{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:38:18Z","timestamp":1781534298271,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"SNUH Lee Kun-hee Child Cancer & Rare Disease Project","award":["24C-014-0000"],"award-info":[{"award-number":["24C-014-0000"]}]},{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2022-ER0603-02#"],"award-info":[{"award-number":["2022-ER0603-02#"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Retinopathy of prematurity (ROP) is influenced by factors, including gestational age (GA), oxygen exposure, and chorioamnionitis. However, the association between histologic chorioamnionitis (HCA) and ROP remains controversial. This study aimed to investigate the association between HCA and severe ROP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilized data from the National Korean Neonatal Network registry, focusing on infants with birthweights\u2009&lt;\u20091500\u2009g and GA\u2009&lt;\u200932 weeks. Univariate and multivariate logistic regression analyses assessed the association between HCA and severe ROP. Sub-cohort analyses were performed to evaluate the effect of HCA on severe ROP across different GA groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Infants in the HCA cohort had lower GA and birth weights, with a higher prevalence of any-stage and severe ROP compared to those in the without-HCA cohort. However, multivariate logistic regression showed an inverse association between HCA and severe ROP. Sub-cohort analyses revealed that HCA was associated with an increased risk of severe ROP in infants born at 26\u201328 and 28\u201331 weeks, while no significant association was observed in infants born at 23\u201325 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HCA may reduce the risk of severe ROP, suggesting that intrauterine inflammation could play a protective role. Further research is needed to elucidate underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Retinopathy of prematurity (ROP) is influenced by numerous perinatal and postnatal factors, including low gestational age, oxygen exposure, and chorioamnionitis. However, the association between chorioamnionitis and ROP remains controversial.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our study showed that histologic chorioamnionitis (HCA) was negatively correlated with severe ROP in preterm infants, even after adjusting for confounding factors such as gestational age and birth weight.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>These findings suggest that HCA may have a protective effect against severe ROP, potentially mediated by inflammatory markers.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-025-04093-y","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T16:11:07Z","timestamp":1747411867000},"page":"2139-2143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between histologic chorioamnionitis and severe retinopathy of prematurity"],"prefix":"10.1038","volume":"98","author":[{"given":"Young Mi","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Han","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-wook","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee-Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Suk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"4093_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/pr.2013.205","volume":"74","author":"H Blencowe","year":"2013","unstructured":"Blencowe, H., Lawn, J. 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The requirement for written informed consent was waived owing to the nature of the study involving the use of de-identified, registered data. With participation from 79 neonatal intensive care units across Korea, informed consent had initially been obtained from the parents of each infant for the participation and the publication of the data before their inclusion in the Korean Neonatal Network (KNN) registry.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}