{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:28:39Z","timestamp":1781760519539,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1038\/s41390-024-03475-y","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T18:01:56Z","timestamp":1723917716000},"page":"1732-1741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of standard and global hemostasis assays in cord and peripheral blood of newborns"],"prefix":"10.1038","volume":"97","author":[{"given":"Belinda V.","family":"Arutunyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina M.","family":"Koltsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita A.","family":"Shpilyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena N.","family":"Lipets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila A.","family":"Timofeeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Karavaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina N.","family":"Balashova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubov V.","family":"Krechetova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazoil I.","family":"Ataullakhanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor V.","family":"Zubkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry N.","family":"Degtyarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennady T.","family":"Sukhikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana K.","family":"Tetruashvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna N.","family":"Balandina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"3475_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1160\/TH05-01-0047","volume":"95","author":"P Monagle","year":"2006","unstructured":"Monagle, P. et al. Developmental haemostasis. Thromb. Haemost. 95, 362\u2013372 (2006).","journal-title":"Thromb. Haemost."},{"key":"3475_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1182\/blood.V70.1.165.165","volume":"70","author":"M Andrew","year":"1987","unstructured":"Andrew, M. et al. Development of the human coagulation system in the full-term infant. Blood 70, 165\u2013172 (1987).","journal-title":"Blood"},{"key":"3475_CR3","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1182\/blood.V72.5.1651.1651","volume":"72","author":"M Andrew","year":"1988","unstructured":"Andrew, M. et al. Development of the human coagulation system in the healthy premature infant. Blood 72, 1651\u20131657 (1988).","journal-title":"Blood"},{"key":"3475_CR4","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.siny.2011.07.007","volume":"16","author":"P Monagle","year":"2011","unstructured":"Monagle, P. & Massicotte, P. Developmental haemostasis: Secondary haemostasis. Semin. Fetal Neonatal. Med. 16, 294\u2013300 (2011).","journal-title":"Semin. Fetal Neonatal. Med."},{"key":"3475_CR5","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","volume":"80","author":"M Andrew","year":"1992","unstructured":"Andrew, M. et al. Maturation of the hemostatic system during childhood. Blood 80, 1998\u20132005 (1992).","journal-title":"Blood"},{"key":"3475_CR6","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1515\/jpme.1997.25.1.55","volume":"25","author":"DM Schneider","year":"1997","unstructured":"Schneider, D. M., von Tempelhoff, G. F., Herrle, B. & Heilmann, L. Maternal and cord blood hemostasis at delivery. J. Perinat. Med. 25, 55\u201361 (1997).","journal-title":"J. Perinat. Med."},{"key":"3475_CR7","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S0022-3476(71)80405-5","volume":"79","author":"WA Bleyer","year":"1971","unstructured":"Bleyer, W. A., Hakami, N. & Shepard, T. H. The development of hemostasis in the human fetus and newborn infant. J. Pediatr. 79, 838\u2013853 (1971).","journal-title":"J. Pediatr."},{"key":"3475_CR8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41390-018-0184-8","volume":"85","author":"EM Koltsova","year":"2019","unstructured":"Koltsova, E. M. et al. Impaired platelet activity and hypercoagulation in healthy term and moderately preterm newborns during the early neonatal period. Pediatr. Res. 85, 63\u201371 (2019).","journal-title":"Pediatr. Res."},{"key":"3475_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/00001721-199401000-00002","volume":"5","author":"MA Blajchman","year":"1994","unstructured":"Blajchman, M. A. An overview of the mechanism of action of antithrombin and its inherited deficiency states. Blood Coagul. Fibrinolysis 5, 5\u201312 (1994).","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"3475_CR10","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/ijlh.13932","volume":"44","author":"G Mitsiakos","year":"2022","unstructured":"Mitsiakos, G. et al. Neonatal haemostatic parameters in correlation to gestational age and birth weight. Int. J. Lab. Hematol. 44, 952\u2013958 (2022).","journal-title":"Int. J. Lab. Hematol."},{"key":"3475_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s11239-007-0046-4","volume":"24","author":"G Lippi","year":"2007","unstructured":"Lippi, G. et al. Routine coagulation tests in newborn and young infants. J. Thromb. Thrombolysis 24, 153\u2013155 (2007).","journal-title":"J. Thromb. Thrombolysis"},{"key":"3475_CR12","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/00001721-200302000-00002","volume":"14","author":"SP Tay","year":"2003","unstructured":"Tay, S. P., Cheong, S. K. & Boo, N. Y. Circulating tissue factor, tissue factor pathway inhibitor and D-dimer in umbilical cord blood of normal term neonates and adult plasma. Blood Coagul. Fibrinolysis 14, 125\u2013129 (2003).","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"3475_CR13","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1055\/s-2007-996039","volume":"24","author":"R Kn\u00f6fler","year":"1998","unstructured":"Kn\u00f6fler, R. et al. Molecular Markers of the Endothelium, the Coagulation and the Fibrinolytic Systems in Healthy Newborns. Semin Thromb. Hemost. 24, 453\u2013461 (1998).","journal-title":"Semin Thromb. Hemost."},{"key":"3475_CR14","doi-asserted-by":"publisher","first-page":"103493","DOI":"10.1016\/j.transci.2022.103493","volume":"61","author":"Z\u0130 Khalilov","year":"2022","unstructured":"Khalilov, Z. \u0130., \u00dcnsal, A. & Altunta\u015f, N. The D-dimer reference intervals in healty term newborns. Transfus. Apher. Sci. 61, 103493 (2022).","journal-title":"Transfus. Apher. Sci."},{"key":"3475_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/adc.65.4_Spec_No.383","volume":"65","author":"IR Hudson","year":"1990","unstructured":"Hudson, I. R. et al. Increased concentrations of D-dimers in newborn infants. Arch. Dis. Child 65, 383\u2013384 (1990).","journal-title":"Arch. Dis. Child"},{"key":"3475_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1651-2227.1997.tb08839.x","volume":"86","author":"Y Nako","year":"1997","unstructured":"Nako, Y., Tomomasa, T. & Morikawa, A. Plasma thrombomodulin level in newborn infants with and without perinatal asphyxia. Acta Paediatr. 86, 91\u201395 (1997).","journal-title":"Acta Paediatr."},{"key":"3475_CR17","first-page":"184","volume":"92","author":"A Murtha","year":"1998","unstructured":"Murtha, A. Umbilical venous d-dimer concentrations with and without labor. Obstet. Gynecol. 92, 184\u2013186 (1998).","journal-title":"Obstet. Gynecol."},{"key":"3475_CR18","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1007\/s00431-021-04154-4","volume":"180","author":"G\u039d Katsaras","year":"2021","unstructured":"Katsaras, G. \u039d et al. The use of thromboelastography (TEG) and rotational thromboelastometry (ROTEM) in neonates: a systematic review. Eur. J. Pediatr. 180, 3455\u20133470 (2021).","journal-title":"Eur. J. Pediatr."},{"key":"3475_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00431-021-04196-8","volume":"181","author":"CA Murphy","year":"2022","unstructured":"Murphy, C. A. et al. The role of the calibrated automated thrombogram in neonates: describing mechanisms of neonatal haemostasis and evaluating haemostatic drugs. Eur. J. Pediatr. 181, 23\u201333 (2022).","journal-title":"Eur. J. Pediatr."},{"key":"3475_CR20","doi-asserted-by":"publisher","first-page":"e87692","DOI":"10.1371\/journal.pone.0087692","volume":"9","author":"E Lipets","year":"2014","unstructured":"Lipets, E. et al. Circulating contact-pathway-activating microparticles together with factors IXa and XIa induce spontaneous clotting in plasma of hematology and cardiologic patients. PLoS One 9, e87692 (2014).","journal-title":"PLoS One"},{"key":"3475_CR21","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1111\/jth.13130","volume":"13","author":"E Neary","year":"2015","unstructured":"Neary, E. et al. Coagulation indices in very preterm infants from cord blood and postnatal samples. J. Throm Haemost. 13, 2021\u20132030 (2015).","journal-title":"J. Throm Haemost."},{"key":"3475_CR22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/archdischild-2019-317860","volume":"105","author":"G Raffaeli","year":"2020","unstructured":"Raffaeli, G. et al. Thromboelastographic profiles of healthy very low birthweight infants serially during their first month. Arch. Dis. Child Fetal Neonatal Ed. 105, 412\u2013418 (2020).","journal-title":"Arch. Dis. Child Fetal Neonatal Ed."},{"key":"3475_CR23","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1160\/TH09-05-0282","volume":"103","author":"T Strauss","year":"2010","unstructured":"Strauss, T. et al. Clot formation of neonates tested by thromboelastography correlates with gestational age. Thromb. Haemost. 103, 344\u2013350 (2010).","journal-title":"Thromb. Haemost."},{"key":"3475_CR24","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41390-020-01310-8","volume":"90","author":"M Wiegele","year":"2021","unstructured":"Wiegele, M. et al. Establishing reference ranges of cord blood: point-of-care hemostatic function assessment in preterm and term neonates. Pediatr. Res 90, 452\u2013458 (2021).","journal-title":"Pediatr. Res"},{"key":"3475_CR25","first-page":"261","volume":"60","author":"ST Nielsen","year":"2021","unstructured":"Nielsen, S. T. et al. Coagulation parameters in the newborn and infant \u2013 the Copenhagen Baby Heart and COMPARE studies. Clin. Chem. Lab. Med. 60, 261\u2013270 (2021).","journal-title":"Clin. Chem. Lab. Med."},{"key":"3475_CR26","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1111\/trf.15785","volume":"60","author":"G Raffaeli","year":"2020","unstructured":"Raffaeli, G. et al. Is placental blood a reliable source for the evaluation of neonatal hemostasis at birth? Transfusion 60, 1069\u20131077 (2020).","journal-title":"Transfusion"},{"key":"3475_CR27","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/ajh.23599","volume":"89","author":"D Whiting","year":"2014","unstructured":"Whiting, D. & DiNardo, J. A. TEG and ROTEM: Technology and clinical applications. Am. J. Hematol. 89, 228\u2013232 (2014).","journal-title":"Am. J. Hematol."},{"key":"3475_CR28","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1080\/09537104.2020.1823360","volume":"32","author":"EM Koltsova","year":"2021","unstructured":"Koltsova, E. M. et al. Determination of fibrin clot growth and spatial thrombin propagation in the presence of different types of phospholipid surfaces. Platelets 32, 1031\u20131037 (2021).","journal-title":"Platelets"},{"key":"3475_CR29","doi-asserted-by":"publisher","first-page":"e0199900","DOI":"10.1371\/journal.pone.0199900","volume":"13","author":"AN Balandina","year":"2018","unstructured":"Balandina, A. N. et al. Thrombodynamics-A new global hemostasis assay for heparin monitoring in patients under the anticoagulant treatment. PLoS One 13, e0199900 (2018).","journal-title":"PLoS One"},{"key":"3475_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0227932","volume":"15","author":"EN Lipets","year":"2020","unstructured":"Lipets, E. N. et al. Use of Thrombodynamics for revealing the participation of platelet, erythrocyte, endothelial, and monocyte microparticles in coagulation activation and propagation. PLoS One 15, 1\u201324 (2020).","journal-title":"PLoS One"},{"key":"3475_CR31","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1111\/j.1538-7836.2005.01128.x","volume":"3","author":"MV Ovanesov","year":"2005","unstructured":"Ovanesov, M. V., Ananyeva, N. M., Panteleev, M. A., Ataullakhanov, F. I. & Saenko, E. L. Initiation and propagation of coagulation from tissue factor-bearing cell monolayers to plasma: initiator cells do not regulate spatial growth rate. J. Thromb. Haemost. 3, 321\u2013331 (2005).","journal-title":"J. Thromb. Haemost."},{"key":"3475_CR32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1055\/s-0039-1692700","volume":"45","author":"RC Gosselin","year":"2019","unstructured":"Gosselin, R. C. & Marlar, R. A. Preanalytical Variables in Coagulation Testing: Setting the Stage for Accurate Results. Semin Thromb. Hemost. 45, 433\u2013448 (2019).","journal-title":"Semin Thromb. Hemost."},{"key":"3475_CR33","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.thromres.2013.12.014","volume":"133","author":"NM Dashkevich","year":"2014","unstructured":"Dashkevich, N. M. et al. Effect of pre-analytical conditions on the thrombodynamics assay. Thromb. Res. 133, 472\u2013476 (2014).","journal-title":"Thromb. Res."},{"key":"3475_CR34","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/MBC.0000000000000920","volume":"31","author":"OM Yis","year":"2020","unstructured":"Yis, O. M., Bugdayci, G., Pehlivan, M. B., Yildiz, R. N. & Alisik, M. Analytical performance evaluation of Sysmex CS-2500 and Stago STA Compact. Blood Coagul. Fibrinolysis 31, 324\u2013329 (2020).","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"3475_CR35","doi-asserted-by":"publisher","first-page":"107602962092909","DOI":"10.1177\/1076029620929092","volume":"26","author":"MA Achey","year":"2020","unstructured":"Achey, M. A. et al. The Developing Balance of Thrombosis and Hemorrhage in Pediatric Surgery: Clinical Implications of Age-Related Changes in Hemostasis. Clin. Appl Thromb. Hemost. 26, 107602962092909 (2020).","journal-title":"Clin. Appl Thromb. Hemost."},{"key":"3475_CR36","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/14767050801891135","volume":"21","author":"T Gursoy","year":"2008","unstructured":"Gursoy, T. et al. Thrombin activatable fibrinolysis inhibitor activity (TAFIa) levels in neonates with meconium-stained amniotic fluid. J. Matern Fetal Neonat. Med. 21, 123\u2013128 (2008).","journal-title":"J. Matern Fetal Neonat. Med."},{"key":"3475_CR37","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1097\/ALN.0000000000003165","volume":"132","author":"KA Nellenbach","year":"2020","unstructured":"Nellenbach, K. A. et al. Comparison of Neonatal and Adult Fibrin Clot Properties between Porcine and Human Plasma. Anesthesiology 132, 1091\u20131101 (2020).","journal-title":"Anesthesiology"},{"key":"3475_CR38","doi-asserted-by":"publisher","first-page":"139","DOI":"10.5492\/wjccm.v11.i3.139","volume":"11","author":"M Al-Biltagi","year":"2022","unstructured":"Al-Biltagi, M. et al. Plasma D-dimer level in early and late-onset neonatal sepsis. World J. Crit. Care Med 11, 139\u2013148 (2022).","journal-title":"World J. Crit. Care Med"},{"key":"3475_CR39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.thromres.2011.01.013","volume":"128","author":"S Schweintzger","year":"2011","unstructured":"Schweintzger, S. et al. Microparticles in newborn cord blood: Slight elevation after normal delivery. Thromb. Res. 128, 62\u201367 (2011).","journal-title":"Thromb. Res."},{"key":"3475_CR40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.thromres.2017.02.017","volume":"153","author":"P Korbal","year":"2017","unstructured":"Korbal, P., S\u0142omka, A., Sadowska-Krawczenko, I. & \u017bekanowska, E. Evaluation of tissue factor bearing microparticles in the cord blood of preterm and term newborns. Thromb. Res. 153, 95\u201396 (2017).","journal-title":"Thromb. Res."},{"key":"3475_CR41","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.talanta.2017.12.055","volume":"180","author":"EI Sinauridze","year":"2018","unstructured":"Sinauridze, E. I. et al. Thrombodynamics, a new global coagulation test: Measurement of heparin efficiency. Talanta 180, 282\u2013291 (2018).","journal-title":"Talanta"},{"key":"3475_CR42","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41390-019-0531-4","volume":"86","author":"H Haidl","year":"2019","unstructured":"Haidl, H. et al. New insights into neonatal coagulation: normal clot formation despite lower intra-clot thrombin levels. Pediatr. Res. 86, 719\u2013724 (2019).","journal-title":"Pediatr. Res."},{"key":"3475_CR43","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1203\/00006450-199912000-00001","volume":"46","author":"EF Grabowski","year":"1999","unstructured":"Grabowski, E. F. et al. Comparison of Tissue Factor Pathway in Human Umbilical Vein and Adult Saphenous Vein Endothelial Cells: Implications for Newborn Hemostasis and for Laboratory Models of Endothelial Cell Function. Pediatr. Res. 46, 742\u2013742 (1999).","journal-title":"Pediatr. Res."},{"key":"3475_CR44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ejogrb.2011.04.026","volume":"158","author":"M Uszy\u0144ski","year":"2011","unstructured":"Uszy\u0144ski, M., \u017bekanowska, E., Uszy\u0144ski, W., Kuczy\u0144ski, J. & \u017byli\u0144ski, A. Microparticles (MPs), tissue factor (TF) and tissue factor inhibitor (TFPI) in cord blood plasma. A preliminary study and literature survey of procoagulant properties of MPs. Eur. J. Obstetr Gynecol. Reprod. Biol. 158, 37\u201341 (2011).","journal-title":"Eur. J. Obstetr Gynecol. Reprod. Biol."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03475-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03475-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03475-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:02:18Z","timestamp":1748430138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03475-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,17]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["3475"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03475-y","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,17]]},"assertion":[{"value":"31 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"FIA is a former employee and cofounder of Hemacore, LLC. Hemacore LLC holds several patents and patent applications related to the diagnostic use of spatial clot growth and has developed the assay under the trade name Thrombodynamics\u00ae. Hemacore LLC did not have any additional role in the design of the study, collection and analysis of the data, or the decision to publish or prepare the manuscript. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. All other authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the ethics committee of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician Kulakov V.I. (Protocol code: 10, date of approval: 23 November 2017).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the legal representatives (parents) of the newborns to publish this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}