{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:58:40Z","timestamp":1789516720456,"version":"build-2803163510"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                <jats:title>Abstract<\/jats:title>\n                <jats:p>The hippocampus is a vital brain structure deep in the medial temporal lobe that mediates a range of functions encompassing emotional regulation, learning, memory, and cognition. Hippocampal development is exquisitely sensitive to perturbations and adverse conditions during pregnancy and at birth, including preterm birth, fetal growth restriction (FGR), acute hypoxic\u2013ischaemic encephalopathy (HIE), and intrauterine inflammation. Disruptions to hippocampal development due to these conditions can have long-lasting functional impacts. Here, we discuss a range of preclinical models of prematurity and FGR and conditions that induce hypoxia and inflammation, which have been critical in elucidating the underlying mechanisms and cellular and subcellular structures implicated in hippocampal dysfunction. Finally, we discuss potential therapeutic targets to reduce the burden of these perinatal insults on the developing hippocampus.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Impact<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>The review explores the preclinical literature examining the association between pregnancy and birth complications, and hippocampal form and function.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>The developmental processes and cellular mechanisms that are disrupted within the hippocampus following perinatal compromise are described, and potential therapeutic targets are discussed.<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/s41390-024-03144-0","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T19:03:01Z","timestamp":1711134181000},"page":"1709-1719","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Perinatal compromise affects development, form, and function of the hippocampus part two; preclinical studies"],"prefix":"10.1038","volume":"95","author":[{"given":"Tegan A.","family":"White","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth J.","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Camm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"3144_CR1","doi-asserted-by":"publisher","first-page":"7853","DOI":"10.1523\/JNEUROSCI.1364-19.2019","volume":"39","author":"E McClendon","year":"2019","unstructured":"McClendon, E. et al. Transient hypoxemia disrupts anatomical and functional maturation of preterm fetal ovine Ca1 pyramidal neurons. J. Neurosci. 39, 7853\u20137871 (2019).","journal-title":"J. Neurosci."},{"key":"3144_CR2","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1017\/S2040174417000307","volume":"8","author":"AL Cumberland","year":"2017","unstructured":"Cumberland, A. L., Palliser, H. K., Rani, P., Walker, D. W. & Hirst, J. J. Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model. J. Dev. Orig. Health Dis. 8, 584\u2013596 (2017).","journal-title":"J. Dev. Orig. Health Dis."},{"key":"3144_CR3","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1093\/cercor\/bhp068","volume":"19","author":"H Chahboune","year":"2009","unstructured":"Chahboune, H. et al. Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessment. Cereb. 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