{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:11:29Z","timestamp":1740136289009,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>We hypothesized that the serum TRX-1 in extremely preterm infants (EPIs) after birth was associated with the development of severe bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This single-centered retrospective study enrolled EPIs treated at our institution. Serum TRX-1 concentrations of the residual samples taken on admission, day 10\u201320 of life, and 36\u201340 weeks of postmenstrual age (PMA) were measured with an enzyme-linked immunosorbent assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The serum TRX-1 levels on admission were not different between the severe BPD (<jats:italic>n<\/jats:italic>\u2009=\u200946) and non-severe BPD groups (<jats:italic>n<\/jats:italic>\u2009=\u200967): [median (interquartile range) 147 (73.0\u2013231) vs. 164 (80.5\u2013248) ng\/mL] (<jats:italic>P<\/jats:italic>\u2009=\u20090.57). These had no significant difference between the severe ROP (<jats:italic>n<\/jats:italic>\u2009=\u200947) and non-severe ROP groups (<jats:italic>n<\/jats:italic>\u2009=\u200966): [164 (71.3\u2013237) vs. 150 (80.9\u2013250) ng\/mL] (<jats:italic>P<\/jats:italic>\u2009=\u20090.93). The TRX-1 levels at 10\u201320 days of life and 36\u201340 weeks of PMA also had no association with the development of severe BPD and ROP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The serum TRX-1 levels after birth are not predictive of severe BPD and ROP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Impact<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>Serum thioredoxin-1 levels in extremely preterm infants on the day of birth are lower than those in term or near-term infants hospitalized for transient tachypnea of the newborn.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>In extremely preterm infants, the serum thioredoxin-1 levels on the day of birth, at 10\u201320 days of life, and at postmenstrual age of 36\u201340 weeks were not associated with severe bronchopulmonary dysplasia and retinopathy of prematurity.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>The thioredoxin system is under development in extremely preterm infants; however, the serum thioredoxin-1 level is not predictive for severe bronchopulmonary dysplasia and retinopathy of prematurity.<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41390-024-03078-7","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T20:02:38Z","timestamp":1708113758000},"page":"1275-1282","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The serum thioredoxin-1 levels are not associated with bronchopulmonary dysplasia and retinopathy of prematurity"],"prefix":"10.1038","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-0565","authenticated-orcid":false,"given":"Mitsuhiro","family":"Haga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniya","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Namba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"3078_CR1","first-page":"173","volume":"68","author":"PW Soothill","year":"1986","unstructured":"Soothill, P. 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