{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T12:28:49Z","timestamp":1763728129757,"version":"3.40.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1038\/s41390-021-01873-0","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T08:02:40Z","timestamp":1642147360000},"page":"946-950","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Thromboembolism in children with multisystem inflammatory syndrome: a literature review"],"prefix":"10.1038","volume":"92","author":[{"given":"Neethu M.","family":"Menon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi V.","family":"Srivaths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"1873_CR1","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1002\/art.41454","volume":"72","author":"LA Henderson","year":"2020","unstructured":"Henderson, L. A. et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 1. Arthritis Rheumatol. 72, 1791\u20131805 (2020).","journal-title":"Arthritis Rheumatol."},{"key":"1873_CR2","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S0140-6736(20)31094-1","volume":"395","author":"S Riphagen","year":"2020","unstructured":"Riphagen, S., Gomez, X., Gonzalez-Martinez, C., Wilkinson, N. & Theocharis, P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 395, 1607\u20131608 (2020).","journal-title":"Lancet"},{"key":"1873_CR3","unstructured":"World Health Organization. Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19: Scientific Brief 15 May 2020 (World Health Organization, 2020)."},{"key":"1873_CR4","unstructured":"Centers for Disease Control and Prevention. Reporting Multisystem Inflammatory Syndrome in Children (MIS-C) (Centers for Disease Control and Prevention, 2020)."},{"key":"1873_CR5","doi-asserted-by":"crossref","unstructured":"Nopp, S., Moik, F., Jilma, B., Pabinger, I. & Ay, C. Risk of venous thromboembolism in patients with COVID-19: a systematic review and meta-analysis. Res. Pract. Thromb. Haemost. 4, 1178\u201391 (2020).","DOI":"10.1002\/rth2.12439"},{"key":"1873_CR6","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1111\/jth.15216","volume":"19","author":"G Del Borrello","year":"2021","unstructured":"Del Borrello, G. et al. SARS-COV-2-associated coagulopathy and thromboembolism prophylaxis in children: a single-center observational study. J. Thromb. Haemost. 19, 522\u201330. (2021).","journal-title":"J. Thromb. Haemost."},{"key":"1873_CR7","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/jpids\/piaa112","volume":"9","author":"SC Aronoff","year":"2020","unstructured":"Aronoff, S. C., Hall, A., Del & Vecchio, M. T. The natural history of severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children: a systematic review. J. Pediatr. Infect. Dis. Soc. 9, 746\u201351. (2020).","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"1873_CR8","doi-asserted-by":"crossref","unstructured":"Hoste, L., Van Paemel, R. & Haerynck, F. Multisystem inflammatory syndrome in children related to COVID-19: a systematic review. Eur. J. Pediatr. 180, 2019\u201334 (2021).","DOI":"10.1007\/s00431-021-03993-5"},{"key":"1873_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.21037\/tp-20-188","volume":"10","author":"Y Tang","year":"2021","unstructured":"Tang, Y. et al. Multisystem inflammatory syndrome in children during the coronavirus disease 2019 (COVID-19) pandemic: a systematic review of published case studies. Transl. Pediatr. 10, 121\u201335. (2021).","journal-title":"Transl. Pediatr."},{"key":"1873_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/MAT.0000000000001270","volume":"67","author":"F Minen","year":"2021","unstructured":"Minen, F., Hands, C., Mustafa, M. R., Pienaar, A. & Lillie, J. Thrombophilia in pediatric patients with multisystem inflammatory syndrome in children secondary to coronavirus disease 2019 supported on extracorporeal membrane oxygenation. ASAIO J. 67, 7\u201311 (2021).","journal-title":"ASAIO J."},{"key":"1873_CR11","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1056\/NEJMoa2021680","volume":"383","author":"LR Feldstein","year":"2020","unstructured":"Feldstein, L. R. et al. Multisystem inflammatory syndrome in U.S. children and adolescents. N. Engl. J. Med. 383, 334\u201346. (2020).","journal-title":"N. Engl. J. Med."},{"key":"1873_CR12","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/S2352-4642(20)30215-7","volume":"4","author":"P Davies","year":"2020","unstructured":"Davies, P. et al. Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc. Health 4, 669\u201377. (2020).","journal-title":"Lancet Child Adolesc. Health"},{"key":"1873_CR13","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1148\/radiol.2020202543","volume":"298","author":"S Hameed","year":"2021","unstructured":"Hameed, S. et al. Spectrum of imaging findings at chest radiography, US, CT, and MRI in multisystem inflammatory syndrome in children associated with COVID-19. Radiology 298, E1\u2013E10 (2021).","journal-title":"Radiology"},{"key":"1873_CR14","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1007\/s00381-020-04755-8","volume":"36","author":"AJ Schupper","year":"2020","unstructured":"Schupper, A. J., Yaeger, K. A. & Morgenstern, P. F. Neurological manifestations of pediatric multi-system inflammatory syndrome potentially associated with COVID-19. Childs Nerv. Syst. 36, 1579\u201380. (2020).","journal-title":"Childs Nerv. Syst."},{"key":"1873_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jpeds.2020.06.045","volume":"224","author":"S Kaushik","year":"2020","unstructured":"Kaushik, S. et al. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2 infection (MIS-C): A Multi-Institutional Study from New York City. J. Pediatr. 224, 24\u201329 (2020).","journal-title":"J. Pediatr."},{"key":"1873_CR16","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.5005\/jp-journals-10071-23658","volume":"24","author":"L Shobhavat","year":"2020","unstructured":"Shobhavat, L. et al. Multisystem inflammatory syndrome in children: clinical features and management-intensive care experience from a pediatric public hospital in western India. Indian J. Crit. Care Med. 24, 1089\u201394. (2020).","journal-title":"Indian J. Crit. Care Med."},{"key":"1873_CR17","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S2352-4642(20)30314-X","volume":"5","author":"L Tiwari","year":"2021","unstructured":"Tiwari, L., Shekhar, S., Bansal, A. & Kumar, S. COVID-19 associated arterial ischaemic stroke and multisystem inflammatory syndrome in children: a case report. Lancet Child Adolesc. Health 5, 88\u201390 (2021).","journal-title":"Lancet Child Adolesc. Health"},{"key":"1873_CR18","doi-asserted-by":"crossref","unstructured":"Appavu, B. et al. Arteritis and large vessel occlusive strokes in children after COVID-19 infection. Pediatrics 147, e2020023440 (2021).","DOI":"10.1542\/peds.2020-023440"},{"key":"1873_CR19","doi-asserted-by":"publisher","unstructured":"Thomas, A. Novel presentation of pediatric inflammatory multisystem syndrome temporally associated with COVID-19. J. Pediatr. Neurol. https:\/\/doi.org\/10.1055\/s-0041-1725982 (2021).","DOI":"10.1055\/s-0041-1725982"},{"key":"1873_CR20","doi-asserted-by":"publisher","first-page":"507","DOI":"10.2214\/AJR.20.24032","volume":"216","author":"E Blumfield","year":"2021","unstructured":"Blumfield, E., Levin, T. L., Kurian, J., Lee, E. Y. & Liszewski, M. C. Imaging findings in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19). Am. J. Roentgenol. 216, 507\u201317. (2021).","journal-title":"Am. J. Roentgenol."},{"key":"1873_CR21","doi-asserted-by":"crossref","unstructured":"Whitworth, H. B. et al. Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C. Blood 138, 190\u20138 (2021).","DOI":"10.1182\/blood.2020010218"},{"key":"1873_CR22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.thromres.2005.01.010","volume":"118","author":"EA Chalmers","year":"2006","unstructured":"Chalmers, E. A. Epidemiology of venous thromboembolism in neonates and children. Thromb. Res. 118, 3\u201312 (2006).","journal-title":"Thromb. Res."},{"key":"1873_CR23","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1111\/jth.15073","volume":"18","author":"NA Goldenberg","year":"2020","unstructured":"Goldenberg, N. A. et al. Consensus-based clinical recommendations and research priorities for anticoagulant thromboprophylaxis in children hospitalized for COVID-19-related illness. J. Thromb. Haemost. 18, 3099\u2013105. (2020).","journal-title":"J. Thromb. Haemost."},{"key":"1873_CR24","doi-asserted-by":"crossref","first-page":"e663","DOI":"10.1097\/CCM.0000000000004971","volume":"49","author":"AJ Doyle","year":"2021","unstructured":"Doyle, A. J. et al. A comparison of thrombosis and hemorrhage rates in patients with severe respiratory failure due to coronavirus disease 2019 and influenza requiring extracorporeal membrane oxygenation. Crit. Care Med. 49, e663\u2013e72. (2021).","journal-title":"Crit. Care Med."},{"key":"1873_CR25","doi-asserted-by":"crossref","unstructured":"Kleineberg, N. N. et al. Neurological symptoms and complications in predominantly hospitalized COVID-19 patients: results of the European multinational Lean European Open Survey on SARS-Infected Patients (LEOSS). Eur. J. Neurol. 28 3925\u201337 (2021).","DOI":"10.1111\/ene.15072"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01873-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01873-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01873-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T10:53:14Z","timestamp":1744195994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-021-01873-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,14]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["1873"],"URL":"https:\/\/doi.org\/10.1038\/s41390-021-01873-0","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"type":"print","value":"0031-3998"},{"type":"electronic","value":"1530-0447"}],"subject":[],"published":{"date-parts":[[2022,1,14]]},"assertion":[{"value":"12 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}