{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:11:38Z","timestamp":1792807898535,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1038\/s41390-025-03965-7","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T17:58:41Z","timestamp":1741370321000},"page":"1426-1435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-term follow-up strategies for children after severe acute kidney injury"],"prefix":"10.1038","volume":"98","author":[{"given":"Giovanni","family":"Ceschia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli A.","family":"Krallman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"3965_CR1","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1053\/j.ajkd.2015.07.019","volume":"67","author":"TL McGregor","year":"2016","unstructured":"McGregor, T. L. et al. Acute kidney injury incidence in noncritically ill hospitalized children, adolescents, and young adults: A retrospective observational study. Am. J. Kidney Dis. 67, 384\u2013390 (2016).","journal-title":"Am. J. Kidney Dis."},{"key":"3965_CR2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S2352-4642(17)30069-X","volume":"1","author":"JG Jetton","year":"2017","unstructured":"Jetton, J. G. et al. Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study. Lancet Child Adolesc. Health 1, 184\u2013194 (2017).","journal-title":"Lancet Child Adolesc. Health"},{"key":"3965_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1611391","volume":"376","author":"A Kaddourah","year":"2017","unstructured":"Kaddourah, A., Basu, R. K., Bagshaw, S. M. & Goldstein, S. L. Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults. N. Engl. J. Med. 376, 11\u201320 (2017).","journal-title":"N. Engl. J. Med."},{"key":"3965_CR4","doi-asserted-by":"publisher","unstructured":"Meena, J., Mathew, G., Kumar, J. & Chanchlani, R. Incidence of Acute Kidney Injury in Hospitalized Children: A Meta-analysis. Pediatrics, 151, https:\/\/doi.org\/10.1542\/peds.2022-058823 (2023).","DOI":"10.1542\/peds.2022-058823"},{"key":"3965_CR5","doi-asserted-by":"publisher","unstructured":"Hasson, D. C. et al. Persistent acute kidney injury and fluid accumulation with outcomes after the Norwood procedure: report from NEPHRON. Pediatric Nephrol. https:\/\/doi.org\/10.1007\/s00467-023-06235-y (2023).","DOI":"10.1007\/s00467-023-06235-y"},{"key":"3965_CR6","doi-asserted-by":"publisher","first-page":"476","DOI":"10.2215\/CJN.12101112","volume":"8","author":"SL Goldstein","year":"2013","unstructured":"Goldstein, S. L., Jaber, B. L., Faubel, S. & Chawla, L. S. AKI transition of care: A potential opportunity to detect and prevent CKD. Clin. J. Am. Soc. Nephrol. 8, 476\u2013483 (2013).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"3965_CR7","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1053\/j.ajkd.2011.10.048","volume":"59","author":"C Mammen","year":"2012","unstructured":"Mammen, C. et al. Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: A prospective cohort study. Am. J. Kidney Dis. 59, 523\u2013530 (2012).","journal-title":"Am. J. Kidney Dis."},{"key":"3965_CR8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41390-019-0737-5","volume":"88","author":"K Benisty","year":"2020","unstructured":"Benisty, K. et al. Kidney and blood pressure abnormalities 6 years after acute kidney injury in critically ill children: a prospective cohort study. Pediatr. Res. 88, 271\u2013278 (2020).","journal-title":"Pediatr. Res."},{"key":"3965_CR9","doi-asserted-by":"publisher","unstructured":"Ameta, P., Stoops, C. & Askenazi, D. J. Risk of chronic kidney disease in children who developed acute kidney injury secondary to nephrotoxic medication exposure in infancy. Ren. Fail. 45, https:\/\/doi.org\/10.1080\/0886022X.2023.2218486 (2023).","DOI":"10.1080\/0886022X.2023.2218486"},{"key":"3965_CR10","doi-asserted-by":"publisher","unstructured":"Hessey, E., Perreault, S., Dorais, M., Roy, L. & Zappitelli, M. Acute Kidney Injury in Critically Ill Children and Subsequent Chronic Kidney Disease. Can. J. Kidney Health Dis. 6, https:\/\/doi.org\/10.1177\/2054358119880188 (2019).","DOI":"10.1177\/2054358119880188"},{"key":"3965_CR11","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.kint.2017.02.021","volume":"92","author":"NL Madsen","year":"2017","unstructured":"Madsen, N. L., Goldstein, S. L., Fr\u00f8slev, T., Christiansen, C. F. & Olsen, M. Cardiac surgery in patients with congenital heart disease is associated with acute kidney injury and the risk of chronic kidney disease. Kidney Int. 92, 751\u2013756 (2017).","journal-title":"Kidney Int."},{"key":"3965_CR12","doi-asserted-by":"publisher","unstructured":"Menon, S., Kirkendall, E. S., Nguyen, H. & Goldstein, S. L. Acute kidney injury associated with high nephrotoxic medication exposure leads to chronic kidney disease after 6 months. J. Pediatr. 165, https:\/\/doi.org\/10.1016\/j.jpeds.2014.04.058 (2014).","DOI":"10.1016\/j.jpeds.2014.04.058"},{"key":"3965_CR13","doi-asserted-by":"publisher","unstructured":"Greenberg, J. H., Coca, S. & Parikh, C. R. Long-term risk of chronic kidney disease and mortality in children after acute kidney injury: A systematic review. BMC Nephrol. 15, https:\/\/doi.org\/10.1186\/1471-2369-15-184 (2014).","DOI":"10.1186\/1471-2369-15-184"},{"key":"3965_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1053\/j.ajkd.2022.07.005","volume":"81","author":"CH Robinson","year":"2023","unstructured":"Robinson, C. H. et al. Long-term Health Care Utilization and Associated Costs After Dialysis-Treated Acute Kidney Injury in Children. Am. J. Kidney Dis. 81, 79\u201389.e1 (2023).","journal-title":"Am. J. Kidney Dis."},{"key":"3965_CR15","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1681\/ASN.2020111665","volume":"32","author":"CH Robinson","year":"2021","unstructured":"Robinson, C. H. et al. Long-term kidney outcomes following dialysis-treated childhood acute kidney injury: A population-based cohort study. J. Am. Soc. Nephrol. 32, 2005\u20132019 (2021).","journal-title":"J. Am. Soc. Nephrol."},{"key":"3965_CR16","doi-asserted-by":"publisher","unstructured":"Silver S. A. et al. Ambulatory care after acute kidney injury: An opportunity to improve patient outcomes. Can J. Kidney Health Dis. 2, https:\/\/doi.org\/10.1186\/s40697-015-0071-8 (2015).","DOI":"10.1186\/s40697-015-0071-8"},{"key":"3965_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/kisup.2012.1","volume":"2","author":"JA Kellum","year":"2012","unstructured":"Kellum, J. A. et al. Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. Suppl. 2, 1\u2013138 (2012).","journal-title":"Kidney Int. Suppl."},{"key":"3965_CR18","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1053\/j.ajkd.2021.08.017","volume":"79","author":"M Wilson","year":"2022","unstructured":"Wilson, M. et al. Biomarkers During Recovery From AKI and Prediction of Long-term Reductions in Estimated GFR. Am. J. Kidney Dis. 79, 646\u2013656.e1 (2022).","journal-title":"Am. J. Kidney Dis."},{"key":"3965_CR19","doi-asserted-by":"publisher","unstructured":"Menez, S. et al. Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight, 6, https:\/\/doi.org\/10.1172\/jci.insight.147464 (2021).","DOI":"10.1172\/jci.insight.147464"},{"key":"3965_CR20","doi-asserted-by":"publisher","unstructured":"Ya-fen, Z., Jing, C., Yue-fei, Z. & Chang-ping, D. Reduction in NGAL at 48 h predicts the progression to CKD in patients with septic associated AKI: a single-center clinical study. Int. Urol. Nephrol. https:\/\/doi.org\/10.1007\/s11255-023-03689-9 (2023).","DOI":"10.1007\/s11255-023-03689-9"},{"key":"3965_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1001\/jamainternmed.2019.6390","volume":"180","author":"CY Hsu","year":"2020","unstructured":"Hsu, C. Y. et al. Post-Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression: The Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study. JAMA Intern. Med. 180, 402\u2013410 (2020).","journal-title":"JAMA Intern. Med."},{"key":"3965_CR22","doi-asserted-by":"publisher","first-page":"948","DOI":"10.2215\/CJN.05431207","volume":"3","author":"M Zappitelli","year":"2008","unstructured":"Zappitelli, M. et al. Ascertainment and epidemiology of acute kidney injury varies with definition interpretation. Clin. J. Am. Soc. Nephrol. 3, 948\u2013954 (2008).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"3965_CR23","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904","volume":"140","author":"JT Flynn","year":"2017","unstructured":"Flynn, J. T. et al. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Pediatrics 140, e20171904 (2017).","journal-title":"Pediatrics"},{"key":"3965_CR24","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.kint.2020.10.047","volume":"99","author":"CB Pierce","year":"2021","unstructured":"Pierce, C. B. et al. Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease. Kidney Int. 99, 948\u2013956 (2021).","journal-title":"Kidney Int."},{"key":"3965_CR25","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.ekir.2021.03.883","volume":"6","author":"A Srivastava","year":"2021","unstructured":"Srivastava, A. et al. Hospitalization Trajectories and Risks of ESKD and Death in Individuals With CKD. Kidney Int. Rep. 6, 1592\u20131602 (2021).","journal-title":"Kidney Int. Rep."}],"container-title":["Pediatric Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-03965-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-03965-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-03965-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:49:24Z","timestamp":1761205764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41390-025-03965-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["3965"],"URL":"https:\/\/doi.org\/10.1038\/s41390-025-03965-7","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"8 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"S.L.G. reports receiving personal fees from Baxter Healthcare, BioPorto Diagnostics, Calcimedica, Fresenius, Novartis, Nuwellis, MediBeacon, Medtronic, Otsuka and SeaStar Medical. None of these entities had any input into the study or manuscript, and these relationships are not relevant to the manuscript. No other disclosures were reported.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Written parental caregiver\/patient informed consent and assent were obtained prior to enrollment in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}