{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:26:28Z","timestamp":1793726788153,"version":"4.6.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1038\/s41390-024-03168-6","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T08:02:05Z","timestamp":1713772925000},"page":"1076-1083","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty"],"prefix":"10.1038","volume":"96","author":[{"given":"Peng","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuilan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-463X","authenticated-orcid":false,"given":"Shijian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"3168_CR1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S2213-8587(15)00418-0","volume":"4","author":"AP Abreu","year":"2016","unstructured":"Abreu, A. P. & Kaiser, U. B. Pubertal development and regulation. Lancet Diabetes Endocrinol. 4, 254\u2013264 (2016).","journal-title":"Lancet Diabetes Endocrinol."},{"key":"3168_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/ppe.12507","volume":"33","author":"N Brix","year":"2019","unstructured":"Brix, N. et al. Timing of puberty in boys and girls: a population-based study. Paediatr. Perinat. Epidemiol. 33, 70\u201378 (2019).","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"3168_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-016-0240-y","volume":"13","author":"MH Lee","year":"2016","unstructured":"Lee, M. H., Kim, S. H., Oh, M., Lee, K. W. & Park, M. J. Age at menarche in Korean adolescents: trends and influencing factors. Reprod. Health 13, 121 (2016).","journal-title":"Reprod. Health"},{"key":"3168_CR4","doi-asserted-by":"publisher","first-page":"e20170085","DOI":"10.1542\/peds.2017-0085","volume":"140","author":"X Meng","year":"2017","unstructured":"Meng, X., Li, S., Duan, W., Sun, Y. & Jia, C. Secular trend of age at menarche in Chinese adolescents born from 1973 to 2004. Pediatrics 140, e20170085 (2017).","journal-title":"Pediatrics"},{"key":"3168_CR5","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s12020-021-02630-3","volume":"72","author":"Y Liu","year":"2021","unstructured":"Liu, Y. et al. Prevalence of precocious puberty among Chinese children: a school population-based study. Endocrine 72, 573\u2013581 (2021).","journal-title":"Endocrine"},{"key":"3168_CR6","doi-asserted-by":"publisher","first-page":"910119","DOI":"10.3389\/fendo.2022.910119","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y. et al. The prevalence of precocious puberty among children in Qufu City, Shandong Province, China, a population-based study. Front. Endocrinol. 13, 910119 (2022).","journal-title":"Front. Endocrinol."},{"key":"3168_CR7","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2400::AID-CNCR15>3.0.CO;2-O","volume":"85","author":"CS Berkey","year":"1999","unstructured":"Berkey, C. S., Frazier, A. L., Gardner, J. D. & Colditz, G. A. Adolescence and breast carcinoma risk. Cancer 85, 2400\u20132409 (1999).","journal-title":"Cancer"},{"key":"3168_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/srep11208","volume":"5","author":"FR Day","year":"2015","unstructured":"Day, F. R., Elks, C. E., Murray, A., Ong, K. K. & Perry, J. R. B. Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. Sci. Rep. 5, 11208 (2015).","journal-title":"Sci. Rep."},{"key":"3168_CR9","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.yhbeh.2013.04.003","volume":"64","author":"JA Graber","year":"2013","unstructured":"Graber, J. A. Pubertal timing and the development of psychopathology in adolescence and beyond. Horm. Behav. 64, 262\u2013269 (2013).","journal-title":"Horm. Behav."},{"key":"3168_CR10","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/ng.714","volume":"42","author":"CE Elks","year":"2010","unstructured":"Elks, C. E. et al. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat. Genet. 42, 1077\u20131085 (2010).","journal-title":"Nat. Genet."},{"key":"3168_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9842","volume":"6","author":"FR Day","year":"2015","unstructured":"Day, F. R. et al. Shared genetic aetiology of puberty timing between sexes and with health-related outcomes. Nat. Commun. 6, 8842 (2015).","journal-title":"Nat. Commun."},{"key":"3168_CR12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/ng.382","volume":"41","author":"KK Ong","year":"2009","unstructured":"Ong, K. K. et al. Genetic variation in LIN28B is associated with the timing of puberty. Nat. Genet. 41, 729\u2013733 (2009).","journal-title":"Nat. Genet."},{"key":"3168_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1477-7827-8-115","volume":"8","author":"O Karapanou","year":"2010","unstructured":"Karapanou, O. & Papadimitriou, A. Determinants of menarche. Reprod. Biol. Endocrin. 8, 115 (2010).","journal-title":"Reprod. Biol. Endocrin."},{"key":"3168_CR14","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.jadohealth.2019.07.004","volume":"65","author":"Y Fujimura","year":"2019","unstructured":"Fujimura, Y., Sekine, M. & Yamada, M. The relationship between quality of life and pubertal timing in adolescence: the Toyama birth cohort study, Japan. J. Adolesc. Health 65, 790\u2013798 (2019).","journal-title":"J. Adolesc. Health"},{"key":"3168_CR15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1530\/EJE-19-0033","volume":"181","author":"Y Sun","year":"2019","unstructured":"Sun, Y., Fang, J., Wan, Y., Su, P. & Tao, F. Role of polygenic risk in susceptibility to accelerated pubertal onset following chronic stress exposure. Eur. J. Endocrinol. 181, 129\u2013137 (2019).","journal-title":"Eur. J. Endocrinol."},{"key":"3168_CR16","doi-asserted-by":"publisher","first-page":"e014004","DOI":"10.1136\/bmjopen-2016-014004","volume":"7","author":"C Chen","year":"2017","unstructured":"Chen, C. et al. Investigating the relationship between precocious puberty and obesity: a cross-sectional study in Shanghai, China. BMJ Open 7, e014004 (2017).","journal-title":"BMJ Open"},{"key":"3168_CR17","doi-asserted-by":"publisher","first-page":"153961","DOI":"10.1016\/j.metabol.2019.153961","volume":"100","author":"Y-C Chen","year":"2019","unstructured":"Chen, Y.-C. et al. Assessing causality between childhood adiposity and early puberty: a bidirectional Mendelian randomization and longitudinal study. Metabolism 100, 153961 (2019).","journal-title":"Metabolism"},{"key":"3168_CR18","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/ijpo.277","volume":"10","author":"T Gavela-P\u00e9rez","year":"2015","unstructured":"Gavela-P\u00e9rez, T., Garc\u00e9s, C., Navarro-S\u00e1nchez, P., L\u00f3pez Villanueva, L. & Soriano-Guill\u00e9n, L. Earlier menarcheal age in Spanish girls is related with an increase in body mass index between pre-pubertal school age and adolescence. Pediatr. Obes. 10, 410\u2013415 (2015).","journal-title":"Pediatr. Obes."},{"key":"3168_CR19","doi-asserted-by":"publisher","first-page":"dgz222","DOI":"10.1210\/clinem\/dgz222","volume":"105","author":"AS Busch","year":"2020","unstructured":"Busch, A. S., H\u00f8jgaard, B., Hagen, C. P. & Teilmann, G. Obesity is associated with earlier pubertal onset in boys. J. Clin. Endocrinol. Metab. 105, dgz222 (2020).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"3168_CR20","doi-asserted-by":"publisher","first-page":"e20150164","DOI":"10.1542\/peds.2015-0164","volume":"137","author":"JM Lee","year":"2016","unstructured":"Lee, J. M. et al. Timing of puberty in overweight versus obese boys. Pediatrics 137, e20150164 (2016).","journal-title":"Pediatrics"},{"key":"3168_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/cen.14631","volume":"96","author":"D Li","year":"2022","unstructured":"Li, D. et al. Obesity-related genetic polymorphisms are associated with the risk of early puberty in Han Chinese girls. Clin. Endocrinol. 96, 319\u2013327 (2022).","journal-title":"Clin. Endocrinol."},{"key":"3168_CR22","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.orcp.2019.06.004","volume":"13","author":"Y Jiang","year":"2019","unstructured":"Jiang, Y. et al. Interaction effects of FTO rs9939609 polymorphism and lifestyle factors on obesity indices in early adolescence. Obes. Res. Clin. Pract. 13, 352\u2013357 (2019).","journal-title":"Obes. Res. Clin. Pract."},{"key":"3168_CR23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s10020-020-00202-1","volume":"26","author":"BL Wei","year":"2020","unstructured":"Wei, B. L. et al. The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity. Mol. Med. 26, 77 (2020).","journal-title":"Mol. Med."},{"key":"3168_CR24","doi-asserted-by":"publisher","first-page":"113365","DOI":"10.1016\/j.envres.2022.113365","volume":"212","author":"Y Hu","year":"2022","unstructured":"Hu, Y. et al. Exposure to antibiotics and precocious puberty in children: a school-based cross-sectional study in China. Environ. Res. 212, 113365 (2022).","journal-title":"Environ. Res."},{"key":"3168_CR25","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1186\/s12887-022-03350-x","volume":"22","author":"T Yu","year":"2022","unstructured":"Yu, T. et al. Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study. BMC Pediatr. 22, 310 (2022).","journal-title":"BMC Pediatr."},{"key":"3168_CR26","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.2047-6310.2012.00064.x","volume":"7","author":"TJ Cole","year":"2012","unstructured":"Cole, T. J. & Lobstein, T. Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr. Obes. 7, 284\u2013294 (2012).","journal-title":"Pediatr. Obes."},{"key":"3168_CR27","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1136\/adc.44.235.291","volume":"44","author":"WA Marshall","year":"1969","unstructured":"Marshall, W. A. & Tanner, J. M. Variations in pattern of pubertal changes in girls. Arch. Dis. Child. 44, 291\u2013303 (1969).","journal-title":"Arch. Dis. Child."},{"key":"3168_CR28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1136\/adc.45.239.13","volume":"45","author":"WA Marshall","year":"1970","unstructured":"Marshall, W. A. & Tanner, J. M. Variations in the pattern of pubertal changes in boys. Arch. Dis. Child. 45, 13\u201323 (1970).","journal-title":"Arch. Dis. Child."},{"key":"3168_CR29","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1007\/s00431-021-04022-1","volume":"180","author":"AV Cheuiche","year":"2021","unstructured":"Cheuiche, A. V., da Silveira, L. G., de Paula, L. C. P., Lucena, I. R. S. & Silveiro, S. P. Diagnosis and management of precocious sexual maturation: an updated review. Eur. J. Pediatr. 180, 3073\u20133087 (2021).","journal-title":"Eur. J. Pediatr."},{"key":"3168_CR30","doi-asserted-by":"publisher","first-page":"4528704","DOI":"10.1155\/2018\/4528704","volume":"2018","author":"C Chen","year":"2018","unstructured":"Chen, C. et al. Association between dietary patterns and precocious puberty in children: a population-based study. Int. J. Endocrinol. 2018, 4528704 (2018).","journal-title":"Int. J. Endocrinol."},{"key":"3168_CR31","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1038\/ng.3951","volume":"49","author":"M Akiyama","year":"2017","unstructured":"Akiyama, M. et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat. Genet. 49, 1458\u20131467 (2017).","journal-title":"Nat. Genet."},{"key":"3168_CR32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature14177","volume":"518","author":"AE Locke","year":"2015","unstructured":"Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197\u2013206 (2015).","journal-title":"Nature"},{"key":"3168_CR33","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13545","volume":"514","author":"JR Perry","year":"2014","unstructured":"Perry, J. R. et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 514, 92\u201397 (2014).","journal-title":"Nature"},{"key":"3168_CR34","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1086\/519795","volume":"81","author":"S Purcell","year":"2007","unstructured":"Purcell, S. et al. Plink: PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559\u2013575 (2007).","journal-title":"Am. J. Hum. Genet."},{"key":"3168_CR35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/genes12020270","volume":"12","author":"W Gong","year":"2021","unstructured":"Gong, W. et al. Effects of gene-environment interaction on obesity among Chinese adults born in the early 1960s. Genes 12, 270 (2021).","journal-title":"Genes"},{"key":"3168_CR36","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1056\/NEJMoa022050","volume":"348","author":"IS Farooqi","year":"2003","unstructured":"Farooqi, I. S. et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 348, 1085\u20131095 (2003).","journal-title":"N. Engl. J. Med."},{"key":"3168_CR37","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.cell.2019.03.044","volume":"177","author":"LA Lotta","year":"2019","unstructured":"Lotta, L. A. et al. Human gain-of-function MC4R variants show signaling bias and protect against obesity. Cell 177, 597\u2013607.e9 (2019).","journal-title":"Cell"},{"key":"3168_CR38","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/ng.686","volume":"42","author":"EK Speliotes","year":"2010","unstructured":"Speliotes, E. K. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937\u2013948 (2010).","journal-title":"Nat. Genet."},{"key":"3168_CR39","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/ng.1087","volume":"44","author":"W Wen","year":"2012","unstructured":"Wen, W. et al. Meta-analysis identifies common variants associated with body mass index in East Asians. Nat. Genet. 44, 307\u2013311 (2012).","journal-title":"Nat. Genet."},{"key":"3168_CR40","doi-asserted-by":"publisher","first-page":"4452","DOI":"10.1093\/hmg\/ddu150","volume":"23","author":"DL Cousminer","year":"2014","unstructured":"Cousminer, D. L. et al. Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Hum. Mol. Genet. 23, 4452\u20134464 (2014).","journal-title":"Hum. Mol. Genet."},{"key":"3168_CR41","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.adolescence.2020.12.001","volume":"86","author":"A Karim","year":"2021","unstructured":"Karim, A., Qaisar, R. & Hussain, M. A. Growth and socio-economic status, influence on the age at menarche in school going girls. J. Adolesc. 86, 40\u201353 (2021).","journal-title":"J. Adolesc."},{"key":"3168_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jadohealth.2021.02.003","volume":"69","author":"RA Hiatt","year":"2021","unstructured":"Hiatt, R. A. et al. Childhood socioeconomic status and menarche: a prospective study. J. Adolesc. Health 69, 33\u201340 (2021).","journal-title":"J. Adolesc. Health"},{"key":"3168_CR43","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1159\/000513787","volume":"93","author":"L Oelkers","year":"2020","unstructured":"Oelkers, L. et al. Socioeconomic status is related to pubertal development in a German cohort. Horm. Res. Paediatr. 93, 548\u2013557 (2020).","journal-title":"Horm. Res. Paediatr."},{"key":"3168_CR44","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s00431-020-03803-4","volume":"180","author":"M Cheng","year":"2021","unstructured":"Cheng, M. et al. The influence of socioeconomic status on menarcheal age among Chinese school-age girls in Tianjin, China. Eur. J. Pediatr. 180, 825\u2013832 (2021).","journal-title":"Eur. J. Pediatr."},{"key":"3168_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01189-0","volume":"13","author":"J Cerutti","year":"2021","unstructured":"Cerutti, J., Lussier, A. A., Zhu, Y., Liu, J. & Dunn, E. C. Associations between indicators of socioeconomic position and DNA methylation: a scoping review. Clin. Epigenetics 13, 221 (2021).","journal-title":"Clin. Epigenetics"},{"key":"3168_CR46","doi-asserted-by":"publisher","first-page":"4328909","DOI":"10.1155\/2019\/4328909","volume":"2019","author":"L Gao","year":"2019","unstructured":"Gao, L. et al. MC4R single nucleotide polymorphisms were associated with metabolically healthy and unhealthy obesity in Chinese northern Han populations. Int. J. Endocrinol. 2019, 4328909 (2019).","journal-title":"Int. J. Endocrinol."},{"key":"3168_CR47","doi-asserted-by":"publisher","first-page":"2821","DOI":"10.3390\/nu13082821","volume":"13","author":"L Rasmussen","year":"2021","unstructured":"Rasmussen, L. et al. The impact of lifestyle, diet and physical activity on epigenetic changes in the offspring-a systematic review. Nutrients 13, 2821 (2021).","journal-title":"Nutrients"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03168-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03168-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03168-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T14:05:05Z","timestamp":1729778705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03168-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3168"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03168-6","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"19 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Informed consent was obtained by the parents or guardians of the participating children.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}