{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T19:03:23Z","timestamp":1763665403596},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Retinopathy of prematurity (ROP) is a major complication in preterm infants. We assessed if plasma levels of midregional pro-atrial natriuretic peptide (MR-proANP) and C-terminal pro-endothelin-1 (CT-proET1) serve as early markers for subsequent ROP development in preterm infants &lt;32 weeks gestation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Prospective, two-centre, observational cohort study. MR-proANP and CT-proET1 were measured on day seven of life. Associations with ROP\u2009\u2265\u2009stage II were investigated by univariable and multivariable logistic regression models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We included 224 infants born at median (IQR) 29.6 (27.1\u201330.8) weeks gestation and birth weight of 1160 (860\u20131435)\u2009g. Nineteen patients developed ROP\u2009\u2265\u2009stage II. MR-proANP and CT-proET1 levels were higher in these infants (median (IQR) 864 (659\u20131564)\u2009pmol\/L and 348 (300\u2013382)\u2009pmol\/L, respectively) compared to infants without ROP (median (IQR) 299 (210\u2013502) pmol\/L and 196 (156\u2013268)\u2009pmol\/L, respectively; both <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). MR-proANP and CT-proET1 levels were significantly associated with ROP\u2009\u2265\u2009stage II in univariable logistic regression models and after adjusting for co-factors, including gestational age and birth weight z-score.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>MR-proANP and CT-proET1 measured on day seven of life are strongly associated with ROP\u2009\u2265\u2009stage II in very preterm infants and might improve early prediction of ROP in the future.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Impact<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>Plasma levels of midregional pro-atrial natriuretic peptide and C-terminal pro-endothelin-1 measured on day seven of life in very preterm infants show a strong association with development of retinopathy of prematurity\u2009\u2265\u2009stage II.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Both biomarkers have the potential to improve early prediction of retinopathy of prematurity.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Vasoactive peptides might allow to reduce the proportion of screened infants substantially.<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41390-024-03091-w","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T12:02:15Z","timestamp":1708776135000},"page":"1868-1874","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vasoactive peptides as biomarkers for the prediction of retinopathy of prematurity"],"prefix":"10.1038","volume":"95","author":[{"given":"Roland P.","family":"Neumann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Gerull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal W.","family":"Hasler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Wellmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven M.","family":"Schulzke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"3091_CR1","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","volume":"382","author":"A Hellstr\u00f6m","year":"2013","unstructured":"Hellstr\u00f6m, A., Smith, L. 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Written informed consent was obtained from a parent\/guardian of each participant in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}