{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:11:33Z","timestamp":1740136293360,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1038\/s41390-024-03305-1","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T10:01:27Z","timestamp":1717840887000},"page":"280-285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dyspnea in young subjects with congenital central hypoventilation syndrome"],"prefix":"10.1038","volume":"97","author":[{"given":"Plamen","family":"Bokov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Dudoignon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigue","family":"Fikiri Bavurhe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Couque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Matrot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-0812","authenticated-orcid":false,"given":"Christophe","family":"Delclaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"3305_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01460-2","volume":"15","author":"H Trang","year":"2020","unstructured":"Trang, H. et al. Guidelines for diagnosis and management of congenital central hypoventilation syndrome. Orphanet J. Rare Dis. 15, 252 (2020).","journal-title":"Orphanet J. Rare Dis."},{"key":"3305_CR2","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1164\/ajrccm\/140.2.368","volume":"140","author":"JY Paton","year":"1989","unstructured":"Paton, J. Y., Swaminathan, S., Sargent, C. W. & Keens, T. G. Hypoxic and hypercapnic ventilatory responses in awake children with congenital central hypoventilation syndrome. Am. Rev. Respir. Dis. 140, 368\u2013372 (1989).","journal-title":"Am. Rev. Respir. Dis."},{"key":"3305_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0034-5687(93)90006-V","volume":"93","author":"SA Shea","year":"1993","unstructured":"Shea, S. A., Andres, L. P., Shannon, D. C., Guz, A. & Banzett, R. B. Respiratory sensations in subjects who lack a ventilatory response to CO2. Respir. Physiol. 93, 203\u2013219 (1993).","journal-title":"Respir. Physiol."},{"key":"3305_CR4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0034-5687(98)00073-5","volume":"114","author":"CM Spengler","year":"1998","unstructured":"Spengler, C. M., Banzett, R. B., Systrom, D. M., Shannon, D. C. & Shea, S. A. Respiratory sensations during heavy exercise in subjects without respiratory chemosensitivity. Respir. Physiol. 114, 65\u201374 (1998).","journal-title":"Respir. Physiol."},{"key":"3305_CR5","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1002\/ppul.25940","volume":"57","author":"RN Ghosh","year":"2022","unstructured":"Ghosh, R. N. et al. Impaired ventilation during 6-min walk test in congenital central hypoventilation syndrome. Pediatr. Pulmonol. 57, 1660\u20131667 (2022).","journal-title":"Pediatr. Pulmonol."},{"key":"3305_CR6","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1152\/japplphysiol.01310.2013","volume":"116","author":"MS Carroll","year":"2014","unstructured":"Carroll, M. S. et al. Residual chemosensitivity to ventilatory challenges in genotyped congenital central hypoventilation syndrome. J. Appl Physiol. 116, 439\u2013450 (2014).","journal-title":"J. Appl Physiol."},{"key":"3305_CR7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1152\/japplphysiol.00182.2023","volume":"135","author":"P Bokov","year":"2023","unstructured":"Bokov, P. et al. Central CO2 chemosensitivity and CO2 controller gain independently contribute to daytime Pco2 in young subjects with congenital central hypoventilation syndrome. J. Appl Physiol. 135, 343\u2013351 (2023).","journal-title":"J. Appl Physiol."},{"key":"3305_CR8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1113\/jphysiol.1993.sp019849","volume":"470","author":"SC Gandevia","year":"1993","unstructured":"Gandevia, S. C. et al. Respiratory sensations, cardiovascular control, kinaesthesia and transcranial stimulation during paralysis in humans. J. Physiol. 470, 85\u2013107 (1993).","journal-title":"J. Physiol."},{"key":"3305_CR9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2170\/jjphysiol.48.291","volume":"48","author":"T Chonan","year":"1998","unstructured":"Chonan, T. et al. Influence of sustained hypoxia on the sensation of dyspnea. Jpn J. Physiol. 48, 291\u2013295 (1998).","journal-title":"Jpn J. Physiol."},{"key":"3305_CR10","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1152\/japplphysiol.00010.2018","volume":"125","author":"P Bokov","year":"2018","unstructured":"Bokov, P., Matrot, B., Gallego, J. & Delclaux, C. Comparison of methods of chemical loop gain measurement during tidal ventilation in awake healthy subjects. J. Appl Physiol. 125, 1681\u20131692 (2018).","journal-title":"J. Appl Physiol."},{"key":"3305_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","volume":"166","author":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories.","year":"2002","unstructured":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. ATS statement: guidelines for the six-minute walk test. Am. J. Respir. Crit. Care Med 166, 111\u2013117 (2002).","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"3305_CR12","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.jpeds.2006.12.052","volume":"150","author":"R Geiger","year":"2007","unstructured":"Geiger, R. et al. Six-minute walk test in children and adolescents. J. Pediatr. 150, 395\u20139, 399.e1-2 (2007).","journal-title":"J. Pediatr."},{"key":"3305_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1217391","volume":"14","author":"P Bokov","year":"2023","unstructured":"Bokov, P. et al. A decrease in plant gain, namely CO2 stores, characterizes dysfunctional breathing whatever its subtype in children. Front Physiol. 14, 1217391 (2023).","journal-title":"Front Physiol."},{"key":"3305_CR14","first-page":"628","volume":"56","author":"DM Cooper","year":"1984","unstructured":"Cooper, D. M., Weiler-Ravell, D., Whipp, B. J. & Wasserman, K. Aerobic parameters of exercise as a function of body size during growth in children. J. Appl Physiol. Respir. Environ. Exerc Physiol. 56, 628\u2013634 (1984).","journal-title":"J. Appl Physiol. Respir. Environ. Exerc Physiol."},{"key":"3305_CR15","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1164\/rccm.201111-2042ST","volume":"185","author":"MB Parshall","year":"2012","unstructured":"Parshall, M. B. et al. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. Am. J. Respir. Crit. Care Med 185, 435\u2013452 (2012).","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"3305_CR16","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1002\/cphy.c200001","volume":"11","author":"RB Banzett","year":"2021","unstructured":"Banzett, R. B., Lansing, R. W. & Binks, A. P. Air Hunger: A Primal Sensation and a Primary Element of Dyspnea. Compr. Physiol. 11, 1449\u20131483 (2021).","journal-title":"Compr. Physiol."},{"key":"3305_CR17","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/s41390-022-02215-4","volume":"93","author":"B Dudoignon","year":"2023","unstructured":"Dudoignon, B. et al. Heart rate variability in congenital central hypoventilation syndrome: relationships with hypertension and sinus pauses. Pediatr. Res 93, 1003\u20131009 (2023).","journal-title":"Pediatr. Res"},{"key":"3305_CR18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.autneu.2015.04.001","volume":"190","author":"M Botek","year":"2015","unstructured":"Botek, M., Krej\u010d\u00ed, J., De Smet, S., G\u00e1ba, A. & McKune, A. J. Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia. Auton. Neurosci. 190, 40\u201345 (2015).","journal-title":"Auton. Neurosci."},{"key":"3305_CR19","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2023.2238923","volume":"45","author":"J Hou","year":"2023","unstructured":"Hou, J. et al. Comprehensive viewpoints on heart rate variability at high altitude. Clin. Exp. Hypertens. 45, 2238923 (2023).","journal-title":"Clin. Exp. Hypertens."},{"key":"3305_CR20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","volume":"1","author":"KJ Rothman","year":"1990","unstructured":"Rothman, K. J. No adjustments are needed for multiple comparisons. Epidemiology 1, 43\u201346 (1990).","journal-title":"Epidemiology"},{"key":"3305_CR21","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1161\/01.CIR.93.8.1520","volume":"93","author":"MS Lauer","year":"1996","unstructured":"Lauer, M. S., Okin, P. M., Larson, M. G., Evans, J. C. & Levy, D. Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation 93, 1520\u20131526 (1996).","journal-title":"Circulation"},{"key":"3305_CR22","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.biopsycho.2007.10.013","volume":"77","author":"L Wan","year":"2008","unstructured":"Wan, L. et al. Repeated experiences of air hunger and ventilatory behavior in response to hypercapnia in the standardized rebreathing test: effects of anxiety. Biol. Psychol. 77, 223\u2013232 (2008).","journal-title":"Biol. Psychol."},{"key":"3305_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0034-5687(95)00050-X","volume":"103","author":"RB Banzett","year":"1996","unstructured":"Banzett, R. B., Lansing, R. W., Evans, K. C. & Shea, S. A. Stimulus-response characteristics of CO2-induced air hunger in normal subjects. Respir. Physiol. 103, 19\u201331 (1996).","journal-title":"Respir. Physiol."},{"key":"3305_CR24","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1152\/japplphysiol.00594.2002","volume":"94","author":"SH Moosavi","year":"2003","unstructured":"Moosavi, S. H. et al. Hypoxic and hypercapnic drives to breathe generate equivalent levels of air hunger in humans. J. Appl Physiol. 94, 141\u2013154 (2003).","journal-title":"J. Appl Physiol."},{"key":"3305_CR25","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1113\/jphysiol.1993.sp019792","volume":"468","author":"SA Shea","year":"1993","unstructured":"Shea, S. A., Andres, L. P., Shannon, D. C. & Banzett, R. B. Ventilatory responses to exercise in humans lacking ventilatory chemosensitivity. J. Physiol. 468, 623\u2013640 (1993).","journal-title":"J. Physiol."},{"key":"3305_CR26","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1183\/09031936.00194909","volume":"37","author":"C Casanova","year":"2011","unstructured":"Casanova, C. et al. The 6-min walk distance in healthy subjects: reference standards from seven countries. Eur. Respir. J. 37, 150\u2013156 (2011).","journal-title":"Eur. Respir. J."},{"key":"3305_CR27","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1007\/s00421-020-04479-2","volume":"120","author":"J Zhang","year":"2020","unstructured":"Zhang, J. et al. A multidimensional assessment of dyspnoea in healthy adults during exercise. Eur. J. Appl Physiol. 120, 2533\u20132545 (2020).","journal-title":"Eur. J. Appl Physiol."},{"key":"3305_CR28","doi-asserted-by":"publisher","first-page":"e1000588","DOI":"10.1371\/journal.pcbi.1000588","volume":"5","author":"SA Sands","year":"2009","unstructured":"Sands, S. A. et al. A model analysis of arterial oxygen desaturation during apnea in preterm infants. PLoS Comput Biol. 5, e1000588 (2009).","journal-title":"PLoS Comput Biol."},{"key":"3305_CR29","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1164\/ajrccm.162.4.9912028","volume":"162","author":"L Grote","year":"2000","unstructured":"Grote, L., Kraiczi, H. & Hedner, J. Reduced alpha- and beta(2)-adrenergic vascular response in patients with obstructive sleep apnea. Am. J. Respir. Crit. Care Med 162, 1480\u20131487 (2000).","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"3305_CR30","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1097\/HJH.0000000000003475","volume":"41","author":"B Dudoignon","year":"2023","unstructured":"Dudoignon, B. et al. Neurogenic hypertension characterizes children with congenital central hypoventilation syndrome and is aggravated by alveolar hypoventilation during sleep. J. Hypertens. 41, 1339\u20131346 (2023).","journal-title":"J. Hypertens."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03305-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03305-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03305-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T11:07:26Z","timestamp":1738753646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03305-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,8]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3305"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03305-1","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"type":"print","value":"0031-3998"},{"type":"electronic","value":"1530-0447"}],"subject":[],"published":{"date-parts":[[2024,6,8]]},"assertion":[{"value":"1 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Patient consent was not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}}]}}