{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:11:49Z","timestamp":1740136309427,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1038\/s41390-024-03181-9","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T16:02:21Z","timestamp":1715011341000},"page":"1210-1219","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoplasmic reticulum stress is attenuated by glycolysis in lymphatic malformations"],"prefix":"10.1038","volume":"96","author":[{"given":"Xuecong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maosheng","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianshuang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congfa","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaodong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongsheng","family":"Mou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoshun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1218-2652","authenticated-orcid":false,"given":"Yu","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"3181_CR1","first-page":"444","volume":"32","author":"W Ma","year":"2017","unstructured":"Ma, W. & Oliver, G. Lymphatic endothelial cell plasticity in development and disease. Physiol. (Bethesda) 32, 444\u2013452 (2017).","journal-title":"Physiol. (Bethesda)"},{"key":"3181_CR2","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ajpath.2020.10.003","volume":"191","author":"H Jiang","year":"2021","unstructured":"Jiang, H. et al. Pyruvate kinase M2 mediates glycolysis in the lymphatic endothelial cells and promotes the progression of lymphatic malformations. Am. J. Pathol. 191, 204\u2013215 (2021).","journal-title":"Am. J. Pathol."},{"key":"3181_CR3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","volume":"140","author":"T Tammela","year":"2010","unstructured":"Tammela, T. & Alitalo, K. Lymphangiogenesis: molecular mechanisms and future promise. Cell 140, 460\u2013476 (2010).","journal-title":"Cell"},{"key":"3181_CR4","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1097\/01.PRS.0000165071.48422.A4","volume":"115","author":"PD Edwards","year":"2005","unstructured":"Edwards, P. D., Rahbar, R., Ferraro, N. F., Burrows, P. E. & Mulliken, J. B. Lymphatic malformation of the lingual base and oral floor. Plast. Reconstructive Surg. 115, 1906\u20131915 (2005).","journal-title":"Plast. Reconstructive Surg."},{"key":"3181_CR5","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1053\/j.sempedsurg.2014.07.002","volume":"23","author":"RG Elluru","year":"2014","unstructured":"Elluru, R. G., Balakrishnan, K. & Padua, H. M. Lymphatic malformations: DiagNOSIS AND MANagement. Semin. Pediatr. Surg. 23, 178\u2013185 (2014).","journal-title":"Semin. Pediatr. Surg."},{"key":"3181_CR6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter, P. & Ron, D. The unfolded protein response: From stress pathway to homeostatic regulation. Science 334, 1081\u20131086 (2011).","journal-title":"Science"},{"key":"3181_CR7","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/332462a0","volume":"332","author":"Y Kozutsumi","year":"1988","unstructured":"Kozutsumi, Y., Segal, M., Normington, K., Gething, M. J. & Sambrook, J. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332, 462\u2013464 (1988).","journal-title":"Nature"},{"key":"3181_CR8","doi-asserted-by":"publisher","first-page":"G820","DOI":"10.1152\/ajpgi.00063.2010","volume":"298","author":"MA McGuckin","year":"2010","unstructured":"McGuckin, M. A., Eri, R. D., Das, I., Lourie, R. & Florin, T. H. Er stress and the unfolded protein response in intestinal inflammation. Am. J. Physiol. Gastrointest. liver Physiol. 298, G820\u2013G832 (2010).","journal-title":"Am. J. Physiol. Gastrointest. liver Physiol."},{"key":"3181_CR9","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.bbamcr.2014.02.009","volume":"1843","author":"M Gal\u00e1n","year":"2014","unstructured":"Gal\u00e1n, M. et al. Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction. Biochimica et. biophysica acta 1843, 1063\u20131075 (2014).","journal-title":"Biochimica et. biophysica acta"},{"key":"3181_CR10","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.molcel.2014.03.022","volume":"54","author":"E Karali","year":"2014","unstructured":"Karali, E. et al. Vegf signals through Atf6 and perk to promote endothelial cell survival and angiogenesis in the absence of Er stress. Mol. Cell 54, 559\u2013572 (2014).","journal-title":"Mol. Cell"},{"key":"3181_CR11","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1161\/CIRCULATIONAHA.112.001337","volume":"127","author":"L Zeng","year":"2013","unstructured":"Zeng, L. et al. Vascular endothelial cell growth-activated Xbp1 splicing in endothelial cells is crucial for angiogenesis. Circulation 127, 1712\u20131722 (2013).","journal-title":"Circulation"},{"key":"3181_CR12","doi-asserted-by":"publisher","first-page":"e12521","DOI":"10.1371\/journal.pone.0012521","volume":"5","author":"ER Pereira","year":"2010","unstructured":"Pereira, E. R., Liao, N., Neale, G. A. & Hendershot, L. M. Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response. PLoS One 5, e12521 (2010).","journal-title":"PLoS One"},{"key":"3181_CR13","doi-asserted-by":"publisher","first-page":"e9575","DOI":"10.1371\/journal.pone.0009575","volume":"5","author":"R Ghosh","year":"2010","unstructured":"Ghosh, R. et al. Transcriptional regulation of Vegf-a by the unfolded protein response pathway. PLoS One 5, e9575 (2010).","journal-title":"PLoS One"},{"key":"3181_CR14","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg, O. On the origin of cancer cells. Sci. (N. Y., NY) 123, 309\u2013314 (1956).","journal-title":"Sci. (N. Y., NY)"},{"key":"3181_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","volume":"27","author":"SY Lunt","year":"2011","unstructured":"Lunt, S. Y. & Vander Heiden, M. G. Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation. Annu Rev. Cell Dev. Biol. 27, 441\u2013464 (2011).","journal-title":"Annu Rev. Cell Dev. Biol."},{"key":"3181_CR16","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.2174\/0929867033457269","volume":"10","author":"JG Pastorino","year":"2003","unstructured":"Pastorino, J. G. & Hoek, J. B. Hexokinase Ii: The integration of energy metabolism and control of apoptosis. Curr. medicinal Chem. 10, 1535\u20131551 (2003).","journal-title":"Curr. medicinal Chem."},{"key":"3181_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115227","volume":"204","author":"M Chai","year":"2022","unstructured":"Chai, M. et al. Bleomycin restricts the glycolysis of lymphatic endothelial cells by inhibiting dimeric Pkm2 formation: A novel mechanism for lymphatic malformation treatment. Biochem Pharm. 204, 115227 (2022).","journal-title":"Biochem Pharm."},{"key":"3181_CR18","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.ajpath.2021.02.010","volume":"191","author":"Y Zou","year":"2021","unstructured":"Zou, Y., Wang, R., Zhao, J., Cai, Y. & Zhong, W. Increased M2 isoform of pyruvate kinase in fibroblasts contributes to the growth, aggressiveness, and osteoclastogenesis of odontogenic keratocysts. Am. J. Pathol. 191, 857\u2013871 (2021).","journal-title":"Am. J. Pathol."},{"key":"3181_CR19","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/bjd.14471","volume":"175","author":"W Zhang","year":"2016","unstructured":"Zhang, W. et al. Infiltration of M2-polarized macrophages in infected lymphatic malformations: Possible role in disease progression. Br. J. Dermatol 175, 102\u2013112 (2016).","journal-title":"Br. J. Dermatol"},{"key":"3181_CR20","first-page":"680","volume":"5","author":"MC Morris","year":"2014","unstructured":"Morris, M. C., Gilliam, E. A. & Li, L. Innate immune programing by endotoxin and its pathological consequences. Front Immunol. 5, 680 (2014).","journal-title":"Front Immunol."},{"key":"3181_CR21","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.cdd.4401373","volume":"11","author":"S Oyadomari","year":"2004","unstructured":"Oyadomari, S. & Mori, M. Roles of Chop\/Gadd153 in endoplasmic reticulum stress. Cell Death Differ. 11, 381\u2013389 (2004).","journal-title":"Cell Death Differ."},{"key":"3181_CR22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/cdd.2014.173","volume":"22","author":"DJ Roberts","year":"2015","unstructured":"Roberts, D. J. & Miyamoto, S. Hexokinase Ii integrates energy metabolism and cellular protection: Akting on mitochondria and torcing to autophagy. Cell Death Differ. 22, 248\u2013257 (2015).","journal-title":"Cell Death Differ."},{"key":"3181_CR23","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1365-2559.2005.02098.x","volume":"46","author":"M Fukunaga","year":"2005","unstructured":"Fukunaga, M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology 46, 396\u2013402 (2005).","journal-title":"Histopathology"},{"key":"3181_CR24","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov, R. Origin and physiological roles of Inflammation. Nature 454, 428\u2013435 (2008).","journal-title":"Nature"},{"key":"3181_CR25","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1136\/jclinpath-2012-201286","volume":"66","author":"FQ Wang","year":"2013","unstructured":"Wang, F. Q. et al. M2-polarised macrophages in infantile haemangiomas: correlation with promoted angiogenesis. J. Clin. Pathol. 66, 1058\u20131064 (2013).","journal-title":"J. Clin. Pathol."},{"key":"3181_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.5487\/TR.2018.34.1.065","volume":"34","author":"BS Chae","year":"2018","unstructured":"Chae, B. S. Pretreatment of low-dose and super-low-dose Lps on the production of in vitro Lps-induced inflammatory mediators. Toxicol. Res. 34, 65\u201373 (2018).","journal-title":"Toxicol. Res."},{"key":"3181_CR27","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ebiom.2015.03.001","volume":"2","author":"K Chen","year":"2015","unstructured":"Chen, K. et al. Super-low dose endotoxin pre-conditioning exacerbates sepsis mortality. EBioMedicine 2, 324\u2013333 (2015).","journal-title":"EBioMedicine"},{"key":"3181_CR28","doi-asserted-by":"publisher","first-page":"R622","DOI":"10.1016\/j.cub.2012.07.004","volume":"22","author":"SS Cao","year":"2012","unstructured":"Cao, S. S. & Kaufman, R. J. Unfolded protein response. Curr. Biol.: CB 22, R622\u2013R626 (2012).","journal-title":"Curr. Biol.: CB"},{"key":"3181_CR29","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/jb\/mvp189","volume":"147","author":"Y Nakayama","year":"2010","unstructured":"Nakayama, Y. et al. Molecular mechanisms of the Lps-induced non-apoptotic Er stress-chop pathway. J. Biochem 147, 471\u2013483 (2010).","journal-title":"J. Biochem"},{"key":"3181_CR30","doi-asserted-by":"publisher","first-page":"6129","DOI":"10.1007\/s00253-020-10614-y","volume":"104","author":"W Li","year":"2020","unstructured":"Li, W. et al. Crosstalk between Er stress, Nlrp3 Inflammasome, And Inflammation. Appl. Microbiol. Biotechnol. 104, 6129\u20136140 (2020).","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"3181_CR31","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.3389\/fimmu.2019.02951","volume":"10","author":"P D\u00edaz-Bulnes","year":"2019","unstructured":"D\u00edaz-Bulnes, P., Saiz, M. L., L\u00f3pez-Larrea, C. & Rodr\u00edguez, R. M. Crosstalk between hypoxia and Er stress response: A key regulator of macrophage polarization. Front Immunol. 10, 2951 (2019).","journal-title":"Front Immunol."},{"key":"3181_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.10.018","volume":"124","author":"JC Duvigneau","year":"2019","unstructured":"Duvigneau, J. C. et al. Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases. Cytokine 124, 154577 (2019).","journal-title":"Cytokine"},{"key":"3181_CR33","doi-asserted-by":"publisher","first-page":"e0200343","DOI":"10.1371\/journal.pone.0200343","volume":"13","author":"H Blesinger","year":"2018","unstructured":"Blesinger, H. et al. Pik3ca mutations are specifically localized to lymphatic endothelial cells of lymphatic malformations. PLoS One 13, e0200343 (2018).","journal-title":"PLoS One"},{"key":"3181_CR34","first-page":"7886","volume":"17","author":"LJ Li","year":"2018","unstructured":"Li, L. J., Chai, Y., Guo, X. J., Chu, S. L. & Zhang, L. S. Effects of endoplasmic reticulum stress on autophagy and apoptosis of human leukemia cells via inhibition of the Pi3k\/Akt\/Mtor signaling pathway. Mol. Med. Rep. 17, 7886\u20137892 (2018).","journal-title":"Mol. Med. Rep."},{"key":"3181_CR35","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.3748\/wjg.v19.i11.1736","volume":"19","author":"XL Pang","year":"2013","unstructured":"Pang, X. L., He, G., Liu, Y. B., Wang, Y. & Zhang, B. Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation. World J. Gastroenterol. 19, 1736\u20131748 (2013).","journal-title":"World J. Gastroenterol."},{"key":"3181_CR36","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1093\/molehr\/gax057","volume":"23","author":"S Park","year":"2017","unstructured":"Park, S., Lim, W., Bazer, F. W. & Song, G. Naringenin induces mitochondria-mediated apoptosis and endoplasmic reticulum stress by regulating Mapk and Akt signal transduction pathways in endometriosis cells. Mol. Hum. Reprod. 23, 842\u2013854 (2017).","journal-title":"Mol. Hum. Reprod."},{"key":"3181_CR37","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","volume":"13","author":"C Hetz","year":"2012","unstructured":"Hetz, C. The unfolded protein response: Controlling cell fate decisions under Er stress and beyond. Nat. Rev. Mol. Cell Biol. 13, 89\u2013102 (2012).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"3181_CR38","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.cell.2012.07.018","volume":"150","author":"W Yang","year":"2012","unstructured":"Yang, W. et al. Pkm2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150, 685\u2013696 (2012).","journal-title":"Cell"}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03181-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03181-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03181-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:47:51Z","timestamp":1730296071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03181-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,6]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["3181"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03181-9","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"type":"print","value":"0031-3998"},{"type":"electronic","value":"1530-0447"}],"subject":[],"published":{"date-parts":[[2024,5,6]]},"assertion":[{"value":"8 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All the patients have signed the informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of the patient consent"}}]}}