{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:45:36Z","timestamp":1767339936712,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1038\/s41390-024-03077-8","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T20:02:29Z","timestamp":1708027349000},"page":"1783-1790","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of cannabidiol in post-stroke mood disorders in neonatal rats"],"prefix":"10.1038","volume":"95","author":[{"given":"Mar\u00eda","family":"Villa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Mart\u00ednez-Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itziar","family":"Muneta-Arrate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"G\u00f3mez-Soria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Muguruza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aar\u00f3n","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"de Hoz-Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F.","family":"Callado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jos\u00e9","family":"Casarejos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-3545","authenticated-orcid":false,"given":"Jos\u00e9","family":"Mart\u00ednez-Orgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"3077_CR1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3389\/fpsyt.2018.00761","volume":"10","author":"Z Wang","year":"2019","unstructured":"Wang, Z. et al. Diversiform etiologies for poststroke depression. Front. Psychiatry 10, 761 (2019).","journal-title":"Front. Psychiatry"},{"key":"3077_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.pharmthera.2017.11.005","volume":"184","author":"RF Villa","year":"2018","unstructured":"Villa, R. F., Ferrari, F. & Moretti, A. Post-stroke depression: Mechanisms and pharmacological treatment. Pharmacol. Ther. 184, 131\u2013144 (2018).","journal-title":"Pharmacol. Ther."},{"key":"3077_CR3","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1016\/j.pediatrneurol.2014.07.031","volume":"51","author":"LL Lehman","year":"2014","unstructured":"Lehman, L. L. & Rivkin, M. J. Perinatal arterial ischemic stroke: Presentation, risk factors, evaluation, and outcome. Pediatr. Neurol. 51, 760\u2013768 (2014).","journal-title":"Pediatr. Neurol."},{"key":"3077_CR4","doi-asserted-by":"publisher","first-page":"e1402","DOI":"10.1542\/peds.2011-1148","volume":"128","author":"A Kirton","year":"2011","unstructured":"Kirton, A. et al. Symptomatic neonatal arterial ischemic stroke: The International Pediatric Stroke Study. Pediatrics 128, e1402\u2013e1410 (2011).","journal-title":"Pediatrics"},{"key":"3077_CR5","doi-asserted-by":"publisher","first-page":"e0263055","DOI":"10.1371\/journal.pone.0263055","volume":"17","author":"M \u00c1lvarez-Garc\u00eda","year":"2022","unstructured":"\u00c1lvarez-Garc\u00eda, M., Cuellar-Flores, I., Sierra-Garc\u00eda, P. & Mart\u00ednez-Orgado, J. Mood disorders in children following neonatal hypoxic-ischemic encephalopathy. PLoS One 17, e0263055 (2022).","journal-title":"PLoS One"},{"key":"3077_CR6","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.3390\/ijms24043229","volume":"24","author":"M Villa","year":"2023","unstructured":"Villa, M. et al. The role of the Dopamine system in post-stroke mood disorders in newborn rats. Int J. Mol. Sci. 24, 3229 (2023).","journal-title":"Int J. Mol. Sci."},{"key":"3077_CR7","doi-asserted-by":"publisher","first-page":"584533","DOI":"10.3389\/fphar.2020.584533","volume":"11","author":"J Mart\u00ednez-Orgado","year":"2021","unstructured":"Mart\u00ednez-Orgado, J., Villa, M. & Del Pozo, A. Cannabidiol for the treatment of neonatal hypoxic-ischemic brain injury. Front Pharm. 11, 584533 (2021).","journal-title":"Front Pharm."},{"key":"3077_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neuropharm.2016.12.017","volume":"116","author":"M Cepri\u00e1n","year":"2017","unstructured":"Cepri\u00e1n, M. et al. Cannabidiol reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke. Neuropharmacology 116, 151\u2013159 (2017).","journal-title":"Neuropharmacology"},{"key":"3077_CR9","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/nrn.2016.57","volume":"17","author":"AA Grace","year":"2016","unstructured":"Grace, A. A. Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression. Nat. Rev. Neurosci. 17, 524\u2013532 (2016).","journal-title":"Nat. Rev. Neurosci."},{"key":"3077_CR10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s42000-018-0007-7","volume":"17","author":"I Giannopoulou","year":"2018","unstructured":"Giannopoulou, I., Pagida, M. A., Briana, D. D. & Panayotacopoulou, M. T. Perinatal hypoxia as a risk factor for psychopathology later in life: the role of dopamine and neurotrophins. Hormones 17, 25\u201332 (2018).","journal-title":"Hormones"},{"key":"3077_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","volume":"106\u2013107","author":"BD Semple","year":"2013","unstructured":"Semple, B. D., Blomgren, K., Gimlin, K., Ferriero, D. M. & Noble-Haeusslein, L. J. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Prog. Neurobiol. 106\u2013107, 1\u201316 (2013).","journal-title":"Prog. Neurobiol."},{"key":"3077_CR12","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0168-0102(98)00096-0","volume":"32","author":"N Derugin","year":"1998","unstructured":"Derugin, N., Ferriero, D. M. & Vexler, Z. S. Neonatal reversible focal cerebral ischemia: A new model. Neurosci. Res. 32, 349\u2013353 (1998).","journal-title":"Neurosci. Res."},{"key":"3077_CR13","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1007\/s11055-012-9677-9","volume":"42","author":"MI Zaichenko","year":"2012","unstructured":"Zaichenko, M. I., Vanetsian, G. L. & Merzhanova, G. K. Differences in the behavior of impulsive and self-controlled rats in the open field and dark-light box tests. Neurosci. Behav. Physiol. 42, 1046\u20131054 (2012).","journal-title":"Neurosci. Behav. Physiol."},{"key":"3077_CR14","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.neuropharm.2012.05.034","volume":"63","author":"MR Pazos","year":"2012","unstructured":"Pazos, M. R. et al. Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function. Neuropharmacology 63, 776\u2013783 (2012).","journal-title":"Neuropharmacology"},{"key":"3077_CR15","unstructured":"Paxinos G., Watson C. The rat brain in stereotaxic coordinates. Academic Press, San Diego 1997."},{"key":"3077_CR16","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/mp.2017.16","volume":"22","author":"AH Ashok","year":"2017","unstructured":"Ashok, A. H. et al. The dopamine hypothesis of bipolar affective disorder: The state of the art and implications for treatment. Mol. Psychiatry 22, 666\u2013679 (2017).","journal-title":"Mol. Psychiatry"},{"key":"3077_CR17","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1080\/09297049.2016.1225708","volume":"24","author":"DD Bosenbark","year":"2018","unstructured":"Bosenbark, D. D., Krivitzky, L., Ichord, R., Jastrzab, L. & Billinghurst, L. Attention and executive functioning profiles in children following perinatal arterial ischemic stroke. Child Neuropsychol. 24, 106\u2013123 (2018).","journal-title":"Child Neuropsychol."},{"key":"3077_CR18","doi-asserted-by":"crossref","unstructured":"Mcpherson R. J., & Juul S. E. Recent Trends in Erythropoietin-mediated Neuroprotection. Int J Dev Neurosci 26, 103\u2013111 (2009).","DOI":"10.1016\/j.ijdevneu.2007.08.012"},{"key":"3077_CR19","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1007\/s43440-021-00305-4","volume":"73","author":"I Egusquiza","year":"2021","unstructured":"Egusquiza, I. et al. Characterization of dopamine D2 receptor coupling to G proteins in postmortem brain of subjects with schizophrenia. Pharm. Rep. 73, 1136\u20131146 (2021).","journal-title":"Pharm. Rep."},{"key":"3077_CR20","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1203\/01.PDR.0000169971.64558.5A","volume":"58","author":"EJ Demers","year":"2005","unstructured":"Demers, E. J., McPherson, R. J. & Juul, S. E. Erythropoietin protects dopaminergic neurons and improves neurobehavioral outcomes in juvenile rats after neonatal hypoxia-ischemia. Pediatr. Res 58, 297\u2013301 (2005).","journal-title":"Pediatr. Res"},{"key":"3077_CR21","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3389\/fphar.2019.01131","volume":"10","author":"M Cepri\u00e1n","year":"2019","unstructured":"Cepri\u00e1n, M. et al. Cannabidiol administration prevents hypoxia-ischemia-induced hypomyelination in newborn rats. Front. Pharm. 10, 1131 (2019).","journal-title":"Front. Pharm."},{"key":"3077_CR22","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1080\/01616412.2019.1651487","volume":"41","author":"T Abrantes De Lacerda Almeida","year":"2019","unstructured":"Abrantes De Lacerda Almeida, T. et al. Intraperitoneal cannabidiol attenuates neonatal germinal matrix hemorrhage-induced neuroinflamation and perilesional apoptosis. Neurol. Res. 41, 980\u2013990 (2019).","journal-title":"Neurol. Res."},{"key":"3077_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-05267-y","volume":"12","author":"M Ruiz Brunner","year":"2022","unstructured":"Ruiz Brunner, M., Cuestas, E., Heinen, F. & Schroeder, A. S. Growth in infants, children and adolescents with unilateral and bilateral cerebral palsy. Sci. Rep. 12, 1\u20139 (2022).","journal-title":"Sci. Rep."},{"key":"3077_CR24","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jad.2018.09.015","volume":"243","author":"F Rice","year":"2019","unstructured":"Rice, F. et al. Adolescent and adult differences in major depression symptom profiles. J. Affect. Disord. 243, 175\u2013181 (2019).","journal-title":"J. Affect. Disord."},{"key":"3077_CR25","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41380-020-0814-5","volume":"26","author":"G Northoff","year":"2021","unstructured":"Northoff, G., Hirjak, D., Wolf, R. C., Magioncalda, P. & Martino, M. All roads lead to the motor cortex: psychomotor mechanisms and their biochemical modulation in psychiatric disorders. Mol. Psychiatry 26, 92\u2013102 (2021).","journal-title":"Mol. Psychiatry"},{"key":"3077_CR26","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1111\/j.1582-4934.2012.01555.x","volume":"16","author":"I Loubinoux","year":"2012","unstructured":"Loubinoux, I. et al. Post-stroke depression: Mechanisms, translation and therapy. J. Cell Mol. Med. 16, 1961\u20131969 (2012).","journal-title":"J. Cell Mol. Med."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03077-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03077-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03077-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T10:08:15Z","timestamp":1720778895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03077-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["3077"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03077-8","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"type":"print","value":"0031-3998"},{"type":"electronic","value":"1530-0447"}],"subject":[],"published":{"date-parts":[[2024,2,15]]},"assertion":[{"value":"10 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}