{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:02:09Z","timestamp":1778209329290,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1038\/s41390-024-03117-3","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T09:02:28Z","timestamp":1709283748000},"page":"663-667","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Caffeine pharmacokinetics following umbilical vein injection during delayed cord clamping in preterm lambs"],"prefix":"10.1038","volume":"96","author":[{"given":"Lida","family":"Zeinali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan","family":"Giusto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Knych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Lesneski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houssam","family":"Joudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Hardie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepika","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyan","family":"Lakshminrusimha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-8118","authenticated-orcid":false,"given":"Payam","family":"Vali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"3117_CR1","unstructured":"UNICEF, W., World Bank, UN-DESA Population Division. Levels and Trends in Child Mortality Report 2019, http:\/\/www.unicef.org\/reports\/levels-and-trends-child-mortality-report-2019 (2019)."},{"key":"3117_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/00003246-199301000-00024","volume":"21","author":"JC Parker","year":"1993","unstructured":"Parker, J. C., Hernandez, L. A. & Peevy, K. J. Mechanisms of ventilator-induced lung injury. Crit. Care Med. 21, 131\u2013143 (1993).","journal-title":"Crit. Care Med."},{"key":"3117_CR3","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.clp.2015.08.006","volume":"42","author":"M Keszler","year":"2015","unstructured":"Keszler, M. & Sant\u2019Anna, G. Mechanical ventilation and bronchopulmonary dysplasia. Clin. Perinatol. 42, 781\u2013796 (2015).","journal-title":"Clin. Perinatol."},{"key":"3117_CR4","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1542\/peds.2005-1707","volume":"117","author":"RH Clark","year":"2006","unstructured":"Clark, R. H., Bloom, B. T., Spitzer, A. R. & Gerstmann, D. R. Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 117, 1979\u20131987 (2006).","journal-title":"Pediatrics"},{"key":"3117_CR5","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1056\/NEJMoa054065","volume":"354","author":"B Schmidt","year":"2006","unstructured":"Schmidt, B. et al. Caffeine therapy for apnea of prematurity. N. Engl. J. Med. 354, 2112\u20132121 (2006).","journal-title":"N. Engl. J. Med."},{"key":"3117_CR6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jpeds.2015.04.040","volume":"167","author":"JV Kraaijenga","year":"2015","unstructured":"Kraaijenga, J. V., Hutten, G. J., de Jongh, F. H. & van Kaam, A. H. The effect of caffeine on diaphragmatic activity and tidal volume in preterm infants. J. Pediatr. 167, 70\u201375 (2015).","journal-title":"J. Pediatr."},{"key":"3117_CR7","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1001\/jamapediatrics.2015.0358","volume":"169","author":"O Andersson","year":"2015","unstructured":"Andersson, O. et al. Effect of delayed cord clamping on neurodevelopment at 4 years of age: a randomized clinical trial. JAMA Pediatr. 169, 631\u2013638 (2015).","journal-title":"JAMA Pediatr."},{"key":"3117_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2017.00001","volume":"5","author":"AC Katheria","year":"2017","unstructured":"Katheria, A. C., Brown, M. K., Rich, W. & Arnell, K. Providing a placental transfusion in newborns who need resuscitation. Front. Pediatr. 5, 1 (2017).","journal-title":"Front. Pediatr."},{"key":"3117_CR9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jpeds.2017.10.037","volume":"194","author":"A Katheria","year":"2018","unstructured":"Katheria, A. et al. A randomized clinical trial of umbilical cord milking vs delayed cord clamping in preterm infants: neurodevelopmental outcomes at 22-26 months of corrected age. J. Pediatr. 194, 76\u201380 (2018).","journal-title":"J. Pediatr."},{"key":"3117_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.resuscitation.2018.07.020","volume":"131","author":"DA Blank","year":"2018","unstructured":"Blank, D. A. et al. Baby-directed umbilical cord clamping: a feasibility study. Resuscitation 131, 1\u20137 (2018).","journal-title":"Resuscitation"},{"key":"3117_CR11","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.midw.2016.01.006","volume":"34","author":"C Fulton","year":"2016","unstructured":"Fulton, C., Stoll, K. & Thordarson, D. Bedside resuscitation of newborns with an intact umbilical cord: experiences of midwives from British Columbia. Midwifery 34, 42\u201346 (2016).","journal-title":"Midwifery"},{"key":"3117_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.cca.2008.08.023","volume":"398","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y., Mehrotra, N., Budha, N. R., Christensen, M. L. & Meibohm, B. A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens. Clin. Chim. Acta 398, 105\u2013112 (2008).","journal-title":"Clin. Chim. Acta"},{"key":"3117_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2165\/00128072-200103010-00005","volume":"3","author":"AM Comer","year":"2001","unstructured":"Comer, A. M., Perry, C. M. & Figgitt, D. P. Caffeine citrate: a review of its use in apnoea of prematurity. Paediatr. Drugs 3, 61\u201379 (2001).","journal-title":"Paediatr. Drugs"},{"key":"3117_CR14","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0022-3476(77)80718-X","volume":"90","author":"JV Aranda","year":"1977","unstructured":"Aranda, J. V., Gorman, W., Bergsteinsson, H. & Gunn, T. Efficacy of caffeine in treatment of apnea in the low-birth-weight infant. J. Pediatr. 90, 467\u2013472 (1977).","journal-title":"J. Pediatr."},{"key":"3117_CR15","first-page":"326","volume":"5","author":"T Turmen","year":"1981","unstructured":"Turmen, T., Davis, J. & Aranda, J. V. Relationship of dose and plasma concentrations of caffeine and ventilation in neonatal apnea. Semin Perinatol. 5, 326\u2013331 (1981).","journal-title":"Semin Perinatol."},{"key":"3117_CR16","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1542\/peds.2006-2986","volume":"119","author":"G Natarajan","year":"2007","unstructured":"Natarajan, G., Botica, M. L., Thomas, R. & Aranda, J. V. Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise? Pediatrics 119, 936\u2013940 (2007).","journal-title":"Pediatrics"},{"key":"3117_CR17","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/S0009-9236(97)90097-7","volume":"61","author":"TC Lee","year":"1997","unstructured":"Lee, T. C., Charles, B., Steer, P., Flenady, V. & Shearman, A. Population pharmacokinetics of intravenous caffeine in neonates with apnea of prematurity. Clin. Pharm. Ther. 61, 628\u2013640 (1997).","journal-title":"Clin. Pharm. Ther."},{"key":"3117_CR18","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/jp.2014.60","volume":"34","author":"I Ulanovsky","year":"2014","unstructured":"Ulanovsky, I., Haleluya, N. S., Blazer, S. & Weissman, A. The effects of caffeine on heart rate variability in newborns with apnea of prematurity. J. Perinatol. 34, 620\u2013623 (2014).","journal-title":"J. Perinatol."},{"key":"3117_CR19","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1055\/s-0034-1543981","volume":"32","author":"AC Katheria","year":"2015","unstructured":"Katheria, A. C. et al. A pilot randomized controlled trial of early versus routine caffeine in extremely premature infants. Am. J. Perinatol. 32, 879\u2013886 (2015).","journal-title":"Am. J. Perinatol."},{"key":"3117_CR20","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/pr.2017.45","volume":"82","author":"J Dekker","year":"2017","unstructured":"Dekker, J. et al. Caffeine to improve breathing effort of preterm infants at birth: a randomized controlled trial. Pediatr. Res. 82, 290\u2013296 (2017).","journal-title":"Pediatr. Res."},{"key":"3117_CR21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/jamapediatrics.2014.2223","volume":"169","author":"A Lodha","year":"2015","unstructured":"Lodha, A. et al. Association of early caffeine administration and neonatal outcomes in very preterm neonates. JAMA Pediatr. 169, 33\u201338 (2015).","journal-title":"JAMA Pediatr."},{"key":"3117_CR22","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/jp.2012.52","volume":"33","author":"RM Patel","year":"2013","unstructured":"Patel, R. M., Leong, T., Carlton, D. P. & Vyas-Read, S. Early caffeine therapy and clinical outcomes in extremely preterm infants. J. Perinatol. 33, 134\u2013140 (2013).","journal-title":"J. Perinatol."},{"key":"3117_CR23","doi-asserted-by":"publisher","first-page":"e20181348","DOI":"10.1542\/peds.2018-1348","volume":"143","author":"A Lodha","year":"2019","unstructured":"Lodha, A. et al. Early caffeine administration and neurodevelopmental outcomes in preterm infants. Pediatrics 143, e20181348 (2019).","journal-title":"Pediatrics"},{"key":"3117_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/jp.2008.193","volume":"29","author":"V Soloveychik","year":"2009","unstructured":"Soloveychik, V., Bin-Nun, A., Ionchev, A., Sriram, S. & Meadow, W. Acute hemodynamic effects of caffeine administration in premature infants. J. Perinatol. 29, 205\u2013208 (2009).","journal-title":"J. Perinatol."},{"key":"3117_CR25","doi-asserted-by":"publisher","first-page":"e0200572","DOI":"10.1371\/journal.pone.0200572","volume":"13","author":"C Binder-Heschl","year":"2018","unstructured":"Binder-Heschl, C. et al. Haemodynamic effects of prenatal caffeine on the cardiovascular transition in ventilated preterm lambs. PLoS One 13, e0200572 (2018).","journal-title":"PLoS One"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03117-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03117-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03117-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T08:04:33Z","timestamp":1729670673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03117-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3117"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03117-3","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"18 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}