{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:34:19Z","timestamp":1792499659361,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Congenital diaphragmatic hernia (CDH) is characterised by ventilation disunity due to unilateral pulmonary hypoplasia. We aimed to describe lung function in each of the ipsilateral (hypoplastic) and contralateral CDH lungs during neonatal intensive care unit (NICU) admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, observational study including infants with left-sided CDH. Electrical impedance tomography (EIT) images of both lungs were obtained over 20\u2009min at three clinically distinct timepoints: pre-repair, post-repair and prior to NICU discharge. Centre of Ventilation (CoV, measure of regional distribution of tidal ventilation; &lt;50% favours contralateral lung), aeration and time constants were calculated between the\u00a0ipsilateral and contralateral lung.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen infants were included with median (range) gestational age 38 (34, 41) completed weeks, observed-to-expected lung-to-head ratio 51 (36, 67)% and 87% Type B or C lesion. Eight infants received high-frequency ventilation during admission. Ventilation was predominantly contralateral, with the ipsilateral lung ventilation increasing from pre-repair CoV 35 (31,\u00a050)% to 42 (36,\u00a049)% pre-discharge. Ipsilateral aeration was unchanged; 45 (38, 49)% of overall aeration pre-repair to 45 (33, 50)% pre-discharge. Time constants were 198 (143,\u00a0290) and 203 (141,\u00a0292) ms in the contra- and ipsilateral lung at discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lung function changes with time in CDH, and monitoring of each lung is possible using EIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Impact<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Respiratory support of infants born with congenital diaphragmatic hernia (CDH) is challenging due to an inability to determine the magnitude of ventilation disunity resulting from unilateral pulmonary hypoplasia.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Electrical impedance tomography (EIT) could describe the aeration and ventilation characteristics of the ipsi- and contra-lateral lungs throughout the NICU course in 15 infants with left-sided CDH.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Ventilation, but not aeration, in the ipsilateral lung increased from the\u00a0pre-repair state by discharge.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>This suggests EIT could be used to define lung function changes with time in CDH, providing a detailed understanding of each lung, which that may assist in refining care.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1038\/s41390-025-04185-9","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T10:00:48Z","timestamp":1750240848000},"page":"1773-1779","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Regional lung function in congenital diaphragmatic hernia assessed using electrical impedance tomography"],"prefix":"10.1038","volume":"98","author":[{"given":"Ellen","family":"Douglas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin N.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-4691","authenticated-orcid":false,"given":"David G.","family":"Tingay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"4185_CR1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S0022-3476(78)80162-0","volume":"92","author":"DL Levin","year":"1978","unstructured":"Levin, D. 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D.G.T. has not received payment for presentations or consultation, and neither entity had input into content of presentations. Sentec AG provided unrestricted consumables and software support for this study. M.C.R.I. purchased the EIT hardware used in the study. Sentec AG did not have any input into the design, conduct, interpretation and reporting of the study. The other authors have no other competing interests or conflicts of interest to declare related to this work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Written, informed, prospective parental consent was obtained for each infant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent Statement"}}]}}