{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:38:32Z","timestamp":1787002712885,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1038\/s41390-024-03308-y","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T13:01:58Z","timestamp":1721048518000},"page":"827-834","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of diastolic blood pressure with coronary perfusion pressure during resuscitation in pediatric swine"],"prefix":"10.1038","volume":"97","author":[{"given":"Jill L.","family":"Sorcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polan T.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kulikowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjay","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald H.","family":"Shaffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"3308_CR1","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1161\/CIRCULATIONAHA.119.041667","volume":"140","author":"MJ Holmberg","year":"2019","unstructured":"Holmberg, M. J. et al. Trends in survival after pediatric in-hospital cardiac arrest in the United States. Circulation 140, 1398\u20131408 (2019).","journal-title":"Circulation"},{"key":"3308_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/0300-9572(88)90111-6","volume":"16","author":"KB Kern","year":"1988","unstructured":"Kern, K. B., Ewy, G. A., Voorhees, W. D., Babbs, C. F. & Tacker, W. A. Myocardial perfusion pressure: a predictor of 24-hour survival during prolonged cardiac arrest in dogs. Resuscitation 16, 241\u2013250 (1988).","journal-title":"Resuscitation"},{"key":"3308_CR3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0196-0644(84)80566-1","volume":"13","author":"SH Ralston","year":"1984","unstructured":"Ralston, S. H., Voorhees, W. D. & Babbs, C. F. Intrapulmonary epinephrine during prolonged cardiopulmonary resuscitation: improved regional blood flow and resuscitation in dogs. Ann. Emerg. Med. 13, 79\u201386 (1984).","journal-title":"Ann. Emerg. Med."},{"key":"3308_CR4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ajem.2009.10.006","volume":"28","author":"HR Halperin","year":"2010","unstructured":"Halperin, H. R. et al. Outcomes from low versus high-flow cardiopulmonary resuscitation in a swine model of cardiac arrest. Am. J. Emerg. Med. 28, 195\u2013202 (2010).","journal-title":"Am. J. Emerg. Med."},{"key":"3308_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s10558-009-9079-y","volume":"9","author":"MP Otlewski","year":"2009","unstructured":"Otlewski, M. P., Geddes, L. A., Pargett, M. & Babbs, C. F. Methods for calculating coronary perfusion pressure during CPR. Cardiovasc. Eng. 9, 98\u2013103 (2009).","journal-title":"Cardiovasc. Eng."},{"key":"3308_CR6","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1097\/00003246-198410000-00007","volume":"12","author":"AB Sanders","year":"1984","unstructured":"Sanders, A. B., Ewy, G. A. & Taft, T. V. Prognostic and therapeutic importance of the aortic diastolic pressure in resuscitation from cardiac arrest. Crit. Care Med. 12, 871\u2013873 (1984).","journal-title":"Crit. Care Med."},{"key":"3308_CR7","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1001\/jama.1990.03440080084029","volume":"263","author":"NA Paradis","year":"1990","unstructured":"Paradis, N. A. et al. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation. JAMA 263, 1106\u20131113 (1990).","journal-title":"JAMA"},{"key":"3308_CR8","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3109\/10903120903349796","volume":"14","author":"JC Reynolds","year":"2010","unstructured":"Reynolds, J. C., Salcido, D. D. & Menegazzi, J. J. Coronary perfusion pressure and return of spontaneous circulation after prolonged cardiac arrest. Prehosp. Emerg. Care 14, 78\u201384 (2010).","journal-title":"Prehosp. Emerg. Care"},{"key":"3308_CR9","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1542\/peds.2006-1724","volume":"118","author":"PA Meaney","year":"2006","unstructured":"Meaney, P. A. et al. Higher survival rates among younger patients after pediatric intensive care unit cardiac arrests. Pediatrics 118, 2424\u20132433 (2006).","journal-title":"Pediatrics"},{"key":"3308_CR10","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0196-0644(85)80774-5","volume":"14","author":"JT Niemann","year":"1985","unstructured":"Niemann, J. T., Criley, J. M., Rosborough, J. P., Niskanen, R. A. & Alferness, C. Predictive indices of successful cardiac resuscitation after prolonged arrest and experimental cardiopulmonary resuscitation. Ann. Emerg. Med. 14, 521\u2013528 (1985).","journal-title":"Ann. Emerg. Med."},{"key":"3308_CR11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.resuscitation.2019.07.030","volume":"143","author":"CE O\u2019Brien","year":"2019","unstructured":"O\u2019Brien, C. E. et al. Association of diastolic blood pressure with survival during paediatric cardiopulmonary resuscitation. Resuscitation 143, 50\u201356 (2019).","journal-title":"Resuscitation"},{"key":"3308_CR12","doi-asserted-by":"publisher","first-page":"e575","DOI":"10.1097\/PCC.0000000000001299","volume":"18","author":"JT Hamrick","year":"2017","unstructured":"Hamrick, J. T. et al. End-tidal CO2-guided chest compression delivery improves survival in a neonatal asphyxial cardiac arrest model. Pediatr. Crit. Care Med. 18, e575\u2013e584 (2017).","journal-title":"Pediatr. Crit. Care Med."},{"key":"3308_CR13","doi-asserted-by":"publisher","first-page":"e352","DOI":"10.1097\/PCC.0000000000001968","volume":"20","author":"JL Hamrick","year":"2019","unstructured":"Hamrick, J. L. et al. The effect of asphyxia arrest duration on a pediatric end-tidal CO2-guided chest compression delivery model. Pediatr. Crit. Care Med. 20, e352\u2013e361 (2019).","journal-title":"Pediatr. Crit. Care Med."},{"key":"3308_CR14","doi-asserted-by":"publisher","first-page":"100174","DOI":"10.1016\/j.resplu.2021.100174","volume":"8","author":"CE O\u2019Brien","year":"2021","unstructured":"O\u2019Brien, C. E. et al. Use of an end-tidal carbon dioxide-guided algorithm during cardiopulmonary resuscitation improves short-term survival in paediatric swine. Resuscitation 8, 100174 (2021).","journal-title":"Resuscitation"},{"key":"3308_CR15","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.resuscitation.2008.12.014","volume":"80","author":"A Neurauter","year":"2009","unstructured":"Neurauter, A. et al. Comparison of mechanical characteristics of the human and porcine chest during cardiopulmonary resuscitation. Resuscitation 80, 463\u2013469 (2009).","journal-title":"Resuscitation"},{"key":"3308_CR16","doi-asserted-by":"publisher","first-page":"e002122","DOI":"10.1161\/JAHA.115.002122","volume":"4","author":"N Jayaram","year":"2015","unstructured":"Jayaram, N., McNally, B., Tang, F. & Chan, P. S. Survival after out-of-hospital cardiac arrest in children. J. Am. Heart Assoc. 4, e002122 (2015).","journal-title":"J. Am. Heart Assoc."},{"key":"3308_CR17","doi-asserted-by":"publisher","first-page":"S469","DOI":"10.1161\/CIR.0000000000000901","volume":"142","author":"AA Topjian","year":"2020","unstructured":"Topjian, A. A. et al. Part 4: Pediatric basic and advanced life support: 2020 American Heart Association Guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 142, S469\u2013S523 (2020).","journal-title":"Circulation"},{"key":"3308_CR18","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/pan.13820","volume":"20","author":"FM Lapid","year":"2020","unstructured":"Lapid, F. M. et al. The use of pressure-controlled mechanical ventilation in a swine model of intraoperative pediatric cardiac arrest. Paediatr. Anaesth. 20, 462\u2013468 (2020).","journal-title":"Paediatr. Anaesth."},{"key":"3308_CR19","doi-asserted-by":"publisher","first-page":"S519","DOI":"10.1161\/CIR.0000000000000265","volume":"132","author":"DL Atkins","year":"2015","unstructured":"Atkins, D. L. et al. Part 11: Pediatric basic life support and cardiopulmonary resuscitation quality: 2015 American Heart Association Guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 132, S519\u2013S525 (2015).","journal-title":"Circulation"},{"key":"3308_CR20","doi-asserted-by":"publisher","first-page":"e009860","DOI":"10.1161\/JAHA.118.009860","volume":"7","author":"EA Hunt","year":"2018","unstructured":"Hunt, E. A. et al. Improved cardiopulmonary resuscitation performance with CODE ACES(2): a resuscitation quality bundle. J. Am. Heart Assoc. 7, e009860 (2018).","journal-title":"J. Am. Heart Assoc."},{"key":"3308_CR21","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1002\/sim.4509","volume":"31","author":"X Liu","year":"2012","unstructured":"Liu, X. Classification accuracy and cut point selection. Stat. Med. 31, 2676\u20132686 (2012).","journal-title":"Stat. Med."},{"key":"3308_CR22","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1152\/jappl.1988.65.6.2641","volume":"65","author":"I von Planta","year":"1988","unstructured":"von Planta, I. et al. Cardiopulmonary resuscitation in the rat. J. Appl Physiol. 65, 2641\u20132647 (1988).","journal-title":"J. Appl Physiol."},{"key":"3308_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.resuscitation.2016.11.018","volume":"111","author":"RW Morgan","year":"2017","unstructured":"Morgan, R. W. et al. A hemodynamic-directed approach to pediatric cardiopulmonary resuscitation (HD-CPR) improves survival. Resuscitation 111, 41\u201347 (2017).","journal-title":"Resuscitation"},{"key":"3308_CR24","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1164\/rccm.201407-1343OC","volume":"190","author":"RM Sutton","year":"2014","unstructured":"Sutton, R. M. et al. Patient-centric blood pressure-targeted cardiopulmonary resuscitation improves survival from cardiac arrest. Am. J. Respir. Crit. Care Med. 190, 1255\u20131262 (2014).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"3308_CR25","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.resuscitation.2012.10.023","volume":"84","author":"RM Sutton","year":"2013","unstructured":"Sutton, R. M. et al. Hemodynamic directed CPR improves short-term survival from asphyxia-associated cardiac arrest. Resuscitation 84, 696\u2013701 (2013).","journal-title":"Resuscitation"},{"key":"3308_CR26","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1097\/CCM.0b013e31828cf0c0","volume":"41","author":"RA Berg","year":"2013","unstructured":"Berg, R. A. et al. Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing. Crit. Care Med. 41, 2292\u20132297 (2013).","journal-title":"Crit. Care Med."},{"issue":"Suppl 2","key":"3308_CR27","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1016\/S0300-9572(11)70147-2","volume":"82","author":"DE Niles","year":"2011","unstructured":"Niles, D. E. et al. Prevalence and hemodynamic effects of leaning during CPR. Resuscitation 82(Suppl 2), S23\u2013S26 (2011).","journal-title":"Resuscitation"},{"key":"3308_CR28","doi-asserted-by":"publisher","first-page":"109716","DOI":"10.1016\/j.resuscitation.2023.109716","volume":"185","author":"C Balzer","year":"2023","unstructured":"Balzer, C., Eagle, S. S., Yannopoulos, D., Aufderheide, T. P. & Riess, M. L. High central venous pressure amplitude predicts successful defibrillation in a porcine model of cardiac arrest. Resuscitation 185, 109716 (2023).","journal-title":"Resuscitation"},{"key":"3308_CR29","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.resuscitation.2016.04.004","volume":"104","author":"RW Morgan","year":"2016","unstructured":"Morgan, R. W. et al. A quantitative comparison of physiologic indicators of cardiopulmonary resuscitation quality: diastolic blood pressure versus end-tidal carbon dioxide. Resuscitation 104, 6\u201311 (2016).","journal-title":"Resuscitation"},{"key":"3308_CR30","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1161\/CIRCULATIONAHA.117.032270","volume":"137","author":"RA Berg","year":"2018","unstructured":"Berg, R. A. et al. Association between diastolic blood pressure during pediatric in-hospital cardiopulmonary resuscitation and survival. Circulation 137, 1784\u20131795 (2018).","journal-title":"Circulation"},{"key":"3308_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04399-5","volume":"27","author":"RW Morgan","year":"2023","unstructured":"Morgan, R. W. et al. The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes. Crit. Care 27, 105 (2023).","journal-title":"Crit. Care"},{"key":"3308_CR32","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1161\/CIR.0b013e31829d8654","volume":"128","author":"PA Meaney","year":"2013","unstructured":"Meaney, P. A. et al. Cardiopulmonary resuscitation quality: [corrected] improving cardiac resuscitation outcomes both inside and outside the hospital: a consensus statement from the American Heart Association. Circulation 128, 417\u2013435 (2013).","journal-title":"Circulation"},{"key":"3308_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/cc4852","volume":"10","author":"MA Mignini","year":"2006","unstructured":"Mignini, M. A., Piacentini, E. & Dubin, A. Peripheral arterial blood pressure monitoring adequately tracks central arterial blood pressure in critically ill patients: an observational study. Crit. Care 10, R43 (2006).","journal-title":"Crit. Care"},{"key":"3308_CR34","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1161\/01.RES.3.6.623","volume":"3","author":"EJ Kroeker","year":"1955","unstructured":"Kroeker, E. J. & Wood, E. H. Comparison of simultaneously recorded central and peripheral arterial pressure pulses during rest, exercise and tilted position in man. Circ. Res. 3, 623\u2013632 (1955).","journal-title":"Circ. Res."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03308-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03308-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03308-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:00:03Z","timestamp":1745305203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03308-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["3308"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03308-y","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]},"assertion":[{"value":"1 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}