{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T21:37:17Z","timestamp":1769981837017,"version":"3.49.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1038\/s41390-024-03253-w","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T18:02:39Z","timestamp":1717178559000},"page":"1590-1596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eltrombopag combined with immunosuppressive therapy for pediatric severe aplastic anemia"],"prefix":"10.1038","volume":"97","author":[{"given":"Bixi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiafeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"3253_CR1","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1056\/NEJMra1413485","volume":"379","author":"NS Young","year":"2018","unstructured":"Young, N. S. Aplastic anemia. N. Engl. J. Med. 379, 1643\u201356 (2018).","journal-title":"N. Engl. J. Med."},{"key":"3253_CR2","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3324\/haematol.12020","volume":"93","author":"E Montane","year":"2008","unstructured":"Montane, E. et al. Epidemiology of aplastic anemia: a prospective multicenter study. Haematologica 93, 518\u201323 (2008).","journal-title":"Haematologica"},{"key":"3253_CR3","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.pcl.2013.08.011","volume":"60","author":"HD Hartung","year":"2013","unstructured":"Hartung, H. D., Olson, T. S. & Bessler, M. Acquired aplastic anemia in children. Pediatr. Clin. North Am. 60, 1311\u201336 (2013).","journal-title":"Pediatr. Clin. North Am."},{"key":"3253_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-017-0511-z","volume":"18","author":"SA Peslak","year":"2017","unstructured":"Peslak, S. A., Olson, T. & Babushok, D. V. Diagnosis and treatment of aplastic anemia[J]. Curr. Treat. Options Oncol. 18, 70 (2017).","journal-title":"Curr. Treat. Options Oncol."},{"key":"3253_CR5","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.jpeds.2008.06.004","volume":"153","author":"P Scheinberg","year":"2008","unstructured":"Scheinberg, P., Wu, C. O., Nunez, O. & Young, N. S. Long-term outcome of pediatric patients with severe aplastic anemia treated with antithymocyte globulin and cyclosporine. [J]. J. Pediatr. 153, 814\u20139 (2008).","journal-title":"J. Pediatr."},{"key":"3253_CR6","doi-asserted-by":"crossref","unstructured":"Rogers, Z. R. et al. Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study[J]. Haematologica 104, 1974\u201383 (2019).","DOI":"10.3324\/haematol.2018.206540"},{"key":"3253_CR7","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.3324\/haematol.2014.109355","volume":"99","author":"N Yoshida","year":"2014","unstructured":"Yoshida, N. et al. First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus immunosuppressive therapy. [J]. Haematologica 99, 1784\u201391 (2014).","journal-title":"Haematologica"},{"key":"3253_CR8","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.3324\/haematol.2014.106096","volume":"99","author":"Carlo","year":"2014","unstructured":"Carlo et al. Outcome of aplastic anemia in adolescence: a survey of the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation. [J]. Haematologica 99, 1574\u201381 (2014).","journal-title":"Haematologica"},{"key":"3253_CR9","doi-asserted-by":"crossref","unstructured":"Garanito, M. P., Carneiro, J. D. A., Filho, V.O. & Scheinberg, P. Outcome of children with severe acquired aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine A, [J]. Jornal de pediatria 90, 523-7 (2014).","DOI":"10.1016\/j.jped.2014.02.004"},{"key":"3253_CR10","doi-asserted-by":"crossref","unstructured":"Dufour, C. et al. Outcome of aplastic anaemia in children. A study by the severe aplastic anaemia and paediatric disease working parties of the European group blood and bone marrow transplant. [J]. Br. J. Haematol 169, 565\u201373 (2015).","DOI":"10.1111\/bjh.13297"},{"key":"3253_CR11","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1056\/NEJMoa1613878","volume":"376","author":"DM Townsley","year":"2017","unstructured":"Townsley, D. M. et al. Eltrombopag added to standard immunosuppression for aplastic anemia[J]. N. Engl. J. Med. 376, 1540\u201350 (2017).","journal-title":"N. Engl. J. Med."},{"key":"3253_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1200931","volume":"367","author":"MJ Olnes","year":"2012","unstructured":"Olnes, M. J. et al. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N. Engl. J. Med. 367, 11\u20139 (2012).","journal-title":"N. Engl. J. Med."},{"key":"3253_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa2109965","volume":"386","author":"R Peffault de Latour","year":"2022","unstructured":"Peffault de Latour, R. et al. Eltrombopag added to immunosuppression in severe aplastic anemia. N. Engl. J. Med. 386, 11\u201323 (2022).","journal-title":"N. Engl. J. Med."},{"key":"3253_CR14","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/bjh.17232","volume":"192","author":"EM Groarke","year":"2021","unstructured":"Groarke, E. M. et al. Eltrombopag added to immunosuppression for children with treatment naive severe aplastic anaemia[J]. Br. J. Haematol. 192, 605\u201314 (2021).","journal-title":"Br. J. Haematol."},{"key":"3253_CR15","doi-asserted-by":"publisher","first-page":"e29066","DOI":"10.1002\/pbc.29066","volume":"68","author":"L Harry","year":"2021","unstructured":"Harry, L. et al. Eltrombopag in children with severe aplastic anemia. Pediatr. Blood Cancer 68, e29066 (2021).","journal-title":"Pediatr. Blood Cancer"},{"key":"3253_CR16","doi-asserted-by":"crossref","unstructured":"Olga, G. et al. Efficacy of combined immunosuppression with or without eltrombopag in children with newly diagnosed aplastic anemia. Blood advances 7, 953\u201362 (2023).","DOI":"10.1182\/bloodadvances.2021006716"},{"key":"3253_CR17","unstructured":"Subspecialty Group of Hematology, Society of Pediatrics, Chinese Medical Association The Editorial Board, Chinese Journal of Pediatrics. Recommendations for diagnosis and treatment of acquired aplastic anemia in children. Zhonghua Er Ke Za Zhi. 52,103-106 (2014)."},{"key":"3253_CR18","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1634\/stemcells.2008-0366","volume":"27","author":"C Erickson-Miller","year":"2009","unstructured":"Erickson-Miller, C. et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist[J]. Stem Cells 27, 424\u201330 (2009).","journal-title":"Stem Cells"},{"key":"3253_CR19","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.1111\/bjh.16766","volume":"190","author":"M Filippidou","year":"2020","unstructured":"Filippidou, M. et al. Longitudinal evaluation of eltrombopag in paediatric acquired severe aplastic anaemia. Br. J. Haematol. 190, e157\u2013e173 (2020).","journal-title":"Br. J. Haematol."},{"key":"3253_CR20","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1182\/bloodadvances.2017010660","volume":"2","author":"TO Kim","year":"2018","unstructured":"Kim, T. O. et al. Eltrombopag for use in children with immunethrombocytopenia. Blood Adv. 2, 454\u201361 (2018).","journal-title":"Blood Adv."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03253-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03253-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03253-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T10:26:18Z","timestamp":1748427978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03253-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3253"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03253-w","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]},"assertion":[{"value":"19 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of Beijing Children\u2019s Hospital affiliated to Capital Medical University (approval number: 2019-k-276), and all the guardians of the subjects were informed","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}