{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:37:55Z","timestamp":1793723875061,"version":"4.6.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T00:00:00Z","timestamp":1695427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T00:00:00Z","timestamp":1695427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>High-quality chest compressions (CC) are an important factor of neonatal resuscitation. Mechanical CC devices may provide superior CC delivery and improve resuscitation outcomes. We aimed to compare the hemodynamic effects of CC delivered by machine and human using a neonatal piglet model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twelve asphyxiated piglets were randomized to receive CC during resuscitation using an automated mechanical CC device (\u201cmachine\u201d) or the two-thumb encircling technique (\u201chuman\u201d). CC was superimposed with sustained inflations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twelve newborn piglets (age 0\u20133 days, weight 2.12\u2009\u00b1\u20090.17\u2009kg) were included in the study. Machine-delivered CC resulted in an increase in stroke volume, and minimum and maximum rate of left ventricle pressure change (dp\/dt<jats:sub>min<\/jats:sub> and dp\/dt<jats:sub>max<\/jats:sub>) compared to human-delivered CC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>During machine-delivered CC, stroke volume and left ventricular contractility were significantly improved. Mechanical CC devices may provide improved cardiopulmonary resuscitation outcomes in neonatal cardiac arrest induced by asphyxia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Impact<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>Machine chest compression leads to changes in hemodynamic parameters during resuscitation of asphyxiated neonatal piglets, namely greater stroke volume and left ventricular contractility, compared with standard two-thumb compression technique. Mechanical chest compression devices may provide improved cardiopulmonary resuscitation outcomes in neonatal and pediatric asphyxia-induced cardiac arrest.<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41390-023-02827-4","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:01:58Z","timestamp":1695474118000},"page":"156-159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of hemodynamic effects of chest compression delivered via machine or human in asphyxiated piglets"],"prefix":"10.1038","volume":"95","author":[{"given":"Megan","family":"O\u2019Reilly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Fun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Yin","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg M.","family":"Schm\u00f6lzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"2827_CR1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1161\/CIR.0000000000000895","volume":"142","author":"MH Wyckoff","year":"2020","unstructured":"Wyckoff, M. H. et al. Neonatal life support: 2020 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Circulation 142, 329\u2013337 (2020).","journal-title":"Circulation"},{"key":"2827_CR2","doi-asserted-by":"publisher","first-page":"F272","DOI":"10.1136\/archdischild-2015-309761","volume":"101","author":"AL Solev\u00e5g","year":"2016","unstructured":"Solev\u00e5g, A. L., Cheung, P.-Y., O\u2019Reilly, M. & Schm\u00f6lzer, G. M. A review of approaches to optimise chest compressions in the resuscitation of asphyxiated newborns. Arch. Dis. Child Fetal Neonatal Ed. 101, F272 (2016).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"2827_CR3","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1055\/s-0037-1620231","volume":"35","author":"D Enriquez","year":"2018","unstructured":"Enriquez, D., Meritano, J., Shah, B., Song, C. & Szyld, E. Fatigue during chest compression using a neonatal patient simulator. Am. J. Perinat. 35, 796\u2013800 (2018).","journal-title":"Am. J. Perinat."},{"key":"2827_CR4","doi-asserted-by":"publisher","first-page":"810","DOI":"10.5811\/westjem.2021.3.50932","volume":"22","author":"M Sheraton","year":"2021","unstructured":"Sheraton, M., Columbus, J., Surani, S., Chopra, R. & Kashyap, R. Effectiveness of mechanical chest compression devices over manual cardiopulmonary resuscitation: a systematic review with meta-analysis and trial sequential analysis. West J. Emerg. Med. 22, 810\u2013819 (2021).","journal-title":"West J. Emerg. Med."},{"key":"2827_CR5","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1136\/archdischild-2020-319473","volume":"106","author":"M Bruckner","year":"2021","unstructured":"Bruckner, M. et al. Effects of varying chest compression depths on carotid blood flow and blood pressure in asphyxiated piglets. Arch. Dis. Child Fetal Neonatal Ed. 106, 553\u2013556 (2021).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"2827_CR6","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/archdischild-2021-321860","volume":"107","author":"M Bruckner","year":"2022","unstructured":"Bruckner, M. et al. Assessment of optimal chest compression depth during neonatal cardiopulmonary resuscitation: a randomised controlled animal trial. Arch. Dis. Child Fetal Neonatal Ed. 107, 262\u2013268 (2022).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"2827_CR7","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1136\/archdischild-2021-323271","volume":"108","author":"M Bruckner","year":"2023","unstructured":"Bruckner, M. et al. Haemodynamic changes with varying chest compression rates in asphyxiated piglets. Arch. Dis. Child Fetal Neonatal Ed. 108, 200\u2013203 (2023).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"2827_CR8","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.3390\/children9121838","volume":"9","author":"M Bruckner","year":"2022","unstructured":"Bruckner, M. et al. Chest compression rates of 90\/min versus 180\/min during neonatal cardiopulmonary resuscitation: a randomized controlled animal trial. Children 9, 1838 (2022).","journal-title":"Children"},{"key":"2827_CR9","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1113\/EP088870","volume":"105","author":"NP du Sert","year":"2020","unstructured":"du Sert, N. P. et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. Exp. Physiol. 105, 1459\u20131466 (2020).","journal-title":"Exp. Physiol."},{"key":"2827_CR10","doi-asserted-by":"crossref","unstructured":"Cheung, P.-Y., Gill, R. S. & Bigam D. L. A swine model of neonatal asphyxia. Journal of visualized experiments: JoVE. 56, 3166 (2011).","DOI":"10.3791\/3166"},{"key":"2827_CR11","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1161\/CIRCULATIONAHA.113.002289","volume":"128","author":"GM Schm\u00f6lzer","year":"2013","unstructured":"Schm\u00f6lzer, G. M. et al. Cardiopulmonary resuscitation with chest compressions during sustained inflations: a new technique of neonatal resuscitation that improves recovery and survival in a neonatal porcine model. Circulation 128, 2495\u20132503 (2013).","journal-title":"Circulation"},{"key":"2827_CR12","first-page":"e011189","volume":"8","author":"A Magliocca","year":"2019","unstructured":"Magliocca, A. et al. LUCAS versus manual chest compression during ambulance transport: a hemodynamic study in a porcine model of cardiac arrest. J. Am. Hear Assoc. Cardiovasc Cerebrovasc. Dis. 8, e011189 (2019).","journal-title":"J. Am. Hear Assoc. Cardiovasc Cerebrovasc. Dis."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-023-02827-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-023-02827-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-023-02827-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T17:06:59Z","timestamp":1705684019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-023-02827-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,23]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["2827"],"URL":"https:\/\/doi.org\/10.1038\/s41390-023-02827-4","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,23]]},"assertion":[{"value":"20 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}