{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:58:17Z","timestamp":1792119497391,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1038\/s41390-024-03778-0","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T14:58:51Z","timestamp":1738853931000},"page":"983-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing bedside measures of autonomic nervous system dysregulation in the PICU"],"prefix":"10.1038","volume":"98","author":[{"given":"Colleen M.","family":"Badke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia R.","family":"Pendergrast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra E.","family":"Weese-Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Nelson","family":"Sanchez-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"3778_CR1","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3389\/fped.2018.00280","volume":"6","author":"CM Badke","year":"2018","unstructured":"Badke, C. M., Marsillio, L. E., Weese-Mayer, D. E. & Sanchez-Pinto, L. N. Autonomic Nervous System Dysfunction in Pediatric Sepsis. Front. Pediatr. 6, 280 (2018).","journal-title":"Front. Pediatr."},{"key":"3778_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1177\/0885066609340519","volume":"24","author":"MW Dunser","year":"2009","unstructured":"Dunser, M. W. & Hasibeder, W. R. Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress. J. Intensive Care Med. 24, 293\u2013316 (2009).","journal-title":"J. Intensive Care Med."},{"key":"3778_CR3","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.jpeds.2011.06.044","volume":"159","author":"JR Moorman","year":"2011","unstructured":"Moorman, J. R. et al. Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial. J. Pediatr. 159, 900\u2013906.e901 (2011).","journal-title":"J. Pediatr."},{"key":"3778_CR4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/00003246-199802000-00040","volume":"26","author":"B Goldstein","year":"1998","unstructured":"Goldstein, B. et al. Decomplexification in critical illness and injury: relationship between heart rate variability, severity of illness, and outcome. Crit. Care Med. 26, 352\u2013357 (1998).","journal-title":"Crit. Care Med."},{"key":"3778_CR5","doi-asserted-by":"crossref","unstructured":"Badke, C. M., Marsillio, L. E., Carroll, M. S., Weese-Mayer, D. E. & Sanchez-Pinto, L. N. Development of a Heart Rate Variability Risk Score to Predict Organ Dysfunction and Death in Critically Ill Children. Pediatr. Crit. Care Med. 22, e437\u2013e447 (2021).","DOI":"10.1097\/PCC.0000000000002707"},{"key":"3778_CR6","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s12028-015-0182-1","volume":"24","author":"DM Olson","year":"2016","unstructured":"Olson, D. M. et al. Interrater Reliability of Pupillary Assessments. Neurocrit Care 24, 251\u2013257 (2016).","journal-title":"Neurocrit Care"},{"key":"3778_CR7","doi-asserted-by":"publisher","first-page":"e0272303","DOI":"10.1371\/journal.pone.0272303","volume":"17","author":"B Nyholm","year":"2022","unstructured":"Nyholm, B. et al. Superior reproducibility and repeatability in automated quantitative pupillometry compared to standard manual assessment, and quantitative pupillary response parameters present high reliability in critically ill cardiac patients. PLoS One 17, e0272303 (2022).","journal-title":"PLoS One"},{"key":"3778_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.resplu.2023.100399","volume":"14","author":"B Nyholm","year":"2023","unstructured":"Nyholm, B. et al. Specific thresholds of quantitative pupillometry parameters predict unfavorable outcome in comatose survivors early after cardiac arrest. Resusc. Plus. 14, 100399 (2023).","journal-title":"Resusc. Plus."},{"key":"3778_CR9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/pr.2011.38","volume":"71","author":"PP Patwari","year":"2012","unstructured":"Patwari, P. P. et al. Pupillometry in congenital central hypoventilation syndrome (CCHS): quantitative evidence of autonomic nervous system dysregulation. Pediatr. Res. 71, 280\u2013285 (2012).","journal-title":"Pediatr. Res."},{"key":"3778_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1152\/physiol.00035.2019","volume":"35","author":"R Yanovich","year":"2020","unstructured":"Yanovich, R., Ketko, I. & Charkoudian, N. Sex Differences in Human Thermoregulation: Relevance for 2020 and Beyond. Physiol. 35, 177\u2013184 (2020).","journal-title":"Physiol."},{"key":"3778_CR11","doi-asserted-by":"publisher","first-page":"S203","DOI":"10.1097\/CCM.0b013e3181aa5568","volume":"37","author":"DI Sessler","year":"2009","unstructured":"Sessler, D. I. Thermoregulatory defense mechanisms. Crit. Care Med. 37, S203\u2013S210 (2009).","journal-title":"Crit. Care Med."},{"key":"3778_CR12","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/ppul.23236","volume":"51","author":"R Saiyed","year":"2016","unstructured":"Saiyed, R. et al. Congenital central hypoventilation syndrome (CCHS): Circadian temperature variation. Pediatr. Pulmonol. 51, 300\u2013307 (2016).","journal-title":"Pediatr. Pulmonol."},{"key":"3778_CR13","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/JNN.0000000000000296","volume":"49","author":"DM Olson","year":"2017","unstructured":"Olson, D. M. et al. Establishing Normative Data for Pupillometer Assessment in Neuroscience Intensive Care: The \u201cEND-PANIC\u201d Registry. J. Neurosci. Nurs. 49, 251\u2013254 (2017).","journal-title":"J. Neurosci. Nurs."},{"key":"3778_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.sleep.2010.12.011","volume":"14","author":"MJ Hasselberg","year":"2013","unstructured":"Hasselberg, M. J., McMahon, J. & Parker, K. The validity, reliability, and utility of the iButton(R) for measurement of body temperature circadian rhythms in sleep\/wake research. Sleep. Med. 14, 5\u201311 (2013).","journal-title":"Sleep. Med."},{"key":"3778_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/PCC.0000000000000558","volume":"17","author":"MM Pollack","year":"2016","unstructured":"Pollack, M. M. et al. The Pediatric Risk of Mortality Score: Update 2015. Pediatr. Crit. Care Med. 17, 2\u20139 (2016).","journal-title":"Pediatr. Crit. Care Med."},{"key":"3778_CR16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10286-013-0209-7","volume":"23","author":"S Muppidi","year":"2013","unstructured":"Muppidi, S. et al. Dynamic pupillometry as an autonomic testing tool. Clin. Auton. Res. 23, 297\u2013303 (2013).","journal-title":"Clin. Auton. Res."},{"key":"3778_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1349-7","volume":"20","author":"MD Larson","year":"2016","unstructured":"Larson, M. D. & Singh, V. Portable infrared pupillometry in critical care. Crit. Care 20, 161 (2016).","journal-title":"Crit. Care"},{"key":"3778_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02801-3","volume":"22","author":"CM Privitera","year":"2022","unstructured":"Privitera, C. M. et al. A differential of the left eye and right eye neurological pupil index is associated with discharge modified Rankin scores in neurologically injured patients. BMC Neurol. 22, 273 (2022).","journal-title":"BMC Neurol."},{"key":"3778_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s10286-019-00639-3","volume":"30","author":"M Winston","year":"2020","unstructured":"Winston, M. et al. Pupillometry measures of autonomic nervous system regulation with advancing age in a healthy pediatric cohort. Clin. Auton. Res. 30, 43\u201351 (2020).","journal-title":"Clin. Auton. Res."},{"key":"3778_CR20","doi-asserted-by":"publisher","first-page":"937","DOI":"10.5664\/jcsm.9740","volume":"18","author":"I Khaytin","year":"2022","unstructured":"Khaytin, I. et al. Evolution of physiologic and autonomic phenotype in rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation over a decade from age at diagnosis. J. Clin. Sleep. Med. 18, 937\u2013944 (2022).","journal-title":"J. Clin. Sleep. Med."},{"key":"3778_CR21","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1136\/jmedgenet-2019-106601","volume":"57","author":"MS Carroll","year":"2020","unstructured":"Carroll, M. S., Ramirez, J. M. & Weese-Mayer, D. E. Diurnal variation in autonomic regulation among patients with genotyped Rett syndrome. J. Med. Genet. 57, 786\u2013793 (2020).","journal-title":"J. Med. Genet."},{"key":"3778_CR22","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0952-8180(00)00207-5","volume":"12","author":"SM Frank","year":"2000","unstructured":"Frank, S. M., El-Rahmany, H. K., Tran, K. M., Vu, B. & Raja, S. N. Comparison of lower extremity cutaneous temperature changes in patients receiving lumbar sympathetic ganglion blocks versus epidural anesthesia. J. Clin. Anesth. 12, 525\u2013530 (2000).","journal-title":"J. Clin. Anesth."},{"key":"3778_CR23","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1213\/ANE.0000000000000314","volume":"120","author":"MD Larson","year":"2015","unstructured":"Larson, M. D. & Behrends, M. Portable infrared pupillometry: a review. Anesth. Analg. 120, 1242\u20131253 (2015).","journal-title":"Anesth. Analg."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03778-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03778-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03778-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:12:24Z","timestamp":1759911144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-024-03778-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["3778"],"URL":"https:\/\/doi.org\/10.1038\/s41390-024-03778-0","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"18 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Parents or legal guardians gave consent for their children to be enrolled in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}