{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:55:56Z","timestamp":1785772556820,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy of Laryngeal Mask Airway (LMA) epinephrine during neonatal resuscitation has not been studied. We hypothesize that LMA epinephrine is as effective as endotracheal tube (ETT) epinephrine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen fetal lambs were randomized in ETT or LMA group for ventilation and airway epinephrine administration after cord occlusion to induce complete cardiac arrest. Lambs were delivered and instrumented to continuously record pulmonary and systemic hemodynamics. After 5\u2009min of cardiac arrest, lambs were resuscitated per NRP guidelines. Blood gases and plasma epinephrine levels were regularly measured during resuscitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were similar between the two groups. Incidence of return of spontaneous circulation (ROSC) was 5\/8 (62.5%) in both groups;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00. Mean time to ROSC was similar in both groups; 6\u2009minutes and 42\u2009\u00b1\u200965\u2009s in the LMA group, and 6\u2009min and 46 \u00b1 51\u2009s in the ETT group;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.92. There was no difference in plasma epinephrine levels at baseline (LMA 0.7\u2009\u00b1\u20090.5 vs. ETT 0.8\u2009\u00b1\u20090.2\u2009ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.88) and post-airway epinephrine administration (LMA 8.0\u2009\u00b1\u20093.1 vs. ETT 7.8\u2009\u00b1\u20094.6\u2009ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.85).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of LMA epinephrine for neonatal resuscitation is a suitable alternative to ETT epinephrine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The Neonatal Resuscitation Program (NRP) recommends a dose of airway epinephrine to be administered via the endotracheal tube (ETT) while intravenous access is being established. Endotracheal intubation is a highly skilled procedure. Laryngeal mask airway (LMA) is as effective in delivering positive pressure ventilation (PPV) and requires less training to achieve adequate competency to secure a stable airway. We show that LMA is a similar method to deliver epinephrine during neonatal resuscitation in the ovine model.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-025-04070-5","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T08:30:19Z","timestamp":1747038619000},"page":"2345-2351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study"],"prefix":"10.1038","volume":"99","author":[{"given":"Hamza","family":"Abbasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clariss","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Prasath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Kasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Gugino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Helman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco A.","family":"Paluch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Chandrasekharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munmun","family":"Rawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"4070_CR1","doi-asserted-by":"crossref","unstructured":"Rosa-Mangeret, F. et al. 2.5 Million annual deaths-are neonates in low- and middle-income countries too small to be seen? 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In the sentence beginning \u2018This was a randomized...\u2019 in this article, the term \u2018non-inferiority\u2019 has been redacted.","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2025","order":9,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":10,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41390-025-04546-4","URL":"https:\/\/doi.org\/10.1038\/s41390-025-04546-4","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}