{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:44:14Z","timestamp":1788468254204,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1038\/s41390-024-03143-1","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T16:01:51Z","timestamp":1710518511000},"page":"1006-1012","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Aerobic physical capacity and health-related quality of life in children with sickle cell disease"],"prefix":"10.1038","volume":"96","author":[{"given":"Corentin","family":"Laurent-Lacroix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vincenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Matecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Mah\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Moulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"De La Villeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guillaumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Requirand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Lalande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Picot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Amedro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-7634","authenticated-orcid":false,"given":"Arthur","family":"Gavotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"3143_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/ejh.13212","volume":"102","author":"A Piccin","year":"2019","unstructured":"Piccin, A. et al. Insight into the complex pathophysiology of sickle cell anaemia and possible treatment. Eur. J. Haematol. 102, 319\u2013330 (2019).","journal-title":"Eur. J. Haematol."},{"key":"3143_CR2","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1056\/NEJMra1510865","volume":"376","author":"FB Piel","year":"2017","unstructured":"Piel, F. B., Steinberg, M. H. & Rees, D. C. Sickle cell disease. N. Engl. J. Med. 376, 1561\u20131573 (2017).","journal-title":"N. Engl. J. Med."},{"key":"3143_CR3","doi-asserted-by":"publisher","first-page":"e1001484","DOI":"10.1371\/journal.pmed.1001484","volume":"10","author":"FB Piel","year":"2013","unstructured":"Piel, F. B., Hay, S. I., Gupta, S., Weatherall, D. J. & Williams, T. N. Global burden of sickle cell anaemia in children under five, 2010\u20132050: modelling based on demographics, excess mortality, and interventions. PLoS Med. 10, e1001484 (2013).","journal-title":"PLoS Med."},{"key":"3143_CR4","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1007\/s00431-023-04900-w","volume":"182","author":"M Ferraresi","year":"2023","unstructured":"Ferraresi, M. et al. Therapeutic perspective for children and young adults living with thalassemia and sickle cell disease. Eur. J. Pediatr. 182, 2509\u20132519 (2023).","journal-title":"Eur. J. Pediatr."},{"key":"3143_CR5","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","volume":"376","author":"DC Rees","year":"2010","unstructured":"Rees, D. C., Williams, T. N. & Gladwin, M. T. Sickle-cell disease. Lancet 376, 2018\u20132031 (2010).","journal-title":"Lancet"},{"key":"3143_CR6","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1182\/blood-2016-05-716910","volume":"128","author":"K Gardner","year":"2016","unstructured":"Gardner, K. et al. Survival in adults with sickle cell disease in a high-income setting. Blood 128, 1436\u20131438 (2016).","journal-title":"Blood"},{"key":"3143_CR7","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1002\/pbc.25608","volume":"62","author":"PQ L\u00ea","year":"2015","unstructured":"L\u00ea, P. Q. et al. Survival among children and adults with sickle cell disease in Belgium: benefit from hydroxyurea treatment. Pediatr. Blood Cancer 62, 1956\u20131961 (2015).","journal-title":"Pediatr. Blood Cancer"},{"key":"3143_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3233\/CH-2011-1465","volume":"49","author":"P Connes","year":"2011","unstructured":"Connes, P., Machado, R., Hue, O. & Reid, H. Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia. Clin. Hemorheol. Microcirc. 49, 151\u2013163 (2011).","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"3143_CR9","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1365-2141.2005.05622.x","volume":"130","author":"JA Panepinto","year":"2005","unstructured":"Panepinto, J. A., O\u2019Mahar, K. M., DeBaun, M. R., Loberiza, F. R. & Scott, J. P. Health-related quality of life in children with sickle cell disease: child and parent perception. Br. J. Haematol. 130, 437\u2013444 (2005).","journal-title":"Br. J. Haematol."},{"key":"3143_CR10","doi-asserted-by":"publisher","first-page":"e12338","DOI":"10.14814\/phy2.12338","volume":"3","author":"RI Liem","year":"2015","unstructured":"Liem, R. I. et al. Reduced fitness and abnormal cardiopulmonary responses to maximal exercise testing in children and young adults with sickle cell anemia. Physiol. Rep. 3, e12338 (2015).","journal-title":"Physiol. Rep."},{"key":"3143_CR11","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1164\/rccm.2002036","volume":"165","author":"LA Callahan","year":"2002","unstructured":"Callahan, L. A. et al. Cardiopulmonary responses to exercise in women with sickle cell anemia. Am. J. Respir. Crit. Care Med. 165, 1309\u20131316 (2002).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"3143_CR12","first-page":"36","volume":"44","author":"RD Woodson","year":"1978","unstructured":"Woodson, R. D., Wills, R. E. & Lenfant, C. Effect of acute and established anaemia on O2 transport at rest, submaximal and maximal work. J. Appl. Physiol. Respir. Environ. Exerc. Physiol. 44, 36\u201343 (1978).","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"3143_CR13","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1164\/arrd.1984.129.2P2.S72","volume":"129","author":"RD Woodson","year":"1984","unstructured":"Woodson, R. D. Hemoglobin concentration and exercise capacity. Am. Rev. Respir. Dis. 129, S72\u2013S75 (1984).","journal-title":"Am. Rev. Respir. Dis."},{"key":"3143_CR14","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1164\/ajrccm\/143.2.226","volume":"143","author":"P Pianosi","year":"1991","unstructured":"Pianosi, P., D\u2019Souza, S. J., Esseltine, D. W., Charge, T. D. & Coates, A. L. Ventilation and gas exchange during exercise in sickle cell anemia. Am. Rev. Respir. Dis. 143, 226\u2013230 (1991).","journal-title":"Am. Rev. Respir. Dis."},{"key":"3143_CR15","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1164\/rccm.200601-125OC","volume":"173","author":"ES Klings","year":"2006","unstructured":"Klings, E. S., Wyszynski, D. F., Nolan, V. G. & Steinberg, M. H. Abnormal pulmonary function in adults with sickle cell anemia. Am. J. Respir. Crit. Care Med. 173, 1264\u20131269 (2006).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"3143_CR16","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/ajh.25003","volume":"93","author":"SM Willen","year":"2018","unstructured":"Willen, S. M. et al. Age is a predictor of a small decrease in lung function in children with sickle cell anemia. Am. J. Hematol. 93, 408\u2013415 (2018).","journal-title":"Am. J. Hematol."},{"key":"3143_CR17","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.1182\/bloodadvances.2021005076","volume":"5","author":"A Dhar","year":"2021","unstructured":"Dhar, A. et al. Longitudinal analysis of cardiac abnormalities in pediatric patients with sickle cell anemia and effect of hydroxyurea therapy. Blood Adv. 5, 4406\u20134412 (2021).","journal-title":"Blood Adv."},{"key":"3143_CR18","doi-asserted-by":"publisher","first-page":"572","DOI":"10.3390\/children9040572","volume":"9","author":"OO Olorunyomi","year":"2022","unstructured":"Olorunyomi, O. O., Liem, R. I. & Hsu, L. L. Motivators and barriers to physical activity among youth with sickle cell disease: brief review. Children 9, 572 (2022).","journal-title":"Children"},{"key":"3143_CR19","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1056\/NEJMoa1005565","volume":"365","author":"F Parent","year":"2011","unstructured":"Parent, F. et al. A hemodynamic study of pulmonary hypertension in sickle cell disease. N. Engl. J. Med. 365, 44\u201353 (2011).","journal-title":"N. Engl. J. Med."},{"key":"3143_CR20","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1179\/1465328110Y.0000000006","volume":"31","author":"F Bode-Thomas","year":"2011","unstructured":"Bode-Thomas, F., Hyacinth, H. I., Ogunkunle, O. & Omotoso, A. Myocardial ischaemia in sickle cell anaemia: evaluation using a new scoring system. Ann. Trop. Paediatr. 31, 67\u201374 (2011).","journal-title":"Ann. Trop. Paediatr."},{"key":"3143_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/adc.2003.027326","volume":"89","author":"Montalembert","year":"2004","unstructured":"Montalembert et al. Myocardial ischaemia in children with sickle cell disease. Arch. Dis. Child. 89, 359\u2013362 (2004).","journal-title":"Arch. Dis. Child."},{"key":"3143_CR22","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1136\/heartjnl-2017-312339","volume":"104","author":"P Amedro","year":"2018","unstructured":"Amedro, P. et al. Cardiopulmonary fitness in children with congenital heart diseases versus healthy children. Heart 104, 1026\u20131036 (2018).","journal-title":"Heart"},{"key":"3143_CR23","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1136\/archdischild-2021-323733","volume":"108","author":"J Moreau","year":"2023","unstructured":"Moreau, J. et al. Cardiopulmonary fitness in children with asthma versus healthy children. Arch. Dis. Child 108, 204\u2013210 (2023).","journal-title":"Arch. Dis. Child"},{"key":"3143_CR24","doi-asserted-by":"crossref","unstructured":"Gavotto, A. et al. Impaired aerobic capacity in adolescents and young adults after treatment for cancer or non-malignant haematological disease. Pediatr. Res. 94, 626\u201331 (2023).","DOI":"10.1038\/s41390-023-02477-6"},{"key":"3143_CR25","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1164\/rccm.167.2.211","volume":"167","author":"American Thoracic Society, American College of Chest Physicians.","year":"2003","unstructured":"American Thoracic Society, American College of Chest Physicians. ATS\/ACCP statement on cardiopulmonary exercise testing. Am. J. Respir. Crit. Care Med. 167, 211\u2013277 (2003).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"3143_CR26","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ijcard.2019.02.069","volume":"285","author":"H Abassi","year":"2019","unstructured":"Abassi, H. et al. Impaired pulmonary function and its association with clinical outcomes, exercise capacity and quality of life in children with congenital heart disease. Int. J. Cardiol. 285, 86\u201392 (2019).","journal-title":"Int. J. Cardiol."},{"key":"3143_CR27","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.ijcard.2015.11.028","volume":"203","author":"P Amedro","year":"2016","unstructured":"Amedro, P. et al. Correlation between cardio-pulmonary exercise test variables and health-related quality of life among children with congenital heart diseases. Int. J. Cardiol. 203, 1052\u20131060 (2016).","journal-title":"Int. J. Cardiol."},{"key":"3143_CR28","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s12955-020-01615-6","volume":"18","author":"H Abassi","year":"2020","unstructured":"Abassi, H. et al. Health-related quality of life in children with congenital heart disease aged 5 to 7 years: a multicentre controlled cross-sectional study. Health Qual. Life Outcomes 18, 366 (2020).","journal-title":"Health Qual. Life Outcomes"},{"key":"3143_CR29","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1017\/S1047951116000056","volume":"26","author":"P Amedro","year":"2016","unstructured":"Amedro, P. et al. Health-related quality of life of patients with pulmonary arterial hypertension associated with CHD: the multicentre cross-sectional ACHILLE study. Cardiol. Young. 26, 1250\u20131259 (2016).","journal-title":"Cardiol. Young."},{"key":"3143_CR30","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/MPH.0b013e318165b298","volume":"30","author":"BB Das","year":"2008","unstructured":"Das, B. B., Sobczyk, W., Bertolone, S. & Raj, A. Cardiopulmonary stress testing in children with sickle cell disease who are on long-term erythrocytapheresis. J. Pediatr. Hematol. Oncol. 30, 373\u2013377 (2008).","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"3143_CR31","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1093\/eurjpc\/zwad054","volume":"30","author":"A Gavotto","year":"2023","unstructured":"Gavotto, A. et al. Reference values of aerobic fitness in the contemporary paediatric population. Eur. J. Prev. Cardiol. 30, 820\u2013829 (2023).","journal-title":"Eur. J. Prev. Cardiol."},{"key":"3143_CR32","first-page":"1233","volume":"2","author":"M Odi\u00e8vre","year":"1995","unstructured":"Odi\u00e8vre, M., Schaison, G., Baruchel, A. & Leblanc, T. H\u00e9matologie de l\u2019enfant. Arch. P\u00e9diatr. 2, 1233 (1995).","journal-title":"Arch. P\u00e9diatr."},{"key":"3143_CR33","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1136\/heart.83.6.667","volume":"83","author":"C Kampmann","year":"2000","unstructured":"Kampmann, C. et al. Normal values of M mode echocardiographic measurements of more than 2000 healthy infants and children in central Europe. Heart 83, 667\u2013672 (2000).","journal-title":"Heart"},{"key":"3143_CR34","doi-asserted-by":"crossref","unstructured":"Bowerman C. et al. A race-neutral approach to the interpretation of lung function measurements. Am. J. Respir. Crit. Care Med. 207, 768\u201374 (2022).","DOI":"10.1164\/rccm.202205-0963OC"},{"key":"3143_CR35","doi-asserted-by":"crossref","unstructured":"Hall G. L. et al. Official ERS technical standard: Global Lung Function Initiative reference values for static lung volumes in individuals of European ancestry. Eur. Resp. J. 57, https:\/\/erj.ersjournals.com\/content\/57\/3\/2000289 (2021). Accessed 15 February 2023.","DOI":"10.1183\/13993003.00289-2020"},{"key":"3143_CR36","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/BF03086280","volume":"17","author":"T Takken","year":"2009","unstructured":"Takken, T. et al. Cardiopulmonary exercise testing in congenital heart disease: equipment and test protocols. Neth. Heart J. 17, 339\u2013344 (2009).","journal-title":"Neth. Heart J."},{"key":"3143_CR37","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1136\/bjsm.2009.063180","volume":"45","author":"AR Barker","year":"2011","unstructured":"Barker, A. R., Williams, C. A., Jones, A. M. & Armstrong, N. Establishing maximal oxygen uptake in young people during a ramp cycle test to exhaustion. Br. J. Sports Med. 45, 498\u2013503 (2011).","journal-title":"Br. J. Sports Med."},{"key":"3143_CR38","doi-asserted-by":"publisher","unstructured":"Amedro, P. et al. Early hybrid cardiac rehabilitation in congenital heart disease: the QUALIREHAB trial. Eur. Heart J. ehae085 https:\/\/doi.org\/10.1093\/eurheartj\/ehae085 (2024).","DOI":"10.1093\/eurheartj\/ehae085"},{"key":"3143_CR39","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2","volume":"3","author":"JW Varni","year":"2003","unstructured":"Varni, J. W., Burwinkle, T. M., Seid, M. & Skarr, D. The PedsQLTM* 4.0 as a pediatric population health measure: feasibility, reliability, and validity. Ambul. Pediatr. 3, 329\u2013341 (2003).","journal-title":"Ambul. Pediatr."},{"key":"3143_CR40","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.erap.2009.06.001","volume":"59","author":"S Tessier","year":"2009","unstructured":"Tessier, S., Vuillemin, A., Lemelle, J.-L. & Brian\u00e7on, S. Propri\u00e9t\u00e9s psychom\u00e9triques du questionnaire g\u00e9n\u00e9rique fran\u00e7ais \u00abPediatric Quality of Life Inventory Version 4.0\u00bb (PedsQLTM 4.0). Eur. Rev. Appl. Psychol. 59, 291\u2013300 (2009).","journal-title":"Eur. Rev. Appl. Psychol."},{"key":"3143_CR41","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12955-021-01714-y","volume":"19","author":"P Amedro","year":"2021","unstructured":"Amedro, P. et al. Psychometric validation of the French self and proxy versions of the PedsQLTM 4.0 generic health-related quality of life questionnaire for 8\u201312 year-old children. Health Qual. Life Outcomes 19, 75 (2021).","journal-title":"Health Qual. Life Outcomes"},{"key":"3143_CR42","first-page":"49","volume":"46","author":"A Vuillemin","year":"1998","unstructured":"Vuillemin, A., Denis, G., Guillemin, F. & Jeandel, C. A review of evaluation questionnaires for physical activity. Rev. Epidemiol. Sante Publ. 46, 49\u201355 (1998).","journal-title":"Rev. Epidemiol. Sante Publ."},{"key":"3143_CR43","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.3390\/ijerph18063065","volume":"18","author":"R Abid","year":"2021","unstructured":"Abid, R., Ammar, A., Maaloul, R., Souissi, N. & Hammouda, O. Effect of COVID-19-related home confinement on sleep quality, screen time and physical activity in Tunisian boys and girls: a survey. Int. J. Environ. Res. Public Health 18, 3065 (2021).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"3143_CR44","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1001\/jama.2009.681","volume":"301","author":"S Kodama","year":"2009","unstructured":"Kodama, S. et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA 301, 2024\u20132035 (2009).","journal-title":"JAMA"},{"key":"3143_CR45","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1164\/ajrccm\/143.2.231","volume":"143","author":"P Pianosi","year":"1991","unstructured":"Pianosi, P. et al. Cardiac output and oxygen delivery during exercise in sickle cell anemia. Am. Rev. Respir. Dis. 143, 231\u2013235 (1991).","journal-title":"Am. Rev. Respir. Dis."},{"key":"3143_CR46","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/bjh.18436","volume":"199","author":"FJ Ogunsile","year":"2022","unstructured":"Ogunsile, F. J., Stewart, K. J., Kanter, J. & Lanzkron, S. M. An evaluation of cardiopulmonary endurance and muscular strength in adults living with sickle cell disease. Br. J. Haematol. 199, 597\u2013602 (2022).","journal-title":"Br. J. Haematol."},{"key":"3143_CR47","doi-asserted-by":"publisher","first-page":"e0228399","DOI":"10.1371\/journal.pone.0228399","volume":"15","author":"CC da Guarda","year":"2020","unstructured":"da Guarda, C. C. et al. Sickle cell disease: a distinction of two most frequent genotypes (HbSS and HbSC). PLoS One 15, e0228399 (2020).","journal-title":"PLoS One"},{"key":"3143_CR48","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/0002-9343(83)91063-X","volume":"74","author":"S Charache","year":"1983","unstructured":"Charache, S., Bleecker, E. R. & Bross, D. S. Effects of blood transfusion on exercise capacity in patients with sickle-cell anemia. Am. J. Med. 74, 757\u2013764 (1983).","journal-title":"Am. J. Med."},{"key":"3143_CR49","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1042\/cs0440113","volume":"44","author":"GJ Miller","year":"1973","unstructured":"Miller, G. J., Serjeant, G. R., Sivapragasam, S. & Petch, M. C. Cardio-pulmonary responses and gas exchange during exercise in adults with homozygous sickle-cell disease (sickle-cell anaemia). Clin. Sci. 44, 113\u2013128 (1973).","journal-title":"Clin. Sci."},{"key":"3143_CR50","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1182\/asheducation-2018.1.418","volume":"2018","author":"RI Liem","year":"2018","unstructured":"Liem, R. I. Balancing exercise risk and benefits: lessons learned from sickle cell trait and sickle cell anemia. Hematol. Am. Soc. Hematol. Educ. Program 2018, 418\u2013425 (2018).","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03143-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03143-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03143-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T14:04:30Z","timestamp":1729778670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03143-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3143"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03143-1","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]},"assertion":[{"value":"26 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in compliance with the Good Clinical Practices protocol and Declaration of Helsinki principles. It was approved by our institutional review board (IRB-MTP_2022_04_202201102) and registered on Clinicaltrials.gov (NCT05995743). Informed consent was obtained from all parents or legal guardians.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}