{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:23:59Z","timestamp":1789273439114,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Physiological changes during the insertion of a rescue nasopharyngeal tube (NPT) after birth are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Observational study of very preterm infants in the delivery room. Data were extracted at predefined timepoints starting with first facemask placement after birth until 5\u2009min after insertion of NPT. End-expiratory lung impedance (EELI), heart rate (HR) and SpO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      -ratio were analysed over time. Changes during the same time span of NIPPV via facemask and NIPPV via NPT were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 1154 inflations in 15 infants were analysed. After NPT insertion, EELI increased significantly [0.33\u2009AU\/kg (0.19\u20130.57),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001]. Compared with the mask period, changes in EELI were not significantly larger during the NPT period [median difference (IQR)\u2009=\u20090.14\u2009AU\/kg (\u22120.14\u20130.53);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12]. Insertion of the NPT was associated with significant improvement in HR [52 (33\u201396);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001] and SpO\n                      <jats:sub>2<\/jats:sub>\n                      \/FiO\n                      <jats:sub>2<\/jats:sub>\n                      -ratio [161 (69\u2013169);\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001] not observed during the mask period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In very preterm infants non-responsive to initial facemask ventilation after birth, insertion of an NPT resulted in a considerable increase in EELI. This additional gain in lung volume was associated with an immediate improvement in clinical parameters. The use of a NPT may prevent intubation in selected non-responsive infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>After birth, a nasopharyngeal tube may be considered as a rescue airway in newborn infants non-responsive to initial positive pressure ventilation via facemask. Although it is widely used among clinicians, its effect on lung volumes and physiological parameters remains unclear.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Insertion of a rescue NPT resulted in a considerable increase in lung volume but this was not significantly larger than during facemask ventilation. However, insertion of a rescue NPT was associated with a significant and clinically important improvement in heart rate and oxygenation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This study highlights the importance of individual strategies in preterm resuscitation and introduces the NPT as a valid option.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-024-03033-6","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T11:05:02Z","timestamp":1706180702000},"page":"141-147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rescue nasopharyngeal tube for preterm infants non-responsive to initial ventilation after birth"],"prefix":"10.1038","volume":"96","author":[{"given":"Carina","family":"Belting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"R\u00fcegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas D.","family":"Waldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Bassler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent D.","family":"Gaertner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"3033_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.resuscitation.2021.02.014","volume":"161","author":"J Madar","year":"2021","unstructured":"Madar, J. et al. 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The company had no role in study planning, data collection, data analysis, data interpretation or manuscript writing. The authors have no additional conflicts of interest to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"The study protocol of the original study was reviewed and approved by the Cantonal Ethics Committee of Zurich (approval number KEK-2020-00890) and prospectively registered on ClinicalTrials.gov (NCT04315636) on March 19, 2020. All parents provided written antenatal consent for participation in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Antenatal written informed consent was obtained from all parents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}