{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:09:01Z","timestamp":1780477741331,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1038\/s41390-024-03092-9","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T16:03:05Z","timestamp":1708185785000},"page":"678-684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis"],"prefix":"10.1038","volume":"96","author":[{"given":"Noah H.","family":"Hillman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Royse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Grzych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Usada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan H.","family":"Jobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Fee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"3092_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jpeds.2020.03.021","volume":"222","author":"E Maisonneuve","year":"2020","unstructured":"Maisonneuve, E. et al. Association of chorioamnionitis with cerebral palsy at two years after spontaneous very preterm birth: the epipage-2 cohort study. J. Pediatr. 222, 71\u201378.e76 (2020).","journal-title":"J. Pediatr."},{"key":"3092_CR2","doi-asserted-by":"publisher","first-page":"745.e1","DOI":"10.1016\/j.ajog.2020.05.001","volume":"223","author":"KK Venkatesh","year":"2020","unstructured":"Venkatesh, K. K. et al. Histologic chorioamnionitis and risk of neurodevelopmental impairment at age 10 years among extremely preterm infants born less than 28 weeks of gestation. Am. J. Obstet. Gynecol. 223, 745.e1\u2013745.e10 (2020).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"3092_CR3","doi-asserted-by":"publisher","first-page":"e1914611","DOI":"10.1001\/jamanetworkopen.2019.14611","volume":"2","author":"E Villamor-Martinez","year":"2019","unstructured":"Villamor-Martinez, E. et al. Association of chorioamnionitis with bronchopulmonary dysplasia among preterm infants: a systematic review, meta-analysis, and metaregression. JAMA Netw. Open 2, e1914611 (2019).","journal-title":"JAMA Netw. Open"},{"key":"3092_CR4","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1542\/peds.97.2.210","volume":"97","author":"KL Watterberg","year":"1996","unstructured":"Watterberg, K. L., Demers, L. M., Scott, S. M. & Murphy, S. Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 97, 210\u2013215 (1996).","journal-title":"Pediatrics"},{"key":"3092_CR5","first-page":"CD004454","volume":"3","author":"D Roberts","year":"2017","unstructured":"Roberts, D., Brown, J., Medley, N. & Dalziel, S. R. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst. Rev. 3, CD004454 (2017).","journal-title":"Cochrane Database Syst. Rev."},{"key":"3092_CR6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1471-0528.2010.02751.x","volume":"118","author":"JV Been","year":"2011","unstructured":"Been, J. V., Degraeuwe, P. L., Kramer, B. W. & Zimmermann, L. J. Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis. BJOG 118, 113\u2013122 (2011).","journal-title":"BJOG"},{"key":"3092_CR7","doi-asserted-by":"publisher","first-page":"e075835","DOI":"10.1136\/bmj-2023-075835","volume":"382","author":"TC Yao","year":"2023","unstructured":"Yao, T. C. et al. Association between antenatal corticosteroids and risk of serious infection in children: nationwide cohort study. BMJ 382, e075835 (2023).","journal-title":"BMJ"},{"key":"3092_CR8","doi-asserted-by":"publisher","first-page":"e1707","DOI":"10.1016\/S2214-109X(22)00434-X","volume":"10","author":"JP Vogel","year":"2022","unstructured":"Vogel, J. P. et al. Updated who recommendations on antenatal corticosteroids and tocolytic therapy for improving preterm birth outcomes. Lancet Glob. Health 10, e1707\u2013e1708 (2022).","journal-title":"Lancet Glob. Health"},{"key":"3092_CR9","doi-asserted-by":"publisher","first-page":"8491","DOI":"10.4049\/jimmunol.179.12.8491","volume":"179","author":"SG Kallapur","year":"2007","unstructured":"Kallapur, S. G. et al. Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis. J. Immunol. 179, 8491\u20138499 (2007).","journal-title":"J. Immunol."},{"key":"3092_CR10","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1203\/PDR.0b013e3181647b3a","volume":"63","author":"NH Hillman","year":"2008","unstructured":"Hillman, N. H. et al. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr. Res. 63, 388\u2013393 (2008).","journal-title":"Pediatr. Res."},{"key":"3092_CR11","doi-asserted-by":"publisher","first-page":"L279","DOI":"10.1152\/ajplung.2001.280.2.L279","volume":"280","author":"CJ Bachurski","year":"2001","unstructured":"Bachurski, C. J., Ross, G. F., Ikegami, M., Kramer, B. W. & Jobe, A. H. Intra-amniotic endotoxin increases pulmonary surfactant components and induces Sp-B processing in fetal sheep. Am. J. Physiol. Lung Cell Mol. Physiol. 280, L279\u2013L285 (2001).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR12","doi-asserted-by":"publisher","first-page":"L452","DOI":"10.1152\/ajplung.00407.2001","volume":"283","author":"BW Kramer","year":"2002","unstructured":"Kramer, B. W., Kramer, S., Ikegami, M. & Jobe, A. Injury, inflammation and remodeling in fetal sheep lung after intra-amniotic endotoxin. Am. J. Physiol. Lung Cell. Mol. Physiol. 283, L452\u2013L459 (2002).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"3092_CR13","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1159\/000524614","volume":"119","author":"SA Becker","year":"2022","unstructured":"Becker, S. A. et al. Early physiological and adrenal effects of budesonide mixed with surfactant in large observational preterm cohort study. Neonatology 119, 474\u2013482 (2022).","journal-title":"Neonatology"},{"key":"3092_CR14","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/s41390-019-0663-6","volume":"87","author":"TB Kothe","year":"2020","unstructured":"Kothe, T. B. et al. Surfactant and budesonide for respiratory distress syndrome: an observational study. Pediatr. Res. 87, 940\u2013945 (2020).","journal-title":"Pediatr. Res."},{"key":"3092_CR15","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1164\/rccm.201505-0861OC","volume":"193","author":"TF Yeh","year":"2016","unstructured":"Yeh, T. F. et al. Intratracheal administration of budesonide\/surfactant to prevent bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 193, 86\u201395 (2016).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"3092_CR16","doi-asserted-by":"publisher","first-page":"e1310","DOI":"10.1542\/peds.2007-1973","volume":"121","author":"TF Yeh","year":"2008","unstructured":"Yeh, T. F. et al. Early intratracheal instillation of budesonide using surfactant as a vehicle to prevent chronic lung disease in preterm infants: a pilot study. Pediatrics 121, e1310\u2013e1318 (2008).","journal-title":"Pediatrics"},{"key":"3092_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/pr.2016.231","volume":"81","author":"F Ricci","year":"2017","unstructured":"Ricci, F., Murgia, X., Razzetti, R., Pelizzi, N. & Salomone, F. In vitro and in vivo comparison between poractant alfa and the new generation synthetic surfactant Chf5633. Pediatr. Res 81, 369\u2013375 (2017).","journal-title":"Pediatr. Res"},{"key":"3092_CR18","doi-asserted-by":"publisher","first-page":"L41","DOI":"10.1152\/ajplung.00203.2019","volume":"318","author":"NH Hillman","year":"2020","unstructured":"Hillman, N. H. et al. Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep. Am. J. Physiol. Lung Cell Mol. Physiol. 318, L41\u2013L48 (2020).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR19","doi-asserted-by":"publisher","first-page":"L888","DOI":"10.1152\/ajplung.00477.2018","volume":"316","author":"TB Kothe","year":"2019","unstructured":"Kothe, T. B. et al. Surfactant plus budesonide decreases lung and systemic inflammation in mechanically ventilated preterm sheep. Am. J. Physiol. Lung Cell Mol. Physiol. 316, L888\u2013L893 (2019).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR20","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/s41390-020-0809-6","volume":"88","author":"NH Hillman","year":"2020","unstructured":"Hillman, N. H. et al. Dose of budesonide with surfactant affects lung and systemic inflammation after normal and injurious ventilation in preterm lambs. Pediatr. Res. 88, 726\u2013732 (2020).","journal-title":"Pediatr. Res."},{"key":"3092_CR21","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/s41390-020-01267-8","volume":"90","author":"NH Hillman","year":"2021","unstructured":"Hillman, N. H. et al. Budesonide with surfactant decreases systemic responses in mechanically ventilated preterm lambs exposed to fetal intra-amniotic lipopolysaccharide. Pediatr. Res. 90, 328\u2013334 (2021).","journal-title":"Pediatr. Res."},{"key":"3092_CR22","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41390-020-0792-y","volume":"88","author":"CT McEvoy","year":"2020","unstructured":"McEvoy, C. T. et al. Dose-escalation trial of budesonide in surfactant for prevention of bronchopulmonary dysplasia in extremely low gestational age high-risk newborns (SASSIE). Pediatr. Res. 88, 629\u2013636 (2020).","journal-title":"Pediatr. Res."},{"key":"3092_CR23","unstructured":"Yeh, T. F. et al. Intra-Tracheal Administration of Budesonide(B) Using Surfactant(S) as Vehicle to Prevent Bpd in Preterm Infant.\u2014a Multicenter Double-Blind Trial. Pediatric Academic Society Meeting. Publication Number: 750.2 (2023)."},{"key":"3092_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-023-07257-5","volume":"24","author":"BJ Manley","year":"2023","unstructured":"Manley, B. J. et al. Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: study protocol for the international, multicenter, randomized pluss trial. Trials 24, 320 (2023).","journal-title":"Trials"},{"key":"3092_CR25","doi-asserted-by":"publisher","first-page":"L380","DOI":"10.1152\/ajplung.00338.2011","volume":"302","author":"E Kuypers","year":"2012","unstructured":"Kuypers, E. et al. Intra-amniotic lps and antenatal betamethasone: inflammation and maturation in preterm lamb lungs. Am. J. Physiol. Lung Cell Mol. Physiol. 302, L380\u2013L389 (2012).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR26","doi-asserted-by":"publisher","first-page":"L193","DOI":"10.1152\/ajplung.00528.2017","volume":"315","author":"TB Kothe","year":"2018","unstructured":"Kothe, T. B. et al. Effects of budesonide and surfactant in preterm fetal sheep. Am. J. Physiol. Lung Cell Mol. Physiol. 315, L193\u2013L201 (2018).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR27","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/1465-9921-10-124","volume":"10","author":"NH Hillman","year":"2009","unstructured":"Hillman, N. H. et al. Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep. Respir. Res. 10, 124 (2009).","journal-title":"Respir. Res."},{"key":"3092_CR28","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1203\/PDR.0b013e3181e9c556","volume":"68","author":"TA Shah","year":"2010","unstructured":"Shah, T. A. et al. Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis. Pediatr. Res. 68, 210\u2013215 (2010).","journal-title":"Pediatr. Res."},{"key":"3092_CR29","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1177\/1753425913488430","volume":"20","author":"T Gisslen","year":"2014","unstructured":"Gisslen, T. et al. Repeated exposure to intra-amniotic lps partially protects against adverse effects of intravenous lps in preterm lambs. Innate Immun. 20, 214\u2013224 (2014).","journal-title":"Innate Immun."},{"key":"3092_CR30","doi-asserted-by":"publisher","first-page":"349 e341","DOI":"10.1016\/j.ajog.2017.12.207","volume":"218","author":"K Visconti","year":"2018","unstructured":"Visconti, K. et al. Extremely preterm fetal sheep lung responses to antenatal steroids and inflammation. Am. J. Obstet. Gynecol. 218, 349 e341\u2013349 e310 (2018).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"3092_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1465-9921-11-151","volume":"11","author":"N Hillman","year":"2010","unstructured":"Hillman, N. et al. Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep. Respir. Res. 11, 1\u20138 (2010).","journal-title":"Respir. Res."},{"key":"3092_CR32","doi-asserted-by":"publisher","first-page":"L815","DOI":"10.1152\/ajplung.00355.2022","volume":"324","author":"L Abugisisa","year":"2023","unstructured":"Abugisisa, L., Royse, E. X., Kemp, M. W., Jobe, A. H. & Hillman, N. H. Preterm ovine respiratory epithelial cell responses to mechanical ventilation, lipopolysaccharide, and interleukin-13. Am. J. Physiol. Lung Cell Mol. Physiol. 324, L815\u2013L824 (2023).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR33","doi-asserted-by":"publisher","first-page":"L412","DOI":"10.1152\/ajplung.00181.2016","volume":"311","author":"N Deptula","year":"2016","unstructured":"Deptula, N. et al. Brief mechanical ventilation causes differential epithelial repair along the airways of fetal, preterm lambs. Am. J. Physiol. Lung Cell Mol. Physiol. 311, L412\u2013L420 (2016).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR34","doi-asserted-by":"publisher","first-page":"e113473","DOI":"10.1371\/journal.pone.0113473","volume":"9","author":"NH Hillman","year":"2014","unstructured":"Hillman, N. H., Kemp, M. W., Miura, Y., Kallapur, S. G. & Jobe, A. H. Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs. PLoS One 9, e113473 (2014).","journal-title":"PLoS One"},{"key":"3092_CR35","doi-asserted-by":"publisher","first-page":"L573","DOI":"10.1152\/ajplung.00211.2003","volume":"286","author":"M Ikegami","year":"2004","unstructured":"Ikegami, M., Kallapur, S. G. & Jobe, A. H. Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before delivery. Am. J. Physiol. Lung Cell Mol. Physiol. 286, L573\u2013L579 (2004).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"3092_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1149-x","volume":"15","author":"R Gussenhoven","year":"2018","unstructured":"Gussenhoven, R. et al. Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus. J. Neuroinflammation 15, 113 (2018).","journal-title":"J. Neuroinflammation"},{"key":"3092_CR37","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1164\/ajrccm.164.6.2103061","volume":"164","author":"BW Kramer","year":"2001","unstructured":"Kramer, B. W. et al. Dose and time response after intraamniotic endotoxin in preterm lambs. Am. J. Respir. Crit. Care Med. 164, 982\u2013988 (2001).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"3092_CR38","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1203\/PDR.0b013e3181dbbd18","volume":"67","author":"GR Polglase","year":"2010","unstructured":"Polglase, G. R. et al. Ventilation-mediated injury after preterm delivery of ureaplasma parvum colonized fetal lambs. Pediatr. Res. 67, 630\u2013635 (2010).","journal-title":"Pediatr. Res."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03092-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03092-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03092-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T08:04:17Z","timestamp":1729670657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03092-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,17]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3092"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03092-9","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,17]]},"assertion":[{"value":"25 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"NHH, AJH, and MWK are listed as authors on patent for the combination of budesonide and surfactant.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethical approval obtained, and no consent necessary.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}