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The high versus low HB group had higher percentiles of office BP: systolic, 75th [61; 81] vs. 57th [47; 69],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049 and diastolic, 70th [60; 78] vs. 55th [46; 65],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007, adjusted for obesity and arousal index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite similar levels of OAHI, children with higher HB demonstrate parasympathetic withdrawal and increased daytime blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>The hypoxic burden predicts cardiovascular morbidity\/mortality in adult obstructive sleep apnea syndrome.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Our study shows that in children with moderate to severe obstructive sleep apnea, despite similar levels of obstructive apnea-hypopnea index, those with higher hypoxic burden show cardiac autonomic nervous system dysfunction and increased daytime blood pressure.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This study is the first one suggesting that the hypoxic burden is a valuable marker of cardiovascular morbidity in childhood obstructive sleep apnea.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-025-04153-3","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T07:32:15Z","timestamp":1747985535000},"page":"270-275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypoxic burden as a cause of cardiovascular morbidity in childhood obstructive sleep apnea"],"prefix":"10.1038","volume":"99","author":[{"given":"Plamen","family":"Bokov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Dudoignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-0812","authenticated-orcid":false,"given":"Christophe","family":"Delclaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"4153_CR1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1081\/CEH-48874","volume":"27","author":"R Ito","year":"2005","unstructured":"Ito, R. et al. 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The experimental protocols were those routinely performed in our patients as usual care and were approved by the Comit\u00e9 d\u2019Evaluation de l\u2019Ethique des Projets de Recherche de Robert Debr\u00e9. The subjects and their parents were informed of the collection of their prospective data for research purposes, and they could request to be exempted from this study in accordance with French law (non-interventional observational research).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}