{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:42:22Z","timestamp":1787002942823,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Meta-analysis of probiotic administration to very preterm or very low birthweight (VP\/VLBW) infants shows reduced risk of necrotising enterocolitis (NEC).<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Separately reported outcomes for extremely preterm infants (&lt;28 weeks) or extremely low birth weight infants (&lt;1000\u2009g) (EP\/ELBW) are lacking meaning some clinicians do not administer probiotics to EP\/ELBW infants despite their high risk of NEC.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>We present data showing the gut microbiome is impacted in EP\/ELBW infants in a similar manner to VP\/VLBW infants, suggesting that risk reduction for necrotising enterocolitis that is microbiome driven will also be seen in EP\/ELBW infants, making probiotic administration beneficial.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-024-03520-w","type":"journal-article","created":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T01:01:43Z","timestamp":1724547703000},"page":"493-496","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of probiotics on gut microbiome of extremely preterm or extremely low birthweight infants"],"prefix":"10.1038","volume":"97","author":[{"given":"Lauren C.","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-2843","authenticated-orcid":false,"given":"Janet E.","family":"Berrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"3520_CR1","first-page":"CD005496","volume":"7","author":"S Sharif","year":"2023","unstructured":"Sharif, S., Meader, N., Oddie, S. J., Rojas-Reyes, M. X. & McGuire, W. Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants. Cochrane Database Syst. Rev. 7, CD005496 (2023).","journal-title":"Cochrane Database Syst. Rev."},{"key":"3520_CR2","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1093\/advances\/nmaa164","volume":"12","author":"M Deshmukh","year":"2021","unstructured":"Deshmukh, M. & Patole, S. Prophylactic probiotic supplementation for preterm neonates - a systematic review and meta-analysis of nonrandomized studies. Adv. Nutr. 12, 1411\u20131423 (2021).","journal-title":"Adv. Nutr."},{"key":"3520_CR3","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1136\/archdischild-2021-322252","volume":"107","author":"C Granger","year":"2022","unstructured":"Granger, C. et al. Necrotising enterocolitis, late-onset sepsis and mortality after routine probiotic introduction in the UK. Arch. Dis. Child Fetal. Neonatal. Ed. 107, 352\u2013358 (2022).","journal-title":"Arch. Dis. Child Fetal. Neonatal. Ed."},{"key":"3520_CR4","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1097\/MPG.0000000000002655","volume":"70","author":"CHP van den Akker","year":"2020","unstructured":"van den Akker, C. H. P. et al. Probiotics and Preterm Infants: A Position Paper by the European Society for Paediatric Gastroenterology Hepatology and Nutrition Committee on Nutrition and the European Society for Paediatric Gastroenterology Hepatology and Nutrition Working Group for Pr. J. Pediatr. Gastroenterol. Nutr. 70, 664\u2013680 (2020).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"3520_CR5","volume-title":"WHO Recommendations for Care of the Preterm or Low-Birth-Weight Infant.","author":"D Ledinger","year":"2022","unstructured":"Ledinger, D., Nu\u00dfbaumer-Streit, B. & Gartlehner, G. WHO Recommendations for Care of the Preterm or Low-Birth-Weight Infant. (World Health Organization, Geneva, 2022). 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Available from https:\/\/www.fda.gov\/media\/172606\/download."},{"key":"3520_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jpn3.12204","volume":"78","author":"CHP van den Akker","year":"2024","unstructured":"van den Akker, C. H. P. et al. Reevaluating the FDA\u2019s warning against the use of probiotics in preterm neonates: A societal statement by ESPGHAN and EFCNI. J. Pediatr. Gastroenterol. Nutr. 78, 1\u20136 (2024).","journal-title":"J. Pediatr. Gastroenterol. Nutr"},{"key":"3520_CR10","doi-asserted-by":"publisher","unstructured":"Embleton, N. D. et al. Probiotics for preterm infants and the recent FDA alert in the US Arch Dis Child Fetal Neonatal Ed. 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Dr Stewart declares lecture honoraria from Nestle\u0301 Nutrition Institute (La Tour-de-Peilz, Switzerland).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Written informed consent was obtained from all parents of participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}