{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:32:53Z","timestamp":1776943973535,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Tilts can induce alterations in cerebral hemodynamics in healthy neonates, but prior studies have only examined systemic parameters or used small tilt angles (&lt;90\u00b0). The healthy neonatal population, however, are commonly subjected to large tilt angles (\u226590\u00b0). We sought to characterize the cerebrovascular response to a 90\u00b0 tilt in healthy term neonates.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a secondary descriptive analysis on 44 healthy term neonates. We measured cerebral oxygen saturation (rcSO<jats:sub>2<\/jats:sub>), oxygen saturation (SpO<jats:sub>2<\/jats:sub>), heart rate (HR), breathing rate (BR), and cerebral fractional tissue oxygen extraction (cFTOE) over three consecutive 90\u00b0 tilts. These parameters were measured for 2-min while neonates\u00a0were in a supine (0\u00b0) position and 2-min while tilted to a sitting (90\u00b0) position. We measured oscillometric mean blood pressure (MBP) at the start of each tilt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>rcSO<jats:sub>2<\/jats:sub> and BR decreased significantly in the sitting position, whereas cFTOE, SpO<jats:sub>2<\/jats:sub>, and MBP increased significantly in the sitting position. We detected a significant position-by-time interaction for all physiological parameters.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A 90\u00b0 tilt induces a decline in rcSO<jats:sub>2<\/jats:sub> and an increase in cFTOE in healthy term neonates. Understanding the normal cerebrovascular response to a 90\u00b0 tilt in healthy neonates will help clinicians to recognize abnormal responses in high-risk infant populations.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Impact<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>Healthy term neonates (\u226414 days old) had decreased cerebral oxygen saturation (~1.1%) and increased cerebral oxygen extraction (~0.01) following a 90\u00b0 tilt.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>We detected a significant position-by-time interaction with all physiological parameters measured, suggesting the effect of position varied across consecutive tilts.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>No prior study has characterized the cerebral oxygen saturation response to a 90\u00b0 tilt in healthy term neonates.<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41390-024-03046-1","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T12:02:19Z","timestamp":1706356939000},"page":"1851-1859","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebrovascular responses to a 90\u00b0 tilt in healthy neonates"],"prefix":"10.1038","volume":"95","author":[{"given":"Nhu N.","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason S.","family":"Chwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Brady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Borzage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary-Lynn","family":"Brecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica X.","family":"Woon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Miner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlin A.","family":"Merkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Friedlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley S.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"3046_CR1","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/j.1651-2227.1995.tb13677.x","volume":"84","author":"CM Chen","year":"1995","unstructured":"Chen, C. 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We obtained written informed parental consent for all neonates prior to study inclusion. We aligned all procedures pertaining to this work with the Helsinki Declaration of 1975, as revised in 2008, and the national guidelines for human experimentation (Good Clinical Practice).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}