020).","DOI":"10.1055\/s-0040-1716341"},{"key":"1834_CR13","doi-asserted-by":"publisher","unstructured":"Yieh, L. et al. Neonates with mild hypoxic-ischaemic encephalopathy receiving supportive care versus therapeutic hypothermia in California. Arch. Dis. Child Fetal Neonatal Ed. https:\/\/doi.org\/10.1136\/archdischild-2021-322250 (2021).","DOI":"10.1136\/archdischild-2021-322250"},{"key":"1834_CR14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","volume":"120","author":"JM Conway","year":"2018","unstructured":"Conway, J. M., Walsh, B. H., Boylan, G. B. & Murray, D. M. Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome\u2014a systematic review. Early Hum. Dev. 120, 80\u201387 (2018).","journal-title":"Early Hum. Dev."},{"key":"1834_CR15","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.earlhumdev.2018.02.006","volume":"120","author":"BH Walsh","year":"2018","unstructured":"Walsh, B. H. & Inder, T. E. MRI as a biomarker for mild neonatal encephalopathy. Early Hum. Dev. 120, 75\u201379 (2018).","journal-title":"Early Hum. Dev."},{"key":"1834_CR16","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1001\/jamapediatrics.2019.4011","volume":"174","author":"M Finder","year":"2020","unstructured":"Finder, M. et al. Two-year neurodevelopmental outcomes after mild hypoxic ischemic encephalopathy in the era of therapeutic hypothermia. JAMA Pediatr. 174, 48\u201355 (2020).","journal-title":"JAMA Pediatr."},{"key":"1834_CR17","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/s41390-018-0174-x","volume":"84","author":"LF Chalak","year":"2018","unstructured":"Chalak, L. F. et al. Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months. Pediatr. Res. 84, 861\u2013868 (2018).","journal-title":"Pediatr. Res."},{"key":"1834_CR18","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/jp.2017.164","volume":"38","author":"C Prempunpong","year":"2018","unstructured":"Prempunpong, C. et al. Prospective research on infants with mild encephalopathy: the PRIME study. J. Perinatol. 38, 80\u201385 (2018).","journal-title":"J. Perinatol."},{"key":"1834_CR19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jpeds.2019.06.026","volume":"214","author":"LF Chalak","year":"2019","unstructured":"Chalak, L. F., Adams-Huet, B. & Sant\u2019Anna, G. A Total Sarnat Score in mild hypoxic-ischemic encephalopathy can detect infants at higher risk of disability. J. Pediatr. 214, 217\u2013221 (2019).","journal-title":"J. Pediatr."},{"key":"1834_CR20","doi-asserted-by":"publisher","unstructured":"Morales, M. M. et al. Association of Total Sarnat Score with brain injury and neurodevelopmental outcomes after neonatal encephalopathy. Arch. Dis. Child Fetal Neonatal Ed. https:\/\/doi.org\/10.1136\/archdischild-2020-321164 (2021).","DOI":"10.1136\/archdischild-2020-321164"},{"key":"1834_CR21","doi-asserted-by":"publisher","unstructured":"Walsh, B. H. et al. Comparison of numerical and standard sarnat grading using the NICHD and SIBEN methods. J. Perinatol. https:\/\/doi.org\/10.1038\/s41372-021-01180-w (2021).","DOI":"10.1038\/s41372-021-01180-w"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01834-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01834-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01834-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T09:12:27Z","timestamp":1665565947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01834-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["1834"],"URL":"https:\/\/doi.org\/10.1038\/s41390-021-01834-7","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]},"assertion":[{"value":"11 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"A waiver of consent was approved by the Partners Healthcare Human Research Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}}]}}